• The Transactions of the Korean Institute of Electrical Engineers A
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• v.48 no.5
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• pp.643-649
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• 1999

In this paper, we proposed that ｉ) noise-tolerant four kinds of AM(Amplitude Modulation)-FM(Frequency Modulation) demodulators are designed, ⅱ) we derived undersampling frequency through the product via energy operator of the monocomponent AM-FM signals separated form two-component AM-FM signals, and ⅲ) these four kinds of AM-FM demodulators detect respectively information signals of the IA(Instantaneous Amplitude) and IF(Instantaneous Frequency) by undersampling frequency to be different each other from the undersampled monocomponet AM-FM signals. Particularly, the proposed algorithm can control undersampling frequency by an integer factor. And these efficient AM-FM demodulators are well worked with the undersampled AM-FM signals.

• Journal of Internet Computing and Services
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• v.9 no.1
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• pp.21-32
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• 2008

In this paper, we propose new modulation schemes using the conventional CACB (Constant Amplitude Coded Multicode Biorthogonal) modulation with constant amplitude property. Also the proposed modulation schemes supports high transmission data rate by increasing the spectral efficiency, In order to obtain the high spectral efficiency, the $Q^2$AM (Quadrature-Quadrature Amplitude Modulation) and CA-$Q^2$AM (Constant Amplitude-$Q^2$AM) are used. We explain the simplest combining modulation scheme of CACB and $Q^2$AM (i.e., CACB-$Q^2$AM). However, this modulation scheme cannot support the constant amplitude property. Hence the first CACB-CA-$Q^2$AM (or CACB-CA-$Q^2$AM I) modulation scheme is proposed for the constant amplitude property. In the modulation scheme, the redundant constant amplitude encoding (spectral efficiency decrease) is required. Therefore, the second CACB-CA-$Q^2$AM (or CACB-CA-$Q^2$AM II) modulation scheme is proposed retaining the constant amplitude and the spectral efficiency. Computer simulations show that the proposed CACB-CA-$Q^2$AM II is the efficient modulation scheme.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.572-577
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• 2001

The feasibility of skin penetration was studied for aspalatone (AM, acetylsalicylic acid maltol ester), a novel antithrombotic agent. In this studys hairless mouse dorsal skins were used as a model to select composition of vehicle and AM. Based on measurements of solubility and partition coefficient, the concentration of PC that showed the highest flux for AM across the hairless mouse skin was found to be 40%. The cumulative amount permeated at 48 h, however, appear inadequate, even when the PC concentration was employed. To identify a suitable absorption enhancer and its optimal concentration for AM, a number of absorption enhancers and a variety of concentration were screened for the increase in transdermal flux of AM. Amongst these, linoleic acid (LOA) at the concentration of 5% was found to have the largest enhancement factor (i.e., 132). However, a further increase in AM flux was not found in the fatty acid concentration greater than 5%, indicating the enhancement effect is in a bell-shaped currie. In a study of the effect of AM concentration on the permeation, there was no difference in the permeation rate between 0.5 and 1% for AM, below its saturated concentration. At the donor concentration of 2%, over the saturated condition, the flux of AM was markedly increased. A considerable degradation of AM was found during permeation studies, and the extent was correlated with protein concentrations in the epidermal and serosal extracts, and skin homogenates. In rat dorsal skins, the protein concentration decreased in the rank order of skin homogenate > serosal extract > epidermal extract. Estimated first order degradation rate constants were $6.15{\pm}0.14,{\;}0.57{\pm}0.02{\;}and{\;}0.011{\pm}{\;}0.004{\;}h^{-1}$ for skin homogenate, serosal extract and epidermal extract, respectively. Therefore, it appeared that AM was hydrolyzed to some extent into salicylmaltol by esterases in the dermal and subcutaneous tissues of skin. taken together, our data indicated that transdermal delivery of AM is feasible when the combination of PC and LOA is used as a vehicle. However, since AM is not metabolically stable, acceptable degradation inhibitors may be nervessary to fully realize the transdermal delivery of the drug.

• International Journal of Contents
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• v.2 no.4
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• pp.1-7
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• 2006

The goal of Ambient Intelligence (AmI) is to build a smart environment for users where they are supported in some of their activities by many interaction mechanisms. The diversity of AmI characteristics requires special support from Operating Systems (OSes). In this paper, in order to support a conscious choice of an operating system for any specific AmI application, features requested by AmI systems were characterized and defined considering various applications. Then, characteristics of existing Operating Systems have been investigated in the context of AmI application support to relate their key characteristics to the typical requirements of AmI systems. Qualitative mapping table between AmI characteristics and as features has been proposed with an illustration of how to use it. As no as completely covers the range of characteristics required by AmI systems, challenging issues are summarized for the development of a new as and a product line of OSes.

• The Journal of Korean Medical History
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• v.22 no.1
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• pp.47-55
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• 2009

The Sa-am acupuncture is the acupuncture method created during Chosun Dynasty. It is a unique acupuncture method that was created solely in Korea. Its theories are based on the 69th article of "Classic of Difficult Issues", or Nanjing (難經), which says "tonify its mother when deficiency occurs, and purgate its son when excess occurs" (虛則補其母, 實則瀉其子); the concept of "controlling the viscera which restrains the target" "抑其官" was added to this theory to form the principle of Sa-am acupuncture. It is significant that it turns to the basic principles of the Five Viscera and Six Bowels rather than the 體針 or 阿是針 of the existing acupuncure. Sa-am acupuncture was established in the middle of Chosun Dynasty and was popularized to the practitioners of Korean Medicine through transcripts and printed books. The medical books of at the time of Japanese imperialism that introduced Sa-am acupuncture are "經絡學總論", "舍岩鍼灸訣", "經濟要訣", "靑囊訣", "察病要訣", "濟世寶鑑", "經驗寢具編", and "舍岩 靑囊訣". The magazine that mentions the Sa-am acupuncture is "韓方醫藥". The books on Traditional Medicine that is related to Sa-am acupuncture were of great help in reconstruction of Sa-am acupuncture after the liberation of Korea and explaining the principle of Sa-am acupunture in various angles.

