• Korean Journal of Clinical Pharmacy
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• v.21 no.4
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• pp.394-399
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• 2011

이 증례는 알코올 중독증을 앓은 병력을 가졌으나 간 기능에 특이한 증후가 없던 환자가, 지역 사회 획득성 폐렴으로부터 유발된 중증 패혈증 치료를 받기 위해서 linezolid, moxifloxacin 과 함께 aztreonam을 초회 정맥주사 맞은 후, 아주 높은 수치의 alanine aminotransferase (ALT), aspartate aminotransferase (AST) 혈중 농도가 검출된 경우이다. 후속 치료에서 상기 3가지 항생제 대신 vancomycin과 ceftazidime을 주사했더니, ALT/AST가 빠르게 정상화됨이 관찰되었다. 이 증례 보고는 linzolid, moxifloxacin과 aztreonam을 함께 사용할 경우, 각별한 주의 관찰이 필요하며, 알코올 중독증을 앓은 병력을 가진 환자에게 투여 시 특별한 주의와 함께 AST/ALT혈중 수치를 검사토록 권하기 위한 것이다.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2005.05a
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• pp.222-231
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• 2005

본 논문에서는 자율 에이전트에 의해 미지의 공간을 탐사하는 실시간 그래프 탐색 알고리즘 $DFS-RTA^{\ast}$와 $DFS-PHA^{\ast}$를 제안하고 그 효율성을 비교한다. 두 알고리즘들은 모두 깊이-우선 탐색(DFS)을 기초로 하고 있으며, 직전 노드로의 빠른 후진(backtrack) 을 위해 각각 실시간 최단 경로 탐색 방법인 $RTA^{\ast}$와 $PHA^{\ast}$를 적용하는 것이 특징이다. 본 논문에서는 대표적인 3차원 온라인 게임 환경인 Unreal Tournament 게임과 지능형 캐릭터 에이전트인 KGBot를 이용한 실험을 통해 두 탐색 알고리즘의 완전성과 효율성을 분석해본다.

• Journal of Information Processing Systems
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• v.15 no.1
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• pp.159-168
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• 2019

Accurate forest fires detection algorithms remain a challenging issue, because, some of the objects have the same features with fire, which may result in high false alarms rate. This paper presents a new video-based, image processing forest fires detection method, which consists of four stages. First, a background-subtraction algorithm is applied to detect moving regions. Secondly, candidate fire regions are determined using CIE $L{\ast}a{\ast}b{\ast}$ color space. Thirdly, special wavelet analysis is used to differentiate between actual fire and fire-like objects, because candidate regions may contain moving fire-like objects. Finally, support vector machine is used to classify the region of interest to either real fire or non-fire. The final experimental results verify that the proposed method effectively identifies the forest fires.

• Preventive Nutrition and Food Science
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• v.12 no.3
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• pp.160-166
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• 2007

Response surface methodology (RSM) was used for the optimization of the baking process of cookies made with onion powders (onion cookie). Experiments were carried out according to a central composite design, selecting onion powder content $(1.15{\sim}8.86%)$ and baking temperature $(155.9{\sim}184.1^{\circ}C)$ as independent variables and pH, titratable acidity, moisture content, density, spread factor, CIE color parameters $(L^{\ast}-$, $a^{\ast}-$, and $b^{\ast}-values)$, and hardness as response variables. pH decreased with increasing amount of onion powder and baking temperature. Moisture content also decreased as the baking temperature increased. $L^{\ast}-$ and $b^{\ast}-values$ decreased but $a^{\ast}-values$ increased with increasing onion content and baking temperature. Most polynomial models developed by RSM were highly effective to describe the relationships between the studied factors and the responses. Overall optimization, conducted by overlaying the contour plots under investigation, was able to point out the optimal range of the independent variables within which the six responses were simultaneously optimized. The point chosen as representative of this optimal region corresponded to 4.01% onion powder content and $161.84^{\circ}C$ baking temperature. The predicted dependent or response values in the optimal region were: pH＝6.87, moisture content＝2.77%, $L^{\ast}-value＝68.45$, $a^{\ast}-value＝1.98$, $b^{\ast}-value＝34.64$, and spread factor＝9.41.

