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http://dx.doi.org/10.7314/APJCP.2012.13.7.3299

Association Between XPD Asp312Asn Polymorphism and Esophageal Cancer Susceptibility: A Meta-analysis  

Duan, Xiao-Li (Department of Digestion Medicine, Taihe Hospital, Hubei University of Medicine)
Gong, Heng (Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine)
Zeng, Xian-Tao (Department of Stomatology, Taihe Hospital, Hubei University of Medicine)
Ni, Xiao-Bing (Department of Stomatology, Taihe Hospital, Hubei University of Medicine)
Yan, Yan (Department of Stomatology, Taihe Hospital, Hubei University of Medicine)
Chen, Wen (Department of Medical Imaging, Taihe Hospital, Hubei University of Medicine)
Liu, Guo-Lei (Department of Otolaryngology, Taihe Hospital, Hubei University of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.7, 2012 , pp. 3299-3303 More about this Journal
Abstract
Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis. Methods: We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2. Results: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI =1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI =1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI =1.02-1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed. Conclusions: This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.
Keywords
XPD; excision repair; polymorphism; esophageal cancer; susceptibility; meta-analysis;
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