• Applied Microscopy
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• v.19 no.2
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• pp.99-118
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• 1989

The cardiotoxic effects of acute and chronic administration of adriamycin (ADR) were evaluated in A/J Swiss albino mice. In acute studies, male mice received intravenous ADR, 5mg or 15mg/kg per day for 3 or 1day and were sacrifice 12 hours later. Because the glutathione-glutathione peroxidase system is major pathway for free radical detoxication, glutathione levels and glutathione peroxidase activity was measured. In acute studies, ADR-treated mice exhibited significantly decreased levels(p<0.05) of total glutathione and unchanged levels of oxidized glutathione and percentage of oxidized glutathione. The earliest myocardial fine structural alterations included swelling and degeneration of mitochondria and dilatation of sarcoplasmic reticulum at all dosage of acute models. In chronic studies, mice received 5mg/kg ADR once a week for up to 16 weeks. Levels of total and reduced glutathione were decreased significantly(p<0.01) and oxidized glutathione and percentage of oxidized glutathione were increased significantly (p<0.05). Chronic myocardial lesions included perinuclear vacuolization, seperation of myofibrils and the fasciae adherens of intercalated disc and hypercontraction band within myocyte. Glutathione peroxidase activity reduced significantly (p<0.01) in any group of acute and chronic ADR-treated animals. Test for lipid peroxidation(malondialdehyde) was increased significantly(P<0.01). Thus, we conclude 1) ADR significantly lowers glutathione levels in heart tissue, and 2) cellular damage progress produced by alteration of this system in mouse models of ADR cardiotoxicity. These results suggest that the glutathione-glutathione peroxidase system may be involved in the modulation of ADR-induced cardiotoxicity.

• Korean Journal of Pharmacognosy
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• v.40 no.1
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• pp.65-69
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• 2009

The present study investigated the antiproliferative effect of Litsea japonica in HL-60/ADR, adriamycin resistant human promyelocytic leukemia cells. The 80% ethanol extract of L. japonica markedly inhibited the growth of HL-60/ADR cells. When HL-60/ADR cells were treated with the extract, several apoptosis events like as DNA fragmentation, chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. In the mechanism of apoptosis induction by L. japonica, we examined the changes of Bcl-2 and Bax protein expression levels, and activation of caspases. After the HL-60/ADR cells were treated with the extract, the Bcl-2 expression was decreased, whereas the expression of Bax was increased in a time-dependent manner compared to the control. In addition, the active forms of caspase-9 and -3 were increased and the cleavage of poly (ADP-ribose) polymerase, a vital substrate of effector caspase, was observed. The results suggest that the inhibitory effect of L. japonica on the growth of the HL-60/ADR appears to arise from the induction of apoptosis via the down-regulation of Bcl-2 and the activation of caspases.

• Journal of the Korean Society of Food Science and Nutrition
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• v.18 no.1
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• pp.62-70
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• 1989

The present study was designed to evaluate whether supplementation of dietary coenzyme Q10 protects the ADR-induced cardiotoxicity in rats. Experiment was undertaken under the condition of simultaneous adminstration of ADR and coenzyme Q10 for 4 weeks. Adriamycin treatment significantly decreased growth performance of rats. But this decrement was not modified by dietary supplementation of conzyme Q10. In the plasma creatine phosphokinase activity, there was no significant difference among experimental groups. Electron microscopic examination revealed a progression of myocardial lesions were dependent upon the level of ADR injection. The most frequently observed fine structural alterations in rat myocardium were mitochondrial swelling, dilation of the sarcoplasmic reticulum and the appearance of a perinuclear vacuolization. But these structural changes were somewhat lesser in defree by dietary supplementation of coenzyme Q10.

