• Biomolecules & Therapeutics
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• 제23권4호
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• pp.386-389
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• 2015

Sibutramine is an anorectic that has been banned since 2010 due to cardiovascular safety issues. However, counterfeit drugs or slimming products that include sibutramine are still available in the market. It has been reported that illegal sibutramine-contained pharmaceutical products induce cardiovascular crisis. However, the mechanism underlying sibutramine-induced cardiovascular adverse effect has not been fully evaluated yet. In this study, we performed cardiovascular safety pharmacology studies of sibutramine systemically using by hERG channel inhibition, action potential duration, and telemetry assays. Sibutramine inhibited hERG channel current of HEK293 cells with an $IC_{50}$ of $3.92{\mu}M$ in patch clamp assay and increased the heart rate and blood pressure ($76{\Delta}bpm$ in heart rate and $51{\Delta}mmHg$ in blood pressure) in beagle dogs at a dose of 30 mg/kg (per oral), while it shortened action potential duration (at $10{\mu}M$ and $30{\mu}M$, resulted in 15% and 29% decreases in $APD_{50}$, and 9% and 17% decreases in $APD_{90}$, respectively) in the Purkinje fibers of rabbits and had no effects on the QTc interval in beagle dogs. These results suggest that sibutramine has a considerable adverse effect on the cardiovascular system and may contribute to accurate drug safety regulation.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.219-222
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• 2004

There are several factors that disturb an Ultra-Wideband (UWB) radio propagation in an indoor environment such as path loss, shadowing and multipath fading. These factors directly affect the quality of the received signal. In this paper, we investigated the influence of the human body shadowing on UWB propagation based on measured wireless channel in an anechoic chamber. The characteristics of the UWB channel including the transmitter and the receiver antenna effects are acquired over the frequency bandwidth of 3${\sim}$11 GHz. The major factors such as the power delay profile (PDP), the angular power distribution (APD), the pulse distortion and the RMS delay spread caused by the human body shadowing are presented.

• 한국입자에어로졸학회지
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• 제13권1호
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• pp.25-31
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• 2017

This paper offer the characteristics for the detection and classification of biological and non-biological aerosol particles in the air by using laser-induced-fluorescence (LIF) based Bio-aerosol Detection System (BDS). The BDS is mainly consist of an optical chamber, in-outlet nozzle system, 405 nm diode laser, an avalanche photo detector (APD) for scattering signal and photomultiplier tubes (PMT) for fluorescence signals in two different wavelength range ; F1, 510-600 nm and F2, 435-470 nm. The detection characteristics, especially ratio of fluorescence signal intensity were examined using well-known components : polystylene latex (PSL), fluorescence PSL, $2{\mu}m$ of SiO2 micro sphere, dried yeast, NADH, ovalbumin, fungicide powder and standard dust. The results indicated that the 405 nm diode laser-based LIF instrument can be a useful bio-aerosol detection system for unexpected biological threaten alter in real-time to apply for dual-use technology in military and civilian fields.

• 산업공학
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• 제15권2호
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• pp.152-158
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• 2002

The explosive growth of the internet traffic in the last few years has imposed tremendous stress on today's routers, particularly in the core network. Recently, ATM LSRs(Label Switching Router) are potentially capable of providing the highest forwarding capacity in the backbone Internet network. VC merging is a mechanism in an ATM LSR that allows many IP routes to be mapped to the same VC label, and provides a scalable mapping method that can support thousands of destinations. VC merging requires reassembly buffers so that cells belonging to different packets intended for the same destination do not interleave with each other. In this study, we propose an architecture of the ATM LSR which supports VC merging. We propose traffic control scheme called APD(Active Packet Discard) algorithm so that predicts and controls the congestion of the Internet traffic effectively. We study the performance of this algorithm using simulation.

• 전기학회논문지P
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• 제66권4호
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• pp.236-241
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• 2017

This paper presents a single-phase grid connected voltage-ed inverter with a power decoupling circuit. In the single-phase grid connected voltage-ed inverter, it is well known that a power pulsation with twice the grid frequency is contained in the input power. In a conventional voltage type inverter, electrolytic capacitors with large capacitance have been used in order to smooth the DC voltage. However, lifetime of those capacitors is shortened by the power pulsation with twice grid frequency. The authors have been studied a active power decoupling(APD) method that reduce the pulsating power on the input DC bus line, this enables to transfer the ripple energy appeared on the input DC capacitors into the energy in a small film capacitor on the additional circuit. Hence, extension of the lifetime of the inverter can be expected because the small film capacitor substitutes for the large electrolytic capacitors. Finally, simulation and experimental results are discussed.

