• Korean Journal of Clinical Pharmacy
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• v.21 no.4
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• pp.364-375
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• 2011

Given that single blockade with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) can achieve only partial and undurable suppression of the Renin Angiotensin System (RAS), it has been hypothesized that dual blockage would be more beneficial in the management of blood pressure (BP) reduction and prevention of progressive chronic kidney disease (CKD) than either agent alone. Thus, it has been suggested that the combination of an ACEI and an ARB might provide renal benefits to hypertensive patients over and above BP reduction. However, this might also expose patients to additive or synergistic side effects. We attempted to conduct a systematic review to evaluate the benefits and harms of combination therapy in hypertensive patients with or without kidney diseases. MEDLINE and KoreaMed were searched for relevant randomized clinical trials in adult hypertensive patients with or without diabetes (restricted to 1997, limited to trials published in English). Results were summarized using the random-effects model, and between-studies heterogeneity was estimated with $I^2$. A final analysis of ten trials (23,928 patients) revealed that the combination of an ACEI and an ARB reduced blood pressure (SBP/DBP) by 3.95/2.02 mmHg (95% confidence interval [CI], -4.38 to -3.53/-2.33 to -1.71) compared with ACEI monotherapy, and 2.83/2.64 mmHg (95% CI, -3.25 to -2.41/-4.95 to -0.33) compared with ARB monotherapy. Eight trials (391 patients) demonstrated a significant reduction in 24h-proteinuria (weighted mean difference, 0.16 g/day, 95% CI, -0.26-0.05), but they did not translate into an improvement in GFR. Tests for heterogeneity showed no difference in effect among the studies. The combination therapy reduced proteinuria by 30% (95% CI, 23% to 37%) and 39% (95% CI, 31% to 48%) compared with ACEI monotherapy and ARB monotherapy, respectively. However, in patients who had proteinuria more than 0.5 g/day, the combination therapy failed to show significant reduction in urinary protein excretion. The current cumulative evidence suggests that diabetic patients with proteinuria on dual RAS blockade have an increase risk of adverse events such as hyperkalemia, hypotension, and so on, compared with ACEI or ARB alone. It is, therefore, proposed that the combination therapy should not be routinely used for the treatment of hypertension with or without compelling indications.

• Korean Architects
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• s.636
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• pp.42-43
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• 2022

• Journal of the Korea Computer Graphics Society
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• v.11 no.2
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• pp.56-63
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• 2005

모바일 환경에서 고급 그래픽스 기술을 적용하고자 하는 시도로 최근 3D 그래픽 엔진을 탑재한 단말기가 출시되고 있다. 이 단말기는 OpenGL ES 1.x 을 기준으로 고정된 파이프라인을 통해 그래픽 연산을 처리하고 있으므로 사용자가 다양한 그래픽 표현을 수행하는데 제약이 따른다. 최근 PC 환경의 그래픽 엔진에서는 고정 기능의 파이프라인이 아닌 프로그래밍 가능한 파이프라인을 제공하여 기존 고정 파이프라인에서 불가능했던 유연한 그래픽스 기술을 제공하고 있다. PC환경의 프로그래밍 가능한 파이프라인은 DirectX 와 OpenGL ARB Extension 그래픽 라이브러리에 의해 제공되고 있지만, 모바일 환경에서는 이를 지원하기 위한 관련 제품이 아직 출시되지 않고 있는 상태이다. 본 논문에서는 OpenGL ARB Extension 1.0 을 근거로 정점 프로세싱 과정을 프로그래밍 가능한 파이프라인 구조로 동작하도록 하는 모바일용 정점 프로그램 가상머신을 제시한다.

• Journal of Korean Society of Water and Wastewater
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• v.27 no.6
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• pp.797-803
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• 2013

Recently, a number of countries are now considering the reuse of effluents from wastewater treatment for various water applications. To improve the reuse of wastewater effluent, the development of appropriate micro-pollutant removal technology is necessary. Although several researche have been studied for removing micro-pollutants in water, little study has been conducted for the removal of emerging contaminant such as antibiotic resistant genes (ARGs) by disinfection processes. Therefore, the aim of this study is to compare the capacity of disinfection technologies such as chlorination, ozone, and electron beam, for removing antibiotic resistant bacteria (ARB) and ARGs. Based on this study, better ARG removal can be achieved by ozonation and electron beam. Relatively, high CT values of chlorination or ozonation are needed to remove ARB and ARG compared to conventional pathogens.

• Journal of Arbitration Studies
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• v.23 no.2
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• pp.37-54
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• 2013

This article focuses on integrating institutional mediation systems, especially the analysis of the leading ADR operation. Mediation is a process in which an impartial third party, a mediator, facilitates the resolution of a dispute by promoting voluntary agreements by the parties to the dispute. A mediator facilitates communications, promotes understanding, focuses the parties on their interests, and seeks agreement. These standards give meaning to this definition of mediation. Standard mediation clauses are construed as broadly as possible, and mediation is compelled unless it may be said with positive assurance that the mediation process is not susceptible to an interpretation that covers the asserted dispute. Performing the conflicts check early in the process helps in eliminating any awkwardness or delays caused by making disclosures after mediation commences. Mediator impartiality is central to the mediation process. A mediator should mediate only those matters in which she or he can remain impartial and evenhanded. If at any time the mediator is unable to conduct the process in an impartial manner, the mediator is obligated to withdraw.

