• Title/Summary/Keyword: ARB

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Beta Blockers or Calcium Channel Blockers as Primary Antianginal Drug after Percutaneous Coronary Intervention: Prescription Pattern and its association with Clinical Outcome (관상동맥중재술 전후 주요 항협심증 약제로서의 베타차단제와 칼슘채널차단제: 처방패턴 및 임상결과에 미치는 영향)

  • Noh, Sun Young;Jo, Yun Hee;Cho, Yoon Sook;Hahn, Hyeon Joo;Lee, Hae-Young;Lee, Ju-Yeun
    • Korean Journal of Clinical Pharmacy
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    • v.26 no.3
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    • pp.213-219
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    • 2016
  • Objective: Although guideline recommends beta blockers (BBs) as first line antianginal agent and calcium channel blockers (CCBs) as alternatives after percutaneous coronary intervention (PCI), the prescription patterns in real practice are not in accordance with the guideline. We aimed to investigate the prescribing patterns of primary antianginal drug and relating factors in patients who underwent PCI. Methods: Patients who have undergone PCI without myocardial infarction (MI) from November 2012 to June 2014 and followed up at least one year in a tertiary teaching hospital were included. Prescribing patterns of primary antianginal drug before, at the time of, and one year after PCI were described. Factors affecting drug selection, and their relationship with incidence of clinical outcomes defined as MI and repeated PCI, unscheduled admission or visit related with heart problem were analyzed with multivariate logistic regression. Results: A total of 506 patients were included and as primary antianginal drugs, BB, CCB, and both were prescribed in 32.2%, 24.5%, and 17.8% of patients, respectively. Also, neither BB nor CCB was prescribed at the time of PCI in 25.5% of patients. Compared with BB, CCBs were more likely prescribed in patients who had hypertension (Odds Ratio, OR 2.18, 95% confidence interval, CI 1.16-4.07), use of same class before PCI (OR 7.18, 3.37-15.2) and concomitant angiotensin receptor blocker (ARB) use (OR, 1.92, 95% CI 1.10-3.33). Incidence of clinical outcomes were not significantly greater in patients who prescribed CCB compared with BB at the time of PCI (aOR 1.32, CI 0.65-2.68). Conclusion: This study demonstrated that half of the patients who underwent PCI were prescribed BB. CCB were favored in patients with hypertension, use of same class before PCI, and concomitant ARB use. Significant difference in clinical outcome was not observed between BB and CCB selection as primary antianginal drug.

Damage Conditions and Assessment for Cut Slope Structures due to Acid Rock Drainage (산성암반배수에 의한 절취사면 구조물의 피해 현황과 평가)

  • Lee Gyoo Ho;Kim Jae Gon;Park Sam-Gyu;Lee Jin-Soo;Chon Chul-Min;Kim Tack Hyun
    • Journal of the Korean Geotechnical Society
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    • v.21 no.5
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    • pp.83-92
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    • 2005
  • The aim of this study was to investigate damage conditions of cut slope structures due to acid rock drainage (ARB) and to assess the acid production potential of various rocks. Acid rock drainage is produced by the oxidation of sulfide minerals contained in coal mine zone and mineralization belt of Pyeongan supergroup and Ogcheon group, pyrite-bearing andesite, and Tertiary acid sulfate soils in Korea. Most of cut slopes producing ARB have been treated with shotcrete to reduce ARD. According to the field observations, ARD had an adverse effect on slope structures. The corrosion of shotcrete, anchors and rock bolts and the bad germination and growth diseases of covering plants due to ARD were observed in the field. The concentration of heavy metals and pH of ARD from cut slope exceeded the environmental standard, indicating a high potential of environmental pollution of surrounding soil, surface water and ground water by the ARD. According to acid base accounting (ABA) of the studied samples, hydrothermally altered volcanic rocks, tuffs, coaly shales, tailings of metallic mine had a relatively high potential of acid production but gneiss and granite had no or less acid production potential. It is expected that the number of cut slopes will increase hereafter considering the present construction trend. In order to reduce the adverse effect of ARD in construction sites, we need to secure the data base for potential ARD producing area and to develop the ARD reduction technologies suitable.

