• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.130-130
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• 1995

AM, SM 및 ASA는 수용액중에서 겉보기 1차반응에 따라 분해되었으며 보존온도가 높을수록 분해가 촉진되는 온도 의존성을 나타내었다. AM의 분해경로는 pH 1.22 및 pH 7.0 이상에서는 AM$\longrightarrow$ SM $\longrightarrow$ SA의 경로로 주로 분해되었으며 pH 2.01 - 6.08의 범위에서는 AM $\longrightarrow$ASA$\longrightarrow$SA의 경로로 분해되는 양상을 보였다. 또 pH가 분해에 미치는 영향을 pH-rate profile로 나타낸 결과 AM, SM 및 ASA의 최대안정 pH는 각각 4.0, 3.0, 2.0 부근이 있고 이 조건에서의 분해 반감기는 114, 168, 113 hr로 나타났다. 전체적으로 보면 pH 2.0 이하에서는 ASA가 AM 보다 약간 안정한 편이나 pH 2.0-8.0 사이에서는 AM의 분해속도가 ASA보다 현저히 낮았다. 또 AM은 pH 7.0 이상에서, SM은 pH 6.0 이상에서, ASA는 9.0 이상에서 특수염기촉매반응에 따라 분해가 이루어지는 것을 알 수 있었다. 이온강도($\mu$)의 영향으로는 pH 7.0에서 이온강도가 0.115에서 1.0으로 증가할수록 $\mu$$^{1}$2/에 대해 AM의 분해속도정수가 직선적으로 완만하게 감소되었다. 또 완충수용액 중 AM의 가수분해 억제효과를 검토하기 위해 시클로덱스트린류를 첨가하였을 때, $\beta$-시클로덱스트린과 히드록시프로필기-$\beta$-시클로덱스트린은 AM의 분해를 각각 1.6배 및 1.1배 촉진시켜 촉매적으로 작용하였으며 디메칠-$\beta$-시클로덱스트린은 약 3.2배 분해속도를 억제시켜 안정화제로 작용하였다.Zn^{2+}$, soybean trypsin inhibtor에 의해 25～50% 정도, serine proteinase inhibitor인 phenylmethylsulfonyl floride에 의해 80%정도 활성이 억제되는 특성이 있음을 규명하였다.면역환성 (immunoreactivity)이 나타났고 pyramidal cell layer (PCL)와 glia에 SOD-1이 강하게 염색되었다. APT 병용 투여로 상당수의 경련이 일어나지 않은 흰쥐는 해마의 DG에 FRA가 경미하게 염색되었고, PCL에 SOD-1도 경미하게 나타났으나, 경련이 나타난 쥐에서는 KA만을 투여한 흰쥐와 구별되지 않았다. 이상의 APT의 항산화 효과는 KA로 인한 뇌세포 변성 개선에 중요한 인자로 작용할 것으로 사료되나, 보다 명확한 APT의 기전을 검색하고 직접 임상에 응응하기 위하여는 보다 다양한 실험 조건이 보완되어야 찰 것으로 생각된다. 항우울약들의 항혈소판작용은 PKC-기질인 41-43 kD와 20 kD의 인산화를 억제함에 기인되는 것으로 사료된다.다. 것으로 사료된다.다.바와 같이 MCl에서 작은 Dv 값을 갖는데, 이것은 CdCl$_{4}$$^{2-}$ 착이온을 형성하거나 ZnCl$_{4}$$^{2-}$ , ZnCl$_{3}$$^{-}$같은 이온과 MgCl$^{+}$, MgCl$_{2}$같은 이온종을 형성하기 때문인것 같다. 한편 어떠한 용리액에서던지 NH$_{4}$$^{+}$의 경우 Dv값이 제일 작았다. 바. 본 연구의 목적중의 하나인 인체유해 중금속이온인 Hg(II), Cd(II)등이 NaCl같은 염화물이 함유된 시료용액에 공해이온으로 존재할 경우 흡착에 의한 제거가 가능하다. 한편 이같

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.185-194
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• 2019

