• 한국음향학회지
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• 제14권3호
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• pp.49-60
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• 1995

본 논문은 소규모 시스템에 적용 가능한 한국어 문자-음성 변환 시스템의 설계 및 구현에 대한 연구를 목적으로 한다. 본 논문에서 채택한 음성합성 방법은 파라메터 합성법으로서 LPC(linear Predictive Coding)계열의 PARCOR(PARtial autoCORrelation) 계수를 음향 파라메터로 사용하였으며, 음성합성 단위로는 가장 기본적인 단위인 음소를 채택하였다. 합성 파라메터로는 유성음의 경우 PARCOR계수, 피치, 진폭을 무성음의 경우 잔차신호와 PARCOR계수를 사용하였다. 특히 무성음의 경우 LPC합성시 음질이 떨어진다는 단점이 있었으나, 본 논문에서는 LPC분석시 얻어지는 잔차신호를 무성음의 여기신호로 사용하여 단어 단위의 합성에서 60%의 이해도를 얻을 수 있었다. 합성결과 단어 단위의 합성에 적용 가능하였고, 문장단위의 합성을 위해서는 음소 지속시간 조절에 대한 연구가 진행되어야 할것이다. 본 논문의 구현환경으로는 486 PC상에서 음성의 입,출력을 위해 70[Hz]-4.5[KHz] 대역통과 필터와 증폭기, 그리고 TMS320C30 디지털 신호처리 프로세서를 장착한 DSP 보드를 사용하였다.

• 대한한방소아과학회지
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• 제26권1호
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• pp.36-45
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• 2012

Objectives Perillae Folium (PF) has been widely used in Korean herbal medicines used for treatment of acute and chronic inflammatory diseases, such as rhinitis, asthma, and enteritis. In this study, to investigate the protective effect of PF on type 1 allergic response, we determined whether PF inhibits early or late allergic responses. Methods The effect of PF was analyzed by ELISA,. RT-PCR and Western blot in RBL-2H3 cells. Levels of ${\beta}$-hexosaminidase, interleukin (IL)-4 and TNF-${\alpha}$ were measured using enzyme-linked immunosorbent assays (ELISAs). mRNA levels of cytokines and enzymes were analyzed with RT-PCR. Signal transduction was analyzed with Western blot. Results We found that PF suppressed ${\beta}$-hexosaminidase release in RBL-2H3 by the IgE-DNP-HSA stimulation. PF also significantly inhibited enzymes level, such as COX-1, COX-2, iNOS, and HDC2, along with reduced cytokine levels, such as IL-2, IL-3, IL-4, IL-6, IL-13, and TNF-${\alpha}$ in RBL-2H3. In addition, PF suppressed the phospholyation of ERK1/2, JNK1/2, and $I{\kappa}B{\alpha}$. Conclusions Our results indicate that PF protects against type 1 allergic response and exert an anti-inflammatory effect through the inhibition of degranulation and expression of cytokines and enzymes via the suppression of signal transduction.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2007년도 추계종합학술대회
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• pp.180-184
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• 2007

최대 토크를 발휘하도록 정현파형 연구자석형 동기전동기를 구동하기 위해서는 회전자 절대위치에 동기화된 120도 위상차를 갖는 3상 정현파 전류 입력이 고정자 코일에 요구된다. 그러므로 회전자 절대위치 검출이 필연적이다. 그리고 고정자 자계와 회전자 자계 사이의 90도 위상 관계가 정류 동작에 의해 유지 되야 한다. 정류를 위한 절대 위치 검출은 일반적으로 모터 축에 부착된 엔코더 출력 신호의 분석에 의해 이루어진다. 본 연구는 현대의 엔코더 시스템을 부착한 모터의 절대위치를 검출 할 수 있는 신호처리 논리회로 설계를 목적으로 하며, 고정자 코일에 정현파 전류 입력을 만들어주기 위한 삼상 기준파형을 발생시킨다.

• Korean Journal of Radiology
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• 제2권1호
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• pp.21-27
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• 2001

Objective: To identify and evaluate the lateral border zone by comparing the size and distribution of the abnormal signal area demonstrated by MR imaging with the infarct area revealed by pathological examination in a reperfused myocardial infarction cat model. Materials and Methods: In eight cats, the left anterior descending coronary artery was occluded for 90 minutes, and this was followed by 90 minutes of reperfusion. ECG-triggered breath-hold turbo spin-echo T2-weighted MR images were initially obtained along the short axis of the heart before the administration of contrast media. After the injection of Gadomer-17 and Gadophrin-2, contrast-enhanced T1-weighted MR images were obtained for three hours. The size of the abnormal signal area seen on each image was compared with that of the infarct area after TTC staining. To assess ultrastructural changes in the myocardium at the infarct area, lateral border zone and normal myocardium, electron microscopic examination was performed. Results: The high signal area seen on T2-weighted images and the enhanced area seen on Gadomer-17-enhanced T1WI were larger than the enhanced area on Gadophrin-2-enhanced T1WI and the infarct area revealed by TTC staining; the difference was expressed as a percentage of the size of the total left ventricle mass (T2= 39.2 %; Gadomer-17 =37.25 % vs Gadophrin-2 = 29.6 %; TTC staining = 28.2 %; p < 0.05). The ultrastructural changes seen at the lateral border zone were compatible with reversible myocardial damage. Conclusion: In a reperfused myocardial infarction cat model, the presence and size of the lateral border zone can be determined by means of Gadomer-17- and Gadophrin-2-enhanced MR imaging.

