• Tuberculosis and Respiratory Diseases
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• 제87권1호
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• pp.52-64
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• 2024

Chronic respiratory diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and respiratory infections injure the alveoli; the damage evoked is mostly irreversible and occasionally leads to death. Achieving a detailed understanding of the pathogenesis of these fatal respiratory diseases has been hampered by limited access to human alveolar tissue and the differences between mice and humans. Thus, the development of human alveolar organoid (AO) models that mimic in vivo physiology and pathophysiology has gained tremendous attention over the last decade. In recent years, human pluripotent stem cells (hPSCs) have been successfully employed to generate several types of organoids representing different respiratory compartments, including alveolar regions. However, despite continued advances in three-dimensional culture techniques and single-cell genomics, there is still a profound need to improve the cellular heterogeneity and maturity of AOs to recapitulate the key histological and functional features of in vivo alveolar tissue. In particular, the incorporation of immune cells such as macrophages into hPSC-AO systems is crucial for disease modeling and subsequent drug screening. In this review, we summarize current methods for differentiating alveolar epithelial cells from hPSCs followed by AO generation and their applications in disease modeling, drug testing, and toxicity evaluation. In addition, we review how current hPSC-AOs closely resemble in vivo alveoli in terms of phenotype, cellular heterogeneity, and maturity.

• Environmental Analysis Health and Toxicology
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• 제5권1_2호
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• pp.37-44
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• 1990

Synthetic detergents and surfactants are in widespread usage as household and industrial detergents. Potential human toxic hazard arises following percutaneous absorption or oral ingestion of solution residues from kitchen and feeding utensils, fruits, and vegetables and contaminated water supplies. A toxicological investigations was performed with the synthetic detergents and surfactants [linear alkyl benzene sulfonate (LAS), ${\alpha}$-olefin sulfonate (AOS), sodium lauryl sulfonate (SLS), sodium lauryl ester sulfonate (SLES)］, In acute toxicity, agents were administered subcutaneously into ICR mice. In acute study, after lowering of spontaneous motility, respiratory failure, death appeared, vomitting was often associated with salivation and or retching. No sex difference was observed in LD$\sub$50/ of mice. In subacute toxicity, agents were administered orally into SD rats. Body weight increase was suppressed and there was no adverse effect on food and water consumption. The weight of organs were not changed by agents as compared with control group. No specific change was observed in biochemical and hematologicalor data.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2004년도 춘계 학술발표회 제16권1호
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• pp.680-683
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• 2004

This study is to obtain basic data concerned with properties of foam for foamed concrete and foaming method. Main factors of this study are types of foaming agents, temperature of solution with foaming agents, and types of foam generator. Testing items are size distribution of foam, foaming ratio to solution, and stability of foam. The results of this study were shown as follow. It is optimum condition of foam generator that length/diameter of foaming tube is 2.0, bead size within foaming tube is $4\~6mm$, and nozzle size of foaming tube is 10mm. AES and AOS are good results to produce high quality foam, and stability of foam is good in foaming temperature of $20^{\circ}C$.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1998년도 하계종합학술대회논문집
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• pp.42-45
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• 1998

Adaptive array antenas have emerged as a useful technique to enhance the cell capacity of mobile communications. In this research, to analyze the noncoherent CDMA systems employing adaptive array antennas, we modeled the transmitting signal of CDMA systems using M-ary orthogonal modulation. And we induced the conditional probability density function about the decision variable, the output of 2D-RAKE receiver and mean symbol error prabability through statistical analysis about MAI(Multiple Access Interference), SI(Self Interference) and Noise. Also, we analyzed the charateristics of adaptive array antenna for noncoherent CDMA systems using M-ary orthogonal modulation according to the distance between the array elements, doppler frequency and AOS(Angle of Spread).