Objective: This study was conducted to investigate the intensity of the extremely low frequency magnetic fields(ELF-MF) generated inside of the cabins during subway operation. Methods: The ELF-MF intensity were investigated on 30 subway lines in Korea, including in the Greater Seoul Metropolitan Area(Seoul and Gyeonggi-do Province), Incheon, Busan, Daegu, Daejeon, and Gwangju. ELF-MF intensity was measured at 0.9 m from the floor using EMDEX II meters with a resolution of $0.01{\mu}T$. All data were collected every three seconds and analyzed with EMCALC 2013 version 3.0B software. Basic characteristics of subway operation, including alternative current(AC) or direct current(DC), voltage level, and opening year of the line were investigated. Real-time information during measurement, such as the time of departure, moving and arrival of trains, were also recorded. Results: The arithmetic mean(AM) and maximum(Max) intensity of ELF-MF were $0.62{\mu}T$ and $11.51{\mu}T$, respectively. Compared by region, the ELF-MF intensity measured inside cabin were the highest in the Seoul Metropolitan Area($AM=0.80{\mu}T$), followed by Busan($AM=0.30{\mu}T$), Daegu($AM=0.29{\mu}T$), Incheon($AM=0.14{\mu}T$), Gwangju($AM=0.04{\mu}T$) and Daejeon($AM=0.03{\mu}T$). The average ELF-MF level measured in AC trains($AM=1.36{\mu}T$) was also significantly higher than in DC trains($AM=0.28{\mu}T$). In terms of the opening year of the subway, trains opened before 1990($AM=0.85{\mu}T$) was the highest and the lowest was 2000-2009($AM=0.24{\mu}T$). Conclusions: The AC supply has the greatest influence on the generation of the ELF-MF intensity in subway cabins.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.2 s.332
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• pp.75-80
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• 2005

In this paper, 2-stage power amplifier has been designed for 5.8GHz wireless LAN application. The power amplifier PldB output power has 21.6dBm at 5.8GHz frequency. Also the power amplifier shows 17.6dB gain and -17.8dB input return loss at 5.725GHz to 5.825GHz. The OFDM modulation and transmission block have been modeled in order to analyse the relationship between the power amplifier distortion and output ACPR for the IEEE 802.11a wireless LAN. The nonlinear characteristic of the power amplifier has been modeled as AM-to-AM and AM-to-PM using the behavioral model, and the output spectrum is analysed with the phase distortion variation. Also, amplifier back-off value from PldB to satisfy the required IEEE 802.11a standard spectrum mask has been simulated with phase distortion, and the simulation data have been compared to the measurement result collected by using the pre-distortion technique.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.2
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• pp.75-80
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• 2020

In this study, we investigated the dose-dependent effects of mixtures of Atractylodes macrocephala (AM) and Amomum villosum (AV) water extracts in a ratio of 3:1 on high fat diet (HFD)-induced obesity model. Oral administration of various concentrations with mixtures of AM and AV extracts in a ratio of 3:1 for 6 weeks inhibited HFD-induced increases of body, liver and epididymal fat weights in a dose-dependent fashions. Those effects may be mediated by decreased expressions of lipogenesis-related genes such as acetyl coA carboxylase (ACC) and fatty acid synthase (FAS) in liver. Also, increase of insulin and decrease of adiponectin in serum by HFD supply were inhibited by three different dosages of mixtures of AM and AV extracts in a ratio of 3:1. HFD supply induced increases of serum total cholesterol, triglyceride and LDL cholesterol. However, hyperlipidemia was significantly decreased in dose-dependent manners by treatment with mixtures of AM and AV extracts. Based on the results of the present study, hypolipidemic and anti-obesity effects by mixtures of AM and AV extracts were found in HFD-induced obesity model. Further clinical investigation is needed to develop anti-obesity therapeutic or preventive agents by using mixtures of AM and AV extracts.

