• 동의신경정신과학회지
• /
• 제24권1호
• /
• pp.1-12
• /
• 2013

Objectives : The purpose of this study was to take around herbal medicine for Attention Deficit Hyperactivity Disorder in China. Methods : A journal search was performed using China National Knowledge Infrastructure (CNKI) from 2007 to 2012. Key words searched were 'ADHD'. Results : 25 studies were selected. Case control studies showed that herbal medicine treatment reported better results than the western medicine treatment group. 12 case reports reported a significant improvement in herbal medicine treatment for patients with ADHD. Frequently used herbal materials were Rhizome of Polygalae Radix and Rhizome of Acori Gramineri Rhizoma (16 times), Root of Glycyrrhiza uralensis Fisch (14 times), Root of Rehmanniae Radix et Rhizoma Preparata and Sclerotium of Poria cocos Wolf (12 times). Conclusions : There have been many studies regarding herbal medicine for Attention Deficit Hyperactivity Disorder in China, and these studies can be applied to the clinical practices in Korea.

• 대한한방소아과학회지
• /
• 제27권4호
• /
• pp.10-16
• /
• 2013

Objectives The purpose of this study was to investigate the acupuncture therapy about Attention Deficit Hyperactivity Disorder (ADHD) in China. Methods We searched for the studies on ADHD at China National Knowledge Infrastructure (CNKI, http://www.cnki.net) from 2011.1 to 2013.8. Results Selected 12 studies were divided into 7 case reports and 5 control studies. 7 case reports reported significant improvements with acupuncture therapy in ADHD. 5 control studies reported results that the acupuncture therapy groups were similar or better than western medicine treatment groups. Frequently used acupuncture points were EX-HN23 (7 times), GV20 ${\bullet}$ P6 ${\bullet}$ SP6 (6 times), G13 ${\bullet}$ EX-HN1 (5 times). Conclusions There have been reported many ADHD clinical studies in China and these studies can be applied to the clinical practices in Korea.

• Clinical and Experimental Pediatrics
• /
• 제64권9호
• /
• pp.489-493
• /
• 2021

Background: There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose: This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Methods: All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. Results: All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 case-control studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90-1.35) and (RR, 1.10; 95% CI, 0.96-1.24). Conclusions: The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제33권2호
• /
• pp.27-34
• /
• 2022

Stimulants, such as amphetamine and methylphenidate, are one of the most effective treatment modalities for attention deficit hyperactivity disorder (ADHD) and may cause various movement disorders. This review discusses various movement disorders related to stimulant use in the treatment of ADHD. We reviewed the current knowledge on various movement disorders that may be related to the therapeutic use of stimulants in patients with ADHD. Recent findings suggest that the use of stimulants and the onset/aggravation of tics are more likely to be coincidental. In rare cases, stimulants may cause stereotypies, chorea, and dyskinesia, in addition to tics. Some epidemiological studies have suggested that stimulants used for the treatment of ADHD may cause Parkinson's disease (PD) after adulthood. However, there is still a lack of evidence that the use of stimulants in patients with ADHD may cause PD, and related studies are only in the early stages. As stimulants are one of the most commonly used medications in children and adolescents, close observations and studies are necessary to assess the effects of stimulants on various movement disorders, including tic disorders and Parkinson's disease.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제28권1호
• /
• pp.25-30
• /
• 2017

Objectives: The study compared the intelligence test profiles of Tourette's Disorder (TD), attention-deficit hyperactivity disorder (ADHD), and TD with ADHD (TD+ADHD) groups. Methods: The Korean Wechsler Intelligence Scale for Children-third edition (K-WISC-III) and Korean Wechsler Intelligence Scale for Children-fourth edition (K-WISC-IV) were administered to 13 children and adolescents with TD, 17 children and adolescents with ADHD, and 15 children and adolescents with TD+ADHD. Each parameter was compared among the groups using the Kruskal-Wallis test. Results: The mean scores of the freedom from distractibility/working memory index (FD/WMI) and the digit span and arithmetic subtests of the TD+ADHD group were significantly lower than those of the TD group. Conclusion: According to the intelligence test results, the comorbid ADHD+TD group showed a significant decrease in working memory compared to the TD group. These findings are similar to those of previous research on cognitive functions and suggest that the TD+ADHD comorbid and TD alone groups exhibit different endophenotypes. The results also imply that WISC-III and WISC-IV, the most commonly used intelligence tests clinically, are effective in evaluating cognitive functions such as attention. Further research is required to confirm these results.