• Journal of Pharmacopuncture
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• v.22 no.1
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• pp.35-40
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• 2019

Objective: Adriamycin (ADR) is an important anti-cancer drug which can cause renal toxicity. Given the known anti-inflammatory and antioxidant effects of Plantago major (P. major), the aim of this study was to determine the effects of hydroalcoholic extract of P. major on ADR- induced nephropathy in rats. Methods: Fifty male Wistar albino rats were randomly divided into 5 groups including: control, ADR (5 mg/kg), ADR + P. major (600 and 1200 mg/kg) and P. major (1200 mg/kg). The animals were treated with P. major extract for 5 consecutive weeks and ADR was intravenously injected on the 7th day of the study. Urine and serum samples were collected on days 0, 14, 21, 28, and 35 for the measurement of serum cholesterol and albumin levels and urine protein excretion rate. At the end of the study, the left kidneys were removed for apoptosis assessment. Results: Administration of ADR significantly decreased serum albumin level and increased serum cholesterol and urine protein excretion rate as well as, apoptotic cell numbers compared to the control group (P < 0.001) while had no effect on glomerular filtration rate (P > 0.05). Treatment with P. major, in both 600 and 1200 mg/kg doses, increased serum albumin level and decreased serum cholesterol concentration, urine protein excretion rate and as well as the number of apoptotic cell compared to the ADR group (P < 0.001). Conclusion: Our results showed that the P. major extract effectively protects against ADR- induced nephropathy by reducing kidney apoptosis and improving renal functioning in rats.

• Journal of Arbitration Studies
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• v.32 no.4
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• pp.143-164
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• 2022

It is not an exaggeration to say that our society is already one of disputes. Since circa 2010, the average number of lawsuits filed every year is upwards of six million cases, and resolving disputes through trials is already fully saturated. The functional roles of the court reflect that there are many lacking areas such as systems, tools, and procedures related to social integration. In addition, ADR, which is carried out in advanced capitalist nations to supplement the judicial functions, has also been implemented in our society for the past 60 years. However, for the reason why the usage rate of ADR did not increase for legal consumers, we cannot overlook government activities that did not make sufficient promotions related to the lack of awareness. In Korea, ADR is mainly composed of government-initiated types, and in particular, there is no ADR framework act that can play an integrated role. Furthermore, for the conciliation system of the court, over 80%of conciliation are conducted focusing on court of lawsuits, and legal basis and procedures between institutes are different for administrative ADR, and communication does not go smoothly, thus making it inefficient. Such examples cannot avoid being a background for criticism when considering the fundamental ideologies and beliefs of ADR. The Vinaya Pitaka of sangha related to ADR is a separate method for operating communities. This is the BDR (Buddhist Dispute Resolution) method that encompasses personal ethics, organizational ethics, harmony through various community gatherings, and adhikaranasamatha on the four issues that could occur in legal review procedures. This has become the sufficient background for succession and development for parisa sangha and gana sangha among individuals.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.05b
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• pp.1491-1495
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• 2005

물 분쟁은 더 이상 다른 나라의 이야기가 아니다. 우리나라 역시 산업구조의 변화와 인구의 증가로 물의 수요가 증가함에 따라 많은 물 분쟁이 발생하고 있다. 물 분쟁은 많은 원인과 다양한 차원의 분쟁주체들이 관계하고 있어 복잡한 네트워크구조로 나타나는 특징이 있다. 이러한 다양한 종류의 물 분쟁을 해결하기 위해서는 그 대책 또한 법률적, 기술적, 사회적으로 다양하게 접근 하여야 할 것이다. 그러나 과거 우리나라의 경우 분쟁이 발생하였을 때 그 분쟁의 최후 결정은 주로 사법기관에 의하여 처리되곤 하였다. 이러한 사법적 분쟁해결은 많은 시간과 비용을 필요로 하며 분쟁당사자 모두 만족할 수 없는 결과를 야기 할 수 있는 큰 단점을 안고 있다. 본 연구에서는 이러한 단점을 보완하고 물 분쟁을 해결하기 위한 방안으로 대안적분쟁해결방안(ADR: Alternative Dispute Resolution)을 소개하고, 적용가능성에 대하여 검토하였다. 물 분쟁의 해결을 위해 ADR을 활용한다면 시간과 비용의 절약, 원만한 분쟁해결, 사후에도 당사자들의 좋은 관계 유지 등의 이점을 기대 해볼 수 있다.