• Animal Systematics, Evolution and Diversity
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• v.27 no.1
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• pp.25-33
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• 2011

Three morphospecies of the genus Uronychia, i.e. U. setigera Calkins, 1902, U. binucleata Young, 1922, and U. multicirrus Song, 1997, were collected from the coastal waters of Gumjin-ri on the East Sea and the public waterfront of Incheon on the Yellow Sea in Korea, respectively. These species are described based on live observation, protargol impregnation, silver nitrate impregnation, and their morphometrics. Diagnostic keys for these species are also provided. In addition, their small subunit ribosomal DNA sequences were compared with previously known sequences of Uronychia species. Diagnostics of three Uronychia species are as follows: U. setigera: $50-80\;{\mu}m$ long in vivo, oval-shaped, 2 macronuclear nodules (Ma), 1 spur on the left margin, 11 adoral membranelles (AM) 1, 4 AM2, 1 buccal cirrus (BC), 4 frontal cirri (FC), 3 left marginal cirri (LMC), 2 ventral cirri (VC), 5 transverse cirri (TC), 3 caudal cirri (CC), 6 dorsal kineties (DK), and approximately 23 cilia in the leftmost kinety. U. binucleata: $70-110\;{\mu}m$ long in vivo, oval to slightly rectangular shaped, 2 Ma, 1 micronucleus (Mi), 2 spurs on the posterior region, 11 AM1, 4 AM2, 1 BC, 4 FC, 3 LMC, 2 VC, 5 TC, 3 CC, 6 DK, and approximately 37 cilia in the leftmost kinety. U. multicirrus: $140-200\;{\mu}m$ long in vivo, oval to slightly rectangular shaped, ca. 7 Ma, 1 Mi, 11 AM1, 4 AM2, 1 BC, 4 FC, 3 LMC, approximately 8 VC, 5 TC, 3 CC, and 6 DK. This study presents the first record of this genus in Korea.

• The Korean Journal of Food And Nutrition
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• v.18 no.1
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• pp.72-80
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• 2005

To prevent and treat the osteoporosis, diverse therapies have been applied, which is still need to solve negative side effects. We investigated the effects of the extract from alternative medicine(AM) on the progress of bone loss in ovariectomized-rats fed with Ca-deficient diet for 7 or 14 weeks. Ovariectomy(OVX) concomitant with Ca-deficiency caused bone loss evidently decreased in bone mineral density and bone strength of femoral epiphysis and vertebrae, which were ameliorated with administration of AM extract. Also, the effect of AM extract on the biochemical markers were measured. The increased serum alkaline phosphatase caused by OVX and Ca-deficiency were observed, which were not affected by administration of AM extract. Administration of AM extract may have preventive effect on the elevated serum acid phosphatase concentrations caused by OVX and Ca-deficiency at 14 wks, implicating that AM extract possibly acts toward reducing born resorption, even though the results were not statistically significant. Serum osteocalcin and urinary deoxypyridinoline, the markers of bone turn over, were not changed by estrogen deficiency or AM extract. We concluded that the AM extract treatment had potently preventive effects on the decreased bone density and bone strength induced by OVX and Ca-deficiency. The changes of biochemical markers related to the effect of AM extract were not manifested but it still suggest that AM extract may inhibit the bone resorption derived from OVX and Ca-deficiency.

• Korean Journal of Acupuncture
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• v.17 no.1
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• pp.1-10
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• 2000

Gamdutang aqua-acupuncture solution(GAS) and Gamdutang water-extracted solution(GWS) were prepared and tested for potential antitumor activites. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of $5{\times}\;and\;10{\times}$ of GAS resulted in more than 70% inhibition of growth in Ehrlich ascites tumor cells(EATC), hepa1c1c7 and A549. GAS at the concentration of $10{\times}\;and\;5{\times}$ revealed that more than 60% inhibition in HeLa. GWS showed more than 50% in hibition of growth with EATC, HeLa at the concentration of $5{\times}\;and\;10{\times}$. Toxicity assay with GWS in hepa1c1c7 and A549 revealed that more than 80% inhibition in growth at the concentration of $5{\times}\;and\;10{\times}$. In morphological study, the number of cells were decreased, and the shape of cells was round-form. Most of cells in detached in EATC, Hepa1c1c7, HeLa, and A549 with GAS. These results suggest that GAS has antitumor activity in vitro.