Die Übersicht des rechtliche Struktur über die Rechtsschutzversicherung (법무비용보험의 법적 구조의 개관 - 독일 입법례를 중심으로 -)

  • Kim, Eun-Kyung
    • Journal of Legislation Research
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    • no.44
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    • pp.315-342
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    • 2013
  • Die Rechtsschutzversicherung ist als eine echte Schadenversicherung eine neue Versicherung, die $Spezialit{\ddot{a}}t$ des versichertes Risikos hat. Das bedeutet, dass der Rechtschutzversicherer nur bestimmte vertraglich vereinbarte Risiken $tr{\ddot{a}}gt$. Diese Risiken sind in den Allgemeinen Bedingungen $f{\ddot{u}}r$ die Rechtsschutzversicheurng (ARB) im Zusammenhang mit Versicherungsvertragsgesetz (VVG) ${\S}$ 125 exact beschrieben. VVG ${\S}$ 125 spricht allegemein von Leistung des Versicherers im vereinbarten versicherten Umfang. Entscheidend ist also die Vereinbarung in den ARB, welche in ${\S}$ 1 die Kostentragung $f{\ddot{u}}r$ den Versicherten als Hauptleistung des Versicherers beschrieben ist. Also in den VVG ${\S}{\S}$ 125 bis 129 gibt es keine Definition ${\ddot{u}}ber$ die Sparte der Rechtsschutzversicherung, jedoch mindestens es $w{\ddot{a}}re$ $m{\ddot{o}}glich$, diese Sparte zu definieren. Um die $k{\ddot{u}}nftige$ Produktentwicklung nicht zu hindern, $enth{\ddot{a}}lt$ die Vorschrift keine gesetzliche Definition der Rechtsschutzversicherung nach Angabe der amtlichen $Begr{\ddot{u}}ndung$. Weil in Korea die Rechtsschutzversicherung relativ neu in Versicherungsmarket ist, sind daher VVG ${\S}{\S}$ 125 ein gutes gesetzgeberisches Vorbild, um pragmatisch und auch dazu rechtswissenschaftlich zu diskutieren und diese fsetzustellen. Im Schritt von Ausdehnungen der juristischen Dienstleistung $w{\ddot{a}}re$ es $n{\ddot{o}}tig$, zu betrachten, wie Leistungsumfang des Versicherers in der Rechtsschutzversicherung erweitert werden kann. And noch dazu ist die Informationspflicht des Versicherers in Hinsicht auf Versicherungsunfall und Leistungsumfang noch weitert zu ${\ddot{u}}berlegen$, weil diese Sparte der Rechtsschutzversicherung noch professioneller als die anderen Versicherungsbereiche ist.

Microstructure and Mechanical Properties of Oxygen Free Copper Severely Deformed by Accumulative Roll-Bonding Process (반복겹침접합압연법에 의해 강소성가공된 무산소동의 미세조직 및 기계적 특성)

  • Lee Seong-Hee;Cho Jun;Han Seung-Zun;Lim Cha-Yong
    • Korean Journal of Materials Research
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    • v.15 no.4
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    • pp.240-245
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    • 2005
  • An oxygen free copper was severely deformed by accumulative roll-bonding (ARB) process for improvement of its mechanical properties. Two copper sheets 1 m thick, 30 mm wide and 300 m long are first degreased and wire-brushed for sound bonding. The sheets are then stacked to each other, and roll-bonded by about $50\%$ reduction rolling without lubrication at ambient temperature. The bonded sheet is then cut to the two pieces of same dimensions and the same procedure was repeated to the sheets up to eight cycles $(\varepsilon-6.4)$. TEM observation revealed that ultrafine grains were developed after the third cycle, and their size was slightly increased at higher cycles. Tensile strength of the copper increased with the strain at low strain levels, but it hardly increased from 3 cycles $(\varepsilon>2.4)$ due to occurrence of dynamic recovery, even if the imposed strain increased.

