• 한국컴퓨터정보학회논문지
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• 제8권4호
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• pp.28-34
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• 2003

ASN.1은 망 관리에 필요한 기초적인 제반기술이다. ASN.1의 개발에는 ASN.1 명세 언어를 파싱하는 컴파일러 작업과 컴파일 결과 생성된 자료들을 DB에 입력하고, 입력된 자료를 사용자에게 프리티프린팅하여 보여주는 작업이 요구된다. 본 논문에서는 ASN.1 명세를 객체지향 언어인 C++로 자동적으로 변환하여 주는 원시 코드 자동 생성기를 설계하고 구현한다. 이와 함께 ASN.1 개발환경에 필요한 그래픽 사용자 인터페이스, DB 인터페이스 및 ASN.1 브라우저를 포함하는 통합 환경을 제공한다. 본 시스템의 구현은 Objectivity 데이타베이스를 이용하였고, 컴파일러 작업에서는 컴파일러 보조 도구인 flex와 byacc을 이용하였으며, 인터페이스 언어로는 Tcl/Tk를 사용하였다.

• 전자공학회논문지A
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• 제33A권3호
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• pp.28-37
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• 1996

Syntax notation one (ASN.1) defined by ITU-T and ISO, is a formal abstrct specification language which has been widely used in international standards specifiation to inteconnect distributed open systems. It si necessary to have well defined encoder/decoder modules which taranslate ASN.1 datum to BER octets stream to interconnect distributed open systems. In this paper, we designed and implemented a new ASN.1-to-C compiler, called HYASNC (hanyang ASN.1-to-C), which atutomatically translates and ASN.1-to-C compiler, called HYASNC (hanyang ASN.1-to-C), which automatically translates an ASN.1 specification into C-language BER encoders and decoders with simple and neat I/F for the defined ASN.1 data types, and enhanced BER (basic encoding rules)encoding/decoding libraries, called HY(hanyang)BER library, and useful utility functions. And this paper discusses HYASNC compiler, HY BER runtime library's design and implementation principles, and also evaluates the perfomrance of HY BER library and the interoperability with other ASN.1 compilers.

• 정보처리학회논문지C
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• 제11C권4호
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• pp.463-470
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• 2004

ASN.1/GDMO는 TMN(Telecommunication Management of Network)에서 망 관리에 이용되는 관리 객체이다. 그러나 ASN.1/GDMO는 망관리를 위해 직접 이용되는 것이 아니라 객체지향 요소를 갖는 또 다른 언어로 변환되어 이용된다. 따라서 ASN.1/GDMO를 조작할 수 있는 개발 환경이 필요하다. 본 논문에서는 ASN.1/GDMO의 요소를 사용자 인터페이스(GUI)를 통해 관리할 수 있는 편집기와 브라우저를 개발하고, DB와 연동될 수 있는 통합환경을 개발하였다. 본 논문의 구현은 UNIX상에서 이루어졌으며, 컴파일러 보조도구인 FLEX와 BYACC을 이용하였다. 또한 DB고는 Objectivity DB를 이용하였으며 인터페이스 언어로 Tcl/Tk를 사용하였다 본 논문의 실험에서는 구현된 ASN.1 및 GDMO의 통합환경을 보여주며, 이 시스템을 활용하면 효율적으로 망 관리를 할 수 있다는 것을 보여준다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3299-3303
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• 2012

Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis. Methods: We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2. Results: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI =1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI =1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI =1.02-1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed. Conclusions: This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.

• 전자공학회논문지A
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• 제33A권6호
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• pp.1-10
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• 1996

Protocol specifications and service definitions for distributed open system applications are defined using ASN.1. Therefore, to implement an open system application likes MHS, it is necessary to have well defined encoding/decoding modules which translate ASN.1 protocol specifications into their transfer syntaxes. However, that work is usually tedius, time consuming, and error prone. In this paper, we designed and implemented a new ASN.1 tool set which includes a new ASN.1 run-time library, called HY BER/DER, and an enhanced ASN.1-to-C compiler, called HYASNC$^{+}$. HYASNC$^{+}$ automatically generates C language encoder/decoder stub files and heder files for basic ASN.1 types and subtypes defiend in X.208 recommandation, and all X400 MHS system macro definitions. And, we evaluated the performance of HYASNC$^{+}$ compiler and HY BER/DER run-tiem library, and tested the interoperability of ASN.1 run-time library.

• Journal of Acupuncture Research
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• 제38권2호
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• pp.140-145
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• 2021

Background: Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100-500 mg/kg) was examined. Methods: Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats' left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results: All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion: ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain.

