• 제목/요약/키워드: Abuse of Process

검색결과 131건 처리시간 0.021초

합성세제의 성분해에 관한 조사연구 (Studies on Biodegradation of Synthetic Detergents)

  • 권숙표;정용;심길순
    • 약학회지
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    • 제21권4호
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    • pp.193-199
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    • 1977
  • ABS, Alkyl benzene sulfonate, persists for long periods in stream because of its resistance to biologic degradation. Its bio-degradation is very varied in the environments. This investigation was therefore undertaken in order to know the biodegradation of synthetic detergents which are comprising soft and hard forms from February 1976 to September 1976. The biodegradations by spontaneuos settling and aeration were determined. The reduction rates of ABS, DBS, and LAS were 9.8%, 13.7% and 10.4% by the settlings for 5 days at $25^{\circ}$ and 63.3%, 27.2%, and 43.9% by aeration respectively. It was not contributed effectively to biodegradate the synthetic detergents by the simulaneous incubation with micro-organisms isolated from sewage such as Enterobacter sp., E. coli, Bacillus sp., Flavobacterium sp., Pseudomonas sp., Staphylococcus sp., and etc. Tricking filter could also eliminate some amount of detergent. By the application of this investigation, it could be designed that detergents would be regulated in abuse in context with water pollution and be treated at a proper process in the sewage treatment plant to be installed.

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Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis

  • Mansoori, Abdul Anvesh;Jain, Subodh Kumar
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권12호
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    • pp.4803-4812
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    • 2015
  • Chronic alcohol and tobacco abuse plays a crucial role in the development of different liver associated disorders. Intake promotes the generation of reactive oxygen species within hepatic cells exposing their DNA to continuous oxidative stress which finally leads to DNA damage. However in response to such damage an entangled protective repair machinery comprising different repair proteins like ATM, ATR, H2AX, MRN complex becomes activated. Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma. There is increasing evidence that the inflammatory process is inherently associated with many different cancer types, including hepatocellular carcinomas. The generated reactive oxygen species can also activate or repress epigenetic elements such as chromatin remodeling, non-coding RNAs (micro-RNAs), DNA (de) methylation and histone modification that affect gene expression, hence leading to various disorders. The present review provides comprehensive knowledge of different molecular mechanisms involved in gene polymorphism and their possible association with alcohol and tobacco consumption. The article also showcases the necessity of identifying novel diagnostic biomarkers for early cancer risk assessment among alcohol and tobacco users.

청소년의 자살생각 관련 요인: 자아존중감과 우울의 매개효과를 중심으로 (Factors Associated With Adolescents' Suicidal Ideation: Focus on Self-Esteem and Depression as Mediators)

  • 박병금
    • 한국생활과학회지
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    • 제16권3호
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    • pp.505-522
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    • 2007
  • This study examined the effects of eco-system factors on adolescents' suicidal ideation and whether self-esteem and depression mediate in the process to provide theoretical basis for prevention and treatment for problems of adolescents who have suicidal ideation. 2,088 high school students were asked to complete self-administering questionnaires on eco-system factors and adolescents' suicidal ideation. Data were analyzed with frequencies, t-test, ANOVA with Scheffe ad-hoc test, correlation analysis using SPSS 12.0 program and AMOS 5.0 program. Study results were ; First, adolescents' suicidal ideation showed significant differences according to their gender, socio-economic financial status, family structure, and the type of school they attended. Second, self-esteem and depression were proved to have significant mediating effect. Child abuse victimization, subjective school achievement and influence of media coverage of celebrity suicide were most important variables which influenced adolescents' suicidal ideation. These results reinforce importance of understanding adolescents' suicidal ideation with eco-system perspective. Moreover, prevention programs for adolescents' suicide require differentiated strategies and tactics according to the target group characteristics.