• Nutritional Sciences
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• v.5 no.4
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• pp.203-210
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• 2002

Aster scaber $T_{HUNB}$ (AST ; Charm-chui), a potent herbal medicinal plant, has a long tradition of use, being harvested as a wild plant, is said to stimulate appetite, and may act as a diuretic, antifebrile agent and painkiller. This study was conducted to investigate the immunomodulative effects of AST In mice, using in vitro and in vivo experiments. The immunomodulative effects were studied in vitro by measuring the proliferation of mice splenocytes and the production of three kinds of cytokines (IL-$\beta$, IL-6, and TNF-$\alpha$) by mice peritoneal macrophages which were cultured with sequential fractions of AST methanol extract (methanol, hexane, chlo-roform, ethylacetate, butanol and water). In an in vivo experiment using mice, different concentrations of AST water extract were orally administrated every other day for two weeks. The production of cytokines (IL-1$\beta$, IL-6, and TNF-$\alpha$) secreted by activated macrophages, and the proliferation of mice splenocytes, were used as indices for immunocompetence. In vitro supplementation using six fractions of AST in the range of 1 to 100$\mu$ g/ml enhanced splenocyte proliferation by 10.5% to 53% compared to the control. IL-1$\beta$production was significantly increased with the supplementation of butanol and water extracts of AST. Higher levels of IL-6 and TNF-$\alpha$production were detected with supplementation of methanol, ethylacetate, butanol or water extracts at the concentration of 100$\mu$ g/ml. In the in vivo study, the highest proliferation of splenocytes was seen in the mice orally administrated with the AST water extract at the concentration of 500mg/kg body weight. In the case of cytokine production, there were no significant differences in the production of IL-1$\beta$and IL-6 among the treated groups and the control. However, TNF-$\alpha$released by activated peritoneal macrophages were augmented by the oral administration of AST water extract. These results indicate that AST may enhance the immune functions by regulating splenocyte proliferation and cytokine production capacity in mice.

• Korean Chemical Engineering Research
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• v.59 no.1
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• pp.16-20
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• 2021

Since the durability evaluation for improving the durability of PEMFC polymer membranes is very important for the development of PEMFC, research and development of the polymer membrane durability evaluation protocol (AST) continues. Recently, DOE's polymer membrane chemical/mechanical durability evaluation AST was developed and applied to Nafion XL for review. In order to shorten the evaluation time, oxygen was used as a cathode gas instead of air, and it was finished in 144 hours. Since DOE AST has a large number of voltage changes with 45 seconds of humidification and 30 seconds of drying, the degradation of the electrode has more influence on the MEA durability. Therefore, one cycle time was lengthened with 60sec of wet/300sec of dry, and the drying time was made longer than the humidification time to further deteriorate the polymer membrane, and it was finished in 240 hours. It was confirmed that the DOE AST for evaluation of the durability of the polymer membrane was accompanied by electrode degradation.

• Clinical and Experimental Reproductive Medicine
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• v.49 no.1
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• pp.26-32
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• 2022

Objective: We investigated the effect of supplementing fertilization medium and/or culture medium with astaxanthin (AST) on the two phases of in vitro fertilization: gamete fertilization and embryo development. Methods: Mouse cumulus-oocyte complexes were divided into four groups with 5 µM AST added to the fertilization medium (group 3, n=300), culture medium (group 2, n=300), or both media (group 4, n=290). No AST was added to the control group (group 1, n=300). Results: The fertilization rate was significantly higher (p<0.001) in the groups using AST supplemented fertilization medium (group 3, 79.0%; group 4, 81.4%) than those without AST (group 1, 56.3%; group 2, 52.3%). The blastocyst rate calculated from the two-cell stage was significantly lower (p<0.001) in the groups using AST-supplemented embryo culture medium (group 2, 58.0%; group 4, 62.3%) than in those without AST (group 1, 82.8%; group 3, 79.8%). The blastocyst rate calculated from the number of inseminated oocytes was highest in group 3 (189/300, 63.0%) and lowest in group 2 (91/300, 30.3%) with statistical significance compared to other groups (p<0.001). There were significantly higher numbers of cells in the inner cell mass and trophectoderm, as well as significantly higher total blastocyst cell counts, in group 3 than in the control group. Conclusion: An increased blastocyst formation rate and high-quality blastocysts were found only in the fertilization medium that had been supplemented with AST. In contrast, AST supplementation of the embryo culture medium was found to impair embryo development.

