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http://dx.doi.org/10.15188/kjopp.2020.04.34.2.75

Effect of Mixture of Atractylodes macrocephala and Amomum villosum Extracts on Body Weight and Lipid Metabolism in High Fat Diet-Induced Obesity Model  

Kim, Ha Rim (Department of Physiology, School of Korean Medicine, Wonkwang University)
Kwon, Yong Kwan (Department of Physiology, School of Korean Medicine, Wonkwang University)
Choi, Bong Keun (NutraPharm Tech Co., Ltd.)
Jung, Hyun Jong (Department of Diagnostics, School of Korean Medicine, Wonkwang University)
Baek, Dong Gi (Department of Korean Internal Medicine, Korean Medicine Hospital, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.34, no.2, 2020 , pp. 75-80 More about this Journal
Abstract
In this study, we investigated the dose-dependent effects of mixtures of Atractylodes macrocephala (AM) and Amomum villosum (AV) water extracts in a ratio of 3:1 on high fat diet (HFD)-induced obesity model. Oral administration of various concentrations with mixtures of AM and AV extracts in a ratio of 3:1 for 6 weeks inhibited HFD-induced increases of body, liver and epididymal fat weights in a dose-dependent fashions. Those effects may be mediated by decreased expressions of lipogenesis-related genes such as acetyl coA carboxylase (ACC) and fatty acid synthase (FAS) in liver. Also, increase of insulin and decrease of adiponectin in serum by HFD supply were inhibited by three different dosages of mixtures of AM and AV extracts in a ratio of 3:1. HFD supply induced increases of serum total cholesterol, triglyceride and LDL cholesterol. However, hyperlipidemia was significantly decreased in dose-dependent manners by treatment with mixtures of AM and AV extracts. Based on the results of the present study, hypolipidemic and anti-obesity effects by mixtures of AM and AV extracts were found in HFD-induced obesity model. Further clinical investigation is needed to develop anti-obesity therapeutic or preventive agents by using mixtures of AM and AV extracts.
Keywords
Atractylodes macrocephala; Amomum villosum; High fat diet; Hyperlipidemia; Obesity;
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Times Cited By KSCI : 8  (Citation Analysis)
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1 Lu S, Zhang T, Gu W, Yang X, Lu J, Zhao R, Yu J. Volatile Oil of Amomum villosum Inhibits Nonalcoholic Fatty Liver Disease via the Gut-Liver Axis. Biomed. Res. Int. 2018:3589874.
2 Chen Z, Ni W, Yang C, Zhang T, Lu S, Zhao R, Mao X, Yu J. Therapeutic Effect of Amomum villosum on Inflammatory Bowel Disease in Rats. Front Pharmacol. 2018;9:639.   DOI
3 Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, et al: The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Chem. Biol. Interact. 2009;178:94-8.   DOI
4 Ha J, Daniel S, Broyles SS and Kim KH: Critical phosphorylation sites for acetyl-CoA carboxylase activity. J. Biol. Chem. 1994;269:22162-8.   DOI
5 Krssak, M, Petersen KF, Dresner A, DiPietro L, Vogel S, Rothman D, Shulman G, Roden M. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 1999;42:113-6.   DOI
6 Musovic S, Olofsson CS. Adrenergic stimulation of adiponectin secretion in visceral mouse adipocytes is blunted in high-fat diet induced obesity. Sci. Rep. 2019;9(1):10680.   DOI
7 de Mendonca M, Dos Santos BAC, de Sousa E, Rodrigues AC. Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet. Mol. Cell Endocrinol. 2019;493:110480.   DOI
8 Lee J, Narayan VP, Hong EY, Whang WK, Park T. Artemisia Iwayomogi Extract Attenuates High-Fat Diet-Induced Hypertriglyceridemia in Mice: Potential Involvement of the Adiponectin-AMPK Pathway and Very Low Density Lipoprotein Assembly in the Liver. Int. J. Mol. Sci. 2017;18(8):E1762.
9 Peng Y, Yu S, Li H, Xiang H, Peng J, Jiang S. MicroRNAs: Emerging roles in adipogenesis and obesity. Cell Signal. 2014;26(9):1888-96.   DOI
10 Ouyang FL, Seo BI. Anti-obesity effect of Cynanchi Wilfordii Radix on High fat diet-induced obese mice. Kor. J. Herbol. 2019;34(2):49-58.   DOI
11 Kim JM, Choi SM, Woo CH, Ahn HD. The Anti-obesity Effect of Seungyangjeseup-tang for High Fat Diet Induced Obese Mice. J. Kor. Med. Rehabil. 2018;28(3):1-11.
12 Jeong MJ, Woo CH, Ahn HD. The Anti-obesity Effects of Younggyechulgam-tang-ga Hwanggi on Obesity in Mice Induced by High Fat Diet. J. Kor. Med. Rehabil. 2018;28(2):1-20.   DOI
13 Kim HR, Kwon YK, Choi BK, Baek DG. Inhibitiory Effects of Mixture of Atractylodes macrocephala and Amomum villosum Extracts on Adipocyte Differentiation in OP9 Cells. J. Physiol & Pathol. Korean Med. 2020;34(1):24-9.   DOI
14 Kim HR, Choi BK, Jung HJ. Anti-Obesity Effects of Mixture of Atractylodes macrocephala and Amomum villosum Extracts. J. Physiol & Pathol. Korean Med. 2019;33(5):282-7.   DOI
15 Kwak TK, Jang HS, Lee MG, Jung YS, Kim DO, Kim YB, Kim JI, Kang H. Effect of Orally Administered Atractylodes macrocephala Koidz Water Extract on Macrophage and T Cell Inflammatory Response in Mice. Evid. Based Complement. Alternat. Med. 2018:4041873.
16 Song MY, Lim SK, Wang JH, Kim H. The Root of Atractylodes macrocephala Koidzumi Prevents Obesity and Glucose Intolerance and Increases Energy Metabolism in Mice. Int. J. Mol. Sci. 2018;19(1):E278.