마리화나 남용환자의 역동적인 발달요인과 문제해결 (Dynamic Developmental Factors and their Problem Solving of Patients that Abuse Marihuana)

  • 원정숙
    • 대한간호학회지
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    • 제4권3호
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    • pp.105-116
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    • 1974
  • This study was made on patients who were Hospitalized due to sickness caused by the abuse of marihuana at the Psychiatric Section of a hospital during the period from Feb. to Oct., 1974. The following conclusion was obtained by reviewing the literature with respect to the nursing, and problem solving of those patients. 1. It appears that marihuana is a comparatively mild intoxicant in ordinary preparation without causing physical dependence or tolerance. 2. According to the status of men who are marihuana smokers, approximately 20% of them were college students, those preparing to retake college entrance examinations, non-employed and pharmacists. The men belong mostly to the middle foreigner′s mistress of higher, income bracket, and in the case of women, most of the smokers were US. servicemen entertainers. 3. Dynamic developmental factors: Case 1. : The patient had a characteristic, hysterical and emotionally unitable character, and was of low intelligence, In addition, to this already existing problem, the added uses of marihuana caused a mental illness to develope. Case 2 : The character, was reserved and introspective, her creative power and sentiment was fading and his ability of self-control was weakened. She used the smoking of marihuana to get rid of her own feeling of inferiority complex and tensions coming from interpersonal relationships. Case 3 : The patient was unconditionally resistive to the authoritativeness of superiors and irresponsible in his relationship with women, in his attitude concerning sex in general. He smoked marihuana because he felt become peace-loving and get enchanted experience through smoking it. 4. The points of issue appearing from the above case; (1) Movement of anti-social feelings against the "established system" by the youngsters. (2) Family problem. (3) Shamelessness, loss of motivation, disorderly attitude toward the sex, (4) Worries concerning the future. (5) Lack of knowledge concerning smoking of cigarette and marihuana. Chronic use of marihuana made, those youngman who had originally been ambitions to achieve something in life, lazy, inefficient, unable to make long-term plans, are such weak mined persons that they did not try to overcome problems when encountered. This will pose a great and important question in the mental health of the society, 5. Treatment and Problem sieving According to the literature, we will have to place importance upon hospitalized treatment The phases of treatment were divided into five parts. (1) Prehospital phase (2) Withdrawal Phase (3) Rehabilitation phase (4) Transitional phase (5) After-care phase The experiments have proved that there was much progress in the recovery of patients through environment therapy, supportive therapy and group psychotherapy. This was the above mentioned 5 phases of treating process in accordance with the weekly schedule of the hospital. It was thought that the patients would require prolonged after care management even after they were released from the hospital and that they will also require periodic visit, to the hospital and doctor′s interview with their family. In conclusion, the question of the young generation and marihuana smoking is becoming a great social problem in which their resistances to the "established system" and society is growing in the from of antiestablishment movements. In our country, the smoking of marihuana is gradually developing, therefore, I think, that it would be a very fortunate thing for us, if this report could be helpful for the motivation of further study on the questions of the young generation and its problems.

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$^{13}C$$^{15}N$ 안정성 동위원소 비율 분석에 의한 원료의약품에서 에페드린 및 슈도에페드린의 기원 판별 (Discrimination of the Origin of Ephedrine and Pseudoephedrine for Pharmaceutical Powder Materials by Carbon and Nitrogen Stable Isotope Ratio Analysis)

  • 백승경;장문희;;정진일;양원경;최화경;정희선;표명윤
    • 약학회지
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    • 제53권5호
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    • pp.293-297
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    • 2009
  • The abuse of methamphetamine (MA) is one of the most serious drug abuses in Asia. And, the prevention of precursor production for abuse drug is one of the most effective drug control system. Isotope ratio analysis at natural abundance levels have been used to establish the environmental source or the geographic origin of various biological and nonbiological materials. Ephedrine, the precursor of MA, is produced by one of three methods; extraction from Ephedra plants, full chemical synthesis or via a semi-synthetic process involving the fermentation of sugar, followed by amination. We investigated the origin of ephedrine and pseudoephedrine based on the carbon and nitrogen values for nineteen pharmaceutical powder materials (PPMs) obtained from pharmaceutical company in Korea by stable isotope ratio mass spectrometry coupled to an elemental analyser (EA-IRMS). The carbon delta values for the ephedrine and pseudoephedrine were -24.21~-22.72 (mean=-23.72) $^{\cir}/_{\circ\circ}$ and -23.79~-22.71 (mean=-23.48) $^{\cir}/_{\circ\circ}$. The nitrogen delta values were 3.51~5.55 (4.43) $^{\cir}/_{\circ\circ}$ and 2.24~8.22 (5.42) $^{\cir}/_{\circ\circ}$. These results indicate that PPMs are semi-synthetic products. Therefore the origins of ephedrine(natural, semi-synthetic or synthetic) could be discriminated by using carbon and nitrogen stable isotope ratios. we are sure tat this stable isotope ratio analysis can discriminate the origins of precursors of methamphetamine.