• BMB Reports
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• v.44 no.9
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• pp.578-583
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• 2011

Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are biochemical markers used to test for liver diseases. Copy number variation (CNV) plays an important role in determining complex traits and is an emerging area in the study various diseases. We performed a genome-wide association study with liver function biomarkers AST and ALT in 407 unrelated Koreans. We assayed the genome-wide variations on an Affymetrix Genome-Wide 6.0 array, and CNVs were analyzed using HelixTree. Using single linear regression, 32 and 42 CNVs showed significance for AST and ALT, respectively (P value < 0.05). We compared CNV-based genes between the current study (KARE2; AST-140, ALT-172) and KARE1 (AST-1885, ALT-773) using NetBox. Results showed 9 genes (CIDEB, DFFA, PSMA3, PSMC5, PSMC6, PSMD12, PSMF1, SDC4, and SIAH1) were overlapped for AST, but no overlapped genes were found for ALT. Functional gene annotation analysis shown the proteasome pathway, Wnt signaling pathway, programmed cell death, and protein binding.

• 한국연소학회:학술대회논문집
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• 2005.10a
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• pp.275-280
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• 2005

At previous study, nitrogen oxide emission was decreased with decreasing pressure index. This tendency was explained by the flame oscillation with changing combustor pressure. In this study, the characteristics of flame oscillation with changing combustor pressure were investigated. It can be found that flame length is extended and flame width is narrowed by decreasing combustor pressure. It can be observed that pilot flame and the surrounding air converge on the inner flame in the $P^{\ast}{\geqq}1$ conditions and that surrounding air and flow pattern was widely dispersed in the $P^{\ast}<1$ conditions. In the respect of average flame length, low fluctuation was shown in the $P^{\ast}<1$ conditions. On the other hands, large fluctuation was shown in the $P^{\ast}<1$ conditions. Flame oscillation are observed from $P^{\ast}=$ 0.98 in the condition of $P^{\ast}<1$ and the amplitude of flame oscillation becomes larger when $P^{\ast}$ is lowered. These results demonstrate that low NOx phenomenon was caused by flame oscillation with changing combustor pressure.

• Korean Journal of Agricultural Science
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• v.47 no.1
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• pp.173-182
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• 2020

Human Astrovirus (HuAstV), known as a waterborne virus, is a group IV positive-sense single-stranded RNA that belongs to Astroviridae. The first outbreak of HuAstV was reported in England in 1975. HuAstV can exist not only among clinical patients but also in various water environments, such as water for agriculture and vegetables. For diagnosis of HuAstV from water samples, a polymerase chain reaction (PCR) system has been developed. However, the PCR-based diagnostic method has problems in field application, such as reaction time, sensitivity and specificity. For this reason, in this study we developed the loop-mediated isothermal amplification assay (LAMP) system, aimed specifically at HuAstV. Three prepared LAMP primer sets were tested by specificity, non-specificity and sensitivity; one LAMP primer set was selected with optimum reaction temperature. The developed LAMP primer set reaction conditions were confirmed at 62℃, and detection sensitivity was 1 fg/μL. In addition, restriction enzyme HaeIII (GG/CC) was introduced to confirm that the LAMP reaction was positive. As a result, selected LAMP primer set was 100 - 1000 times more specific, rapid, and sensitive than conventional-nested PCR methods. For verification of the developed LAMP assay, twenty samples of cDNA from groundwater samples were tested. We expect that the developed LAMP assay will be used to diagnose HuAstV from various samples.