• 소프트웨어공학소사이어티 논문지
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• 제25권2호
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• pp.35-47
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• 2012

Variable Message Format(VMF)는 제한된 대역폭을 가지는 통신 환경에서 전술 정보를 효율적으로 교환하기 위하여 개발된 통신 메시지 표준으로, 지시자의 사용을 통해 단지 요구된 정보만을 전송할 수 있도록 메시지 길이 및 구조를 가변적으로 정의할 수 있도록 설계되었다. 그러나 이러한 가변성은 메시지를 효과적으로 분석하고 그 의미를 추출하는 것을 어렵게 할 뿐만 아니라, 메시지의 추가나 변경 시에 메시지 처리와 관련된 소프트웨어를 매번 수정하고, 이를 사용하는 모든 기기에 다시 배포해야 하는 번거로움이 있다. 본 논문에서는 국제 표준의 정형 기법인 ASN.1을 이용하여 VMF 메시지를 표현하는 체계적인 방법을 제안한다. 비트열 형태의 VMF메시지를 구조적인 ASN.1 자료 구조로 표현함으로써 프로토콜 설계자는 고 수준에서 메시지의 구조와 그 값을 다룰 수 있으며, ASN.1을 지원하는 다양한 도구들을 사용할 수 있다. 제안하는 방법은 VMF 메시지 세그먼트들에 대해 템플릿을 정의하고, 이를 조합하여 다양한 VMF 메시지를 표현한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3821-3824
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• 2012

Aim: SNPs of ERCC1 and ERCC2 genes have been found to be associated with response to platinum therapy in different clinical settings. In the current study, we investigated the relationship of SNPs in ERCC1 and ERCC2 to cisplain response and survival in osteosarcoma patients. Methods: 267 consecutive patients diagnosed with osteosarcoma between January 2003 to January 2005 were followed up until the end of January 2010. ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln polymorphisms were detected based upon the Sequenom MassARRAY platform.Results: For ERCC1 Asn118Asn, the variant genotype T/T was strongly significantly associated with a higher event free survival when compared with the wild-type C/C, with an adjusted OR (95% CI) of 0.39 (0.14-0.95). ERCC2 751 A/A genotype showed increased event free survival of osteosarcoma (HR=0.44; 95%CI=0.10-0.87). However, we did not find significant association of ERCC1 Gln504Lys and ERCC2 Asp312Asn polymorphisms with prognosis of osteosarcoma. Conclusions: We first report associations of four SNPs, ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln, with risk of death from osteosarcoma in a Chinese population, indicating ERCC1 118T/T and ERCC2 A/A may be used as surrogate markers for clinical outcome of osteosarcoma treatmetn with cisplain.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.231-236
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• 2013

Background: Published data regarding the association between xeroderma pigmentosum group D (XPD) Lys751Gln and Asp312Asn polymorphisms and gastric cancer susceptibility havew been inconclusive. This meta-analysis was therefore performed toobtain a more precise estimation of any relationship. Materials and Methods: A comprehensive literature search was conducted to identify all case-control studies of Lys751Gln and Asp312Asn polymorphisms and susceptibility to gastric cancer. Summary odds ratios (ORs) and its 95% confidence intervals (95% CIs) were calculated using a random-effects model with the software STATA (version10.0). Results: A total of 12 case-control studies including 3,147 cases and 4,736 controls were included. Overall, no significant associations were found in some models (for Lys751Gln: Lys/Gln vs Lys/Lys: OR=1.144, 95% CI=0.851-1.541, Gln/Gln vs Lys/Lys: OR=1.215, 95% CI = 0.740-1.955, dominant model: OR=1.137, 95% CI=0.818-1.582; recessive model: OR=1.123, 95% CI=0.765-1.650; for Asp312Asn: Asp/Asn vs Asp/Asp: OR=1.180, 95% CI=0.646-2.154, dominant model: OR=1.380, 95% CI = 0.812-2.346), but significantly elevated susceptibility was found for Asp312Asn polymorphism in some models (Asn/Asn vs Asp/Asp: OR=2.045, 95% CI=1.254-3.335, recessive model: OR=1.805, 95% CI =1.219-2.672), for the additive model, the XPD Lys751Gln and Asp312Asn polymorphisms were not significantly associated with gastric cancer susceptibility. In stratified analyses, significantly elevated susceptibility was found for some models in the Chinese population. Conclusion: This meta-analysis suggested the XPD Asp312Asn polymorphism might be a potential biomarker of gastric cancer susceptibility in overall population, while both XPD Lys751Gln and Asp312Asn polymorphisms might be risk factors of gastric cancer susceptibility in Chinese.

• Mycobiology
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• 제42권4호
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• pp.322-330
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• 2014

The aim of this study was to identify and characterize new Flammulina velutipes laccases from its whole-genome sequence. Of the 15 putative laccase genes detected in the F. velutipes genome, four new laccase genes (fvLac-1, fvLac-2, fvLac3, and fvLac-4) were found to contain four complete copper-binding regions (ten histidine residues and one cysteine residue) and four cysteine residues involved in forming disulfide bridges, fvLac-1, fvLac-2, fvLac3, and fvLac-4, encoding proteins consisting of 516, 518, 515, and 533 amino acid residues, respectively. Potential N-glycosylation sites (Asn-Xaa-Ser/Thr) were identified in the cDNA sequence of fvLac-1 (Asn-454), fvLac-2 (Asn-437 and Asn-455), fvLac-3 (Asn-111 and Asn-237), and fvLac4 (Asn-402 and Asn-457). In addition, the first 19~20 amino acid residues of these proteins were predicted to comprise signal peptides. Laccase activity assays and reverse transcription polymerase chain reaction analyses clearly reveal that $CuSO_4$ affects the induction and the transcription level of these laccase genes.