A Study on Air Temperature-reducing Effects by Irrigation Reservoir (도시 내 소규모 관개저수지의 기온 저감효과에 관한 연구 - 수원시 일월저수지를 대상으로 -)

  • Zheng, Hai-Yan;Jin, Wen-Cheng;Lee, Kyoo-Seock;Oh, Sung-Nam
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.13 no.1
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    • pp.32-39
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    • 2010
  • The air temperature-reducing effects by irrigation reservoir in urban area was investigated at Ilwol Pond (IWP). Air temperature and humidity data were observed at 10minute interval from September 1th, 2008 to August 31th, 2009. Air temperature of IWP and Sumsung Apartment (SAT) were analyzed to examine air temperature-reducing effects by IWP in terms of diurnal and seasonal variation. As a result, the average air temperature difference between IWP and SAT was $0.6^{\circ}C$ and the nighttime shows more air temperature-reducing effects. The dominant air temperature-reducing effects by IWP occurred at fall night and summer daytime. However, the air temperature-reducing effects by IWP is lower to that by Arboretum (ARB).

Review of advanced oxidation processes (AOPs) for treatment of pharmaceutical wastewater

  • Verma, Manisha;Haritash, A.K.
    • Advances in environmental research
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    • v.9 no.1
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    • pp.1-17
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    • 2020
  • Pharmaceutically active compounds (PhACs) have become an environmental havoc in last few decades with reported cases of antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARGs), lethal effects over aquatic organisms, interference in natural decomposition of organic matter, reduced diversity of microbial communities in different environmental compartments, inhibition of growth of microbes resulting in reduced rate of nutrient cycling, hormonal imbalance in exposed organisms etc. Owing to their potential towards bioaccumulation and persistent nature, these compounds have longer residence time and activity in environment. The conventional technologies of wastewater treatment have got poor efficiency towards removal/degradation of PhACs and therefore, modern techniques with efficient, cost-effective and environment-friendly operation need to be explored. Advanced oxidation processes (AOPs) like Photocatalysis, Fenton oxidation, Ozonation etc. are some of the promising, viable and sustainable options for degradation of PhACs. Although energy/chemical or both are essentially required for AOPs, these methods target complete degradation/mineralization of persistent pollutants resulting in no residual toxicity. Considering the high efficiency towards degradation, non-toxic nature, universal viability and acceptability, AOPs have become a promising option for effective treatment of chemicals with persistent nature.

Drawing Process Design and Mechanical Properties Control for High Strengthening of CP Titanium (순수 타이타늄 고강도화를 위한 인발공정설계 및 기계적 특성 제어 기술)

  • Choi, Seong Woo;Park, Chan Hee;Lee, Sang Won;Yeom, Jong Taek;Hong, Jae Keun
    • Journal of the Korean Society for Precision Engineering
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    • v.34 no.2
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    • pp.77-81
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    • 2017
  • CP (Commercially Pure) titanium has been widely used in various industries such as in energy plants and bio-materials because of an excellent corrosion resistance and its non-toxicity to the human body. But there are limitations for usage as structural materials due to low strength. The tensile properties of CP titanium could be improved by microstructure refinement such as in a SPD (Severe Plastic Deformation) process. However, high strengthening of CP titanium wire is impossible by SPD processes like ECAP (Equal Channel Angular Pressing), HPT (High-Pressure Torsion), and the ARB (Accumulative Roll Bonding) process. The study purposes are to increase the strength of CP titanium wire by optimization of the cold drawing process and the harmonization with mechanical properties by heat treatments for the next forming process. The optimization process was investigated with regard to the design of drawing dies and the reduction ratio of cross sections. The elongations of high strength CP titanium were controlled by heat treatment.

