Browse > Article

Effects of Alternative Medicine Extract on Bone Mineral Density, Bone Strength and Biochemical Markers of Bone Metabolism in Ovariectomized Rats  

Lee Joo-Won (Department of Pharmacology & Clinical Pharmacology Laboratory, College of Medicine, Hanyang University)
Kim Hyunjin (Department of Pharmacology & Clinical Pharmacology Laboratory, College of Medicine, Hanyang University)
Jhee Okhwa (Department of Pharmacology & Clinical Pharmacology Laboratory, College of Medicine, Hanyang University)
Won Haedan (Department of Pharmacology & Clinical Pharmacology Laboratory, College of Medicine, Hanyang University)
Yu Youngjo (Department of Internal Medicine, College of Medicine, Hanyang University)
Lee Minho (Department of Internal Medicine, College of Medicine, Hanyang University)
Kim Taewha (Department of Internal Medicine, College of Medicine, Hanyang University)
Om Aeson (Department of Food Science and Nutrition, College of Human Ecology, Hanyang University)
Kang Juseop (Department of Pharmacology & Clinical Pharmacology Laboratory, College of Medicine, Hanyang University)
Publication Information
The Korean Journal of Food And Nutrition / v.18, no.1, 2005 , pp. 72-80 More about this Journal
Abstract
To prevent and treat the osteoporosis, diverse therapies have been applied, which is still need to solve negative side effects. We investigated the effects of the extract from alternative medicine(AM) on the progress of bone loss in ovariectomized-rats fed with Ca-deficient diet for 7 or 14 weeks. Ovariectomy(OVX) concomitant with Ca-deficiency caused bone loss evidently decreased in bone mineral density and bone strength of femoral epiphysis and vertebrae, which were ameliorated with administration of AM extract. Also, the effect of AM extract on the biochemical markers were measured. The increased serum alkaline phosphatase caused by OVX and Ca-deficiency were observed, which were not affected by administration of AM extract. Administration of AM extract may have preventive effect on the elevated serum acid phosphatase concentrations caused by OVX and Ca-deficiency at 14 wks, implicating that AM extract possibly acts toward reducing born resorption, even though the results were not statistically significant. Serum osteocalcin and urinary deoxypyridinoline, the markers of bone turn over, were not changed by estrogen deficiency or AM extract. We concluded that the AM extract treatment had potently preventive effects on the decreased bone density and bone strength induced by OVX and Ca-deficiency. The changes of biochemical markers related to the effect of AM extract were not manifested but it still suggest that AM extract may inhibit the bone resorption derived from OVX and Ca-deficiency.
Keywords
osteoporosis; bone mineral density; bone strength; biochemical markers;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Balena, R, Toolan, BC, Shea, M, Markatos, A, Myers, ER, Lee, SC, Opas, EE, Seedor, JG, Klein, H, Frankenfield, D, Quartuccio, H, Fioravanti, C, Clair, J, Brown, E, Hayes, WC and Rodan, GA. The effects of 2-year treatment with the arninobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J. Clin. Invest. 92:2577-2586. 1993   DOI   ScienceOn
2 Reddy, PN and Lakshmana, M. Prevention of bone loss in calcium deficient ovariectomized rats by OST-6, a herbal preparation. J. Ethnopharmacol. 84:259-264. 2003   DOI   PUBMED   ScienceOn