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 추계 학술논문 발표대회
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• pp.247-249
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• 2011

Pre-foaming, one of the manufacturing way of foamed concrete, is influenced by foaming agent. When the foaming agent diluted with water, surface tension and viscosity are varied. Therefore, this study is reviewing the surface tension, viscosity and unit weight of foam by experimental factor such as foaming agent types(AES, AOS, VS FP) and foam agent dilution concentration (1, 3, 5%) and temperature of materials (5, 10, 20℃). As an expeimental result, the surface tension and viscosity slightly increased with increasing concentrations. Meanwhile, when increasing temperature, the viscosity has decreased. FP produce relatively stable foams only in case 3% or more, which produce unstable foams containing large amount of water content by decreasing only insignificant surface tension when diluted at concentration of 1%.

• 한국국방경영분석학회지
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• 제15권1호
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• pp.14-27
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• 1989

This paper deals with the mission effectiveness of an airfleet, Airfleet operating system consists of a finite number of units performing the several mission types. Earlier works for the mission effectiveness of a fleet is limited to only one mission type and computer simulation approaches. The mission effectiveness. model of a fleet is constructed by three attributes - the mission readiness of the units, the mission reliability and capability of units. The environmental conditions and human factors affecting the mission success are considered together. The solution of the model is obtained by analytical technique. Especially, AOS is considered a closed queueing network with a finite number of units and a single job class. And then, the mission readiness of the units is found by the mean value analysis. The model would be a useful tool to readily evaluate mission effectiveness of a airfleet as it is and provide a criterion for determining the optimal operating policy.

• Journal of Computing Science and Engineering
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• 제6권1호
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• pp.26-38
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• 2012

Java has been increasingly used in programming for real-time systems. However, some of Java's features such as automatic memory management and dynamic compilation are harmful to time predictability. If these problems are not solved properly then it can fundamentally limit the usage of Java for real-time systems, especially for hard real-time systems that require very high time predictability. In this paper, we propose to exploit multicore computing in order to reduce the timing unpredictability that is caused by dynamic compilation and adaptive optimization. Our goal is to retain high performance comparable to that of traditional dynamic compilation, while at the same time, obtain better time predictability for Java virtual machine (JVM). We have studied pre-compilation techniques to utilize another core more efficiently, preoptimization on another core (PoAC) scheme to replace the adaptive optimization system (AOS) in Jikes JVM and the counter based optimization (CBO). Our evaluation reveals that the proposed approaches are able to attain high performance while greatly reducing the variation of the execution time for Java applications.

• Mycobiology
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• 제34권3호
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• pp.120-123
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• 2006

Phytoterpenoid isolated from Artabotrytis odoratissimus inhibited spore germination of some plant pathogenic as well as saprophytic fungi e.g. Alternaria alternata, A. solani, Cercospora sp., Curvularia maculans, C. pennisetti, Fusarium udum, Helminthosporium echinochlova, H. frumentacie, H. penniseti and Ustilago cynodontis. In Curvularia maculans and H. frumentacie, spore germination was completely inhibited at 2000 ppm. However, Curvularia maculans and C. pennisetti showed considerable sensitivity to this chemical even at 500 ppm.

• Journal of Electrical Engineering and Technology
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• 제13권3호
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• pp.1052-1059
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• 2018

This paper deals with commutation failure of the line-commutated converter high voltage direct current (LCC HVDC) system caused by a three phase fault in the ac power system. An analytic calculation method is proposed to estimate the maximum permissible voltage drop at the LCC HVDC station on various operating point and to assess the area of vulnerability for commutation failure (AOV-CF) in the power system based on the residual phase voltage equation. The concept is extended to multi-infeed HVDC power system as the area of severity for simultaneous commutation failure (AOS-CF). In addition, this paper presents the implementation of a shunt compensator applying to the proposed method. An analysis and simulation have been performed with the IEEE 57 bus sample power system and the Jeju island power system in Korea.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.100-101
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• 2012