• Journal of Marine Bioscience and Biotechnology
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• v.6 no.2
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• pp.53-61
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• 2014

This study was investigated the antimicrobial activity of glutaraldehyde cross-linked glucosamine. Glutaraldehyde was used as a cross-linker which specifically combines an amine-group of molecules. To optimize the mixing ratio of glutaraldehyde and glucosamine, mixing ratio was set up 1:1, 2:1, 3:1 and 0.5:1 in molarity, respectively. The optimum mixing ratio of glucosamine and glutaraldehyde was found to be 3:1 using thin layer chromatography based on the production of complex. Glucosamine-glutaraldehyde cross-linked complex (Ggcc) revealed significant antimicrobial activity toward PWG than F1, both microbial strains were isolated from porcine semen as antibiotics resistance bacteria (ARB). These results clearly demonstrate that Ggcc has potential bactericidal activity toward ARB in porcine semen.

• Proceedings of the Materials Research Society of Korea Conference
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• 2007.11a
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• pp.35.2-35.2
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• 2007

• Journal of Preventive Medicine and Public Health
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• v.53 no.6
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• pp.476-486
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• 2020

Objectives: The objective of this study was to estimate the risk of lung cancer in relation to angiotensin II receptor blocker (ARB) use among patients with hypertension from the Korean National Health Insurance Service-National Health Screening Cohort. Methods: We conducted a retrospective cohort study of patients with hypertension who started to take antihypertensive medications and had a treatment period of at least 6 months. We calculated the weighted hazard ratios (HRs) and their 95% confidence intervals (CIs) of lung cancer associated with ARB use compared with calcium channel blocker (CCB) use using inverse probability treatment weighting. Results: Among a total of 60 469 subjects with a median follow-up time of 7.8 years, 476 cases of lung cancer were identified. ARB use had a protective effect on lung cancer compared with CCB use (HR, 0.75; 95% CI, 0.59 to 0.96). Consistent findings were found in analyses considering patients who changed or discontinued their medication (HR, 0.50; 95% CI, 0.32 to 0.77), as well as for women (HR, 0.56; 95% CI, 0.34 to 0.93), patients without chronic obstructive pulmonary disease (HR, 0.75; 95% CI, 0.56 to 1.00), never-smokers (HR, 0.64; 95% CI, 0.42 to 0.99), and non-drinkers (HR, 0.69; 95% CI, 0.49 to 0.97). In analyses with different comparison antihypertensive medications, the overall protective effects of ARBs on lung cancer risk remained consistent. Conclusions: The results of the present study suggest that ARBs could decrease the risk of lung cancer. More evidence is needed to establish the causal effect of ARBs on the incidence of lung cancer.

• Journal of Life Science
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• v.18 no.7
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• pp.918-923
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• 2008

The angiotensin II receptor ($AT_1R$) antagonists are effective in treating patients with hypertension and showed beneficial effects in diabetes and other metabolic diseases. The beneficial effects of $AT_1R$ antagonists are mainly considered to be from inhibition of Ang $II-AT_1R$ signaling pathway such as the activation of NADPH oxidase and the generation of reactive oxygen species. In this study, we examined whether antagonist of the $AT_1R$ could account for phosphorylation of proteins in cells using antibody array. We have selected 6 proteins with Ser/Thr-phosphorylation sites and 12 proteins with Tyr-phosphorylation sites based on literature search. Upon $AT_1R$ antagonist losartan treatment to serum-starved COS-1 cells, there was ${\sim}20%$ increase of Ser phosphorylation in small GTPase RhoA. RhoA is known to be responsible for cytoskeleton rearrangement and is down-regulated upon Ser phosphorylation in vivo. Our finding provides a new insight into the mechanism and signaling pathway of the $AT_1R$ antagonist in cells.

• Journal of Korean Society of Forest Science
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• v.10 no.1
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• pp.5-6
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• 1970

Abies koreansa Wilson grows at the upper part of Mts. Halla, Chiri, Mudung, Kaji and Dokyu. It was at first collected by Father U. Faurie on the May of 1907 from the Mt. Halla, Quelpaert. Cone colour of this species varies from green to black purple and the typical colour of it is violet purple. A form of black purple was named by Hatushima in 1934. Green and reddish brown or reddish purple colours of this species were discovered recently at the Mt. Halla. All these forms can be identified as the following. for. koreana - Abies koreana Wilson in Journ. Arn. Arb. 1, 188(1920) ; Mori, En. 27(1922) ; Uyeki, Timb. Tr. 117(1926) et Woody Pl. 5(1940) ; Chung et al, Comm. Nam. 12(1937) ; Handb. Kor. Manch. For. 71(1939) ; Kawamoto, III. For. P1. 16(1940) ; T. Lee, Arb. Kor. 12(1947) et Billiogr. Woody P1. 233(1966) ; Nakai, Synopt. 23(1952)-A. nephrolepis sensu Nakai, Rep. Veg. Chirisan 23, no. 27(1915) et Rep. Veg. Quelpaert Isl. 13, no. 142 (1915), non Max. (1866) Strobili violaceo-purpurei, bracteis viridibus juvenilibus vel stramineis matureis. Mt. Halla ( Lee, no. 970527K. ) for. chlorocarpa, forma nova ; Strobili et bracteae viridi sed rubescent in apice juvenili inflerescentiae. Mt. Halla ( Lee, no. 970527C. ) for. rubrocarpa, forma nova ; Strobili et bracteae rubro-purpurei vel rubro-fusui Mt. Halla ( Lee, no. 970527R. ) for nigrocarpa Hatushima, Rep. Exp. For. Kyushu U. 40(1934) ; T. Lee, Arb. Kor. 12(1947) et Bibliogr. Woody P1,233(1966). Strobili et bracteae nigro-purpurei. Mt. Halla (Lee, no. 970527N. )