• Nutrition Research and Practice
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• 제16권5호
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• pp.577-588
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• 2022

BACKGROUND/OBJECTIVES: Poorly regulated inflammation is believed to be the most predominant factor that can result in a wide scope of diseases including atopic dermatitis (AD). Despite many studies on the effect of pear pomace in obesity-related disorders including dysregulated gut microbiota, the protective effect of pear pomace in AD is still unknown. This study aimed to evaluate the effect of pear pomace ethanol extract (PPE) on AD by inhibiting inflammation. MATERIALS/METHODS: In the in vivo experiment, 2, 4-dinitrochlorobenzene (DNCB) was applied to NC/Nga mice to induce AD-like skin lesions. After the induction, PPE was administered daily by oral gavage for 4 weeks. The clinical severity score, serum IgE levels, spleen weight, histological changes in dorsal skin, and inflammation-related proteins were measured. In the cell study, RAW 264.7 cells were pretreated with PPE before stimulation with lipopolysaccharide (LPS). Nitrite oxide (NO) production and nuclear factor kappa B (NF-𝛋B) protein expression were detected. RESULTS: Compared to the AD control (AD-C) group, IgE levels were dramatically decreased via PPE treatment. PPE significantly reduced scratching behavior, improved skin symptoms, and decreased ear thickness compared to the AD-C group. In addition, PPE inhibited the DNCB-induced expression of inducible nitrite oxide synthase (iNOS), the receptor for advanced glycation end products, extracellular signal-regulated kinase (ERK) 1/2, and NF-𝛋B. PPE inhibited the LPS-induced overproduction of NO and the enhanced expression of iNOS and cyclooxygenase-2. Moreover, the phosphorylation of ERK1/2 and NF-𝛋B in RAW 264.7 cells was suppressed by PPE. CONCLUSIONS: These results suggest that PPE could be explored as a therapeutic agent to prevent AD.

• 대한의생명과학회지
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• 제23권4호
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• pp.303-309
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• 2017

${\beta}$-sitosterol, one of phytosterols, exhibited numerous pharmacological effect including anti-inflammatory, anti-cancer and immune-modulating properties. This study attempted to determine the pharmacological effects of ${\beta}$-sitosterol on atopic dermatitis (AD). We investigated to ascertain the pharmacological effects of ${\beta}$-sitosterol on 2, 4-dinitrochlrobenzene (DNCB)-induced AD symptom and histamine-induced scratching behaviors in mice. Additionally, we evaluated the effects of ${\beta}$-sitosterol on the interleukin (IL)-6 levels in HaCaT cells and skin tissue of AD. The findings of this study demonstrated that ${\beta}$-sitosterol reduced AD clinical symptoms such as eczematous, erythema and dryness and serum histamine and IgE levels in DNCB-induced AD model and histamine-induced scratching behaviors in mice. Additionally, ${\beta}$-sitosterol inhibited the IL-6 expression in AD-like skin lesion and HaCaT cells. Collectively, these findings provide that ${\beta}$-sitosterol could be a therapeutic agent for skin inflammation including AD.

• 수면정신생리
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• 제5권2호
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• pp.134-154
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• 1998

This paper first reviewed the definition, criteria, and neurological theories concerning the etiology of AD/HD, and the empirical studies dealing with the comorbidity of AD/HD with other psychiatric disorders. Secondly, results of studies using various neuropsychological tests for assessing the cognitive and behavioral problems in AD/HD children were examined, which suggest the possibility that dysfunction may exist in neural pathways involving many areas of the brain in AD/HD. However, because most of neuropsychological test used in Korea for ADHD children had been developed abroad, further study involving AD/HD, normal control, and other psychiatric control groups is needed to obtain developmental norms for interpreting the results, and to make more accurate diagnosis, and to clarify comorbidity of AD/HD with other disorders.