The plasma damage free and room temperature processedthin film deposition technology is essential for realization of various next generation organic microelectronic devices such as flexible AMOLED display, flexible OLED lighting, and organic photovoltaic cells because characteristics of fragile organic materials in the plasma process and low glass transition temperatures (Tg) of polymer substrate. In case of directly deposition of metal oxide thin films (including transparent conductive oxide (TCO) and amorphous oxide semiconductor (AOS)) on the organic layers, plasma damages against to the organic materials is fatal. This damage is believed to be originated mainly from high energy energetic particles during the sputtering process such as negative oxygen ions, reflected neutrals by reflection of plasma background gas at the target surface, sputtered atoms, bulk plasma ions, and secondary electrons. To solve this problem, we developed the NBAS (Neutral Beam Assisted Sputtering) process as a plasma damage free and room temperature processed sputtering technology. As a result, electro-optical properties of NBAS processed ITO thin film showed resistivity of $4.0{\times}10^{-4}{\Omega}{\cdot}m$ and high transmittance (>90% at 550 nm) with nano- crystalline structure at room temperature process. Furthermore, in the experiment result of directly deposition of TCO top anode on the inverted structure OLED cell, it is verified that NBAS TCO deposition process does not damages to the underlying organic layers. In case of deposition of transparent conductive oxide (TCO) thin film on the plastic polymer substrate, the room temperature processed sputtering coating of high quality TCO thin film is required. During the sputtering process with higher density plasma, the energetic particles contribute self supplying of activation & crystallization energy without any additional heating and post-annealing and forminga high quality TCO thin film. However, negative oxygen ions which generated from sputteringtarget surface by electron attachment are accelerated to high energy by induced cathode self-bias. Thus the high energy negative oxygen ions can lead to critical physical bombardment damages to forming oxide thin film and this effect does not recover in room temperature process without post thermal annealing. To salve the inherent limitation of plasma sputtering, we have been developed the Magnetic Field Shielded Sputtering (MFSS) process as the high quality oxide thin film deposition process at room temperature. The MFSS process is effectively eliminate or suppress the negative oxygen ions bombardment damage by the plasma limiter which composed permanent magnet array. As a result, electro-optical properties of MFSS processed ITO thin film (resistivity $3.9{\times}10^{-4}{\Omega}{\cdot}cm$, transmittance 95% at 550 nm) have approachedthose of a high temperature DC magnetron sputtering (DMS) ITO thin film were. Also, AOS (a-IGZO) TFTs fabricated by MFSS process without higher temperature post annealing showed very comparable electrical performance with those by DMS process with $400^{\circ}C$ post annealing. They are important to note that the bombardment of a negative oxygen ion which is accelerated by dc self-bias during rf sputtering could degrade the electrical performance of ITO electrodes and a-IGZO TFTs. Finally, we found that reduction of damage from the high energy negative oxygen ions bombardment drives improvement of crystalline structure in the ITO thin film and suppression of the sub-gab states in a-IGZO semiconductor thin film. For realization of organic flexible electronic devices based on plastic substrates, gas barrier coatings are required to prevent the permeation of water and oxygen because organic materials are highly susceptible to water and oxygen. In particular, high efficiency flexible AMOLEDs needs an extremely low water vapor transition rate (WVTR) of $1{\times}10^{-6}gm^{-2}day^{-1}$. The key factor in high quality inorganic gas barrier formation for achieving the very low WVTR required (under ${\sim}10^{-6}gm^{-2}day^{-1}$) is the suppression of nano-sized defect sites and gas diffusion pathways among the grain boundaries. For formation of high quality single inorganic gas barrier layer, we developed high density nano-structured Al2O3 single gas barrier layer usinga NBAS process. The NBAS process can continuously change crystalline structures from an amorphous phase to a nano- crystalline phase with various grain sizes in a single inorganic thin film. As a result, the water vapor transmission rates (WVTR) of the NBAS processed $Al_2O_3$ gas barrier film have improved order of magnitude compared with that of conventional $Al_2O_3$ layers made by the RF magnetron sputteringprocess under the same sputtering conditions; the WVTR of the NBAS processed $Al_2O_3$ gas barrier film was about $5{\times}10^{-6}g/m^2/day$ by just single layer.