3 Mitra, SK, Venkataranganna, MY, Gopumadhavan, S, Seshadri, SJ, Rafiq, M, Anturlikar, SD, Sundraram, R and Tripathi, M The beneficial effect of OST-6(osteoCare), herbomineral formulation, in experimental osteoporosis. Phytomedicine 8:195-201. 2001   DOI   ScienceOn
4 Grigoriadis, AE, Heersche, JN and Aubin, JE. Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J. Cell Biol. 106:2139-2151. 1988   DOI   ScienceOn
5 Kobayashi, M, Hara, H and Akiyama, Y. Effect of menatetrenone $(V.K_2)$ on bone mineral density and bone strength in Ca/Mg deficient rats. Folia. Pharm. Jpn. 120:195-204. 2002   DOI   ScienceOn
6 Courpron, P. Bone tissue mechanism underlying osteoporosis Orthp. Clin. N. Am. 12:513-545. 1981
7 Lee, HJ. Review of biochemical bone metabolism markers change in osteoporosis incidence factors. J. Kor. Soc. Phys. Ther. 14:213-220. 2002
8 McSheey, PM and Chembers, TJ. Osteoblastic cell mediate osteoclastic responsiveness to parathyroid hormone. Endocrinology 118:824-828. 1986   DOI   ScienceOn
9 Slemenda, C, Hui, SL, Longcope, C and Johnston, CC. Sex steroids and bone mass: a study of changes about the time of menopause. J. Clin. Invest. 80: 1261-1269. 1987   DOI
10 Wang, X, Wu, J, Chiba, H, Umegaki, K, Yamada, K and Ishimi, Y. Puerariae radix prevents bone loss in ovariectomized mice. J. Bone Miner. Metab. 21:268-275. 2003   DOI   ScienceOn
11 Kim, MS, Seo, BI, Kwak, MA and Jee, SY. Effect of Chungajihwangtang on osteoporosis in overiectomized rats. Kor. J. Herbology 18:49-58. 2003
12 Lee, Y-B, Lee, HJ, Kim, KS, Lee, J-Y, Nam, S-Y, Cheon, S-H, and Shon, H-S. Evalution of the preventive effect of isoflavone extract on bone loss in ovariectomized rats. Biosci. Biotechnol. Biochem. 68:1040-1045. 2004   DOI   ScienceOn
13 Frolik, CA, Bryant, HU, Black, EC, Magee, DE and Chandrasekhar, S. Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: Effects of raloxifene HCl, tamoxifen, estrogen and alendronate. Bone 18 :621627. 1996
14 Das, AS, Mukherjee, M and Mitra, C. Evidence for a prospective anti-osteoporosis effect of black tea (Camellia sinensis) extract in a bilaterally ovariecotrnized rat model. Asia Pac. J. Clin. Nutr. 13:210-216. 2004
15 Kim, C, Ha, H, Lee, JH, Kim, JS, Song, K and Park, SW. Herbal extract prevents bone loss in ovariectomized rats. Arch. Pharm. Res. 26:917-924. 2003   DOI   ScienceOn
16 Kalu, DN, Arjmandi, BH, Liu, C-C, Salih, MA and Bimbaum, RS. Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3. Bone Miner. 25:135-148. 1994   DOI   ScienceOn
17 Dempster, DW and Lindsay, R. Pathogenesis of osteoporosis. Lancet 341 :781-801. 1993
18 Notelovitz, M. Osteoporosis: screening, prevention and management. Fertility Sterility 59:714-715. 1993
19 Riggs, BL and Melton, III, LJ. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17:505S-511S
20 Nordin, BEC, Wishart, JM, Clifton, PM, McArthur, R, Scopacasa, F, Need, AG, Morris, HA, O'Loughlin, PD and Horowitz, M. A longitudinal study of bone-related biochemical changes at the menopause. Clin. Endocrinology 61: 123-130. 2004   DOI   ScienceOn
21 Lee, JA, Noh, SH, Ahn, DK and Choi, HY. Effects of the Eucommiae cotrtex and Chanenomelis fructus on the aged overiectomized rat of postmenopausal osteoporosis. Kor. J. Herbology 16:201-206. 2001
22 Kanis, JA, Melton, LJ, Christiansen, C, Johnston, CC and Khaltaev, N. The diagnosis of osteoporosis. J. Bone Miner. Res. 9:1137-1141. 1994
23 Booth, SL, Tucker, KL, Chen, H, Hannan, MT, Gagnon, DR, Cupples, LA, Wilson, PW, Ordovas, J, Schaefer, EJ, Dawson-Hughes, B and Kiel, DP. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am. J. Clin. Nutr. 71:1201-1208. 2000
