• Journal of Microbiology and Biotechnology
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• 제16권4호
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• pp.531-537
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• 2006

Lactic acid-producing bacteria (LABs) are known to have various beneficial properties for health. However, they are generally considered to have an adverse effect on teeth, since they produce acid. Nonetheless, milk and cheese containing specific LAB strains were recently found to have an inhibitory effect on dental caries in children, with an inhibitory activity towards the growth of Streptococcus mutans suggested as the responsible mechanism. Accordingly, the current study selected a probiotic candidate for oral health and studied its inhibitory mechanism against dental caries. Twenty-two LAB species belonging to eleven genuses were screened for promoting bone nodule formation using direct microscopic examination. Only one isolate, Weissella kimchii strain PL9001, increased the bone nodule formation significantly. The addition of W. kimchii strain PL9001 to bone cells prepared from mouse calvaria increased the bone nodule formation, calcium accumulation, and activity of alkaline phosphatase (the osteoblastic marker). Moreover, W. kimchii strain PL9001 inhibited the invasion of Streptococcus mutans into bone cells, and an organic extract of the culture supernatant of W. kimchii strain PL9001 inhibited the growth of Strep. mutans. Therefore, the results suggest that W. kimchii strain PL9001 can be used as a preventive measure against dental caries. This is the first time that a LAB has been shown to promote bone nodule formation and prevent the invasion of Strep. mutans into bone cells.

• 한국콘텐츠학회논문지
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• 제7권12호
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• pp.231-237
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• 2007

최근에 많은 정부출연 연구기관과 정보유통서비스 기관들이 ISO 9001 품질경영시스템을 도입하여 그들 조직의 업무 수행도를 향상시키는데 대한 관심이 두드러지게 증가하고 있는 실정이다. 하지만 도입시에 조직의 특성 및 현황을 제대로 반영하지 않아서 시스템의 요구사항과 프로세스가 지향하는 목표화의 현실적 차이 때문에 ISO 9001 품질경영시스템 운영에 따른 효과를 제대로 누리지 못하고 있다. 이에 한국과학기술정보연구원(KISTI)은 프로세스 표준화를 통한 생산성 증대 및 조직의 경쟁력 증가를 위해 ISO 9001 시스템의 요구사항을 반영하기 위한 프로세스 분석을 통하여 표준시스템 지향적 프로세스를 도출하였다. 그 결과, KISTI는 2003년 11월 11일에 ISO 9001:2000 인증을 받았고, 품질경영 업무를 수행함으로서, 고객 만족도 증가, 업무의 효율성 증대 및 업무처리 시간 단축 등의 효과를 얻을 수 있었다.

• 디지털융복합연구
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• 제14권11호
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• pp.181-191
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• 2016

본 연구의 목적은 융 복합 시대에 자동차 전장부품인 자동차 고무 자바라를 생산하는 중소제조업체의 기업 경쟁력을 확보하기 위한 경영혁신에 대한 새로운 경영기법인 ISO9001품질경영시스템 요구사항 관점에서 고무자바라제품 생산기업의 경영성과를 분석하는데 있다. 이를 위해서, 자동차 부품 생산업체중, 고무 자바라 제품을 생산하는 업체를 대상으로 방문조사를 실시하였다. 연구결과, 첫째, 중소자동차 고무 자비라 부품업체에서 ISO 9001 품질경영 시스템의 4가지 핵심 요구사항 중, 경영자 책임과 자원관리가 경영성과에 긍정적 영향을 미치는 것으로 나타났다. 또한, 직급별로 차이를 조사한 결과, 상위 직급 집단은 경영자 책임이, 하위 직급 집단은 ISO 9001에 따른 품질경영에 대한 인식도가 저조한 것으로 나타났다. 이는 중소 자동차 전장부품인 자동차 고무 자바라 생산에 대한 개선 방향 컨설팅 지칭과 생산성 향상 전략 방안을 수립하는데 기여하게 될 것이다.

• 산업경영시스템학회지
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• 제40권3호
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• pp.38-48
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• 2017

ISO 9001 Quality Management Systems-Requirements has been revised in 2015. It has been updated four times since its publication in 1987. It is the most widely used International Standard in the world. There are over one million companies and organizations in over 170 countries certified to ISO 9001 from an ISO survey. Organizations are supposed to be certified to this new version by late 2018. The key changes in ISO 9001:2015 are to establish a High Level Structure (HLS) and focus on Risk-Based Thinking (RBT). Risk-Based Thinking means the process approach to decide how risk is addressed in establishing the processes to improve process outputs and prevent undesirable results. It pursues process planning and controls based on risks so that organizations can improve the effectiveness of the quality management system. It maintains and manages a Quality Management System that inherently addresses risks and meets objectives. In this article we firstly attempt to explain how to understand the fundamental concept of Risk-Based Thinking which is a systematic approach to consider risks rather than treating prevention as a separate component of a Quality Management System. We comment on the detailed requirements that contain risks in ISO 9001:2015 clauses. We also summarize recent advances on the risk assessment and management in line with ISO 31000:2009 Risk Management-Principles and Guidelines. We finally propose the practical risk management procedures for implementing ISO 9001:2015 with an emphasis on RBT. This article would contribute to help quality managers and practitioners convert to ISO 9001:2015.

