• Journal of the Korean Society for Precision Engineering
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• v.34 no.1
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• pp.41-46
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• 2017

Magnetically levitated (Maglev) vehicles maintain a constant air gap between guideway and car bogie, and thereby achieves non-contact riding. Since the straightness and the flatness of the guideway directly affect the stability of levitation as well as the ride comfort, it is necessary to monitor the status of the guideway and to alert the train operators to any abnormal conditions. In order to develop a signal processing algorithm that extracts guideway irregularities from sensor data, virtual testing using a simulation model would be convenient for analyzing the exact effects of any input as long as the model describes the actual system accurately. Simulation model can also be used as an estimation model. In this paper, we develop a state-space dynamic model of a maglev vehicle system, running on the guideway that contains jumps. This model contains not only the dynamics of the vehicle, but also the descriptions of the power amplifier, the anti-aliasing filter and the sampling delay. A test rig is built for the validation of the model. The test rig consists of a small-scale maglev vehicle, tracks with artificial jumps, and various sensors measuring displacements, accelerations, and coil currents. The experimental data matches well with those from the simulation model, indicating the validity of the model.

• The Journal of Internal Korean Medicine
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• v.40 no.6
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• pp.1015-1025
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• 2019

Objectives: There have been many studies reporting the clinical value of Euphorbia kansui Radix or Melonis Calyx, but few systematic studies of the changes that may occur after taking such herbal medication. This study aimed to investigate the characteristics of the patient group, possible changes in blood test and InBody test results, and to discover the current state and future direction of clinical use of Euphorbia kansui Radix or Melonis Calyx. Methods: This study investigated patients who were hospitalized at Kyung-Hee University Korean Medicine Hospital for at least two days from 1 March 2016 to 1 March 2019, specifically evaluating patients aged 19 and over who underwent blood tests, including an electrolyte test and an InBody test before and after taking Euphorbia kansui Radix or Melonis Calyx. Results: Among a total of 134 patients, 72 patients (53.7%) were treated with Euphorbia kansui Radix and 62 patients (46.3%) were treated with Melonis Calyx, in the context of previously diagnosed abnormal weight gain. Laboratory findings were that Na and K levels were significantly reduced in both groups. In an InBody test, body mass index (BMI), intracellular water, extracellular water, protein, mineral, and skeletal muscle were significantly reduced in both groups. Conclusions: From these results, we suggest that, although Euphorbia kansui Radix and Melonis Calyx may not induce serious adverse effects, attention should be paid to the electrolyte level with the use of these treatments. In terms of syndrome differentiation, more clinical uses will be available in the future.

• Journal of Oriental Neuropsychiatry
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• v.1 no.1
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• pp.81-93
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• 1990

On the Scholastic Achievement Test grads it was compared Chung Nam's with Cheon Puk by dividing a city, a farm village, a fishing village and a mountine village. The results were as follows ; 1. The regional difference of arerage grades were that the first is a large city, the second amiddle city, the third a mountine villgae, the fourth a fishing village, the last a farm village all the same Chung Nam and Cheon Puk. 2. The grades of acity and a farm of Chung Nam are higher then these of Cheon Puk. 3. Cheon Puk is higher than Chung Nam on a middle city, a mountine and a fishing's grades. 4. The characteristic was that the region of non benefits of civilization effect obstruction of intelligence less than a city mountine village. 5. It is considered that the obstruction of intelligence may diminish when eating marine products at a fishing village than a city-fishing village by side dish. From the above results, acknowledging a regional charater, it is suggested that improrement of food life imitate city shund sublate lest the physiological function of Bie Wee(脾胃) should converse a puthological state, get out of the food life civilization misled abnormal food life to normal. Systemic study must continue for maintaining of tradition of regional difference food life. By that manner excellent food life civilization may creat. Therefore it is recognized that experience accumulation of Oriental Medicine theory also close contact food life, so may make constent effort.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.1
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• pp.93-99
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• 2014