Novel Approaches to Monitoring and Remediation of Veterinary Antibiotics in Soil and Water: A Review

  • Awad, Yasser M.;Lee, Sang-Soo;Kim, Sung-Chul;Yang, Jae-E.;Ok, Yong-Sik
    • Korean Journal of Environmental Agriculture
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    • v.29 no.4
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    • pp.315-327
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    • 2010
  • A vast increase of antibiotics usage in concentrated animal feeding operations (CAFOs) over the last few decades has led to an environmental risk due to the presence of antibiotic residuals in different environmental compartments. Especially in Korea, the use of antibiotics in CAFOs is much greater than in other developed countries. One of the primary adverse impacts of antibiotic residuals in the environment is that they readily produce antibiotic resistant bacteria (ARB), which exert detrimental effects on the ecosystem as well as human health. In this article, the impacts of veterinary antibiotic residuals with regard to their quantification and management, and desirable remediation technologies have been widely reviewed. This review article concluded that the continuous monitoring should be required to ensure the safety of antibiotic residuals in the surrounding environments. Furthermore, the management guidelines of antibiotic residuals need to be developed in the future.

A Study on Evaluation Method of Floor Noise Reduction and Blocking Performance for Apartment Buildings in Korea (국내 공동주택 건축물 층간소음 저감 방안 및 차단 성능 등급평가법에 관한 고찰)

  • Jung, Kyung-Tae
    • Journal of Korean Association for Spatial Structures
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    • v.24 no.3
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    • pp.69-77
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    • 2024
  • The purpose of this study is to present a plan for reducing noise between floors of apartment houses in Korea and to examine the method for evaluating noise blocking performance rating between floors. The definition of floor noise and classification method of floor noise can be described, and floor noise can be distinguished into lightweight impact sound and heavy impact sound. The wall-type structure, which is mainly adopted in domestic apartments, relatively transmits vibration caused by impact sources rather than using columns and beams, so noise problems between floors are relatively higher than systems using columns and beams. Three representative methods for reducing and blocking floor noise are described, and criteria for evaluating the effectiveness of floor noise reduction by each method are described. In addition, the method for noise reduction and blocking grades for each construction method currently applied in Korea was described, and as a result, it was judged that the domestic rating evaluation method was not suitable for the current domestic situation, and a new evaluation method and standard were needed.

The Level of Squamous Cell Carcinoma Antigen and Lymph Node Metastasis in Locally Advanced Cervical Cancer

  • Lekskul, Navamol;Charakorn, Chuenkamon;Lertkhachonsuk, Arb-Aroon;Rattanasiri, Sasivimol;Ayudhya, Nathpong Israngura Na
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.11
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    • pp.4719-4722
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    • 2015
  • Background: This study aimed to determine the utility and a cut-off level of serum squamous cell carcinoma antigen (SCC-Ag) to predict lymph node metastasis in locally advanced cervical cancer cases. We also investigated the correlation between SCC-Ag level and lymph node status. Materials and Methods: From June 2009 to June 2014, 232 patients with cervical cancer stage IB2-IVA, who were treated at Ramathibodi Hospital, were recruited. Receiver operating characteristic (ROC) curves were used to identify the best cut-off point of SCC-Ag level to predict lymph node metastasis. Quantile regression was performed to evaluate the correlation between SCC-Ag levels and pelvic lymph node metastasis, paraaortic lymph node metastasis, and parametrial involvement as well as tumor size. Results: Pelvic lymph node metastasis and paraaortic lymph node metastasis were diagnosed in 46.6% and 20.1% of the patients, respectively. The median SCC-Ag level was 6 ng/mL (range, 0.5 to 464.6 ng/mL). The areas under ROC curves between SCC-Ag level and pelvic lymph node metastasis, paraaotic lymph node metastasis, parametrial involvements were low. SCC-Ag level was significantly correlated with paraaortic lymph node status (p=0.045) but not with pelvic lymph node status and parametrial involvement. SCC-Ag level was also related to the tumor diameter (p<0.05). Conclusions: SCC-Ag level is not a good predictor for pelvic and paraaortic lymph node metastasis. However, it is still beneficial to assess the tumor burden of squamous cell carcinoma of the cervix.