• Journal of Microbiology and Biotechnology
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• 제14권4호
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• pp.680-685
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• 2004

The capability of lactic acid bacteria (LABs) to adhere to intestinal epithelial cells and vaginal epithelial cells is an important factor in the formation of a barrier to prevent the colonization of pathogenic bacteria. In addition, the ability to coaggregate with pathogens and production of antimicrobial agents also allow LABs to fight against pathogens. In this work, Weissella confusa PL9001 was tested for its ability to inhibit the growth and adherence of genitourinary pathogens, including Candida albicans, Escherichia coli, Staphylococcus aureus, and vancomycin-resistant Enterococcus faecium (VRE), isolated from the urine of hospitalized female patients. W. confusa PL9001 was found to coaggregate with the four pathogens, as observed with a light microscope and scanning electron microscope. In competition, exclusion, and displacement tests, the adherence of the pathogens to T24 bladder epithelial cells was also inhibited by W. confusa PL9001. Accordingly, these results suggest that W. confusa PL9001 is potentially useful for both preventive and therapeutic treatment of genitourinary infections.

• 산업경영시스템학회지
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• 제30권3호
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• pp.135-149
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• 2007

This paper investigates the relative effect of each ISO 9001 : 2000 quality management system's requirement and business performance. The empirical tests are conducted in ISO 9001 certification companies. As a result, the $1^{st}$, it shows the requirements positively affect performance of financial. The $2^{nd}$, also it shows the requirements positively affect non-financial performance. The $3^{rd}$ also it show the non-financial performance positively effect performance of financial performance.

• 산업융합연구
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• 제13권3호
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• pp.27-39
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• 2015

This Study aims to analyze the management performances of the rubber products from the perspectives of ISO9001 Quality Management System, which is a new management technique for management innovation, in order to secure the competitiveness of the small and medium manufacturers of rubber products for automobile as automobile application components. The results of the analysis can be summarized as follows: First, as the results of the analysis of effect of the (1) responsibility of the management, (2) resources management, (3) realization of the products, and (4) measurement, analysis and improvement, which are the 4 core requirements of the ISO9001 Quality Management System, on the management performances of the small and medium sized manufacturers of the rubber components for automobile, it was found that only the responsibility of the management and resources management affect the management performance. The above research findings imply that the company must absolutely rely on the upper ranked groups rather than the lower ranked groups, and on the responsibilities of the management rather than the upper ranked groups in order to elevate the management performance of the small and medium sized manufacturers of the rubber components for automobile.

• 산업경영시스템학회지
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• 제39권3호
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• pp.71-82
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• 2016

The ISO (International Organization for Standardization) 9000 QMS (Quality Management System) standards specify requirements that need to demonstrate an organization's ability to consistently provide products or services. Korean companies have been implementing ISO 9000 QMS to compete in global markets. ISO 9000 QMS standards have been revised in 1994, 2000, 2008, and 2015 since the first release in 1987. The key change in ISO 9001:2015 is focused on risk-based thinking. It means that risk inherent within an organization is early identified and proactively controlled by use of all aspects of QMS rather than taking preventive actions. In this article we did literature review mainly on empirical study related to motivation and operation performance of ISO 9000 implementation. We present the necessity of changeover, features of new version, and comparison between new and old version. In order to see how well organizations can implement the new ISO 9001:2015 we focus on manufacturing companies that are going to convert to ISO 9001:2015 registration. We collect their key characteristics such as yearly sales, the number of MPI (Management Performance Indicators), the number of KPI (Key Performance Indicators), the number of quality control engineers, quality control engineer work experience, and the degree of adaptiveness between new ISO 9001:2015 QMS and QMS currently operating in manufacturing companies. Especially the degree of adaptiveness is analyzed by correlation analysis, regression analysis, ANOVA, and t-tests to discover the relationships among their characteristics. We found out that the degree of adaptiveness is linearly related to quality control engineer work experience and the number of MPI and KPI that is practically utilized in manufacturing companies. We summarize the implications discovered to help manufacturing industry convert to ISO 9001:2015 registration.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2006년도 춘계공동학술대회
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• pp.355-362
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• 2006

This paper is to introduce guidelines for automotive and food quality management system. International standards such as ISO/TS 16949 and ISO 15161 are considered. This study is to discuss particular requirements for the application of ISO 9001 : 2000 for automotive production and relevant service part organization , and guidelines on the application of ISO 9001 : 2000 for the food and drink industry.

• The Plant Pathology Journal
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• 제29권2호
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• pp.168-173
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• 2013

Apple ring rot disease, caused by Botryosphaeria dothidea (Moug. ex. Fr) Ces. et de Not., is one of the most important diseases on apple fruits. In this study, strain 9001 isolated from healthy apple fruits from an infested orchard was evaluated for its biocontrol activity against apple ring rot in vitro and in vivo. Strain 9001 showed obvious antagonistic activity to B. dothidea YL-1 when plated on potato dextrose agar. Soaking healthy apples in the bacterial suspensions of strain 9001 prior to artificial inoculation of fungal pathogen resulted in a dramatic decrease in disease incidence when compared to the control. Moreover, either field application in the growth season or postharvest treatment of apples from infected orchards with bacterial suspensions of strain 9001 resulted in significantly reduced disease incidence within the storage period for 4 months at room temperature. Based on the phylogenetic analysis of 16S rRNA and the gyrA gene, strain 9001 was identified as Bacillus amyloliquefaciens. These results indicated that B. amyloliquefaciens 9001 could be a promising agent in biocontrol of apple ring rot on fruit, which might help to minimize the yield loss of apple fruit during the long postharvest period.