강력범죄 피의자의 신상공개에 대한 법적 고찰 (A Legal Analysis of Identity Revelation of Malicious Crime's Suspect)

  • 정철호
    • 한국콘텐츠학회논문지
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    • 제12권7호
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    • pp.156-168
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    • 2012
  • 최근에 강도, 살인, 강간 등 강력범죄의 발생이 사회적 문제로 대두되면서, 추가적인 범죄피해의 예방과 국민의 알권리의 보장을 위해 범죄인에 대한 신상공개제도를 입법화하고 이를 확대하려는 경향이 대두되고 있다. 이러한 분위기는 재판절차를 통해 형이 확정되지 아니한 특정 범죄의 피의자의 얼굴 등 신상을 수사단계에서 공개하는 입법을 가능하게 하여, 피의자의 얼굴 공개를 허용하는 것을 뼈대로 한 '특정강력범죄 처벌에 관한 특례법 개정안'이 2010년 4월 국회에서 통과되었다. 그러나 특정 강력범죄에 대한 신상공개가 범죄피해의 예방에 큰 효과가 있다는 사실이 경험적으로 확인된 바가 없을 뿐만 아니라, 법원의 판결이 있기도 전에 피의자의 신상정보가 언론에 공개됨으로써 헌법이 보장하고 있는 피의자의 프라이버시나 인격권 및 공정한 재판을 권리와 같은 기본권을 침해하는 것일 뿐만 아니라, 헌법상 무죄추정의 원칙, 적법절차의 원칙, 이중처벌금지의 원칙(일사부재리의 원칙), 명확성의 원칙, 과잉금지의 원칙에도 위배되고, 형법상 책임원칙에도 위배된다 할 것이다.

주의력결핍 과잉행동장애 치료의 역사적 재조명 : 약물치료적 접근 (Revisiting History of Treatment of Attention Deficit Hyperactivity Disorder : Pharmacologic Approach)

  • 반건호;홍민하;이연정;한주희;오수현
    • 생물정신의학
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    • 제21권2호
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    • pp.37-48
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    • 2014
  • Besides from medical data, the patients who were previously called as attention disorder, mental instability, moral imbeciles, or moral defectives, can also be identified by exploring literatures and historical figures. In the past, as we can notice from the titles, they were recognized as a 'moral defect group'. And rather than treating them, separation from the society was the main solution. After the endemic encephalitis from 1917 to late 1920s, however, many survivors suffered from behavioral problems similar to those of the previous 'moral defect group' and studies on the relationship between brain damage and behavior problems were started henceforth. After being known as the 'minimal brain dysfunction', it was developed into the current attention-deficit/hyperactivity disorder. While the disease concept changed and developed over time, after numerous trials and errors, treatment medication starting from central nervous system stimulants such as amphetamine and methylphenidate is used for treatment in children and adult patients with ADHD, and most recently non-stimulants such as atomoxetine has become the one of the first line treatment options. Although we went through a thorough verification process of the safety and efficacy of the medication by contemplating the historical development process, we believe that adjustment is needed for remaining concerns on medication abuse and slight differences in disease paradigm and therapeutic philosophy depending on cultures.

단주과정에 있는 여성의 자기실현에 관한 생애사 연구 (Life History Study on the Self-realization of Woman in the Abstinence Process)

  • 강선경;이중교;차명희
    • 한국콘텐츠학회논문지
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    • 제20권1호
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    • pp.505-518
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    • 2020
  • 본 연구는 단주과정에 있는 여성의 자기실현에 관한 생애사 연구이다. 연구의 목적은 여성 알코올 중독에 관한 정황들을 탐색하여 치료 및 회복을 위한 논의의 지평을 확장시키고 사회복지적인 개입방안을 제시하는데 있다. 이를 위해 7년 이상 단주 중인 여성 알코올 중독 회복자가 참여했으며, 생애사 분석을 위한 텍스트는 Mandelbaum이 제안한 생애사 분석틀에 의거하여 '삶의 영역', '전환점', '적응'으로 나눴다. 자료분석 결과 <삶의 영역>은 '개인적인 삶의 차원', '자족차원의 삶의 차원', '사회적인 삶의 차원'의 총 3개의 영역으로 분석되었다. <전환점>은 '술을 마시고 폭력을 행사하는 아버지로부터 탈출', '상사의 폭행을 피해 직장을 포기함', 'AA(단주 자조모임) 참여로 서서히 치유의 길을 걸어감'으로 드러났다. <적응>은 '공부를 잘하는 적응전략', '술을 마심으로써 분노를 삭이는 적응전략', 'AA로의 의탁과 자기실현을 생각하는 적응전략' 으로 도출되었다. 이러한 연구결과를 바탕으로 자기실현에 입각한 사회복지 실천 및 정책 차원의 논의를 제시하였다.