• 예술인문사회 융합 멀티미디어 논문지
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• 제8권6호
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• pp.957-966
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• 2018

최근 들어 고령화 및 1인 가구 증가로 인해 IoT기반 원격환자모니터링에 대한 요구가 증대되고 있다. 본 논문에서는 원격환자모니터링을 위한 다중의 IR-UWB레이더를 이용한 비접촉식 생체신호측정시스템을 제안하였다. 기존에는 생체신호처리를 위해 배경차분알고리즘을 적용하였으나, 전압노이즈, 계단현상 등의 에러 발생을 없애고자 다중 배경차분 알고리즘을 적용하였다. 다중배경차분알고리즘은 이전 클러터와 현재 클러터의 변화량을 계산하여 신호를 추출하며, 본 연구에서는 SVD알고리즘을 이용하였다. 개선된 다중배경차분알고리즘을 생체신호측정에 응용하여 고속 푸리에 변환을 통해 호흡수를 계산하였다. 제안한 IR-UWB레이더를 이용한 시스템 및 다중배경차분알고리즘의 검증을 위해 호흡수 측정을 진행하였다. Neulog사의 부착형 공기압착식 호흡측정기를 대조군으로 실험한 결과 97.36%의 정밀도를 확보함으로서 본 연구의 타당성을 검증하였다. 구현된 알고리즘은 기존의 접촉식 웨어러블 방식의 불편함을 개선하였다.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 1999년도 제29회 춘계학술대회
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• pp.170-174
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• 1999

In order to analysis contact mechanism of head/ disk interface on hard disk drive, many techniques of analysis have been developed. Acoustic Emission sensor can be used for detect elastic energy of contact at head/disk interface. This work presents a good understanding of slider characteristics in frequency domain. The results show that torsional and bending mode of slider are dominant in head/disk contact.

• ETRI Journal
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• 제29권2호
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• pp.240-242
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• 2007

This letter proposes a simplified maximum likelihood detection (SMLD) scheme to improve the detection performance of multiple-input multiple-output receivers. The SMLD detects V streams according to the first detected V sub-streams. Through an ML test, the most probable stream is selected. Moreover, to detect the layer with the worst post-detection SNR accurately, reverse ordering is applied to the SMLD. Simulation results show that the performance of the Vertical Bell Laboratories layered space-time (V-BLAST) system can be improved by adopting the SMLD technique. In the case of reverse ordering, the SMLD can achieve a similar ML performance with significant reduction in computational complexity.

• Bulletin of the Korean Chemical Society
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• 제27권9호
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• pp.1353-1358
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• 2006

We investigated in vitro T-cell inhibitory activity and bioavailability of small chemical inhibitors for Lck SH2 domain, which had a different scaffold such as an amide bond, reduced amide bond, N-methyl amide bond, thioamide bond, and urethane bond. Each of these compounds, with its particular scaffold, showed a different logP value, stability against serum enzyme, stability in buffer solution, and in vitro T-cell inhibitory activity. Overall results indicated that the SH2 inhibitor containing urethane bond can be a new lead compound because of its superior bioavailability, potent in vitro T-cell inhibitory activity, and facile synthesis.

• Bulletin of the Korean Chemical Society
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• 제31권7호
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• pp.2011-2014
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• 2010

The fluorescence intensity of a single-stranded oligonucleotide containing a fluorene-labeled deoxyuridine $(U^{Fl})$ unit increases by only 1.5-fold upon formation of its perfectly matched duplex. To increase the fluorescence signal during hybridization, we positioned a quencher strand containing a deoxyguanine (dG) nucleobase, functioning as an internal quencher, opposite to the $U^{Fl}$ unit to reduce the intrinsic fluorescence upon hybridization with a probe. From an investigation of the optimal length of the quencher strand and the effect of the neighboring base sequence, we found that a short strand (five-nucleotide) containing all natural nucleotides and dG as an internal quencher was effective at reducing the intrinsic fluorescence of a linear beacon; it also exhibited high total discrimination factors for the formation of perfectly matched and single base-mismatched duplexes. Such assays that function based on clear changes in fluorescence in response to single-base nucleotide mutations would be useful tools for accelerating diagnoses related to various diseases.

• 한국기계가공학회지
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• 제1권1호
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• pp.117-122
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• 2002

The chatter to raise grinding operating is reduce the precision and the quality. In this study, In reply to AE signal and the normal force generated in the grinding operating were measured (1) the amplitude in the mathematical model of the normal force is the form as to transform an exponential (2) the chatter growth is minus point of an exponent. (3) From the observed wheel aspect after the chatter growth, it was to investigated the concern of the chatter growth and the wheel life.