This paper deals with the FC-MMA (Fast Convergence-Multi Modulus Algorithm) which is improving the convergence characteristics of the MMA (Multiple Modulus Algorithm) adaptive equalization algorithm that is used for the minimization of the intersymbol interference which occurs in the time dispersive communication channel. In the time varying charateristics and the abnormal situation like as outage of the communication channel, the adaptive equalizer needs to adapting the new environment more rapidly. For this problem, the residual isi and the maximum distortion performance index which are meaning the convergence characteristics are widely adapted in the adaptive equalizer. The 16-QAM signal is transmitted and it was confirmed that the proposed algorithm, the FC-MMA has the fast convergence performance such as in the 1.75 times fast in residual isi and 2.5 times fast in the maximum distortion in order to reaching the steady state compare to the MMA algorithm in the same channel environment by the computer simulation.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1957-1962
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• 2012

Bladder cancer is a common malignancy worldwide. Despite the increased use of cisplatin-based combination therapy, the outcomes for patients with advanced disease remain poor. Recently, altered activation of the PI3K/Akt/mTOR pathway has been associated with reduced patient survival and advanced stage of bladder cancer, making its upstream or downstream components attractive targets for therapeutic intervention. In the present study, we showed that treatment with DTCM-glutaramide, a piperidine that targets PDK1, results in reduced proliferation, diminished cell migration and G1 arrest in 5637 and T24 bladder carcinoma cells. Conversely, no apoptosis, necrosis or autophagy were detected after treatment, suggesting that reduced cell numbers in vitro are a result of diminished proliferation rather than cell death. Furthermore previous exposure to 10 ${\mu}g/ml$ DTCM-glutarimide sensitized both cell lines to ionizing radiation. Although more studies are needed to corroborate our findings, our results indicate that PDK1 may be useful as a therapeutic target to prevent progression and abnormal tissue dissemination of urothelial carcinomas.

• Journal of Korean Medical classics
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• v.31 no.3
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• pp.33-58
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• 2018

Objectives : Literatures related to Bianque are studied to discover the path of development and the impact of Bianque school's pulse diagnosis system. Methods : Texts regarding Bianque were searched in history books such as Shiji and Zhanguoce, and medical texts such as the medical books of Mawangdui Han Tomb, Huangdineijng, Maijing, and Qianjinyifang to understand how the Bianque school's pulse diagnosis system was developed. Results : 1. Bianque school's pulse diagnosis system was used to inspect the distribution pattern of blood vessels and discover the location of the disease including the palpatation realm such as only hard or only fall. 2. The system of inspection was created when the diagnosis method that uses the color of the pulse by using the color of blood vessels was added to the diagnostic method of pulse condition. 3. Adding the concept of pulse to the visual information that derives from pulse condition becomes pulsation. This is a diagnostic method that falls under the realm of palpation, and it was used to discover the location of disease. 4. The qi of pulse is motor that induces pulse, and this concept is used in order to understand how normal and abnormal pulsations appear, and to treat the circulation disorder of qi and blood. 5. Cubit skin examination is a method that comprehensively take into account the upper arm skin's cold and heat, slippery and roughness, and relax and tension state. This method was used together with other diagnostic methods. As described above, it seems that the diagnostic method with blood vessels used by Bianque school seems to have developed from Bianque's special inspection ability to the stage where it uses palpation, and then to the stage of cubit skin examination which uses both palpation and inspection.

• Journal of Korean Neurosurgical Society
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• v.37 no.1
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• pp.8-15
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• 2005

Objective: We evaluate temporal correlations between postoperative symptomatic and electrophysiological improvements, and assessed the recovery time required for patients with carpal tunnel syndrome(CTS) before returning to routine activities. Methods: 30 CTS patients were treated via the endoscopic monoportal approach, from March 2001 to September 2003. We assessed the symptoms (hyperesthesia in the finger tips, or abnormal sensations and painful numbness or night pain) and electrophysiological changes in the preoperative state, 1 month and 6 months after surgery. We marked the times at which patients became able to return to activities of daily living and work, after undergoing endoscopic carpal tunnel release. Results: At the end of the follow-up period, high levels of achievement and good outcomes were observed, with respect to both the symptoms and electrophysiological studies. We discovered significant differences between the preoperative and postoperative periods, especially in terms of motor nerve onset latency from $4.50{\pm}1.43$ to $3.97{\pm}0.69$ and sensory nerve conduction velocity, the wrist-to-finger from $19.81{\pm}10.03$ to $28.18{\pm}11.01$ and wrist-to-palm from $23.34{\pm}13.40$ to $31.79{\pm}13.38$(P<0.05 for each comparison). The average time interval required before return to activities of daily living was 26.4 days, and time interval required before return to work was 48.08 days. Conclusion: Electrophysiological improvements are largely consistent with symptomatic relief, but there is some disparity between electrophysiological and symptomatic improvement.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.1
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• pp.130-140
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• 2010