• The Korea Journal of Herbology
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• v.38 no.1
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• pp.45-53
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• 2023

Objectives : Network pharmacology-based research is one of useful tool to predict the possible efficacy and molecular mechanisms of natural materials with multi compounds-multi targeting effects. In this study, we investigated the functional underlying mechanisms of Astragalus membranaceus Bunge (AM) on its anti-obesity effects using a network pharmacology analysis. Methods : The constituents of AM were collected from public databases and its target genes were gathered from PubChem database. The target genes of AM were compared with the gene set of obesity to find the correlation. Then, the network was constructed by Cytoscape 3.9.1. and functional enrichment analysis was conducted to predict the most relevant pathway of AM. Results : The result showed that AM network contained the 707 nodes and 6867 edges, and 525 intersecting genes were exhibited between AM and obesity gene set, indicating that high correlation with the effects of AM on obesity. Based on GO biological process and KEGG Pathway, 'Response to lipid', 'Cellular response to lipid', 'Lipid metabolic process', 'Regulation of chemokine production', 'Regulation of lipase activity', 'Chemokine signaling pathway', 'Regulation of lipolysis in adipocytes' and 'PPAR signaling pathway' were predicted as functional pathways of AM on obesity. Conclusions : AM showed high relevance with the lipid metabolism related with the chemokine production and lipolysis pathways. This study could be a basis that AM has promising effects on obesity via network pharmacology analysis.

• Journal of IKEEE
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• v.24 no.4
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• pp.1081-1085
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• 2020

Instantaneous frequencies (IF) of the AM-FM signal is estimated based on the inflection point detection (IPD) method. Local maxima/minima are detected using the IPD, and they are exploited to find the IF of AM and FM components, respectively. The envelope of the maxima/minima is obtained to estimate the IF of the AM part. And the distance between neighboring maxima (or minima) is used to estimate the IF of the FM component. Computer simulation shows that the proposed method properly estimates the IF of the AM and FM when the signal has fixed frequencies for both parts. In the case of the time-varying IF of the FM part, the estimated IF shows some deviation from the true IF due to the rough sampling effect of the maximum/minimum points. Thus, the post-processing such as the lowpass filtering of the estimated IF is required to refine the resulting IF estimation.

• Journal of Microbiology and Biotechnology
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• v.14 no.1
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• pp.121-127
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• 2004

Amphotericin B (AmB), an amphipathic polyene macrolide, is an antifungal drug produced by Streptomyces nodosus. Recently, AmB has been shown to exert antiviral activity against rubella virus and human immunodeficiency virus by different mechanisms. In this study, we evaluated the antiviral effect of AmB against Japanese encephalitis virus (JEV) and investigated which step of the viral life cycle was inhibited by AmB to understand the mechanism of antiviral action of AmB. AmB reduced both plaque size and number in the infected cells in a dose-dependent manner. In addition, a 200-fold reduction of infectious virus titer was observed by treatment of infected cells with $5\mug/ml$ of AmB. AmB acted at the post virus-infection step, but not during adsorption of virus to host cells. Western blot analysis revealed that the accumulated level of JEV envelope protein dramatically decreased in the infected cells by treatment with $5-10\mug/ml$ of AmB. Our results indicate that AmB inhibits the replication of JEV at the postinfection step by interfering with viral replication and/or by inhibiting the synthesis of viral proteins.

• KIPS Transactions on Computer and Communication Systems
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• v.7 no.12
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• pp.289-294
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• 2018

This paper proposes an implicit d-ary priority queue, called AM(d)-heap that is a generalized version of AM-heap, in which insert operation takes constant amortized time and remove operation takes O(logn) time. According to our experimental results, the best performance was shown when d is 4 or 8. Also, AM(d)-heap is about 1.5~1.8 times faster than the postorder heap.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.6
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• pp.313-327
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• 2017

The purpose of this study is to predict the effects of macroscopic and integrative therapies by finding active ingredients, potential targets of Astragalus membranaceus (Am) and Cornus officinalis (Co) for diabetic nephropathy. We have constructed network pharmacology-based systematic and network methodology by system biology, chemical structure, chemogenomics. We found several active ingredients of Astragalus membranaceus (Am) and Cornus officinalis (Co) that were speculated to bind to specific receptors which had been known to have a role in the progression of diabetic nephropathy. Four components of Am and eleven components of Co could bind to iNOS; two ingredients of Am and six ingredients of Co could docking to cGB-PDE; one component of Am and nine components of Co could bind to ACE; three ingredients of Co with neprilysin; three components of Co with ET-1 receptor; four ingredients of Am and fourteen ingredients of Co with mineralocorticoid receptor; one component of Am and seven components of Co with interstitial collagenase; one ingredient of Am and ten ingredients of Co with membrane primary amine oxidase; one component of Am and four components of Co with JAK2; two ingredients of Am and one ingredient of Co with MAPK 12; one component of Am and five components of Co could docking to TGF-beta receptor type-1. From this work we could speculate that the possible mechanisms of Am and Co for diabetic nephropathy are anti-inflammatory, antioxidant and antihypertensive effects.