조건값의 개수에 독립적인 조건부 프록시 재암호화 기법 (A Single Re-encryption key based Conditional Proxy Re-Encryption Scheme)

  • 손정갑;오희국;김상진
    • 정보보호학회논문지
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    • 제23권2호
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    • pp.147-155
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    • 2013
  • 프록시 재암호화 기법은 데이터를 재암호화 하는 과정에서 평문이 노출되지 않는 장점이 있다. 이 기법은 최근 클라우드 컴퓨팅, 모바일 오피스 등 서버를 이용하는 환경에서 저장된 데이터를 안전하게 공유하기 위한 기법으로 각광 받고 있다. 하지만 기존 기법은 재암호화 키를 반복적으로 사용할 수 있어 재암호화 오남용 문제가 발생한다. 이를 해결하기 위해 조건부 프록시 재암호화 기법이 제안되었지만 조건값의 수만큼 재암호화키를 생성해야하는 부담이 있다. 본 논문에서는 재암호화 키 생성 측면에서 효율적인 조건부 프록시 재암호화 기법을 제안하였다. 제안하는 기법은 조건값의 사용을 암호화와 복호화 과정으로 제한하여 조건값이 많아지더라도 재암호화 키를 추가로 생성하지 않아도 되는 장점이 있다. Weng 등의 기법이 재암호화 키 생성에 따른 시간 복잡도가 O(n)인 것에 비해, 제안하는 기법은 O(1)의 시간 복잡도를 가진다. 또한, 제안하는 기법은 선택적 암호문 공격에 안전하도록 설계되었다.

정보저장매체 반출 및 디지털 증거탐색 과정에서의 참여권 보장 환경에 대한 중요도-이행도 분석 (Enabling Environment for Participation in Information Storage Media Export and Digital Evidence Search Process using IPA)

  • 양상희;이중정;윤혜정
    • 한국전자거래학회지
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    • 제23권3호
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    • pp.129-143
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    • 2018
  • 최근 컴퓨터, 스마트 기기 등 디지털 매체의 사용이 급격히 늘어나면서, 이들 기기에 저장되는 정보 또한 방대하고 다양한 방식으로 저장되고 있다. 이들 정보는 수사기관의 영장에 기재된 범죄와 무관한 정보, 즉 별건 정보도 포함하고 있으므로, 이를 압수수색 할 경우 피압수자의 기본권과 방어권, 사생활 침해가 우려된다. 최근 들어 정보저장매체 등의 압수수색절차에서 피압수자 참여권의 중요성을 강조함으로써 참여권에 대한 관심이 커지고 있다. 이에 각 수사 기관은 참여권을 보장하기 위해 노력하고 있으나 구체적인 가이드라인이 없는 상태로 상황과 환경에 따라 각기 다른 방식으로 시행하고 있다. 이 과정에서 피압수자 측의 참여권 보장 악용으로 수사의 신속성 보안성이 저하되거나, 참여 시 원격초기화 등을 통한 증거인멸까지 시도되는 부작용이 발생하고 있다. 본 연구에서는 정보저장매체의 현장 외 반출 및 디지털 증거탐색 과정에서의 참여권 보장 환경에 대하여 4개 상위 영역과 30개 하위 측정 항목으로 전국의 디지털 증거분석관을 대상으로 설문조사를 실시하였다. 중요도 수준과 이행도 수준의 차이를 IPA 매트릭스 분석기법을 통해 절차, 장소, 사람, 기술요인 평가로 나누어 분석 하였다. 중점개선영역에 속한 7개 항목은 절차 항목 1개, 장소 항목 3개, 사람 항목 3개로 나타났다. 우선적인 지원 및 개선 사항이 요구되는 항목에 대한 피압수자의 기본권, 방어권, 사생활 침해에 대한 권리 보장과 부작용 사례를 최소화하고, 디지털 증거분석관의 신속도, 효율성을 저하시키지 않는 참여권 보장 환경을 만들기 위한 유용한 근거로 활용 되는 것에 본 연구의 의의가 있다.