SIP (Session Initiation Protocol) is a signaling protocol to provide IP-based VoIP (Voice over IP) service. However, many security vulnerabilities exist as the SIP protocol utilizes the existing IP based network. The SIP Malformed message attacks may cause malfunction on VoIP services by changing the transmitted SIP header information. Additionally, there are several threats such that an attacker can extract personal information on SIP client system by inserting malicious code into SIP header. Therefore, the alternative measures should be required. In this study, we analyzed the existing research on the SIP anomaly message detection mechanism against SIP attack. And then, we proposed a Co-occurrence based SIP packet analysis mechanism, which has been used on language processing techniques. We proposed a association rule generation and an attack detection technique by using the actual SIP session state. Experimental results showed that the average detection rate was 87% on SIP attacks in case of using the proposed technique.

• The Plant Pathology Journal
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• v.30 no.2
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• pp.136-150
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• 2014

Although multiple transcription factors (TFs) have been characterized via mutagenesis to understand their roles in controlling pathogenicity and infection-related development in Magnaporthe oryzae, the causal agent of rice blast, if and how forkhead-box (FOX) TFs contribute to these processes remain to be characterized. Four putative FOX TF genes were identified in the genome of M. oryzae, and phylogenetic analysis suggested that two of them (MoFKH1 and MoHCM1) correspond to Ascomycota-specific members of the FOX TF family while the others (MoFOX1 and MoFOX2) are Pezizomycotina-specific members. Deletion of MoFKH1 (${\Delta}Mofkh1$) resulted in reduced mycelial growth and conidial germination, abnormal septation and stress response, and reduced virulence. Similarly, ${\Delta}Mohcm1$ exhibited reduced mycelial growth and conidial germination. Conidia of ${\Delta}Mofkh1$ and ${\Delta}Mohcm1$ were more sensitive to one or both of the cell cycle inhibitors hydroxyurea and benomyl, suggesting their role in cell cycle control. On the other hand, loss of MoFOX1 (${\Delta}Mofox1$) did not show any noticeable changes in development, pathogenicity, and stress response. Deletion of MoFOX2 was not successful even after repeated attempts. Taken together, these results suggested that MoFKH1 and MoHCM1 are important in fungal development and that MoFKH1 is further implicated in pathogenicity and stress response in M. oryzae.

• Toxicological Research
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• v.31 no.2
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• pp.97-104
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• 2015

The skin exposure to solar irradiation and photoreactive xenobiotics may produce abnormal skin reaction, phototoxicity. Phototoxicity is an acute light-induced response, which occurs when photoreacive chemicals are activated by solar lights and transformed into products cytotoxic against the skin cells. Multifarious symptoms of phototoxicity are identified, skin irritation, erythema, pruritis, and edema that are similar to those of the exaggerated sunburn. Diverse organic chemicals, especially drugs, are known to induce phototoxicity, which is probably from the common possession of UV-absorbing benzene or heterocyclic rings in their molecular structures. Both UVB (290~320 nm) and UVA (320~400 nm) are responsible for the manifestation of phototoxicity. Absorption of photons and absorbed energy (hv) by photoactive chemicals results in molecular changes or generates reactive oxygen species and depending on the way how endogenous molecules are affected by phototoxicants, mechanisms of phototoxcity is categorized into two modes of action: Direct when unstable species from excited state directly react with the endogenous molecules, and indirect when endogeneous molecules react with secondary photoproducts. In order to identify phototoxic potential of a chemical, various test methods have been introduced. Focus is given to animal alternative test methods, i.e., in vitro, and in chemico assays as well as in vivo. 3T3 neutral red uptake assay, erythrocyte photohemolysis test, and phototoxicity test using human 3-dimensional (3D) epidermis model are examples of in vitro assays. In chemico methods evaluate the generation of reactive oxygen species or DNA strand break activity employing plasmid for chemicals, or drugs with phototoxic potential.