• 대한감각통합치료학회지
• /
• 제17권1호
• /
• pp.43-53
• /
• 2019

목적 : 본 연구는 주의력결핍과잉행동장애아동(Attention Deficit Hyperactivity disorder; ADHD)을 대상으로 국내에서 제공되는 중재 방법을 체계적으로 고찰하여 최신의 국내 치료 경향을 제시하고자 하였다. 연구방법 : 2004년 1월부터 2018년 12월까지 최근 15년간 국내 학회지에 게재된 연구를 대상으로 하였다. 누리미디어(DBpia), 스콜라(Scholar), 학술연구정보서비스(RISS), 한국학술정보(KISS)에서 '주의력결핍과잉행동', '아동', '중재'를 키워드로 검색하였다. 연구대상으로 선정된 연구는 총 14개로, 각 연구는 근거의 질적 수준과 방법론적 질적 수준으로 분석한 후 그 결과를 대상자, 중재, 대조, 결과의 순으로 제시하였다. 결과 : 분석 결과 근거기반 실행의 질적 수준은 수준 IV의 연구가 가장 많았고, 방법론적 질적 수준은 '보통'의 연구가 가장 많았다. 중재는 상호작용식 메트로놈 중재(Interactive metronome; IM)의 빈도가 가장 높았고, 측정된 평가도구는 상호작용식 메트로놈 전체형 검사(Long form assessment of IM), 아동 청소년 행동평가척도(Korean behavior child checklist; K-CBCL)의 사용이 높았다. 중재결과 ADHD아동의 집중력, 과잉행동, 과제 수행, 과다언어 사용, 그리고 타이밍 등에서 유의한 효과가 나타났다. 결론 : 국내 ADHD아동을 대상으로 다양한 중재방법이 제공되었고, 그 결과 ADHD증상에서 효과적인 결과가 나타났다. 따라서 본 연구결과는 임상에서 근거기반 실행을 위한 기초자료로 사용할 수 있다. 앞으로 ADHD아동을 대상으로 한 지속적인 연구가 이루어져야 할 것이다.

• Journal of Yeungnam Medical Science
• /
• 제17권2호
• /
• pp.108-122
• /
• 2000

Background: Models of attention deficit hyperactivity disorder(ADHD) that have proposed a hypodopaminergic state resulting in hypofunction of the prefrontal circuitry have assumed a unitary dopamine system, which largely ignores the distinct functional differences between mesocortical dopamine system and nigrostriatal dopamine system. Purpose: The author's goal was to develop a pathophysiological model for ADHD with greater explanotory power than dopaminergic hypofunction hypothesis in prefronal circuitry. Material and Methods: Published clinical findings on ADHD were integrated with data from genetic, pharmacological, neuroimaging studies in human and animals. Results: Molecular genetic studies suggest that three genes may increase the susceptibility to ADHD. The three candidate genes associated with ADHD are each involved in dopaminergic function, and this consistent with the neurobiologic studies implicating catecholamines in the etiology of ADHD. Pharmacological data also provide compelling support for dopamine and noradrenergic hypothesis of ADHD. Neuroimaging studies lend substantial support for the hypothesis that right-sided abnormalities of prefrontal-basal ganglia circuit would be found in ADHD. Conclusions: The present hypothesis takes advantage of the major differences between the two pertinent dopamine systems. Mesocortical dopamine system, which largely lacks inhibitory autoreceptors, is ideally positioned to regulate cortical inputs, thus improving the signal-to-noise ratio for biologically valued signals. In this circuit, therapeutic doses of stimulants are hypothesized to increase postsynaptic dopamine effects and enhance executive functions. By contrast, symptoms of hyperactivity/impulsivity in ADHD are hypothesized to be associated with relative overactivity of nigrostriatal circuit. This nigrostriatal circuit is tightly regulated by inhibitory autoreceptoors as well as by long distance feedback from the cortex, and slow diffusion of therapeutic doses of stimulant via oral administration is hypothesized to produce a net inhibition of dopaminergic neurotransmission and improves hyperactivity.