• Journal of Electrical Engineering and Technology
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• 제4권4호
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• pp.457-466
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• 2009

This paper presents efficient parallel genetic algorithm (EPGA) based decomposed network for optimal power flow with various kinds of objective functions such as those including prohibited zones, multiple fuels, and multiple areas. Two coordinated sub problems are proposed: the first sub problem is an active power dispatch (APD) based parallel GA; a global database generated containing the best partitioned network: the second subproblem is an optimal setting of control variables such as generators voltages, tap position of tap changing transformers, and the dynamic reactive power of SVC Controllers installed at a critical buses. The proposed approach tested on IEEE 6-bus, IEEE 30-bus and to 15 generating units and compared with global optimization methods (GA, DE, FGA, PSO, MDE, ICA-PSO). The results show that the proposed approach can converge to the near solution and obtain a competitive solution with a reasonable time.

• Childhood Kidney Diseases
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• 제19권1호
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• pp.8-13
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• 2015

Antenatal hydronephrosis (ANH) is one of the most common abnormal findings detected on prenatal ultrasound (US), and it has been reported in 1-5% of all pregnancies. The likelihood of significant postnatal pathologic abnormality in the urinary tract correlates with the degree of anterior-posterior diameter (APD) according to the gestational age. Detection of urologic anomalies prenatally permits fetal interventions that avoid complications in rare cases of bladder outlet obstruction with oligohydramnios even though their final benefits still remain controversial. There is no clear consensus on the extent and mode of postnatal imaging after a diagnosis of ANH. US is the mainstay of the postnatal evaluation and helps guide further testing with voiding cystourethrography (VCUG) and diuretic renography. Although most algorithms continue to recommend generous VCUG for identification of lower urinary tract anomalies, VCUG may be safely reserved for high grade ANH cases or any grade of ANH with dilated distal ureter without increasing the risk of urinary tract infection (UTI). There are conflicting studies about efficacy of postnatal prophylactic antibiotics. It still seems reasonable to consider use of a prophylactic antibiotic to prevent infant UTIs in high-risk populations, such as females and uncircumcised males with high grades of hydronephrosis, hydroureteronephrosis, or vesicouretral reflux.

• The Journal of Asian Finance, Economics and Business
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• 제7권3호
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• pp.115-125
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• 2020

This paper investigates the impact of working capital management on the firm's profitability. The research sample includes 119 non-financial listed companies on Vietnam stock market over a period of 9 years from 2010 to 2018. Two statistical approaches include Ordinary least squares (OLS) and fixed effects model (FEM) are employed to address econometric issues and to improve the accuracy of the regression coefficients. The empirical results show the negative and significant impacts of the working capital management, which measured by cash conversion cycle (CCC) and three components of the CCC including accounts receivable turnover in days (ARD), inventory turnover in days (INVD), and accounts payable turnover in days (APD) on the firm's profitability measured by return on assets (ROA) and Tobin's Q. It implies that firms can increase profitability by keeping the optimization of the working capital management measured by the CCC, which includes shortening the time to collect money from clients, accelerating inventory flow and hold the low payment time to creditors. Besides, the profitability of firms was impacted by the sale growth rate, firm size, leverage, and age. Therefore, this paper provides a new insight to managers on how to improve the firm's profitability with working capital management.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권2호
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• pp.95-101
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• 2003

The purpose of this study was to evaluate the patterns of skeletal changes of proximal and distal segments after one jaw surgery and two jaw surgery with posterior impaction using SSRO on mandible in order to determine the skeletal origin of relapse and compare the stability of surgical methods in anterior open bite. The points and lines from lateral cephalometrics were measured before, after surgery, and at least 6-month follow up period. And then, the positional change of the proximal and distal segment were evaluated respectively. The results obtained were as follows; In cases of two jaw surgery, the results were stabler because they had less relapse factors. In cases of one jaw surgery, the value of APD were increased but it didn't relapse to the original value. Both of proximal and distal segments were responsible for the relapse tendency. But in one jaw surgery, the rotation of proximal segment was more responsible, and in two jaw surgery, the rotation of distal segment was.

• 한국마이크로전자및패키징학회:학술대회논문집
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• 한국마이크로전자및패키징학회 2007년도 SMT/PCB 기술세미나
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• pp.37-47
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• 2007

Factor : Structure Metal pad & SMO size Board level TC test : - Large SMO size better Board level Drop test : - Large SMO size better Factor : Structure Substrate thickness Board level TC test : - Thick substrate better Board level Drop test : - Substrate thickness is not a significant factor for drop test Factor : Material Solder alloy Board level TC test : - Not so big differences over Pb-free solder and NiAu, OSP finish Board level Drop test : - Ni/Au+SAC105, CuOSP+LF35 are better Factor : Material Pad finish Board level TC test : - NiAu/NiAu is best Board livel Drop test : - CuOSP is best Factor : Material Underfill Board level TC test - Several underfills (reworkable) are passed TCG x500 cycles Board level Drop test : - Underfill lots have better performance than non-underfill lots Factor : Process Multiple reflow Board level TC test : - Multiple reflow is not a significant actor for TC test Board level Drop test : N/A Factor : Process Peak temp Board level TC test : - Higher peak temperature is worse than STD Board level Drop test : N/A Factor : Process Stack method Board level TC test : - No big difference between pre-stack and SMT stack Board level Drop test : - Flux dipping is better than paste dipping but failure rate is more faster