• Korean Journal of Pharmacognosy
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• v.31 no.1
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• pp.7-15
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• 2000

Glycyrrhizae Radix aqua-acupuncture solution (GRAS) and Glycyrrhizae Radix water-extracted solution (GRWS) were prepared and tested for organ toxicities, antitumor activities, and immunomodulatory effects. The organ-toxicity of GRAS to male ICR mice was studied by the measurements of glutamic oxaloacetic transaminase (GOT), glutamic pyruvate transaminase (GPT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP-s) activities after injection of GRAS for 7 days. The activities of GOT, GPT, LDH, ALP-s were decreased with GRAS. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of GRAS at 1.5g/ml and 3g/ml resulted in more than 80% inhibition of growth in Ehrlich ascites tumor cells (EATC), Hepa1c1c7, and HeLa cells. Toxicity of GRAS to A549 revealed that 68% inhibition of growth. GRWS at the concentration of 3g/ml showed more than 80% inhibition of growth with EATC, Hepalclc7, A549 and HeLa. In morphological study, the number of cells were decreased, and the shape of cells was round-form in EATC, Hepalclc7, A549 and HeLa cells with GRAS. Administration of GRAS inhibited the growth of EATC in vivo. Mice given EATC at 1.5g/ml or 0.3g/ml GRAS had 16.7% to 50% survival after 21 days. GRAS increased the proliferation of T and B cells and the cytolytic activity of purified T cell. The biosyntheses of nucleic acid and protein of EATC, Hepalclc7, A549 and HeLa cells were inhibited by GRAS.

• Transactions of Materials Processing
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• v.23 no.2
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• pp.116-121
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• 2014

Low pressure die casting and flow forming have been successfully used to produce sound road wheels from magnesium alloy AM80. In the current study, high speed compression testing was initially conducted to simulate the flow forming of a Mg wheel. Subsequently the flow forming was simulated with "Forge$^{TM}$", an FEM software package. On the basis of flow forming simulations, the flow forming of the Mg wheel was performed under different conditions. For the flow forming experiments, the preform castings were made by low pressure die casting from AM80, a commercial magnesium alloy. In flow forming of the magnesium preform wheel, the flow forming of the Mg wheel was successfully accomplished when the feed rate was less than half that for the forming of an aluminum road wheel. The reduction in feed rate was 52%. Finally, a comparison with the flow forming simulations was made.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.6
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• pp.859-865
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• 2002

The aim of this research was to clarify the direct effects of a hot environment on ruminal motility in sheep fed twice a day. In the first experiment, in order to equalize variable factors excluding the ambient temperature between the thermoneutral environment ($23^{\circ}C$, relative humidity 80%) and the hot environment ($32^{\circ}C$, relative humidity 80%), sheep were fed equal amounts of the same quality feed twice a day. The sheep were allowed free access to water for the duration of the two one-hour feeding periods (10:00 am-11:00 am, 5:00 pm-6:00 pm). On the fourth day after exposure to the hot environment, the frequency and strength of ruminal contractions were continuously recorded between 9:30 am and 11:00 pm. Prior to the exposure to a hot environment the frequency and strength of ruminal contractions were recorded in a thermoneutral environment during the period 9:30 am-11:00 pm. In the second experiment, in order to maintain the stomach content of the sheep at equal levels in both environments, the sheep were fed equal amounts of the same quality feed twice a day. Following the completion of the two one-hour feeding periods, a fixed amount of warm water was infused into the rumen. Rumen motility was then recorded during the same period as for the first experiment (9:30 am-11:00 pm). In the first experiment, when the frequency of ruminal contractions prior to (24, 24 frequency/15 min), during (48, 47 frequency/min) and after (22, 19 frequency/min) both the morning and afternoon feeding in a hot environment was compared with the values from the thermoneutral environment (20, 22; 50, 50; 21, 20 frequency/min), there was found to be no difference. However, the strength of ruminal contractions after morning and afternoon feeding (3.7, 3.1 mm Hg) in the hot environment decreased significantly in comparison with the thermoneutral environment (4.3, 3.8 mm Hg). In the second experiment, the frequency of ruminal contractions in the hot environment was not significantly different from that in the thermoneutral environment. The strength of ruminal contractions after ruminal infusion of warm water in the hot environment (morning: 4.6, afternoon: 4.5 mm Hg) was significantly lower than that in the thermoneutral environment (morning: 5.6, afternoon: 5.0 mm Hg). The results suggest that a hot environment acts directly on the strength of ruminal contractions in sheep fed twice a day rather than on the frequency.