• 생물정신의학
• /
• 제12권2호
• /
• pp.221-226
• /
• 2005

교통사고 등에 의한 외상성 뇌손상에서 이차적으로 주의력결핍 과잉행동장애가 나타나는 경우가 점차 증가하고 있으며, 이에따른 치료방법도 점차 다양화되고 있는 추세이다. 주의력결핍 과잉행동장애에서 많이 사용되어지는 OROS Methylphenidate를 환자에게 투여하여 인지적인 개선뿐만아니라 충동성, 산만함, 공격성 등의 증상에 효과가 있는지의 여부를 살펴보고자 하였다. 약물투여 전에 비하여 약물투여 후에 환자는 충동성, 공격성, 부주의의 개선효과를 나타내었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제27권3호
• /
• pp.207-215
• /
• 2016

Objectives: This study aimed to investigate the differences in the facial emotion recognition and discrimination ability between children with attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Methods: Fifty-three children aged 7 to 11 years participated in this study. Among them, 43 were diagnosed with ADHD and 10 with ASD. The parents of the participants completed the Korean version of the Child Behavior Checklist, ADHD Rating Scale and Conner's scale. The participants completed the Korean Wechsler Intelligence Scale for Children-fourth edition and Advanced Test of Attention (ATA), Penn Emotion Recognition Task and Penn Emotion Discrimination Task. The group differences in the facial emotion recognition and discrimination ability were analyzed by using analysis of covariance for the purpose of controlling the visual omission error index of ATA. Results: The children with ADHD showed better recognition of happy and sad faces and less false positive neutral responses than those with ASD. Also, the children with ADHD recognized emotions better than those with ASD on female faces and in extreme facial expressions, but not on male faces or in mild facial expressions. We found no differences in the facial emotion discrimination between the children with ADHD and ASD. Conclusion: Our results suggest that children with ADHD recognize facial emotions better than children with ASD, but they still have deficits. Interventions which consider their different emotion recognition and discrimination abilities are needed.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제16권2호
• /
• pp.192-198
• /
• 2005

본 고찰에서는 DSM-IV의 주의력결핍과잉행동장애(attention-deficit hyperactivity disorder, ADHD)와 ICD-10의 과잉행동장애(hyperkinetic disorder, HKD)의 진단 체계를 비교하였고 그 차이점을 분석하여 임상 및 연구 측면에서 어떠한 의의가 있는지를 살펴보았다. 아직까지 DSM의 ADHD와 ICD의 HKD를 직접 비교한 연구들은 매우 부족한 상태이지만, DSM-IV의 ADHD가 ICD-10의 HKD 보다 광범위한 ADHD의 한 아형라는 것을 알 수 있었다. DSM-IV ADHD의 유병율은 ICD-10 HKD과 비교했을 때 더 높았으며 그 차이는 뚜렷했다. 이러한 결과가 DSM-IV 진단 알고리즘에서 부주의 우세형과 과잉행동-충동성 우세형이 포함되어 ADHD의 범위가 더욱 확장되어 나타난 것인지에 대해서는 아직까지 알 수 없다. 그리고 현재까지 진행된 연구들을 종합해 보았을 때, DSM-IV HKD와 DSM-IV ADHD가 질적으로 같거나 혹은 다르다고 주장할 수는 있는 충분한 근거는 없어 보인다. 다만 HKD가 보다 심한 형태의 ADHD의 한 아형일 가능성이 시사되고 있다. 그러므로 현재로써는 임상에서 환자를 진단하는데 있어 DSM-IV 혹은 ICD-10 중 일방에만 의존하여 ADHD/HKD 장애를 과다하게 진단 내리거나 혹은 실제보다 적게 진단내리는 것을 경계하여야 할 것이다. 특히 질병통계와 보험체계는 WHO의 ICD진단 체계에 맞춰져 있으나 대학이나 전공의 과정 중에는 주로 APA의 DSM진단 기준에 맞춰 학습하는 우리나라의 현실을 감안했을 때 과연 ADHD/HKD에 대한 진단율이 실제 유병율에 비해 과다한지 혹은 부족한지에 대해서도 관심을 기울일 필요가 있다. DSM-IV ADHD와 ICD-10 HKD가 진단적으로 얼마만큼 근접하고 있는지에 대해서는 주요 임상 변인과 endophenotype을 포함한 진단적 타당성에 대한 연구들이 더 진행되고, 관련된 가족연구와 장기 추적 연구들이 뒷받침 되었을 때 보다 명확해질 것으로 생각되며, 또한 ADHD/HKD에 대한 APA와 WHO가 보다 근접하고 일치되는 진단 알고리즘이 개발될 수 있을 것이라 예상된다.