24 Lee, DS and Byun, SY. Effects of the dietary mixture of Eucommiae ulmoides oliver on osteoporosis. Kor. J. Biotechnol. Bioeng. 16:614-619. 2001
25 Mizrahi, J, Margulies, JY, Leichter, I and Deutsch, D. Fracture of the human femoral neck: effect of density of the cancellous core. J. Biomed Eng. 6:56-62. 1984   DOI   ScienceOn
26 Delmas, PD. Biochemical markers of bone turnover. J. Bone Miner. Res. 8 Suppl 2:S549-555. 1993
27 Azuma, Y, Oue, Y, Kanatani, H, Ohta, T, Kiyoki, M and Komoriya, K. Effects of continous alendronate treatment on bone mass and mechanical properties in ovariectomized rats: comparison with parnidronate and etidronate in growing rats. J. Pharmacol. Exp. Ther. 286:128-135. 1998
28 Kim, KY, Kim, SB and Lim, JW. Effects of safflower seed yougurt on the osteoporosis in ovariectomized rat. Kor. J. Anim. Sci. & Technol. 46:69-76. 2004   DOI
29 Riggs, BL and Melton, LJ. The prevention and treatment of osteoporosis. N Engl. J. Med. 327:62-627. 1992   DOI
30 Johansen, JS, Riis, BJ, Delmas, PD and Christiansen, C. Plasma BGP: an indicator of spontaneous bone loss and of the effect of estrogen treatment in postmenopausal women. Eur. J. Clin. Invest. 18:191-195. 1988   DOI   ScienceOn
31 Ito, M, Azuma, Y, Takagi, H, Kamimura, T, Komoriya, K, Ohta, T and Kawaguchi, H. Preventive effects of sequential treatment with alendronate and l-hydroxyvitarnin $D_3$ on bone mass and strength in ovariectomized rats. Bone 33:90-99. 2003   DOI   ScienceOn
32 Richardson, ML, Genant, HK, Cann, CE, Ettinger, B, Gordan, GS, Kolg, FO and Reiser, UJ. Assessment of metabolic bone disease by quantitative computed tomography Clin. Orthop. 195:224-238. 1985
33 장준섭, 골다공증성 골절의 예방과 치료, 대한골대사학회지 1:147-505S-511S. 1994
34 Turner, RT, Riggis, BL and Spelsberg, TC. Skeletal effects of estrogen. Endocrine Rev. 15:275-300. 1994
35 Okasaki, R, Inoue, D, Shibata, M, Saika, M, Kido, S, OOka, H, Tomiyama, H, Sakamoto, Y and Matsumoto, T. Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) ${\alpha}\;or\;{\beta}$. Endocrinology 143: 2349-2356. 2002   DOI   PUBMED   ScienceOn
36 Kim, HY. Method for preparing composition for treating osteoporosis. Korea. Patent 2003-0042183. 2003
37 Bone, HG, Hosking, D, Devogelaer, J-P, Tucci, JR, Emkey, RD, Tonino, RP, Rodriguez-Portales, JA, Downs, RW, Gupta, J, Santora, AC and Liberman, UA. Ten year's experience with alendronate for osteoporosis in postmenopausal women. N. Engl. J. Med. 350:1189-1199. 2004   DOI   ScienceOn
38 Reddy, PN, Lakshrnana, M and Venkatesh Udupa, U. Effect of Praval bhasma( Coral calx), a natural source of rich calcium on bone mineralization in rats. Phramcol. Res. 48:593-599. 2003   DOI   ScienceOn
39 Sarioglu, M, Tuzun, C, Unlu, Z, Tikiz, C, Taneli, F and Uvanik, BS. Comparison of the effects of alendronate and risedronate on bone mineral density and bone turnover markers in postmenopasual osteoporosis. Rheumatol. Int Epub ahead of print. 2004
40 Riggs, BL and Melton, LJ. Involutional osteoporosis. N. Engl. J. Med. 314:1676-1686. 1986   DOI   ScienceOn
41 Cranney, A, Wells, G, Willan, A, Griffith, L, Zytaruk, N, Robinson, V, Black, D, Adachi, J, Shea, B, Tugwell, P and Guyatt, G. Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Endocirne Rev. 23:508-516. 2002   DOI   ScienceOn
42 Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am. J. Med. 94:645-650. 1993