• Journal of Arbitration Studies
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• v.25 no.3
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• pp.135-154
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• 2015

The European Union has adopted the ADR Directive and ODR Regulation in 2013 with the purpose to strengthen the e-commerce within the EU. Not covered by these legislations is the trade in the B2B sector. The author examines the question of whether online ADR under the currently applicable legal framework would be possible in Germany. At the center of his review is the possibility of an arbitration clause which refers exclusively to an online ADR scheme, may be included in the General Terms and Conditions of an online trader.

• The Korean Journal of Financial Management
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• v.15 no.1
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• pp.41-71
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• 1998

글로벌화가 진전된 산업의 경우에는 세계산업 내지 세계시장 요인이 현지시장 내지 현지산업 요인보다 더 중요한 ADR과 원주 수익률의 결정요인으로 실증된다. 원주의 움직임에 대해서는 대체로 현지산업, 현지시장 요인, 세계시장 요인, 세계산업 요인순으로 설명력이 높게 나타난 반면, 글로벌화가 진전된 산업의 기업 원주에 대해서는 세계시장 또는 세계산업 요인, 현지시장 또는 현지산업 요인 순으로 설명력이 높다. ADR의 움직임은 대체로 세계시장 요인, 현지산업 요인, 현지시장 요인, 환율 요인, 세계산업 요인, 미국산업 요인, 미국시장 요인 순으로 설명되는 반면, 글로벌화가 진전된 산업의 경우에는 세계시장 또는 세계산업 요인, 환율 요인, 현지산업 요인, 현지시장 요인 순으로 설명력이 높다. 한편, 원주와 ADR간에 수익률과 변동성은 모두 상호관련성이 높고, 원주 수익률을 설명하는 요인과 동일 외국기업의 ADR을 설명하는 요인은 대체로 일치한다.

• Journal of Arbitration Studies
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• v.25 no.4
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• pp.97-117
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• 2015

As women's social advance had accomplished improvements to standard of living and equal employment, new forms of dispute such as gender inequality, sex crimes, and divorce rate increases have begun to generate. Disputes between men and women are desirable to settle by ADR rather than by traditional litigation owing to difficulties of legal resolution, cost and time, need for amicable dispute, etc. This study aims to reveal whether there is a relationship between ADR and gender. Through review of previous articles, this study finds that gender difference makes a visible difference depending on case type, context, and sex role of participants. For example, women were selected as mediators and arbitrators in non-monetary and small-claims disputes, family, labor, and consumer disputes and men were selected in large-scale disputes and construction, corporate and commercial, and intellectual property disputes owing to differences of experience and professionalism. Women were relatively frequently selected as mediators owing to active communication skills and men were selected as arbitrators because of decision-making skills.

• Journal of Arbitration Studies
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• v.29 no.3
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• pp.121-140
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• 2019

First, the purpose of this research is to review the Online Dispute Resolution (ODR) regulations in Korea to resolve disputes which can arise in international e-commerce in the near future. Second, this research tries to look for alternative solutions to dispute resolutions according to these regulations. Third, this research pursues to enhance the effectiveness of business deals by providing efficient and satisfactory dispute resolution methods for e-commerce business. Furthermore, this study evaluates the definition of global e-commerce by comparing Online Dispute Resolution (ODR) with Alternative Dispute Resolution (ADR). Through analyzing the domestic ODR system and ADR system, this research could boost the employment of settlements in small-sized disputes through easy and convenient consumer access to both ODR and ADR procedures. The enhancement of the competitiveness of Korean companies in the global market is estimated to take place as a result. This research is estimated to provide benefits to our businesses both domestically and internationally by using ODR regulations and ADR methods. Moreover, this research is anticipated to verify usefulness in terms of consumer protection by advancing consumers' access to dispute solution authorities locally and abroad.