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Effect of Mixture of Atractylodes macrocephala and Amomum villosum Extracts on Body Weight and Lipid Metabolism in High Fat Diet-Induced Obesity Model

고지방식이 유도 비만 모델에서 백출과 사인 추출 혼합물이 체중 및 지질대사에 미치는 영향

  • Kim, Ha Rim (Department of Physiology, School of Korean Medicine, Wonkwang University) ;
  • Kwon, Yong Kwan (Department of Physiology, School of Korean Medicine, Wonkwang University) ;
  • Choi, Bong Keun (NutraPharm Tech Co., Ltd.) ;
  • Jung, Hyun Jong (Department of Diagnostics, School of Korean Medicine, Wonkwang University) ;
  • Baek, Dong Gi (Department of Korean Internal Medicine, Korean Medicine Hospital, Wonkwang University)
  • 김하림 (원광대학교 한의과대학 생리학교실) ;
  • 권용관 (원광대학교 한의과대학 생리학교실) ;
  • 최봉근 ((주)뉴트라팜텍) ;
  • 정현종 (원광대학교 한의과대학 진단학교실) ;
  • 백동기 (원광대학교 한의과대학 한방병원 한방내과)
  • Received : 2020.04.02
  • Accepted : 2020.04.22
  • Published : 2020.04.25

Abstract

In this study, we investigated the dose-dependent effects of mixtures of Atractylodes macrocephala (AM) and Amomum villosum (AV) water extracts in a ratio of 3:1 on high fat diet (HFD)-induced obesity model. Oral administration of various concentrations with mixtures of AM and AV extracts in a ratio of 3:1 for 6 weeks inhibited HFD-induced increases of body, liver and epididymal fat weights in a dose-dependent fashions. Those effects may be mediated by decreased expressions of lipogenesis-related genes such as acetyl coA carboxylase (ACC) and fatty acid synthase (FAS) in liver. Also, increase of insulin and decrease of adiponectin in serum by HFD supply were inhibited by three different dosages of mixtures of AM and AV extracts in a ratio of 3:1. HFD supply induced increases of serum total cholesterol, triglyceride and LDL cholesterol. However, hyperlipidemia was significantly decreased in dose-dependent manners by treatment with mixtures of AM and AV extracts. Based on the results of the present study, hypolipidemic and anti-obesity effects by mixtures of AM and AV extracts were found in HFD-induced obesity model. Further clinical investigation is needed to develop anti-obesity therapeutic or preventive agents by using mixtures of AM and AV extracts.

Keywords

References

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