• 전자통신동향분석
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• 제18권2호통권80호
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• pp.11-24
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• 2003

이동 Ad Hoc 네트워크는 고정적이고 계층적인 인프라스트럭처 네트워크와는 비교되는, 이동 노드만으로 구성된 자율적이고 수평적인 네트워크이다. 이동 Ad Hoc 네트워크의 이동 노드는 중재자의 도움 없이 능동적인 연결 설정이 가능하고 네트워크의 참여 또는 이탈이 자유로우며 에너지원의 공급이 제한되어 빈번하게 네트워크의 토폴로지를 변화시킨다. 이러한 망의 특성상 이동 Ad Hoc 네트워크 기술은 하위 계층의 전파 전파, 전파 간섭 및 전력 제어에서부터 링크 계층의 다중 접속 및 자원 할당, 네트워크 계층의 라우팅, 트랜스포트 계층의 연결 설정 및 유지, 그리고 보안 및 상위 계층 애플리케이션에 이르기까지 다양한 기술적 해결 요구사항을 갖는다. 본 고에서는 이러한 Ad Hoc 네트워크의 특징과 특성을 살펴보고 관련 주요 요소 기술과 과거부터 현재까지 이동 Ad Hoc 네트워크 기술 분야에서 진행되어온 연구동향을 살펴본다.

• 한국인쇄학회지
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• 제30권2호
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• pp.13-22
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• 2012

This research attempts to analyze communication effects of print ad having pictorial typography. 150 Questionnaires were distributed to respondents staying Daejeun City and 148 copies were retreated for five days from April 22nd to 26th, 2012. Frequency analysis, factor analysis, Cronbach's alpha for reliability analysis were utilized for data analysis with SPSS 12.0. For testing hypothesis, regression analysis was used. As result of testing hypothesis, 'informative, beneficial, creative, reliable' were partially significant to attitude towards print ad having pictorial typography. That means 'creative' and 'reliable' were insignificant, while 'informative' and 'beneficial' are significant. Variable of the most influencing on attitude towards advertising is 'informative.' 'Informative, beneficial, creative, and reliable' were partially significant to brand attitude, too. That means 'beneficial' and 'creative' were insignificant, while 'informative' and 'reliable' were significant. Variable of the most influencing on brand attitude was 'reliable.' Therefore, to enhance communication effect of print ad having pictorial typography, 'informative' and 'reliable' are most significant variables.

• 한국인쇄학회지
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• 제30권2호
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• pp.69-78
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• 2012

This research attempts to analyze how attributes of ad model influence on brand familiarity, personality, and preference among consumers. Attributes of ad model was classified into three; attractiveness, professionalism, and reliability. One hundred of consumers who lived in Daejeun City were selected as respondents for this research. The result of hypothesis I showed that attributes of ad model significantly influenced on brand familiarity. it was the result of hypothesis II that both Attractiveness and professionalism of ad model affected brand personality. It was also found that attractiveness and professionalism are significantly brand preference from the result of hypothesis III. In conclusion, findings showed that attractiveness of ad model mostly influenced on brand familiarity, personality, preference.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.150-165
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• 2008

Objective : An adequate measurement for Atopic Dermatitis(AD) is essential for studies about the treatment of AD. To establish a new and adequate scoring system for AD in Korean medicine, we reviewed existing studies on AD outcome measurement in Korean medicine. Method : We searched for reviews on measurements of AD or studies which used an AD outcome measurement at the Korean Traditional Knowledge Portal from 1995 to June, 2008. And then we reviewed the pattern identification in AD patients and the outcome measurements for AD in each study. Results : 1. Among 25 studies, the most common measurement for AD was SCORAD(the severity SCORing of Atopic Dermatitis index), there were 16 studies. There was one study which used the Jakob T scoring system, one study which used ADSI(the Atopic Dermatitis Severity Index), and there were 7 studies which established or used a new severity scoring system for AD. 2. In Korean medicine, AD caused by Damp-Heat is accompanied by erythema, papulation, oozing and crust, Damp-Heat accompanied by Spleen-Gi deficiency is frequently found in pediatric patients, and in adults who have indigestion. Symptoms of AD caused by blood deficiency and Wind-Dryness include lichenification, dryness, scale and pigmentation. AD caused by toxic Heat in the blood system has symptoms similar to some Damp-Heat pattern along with symptoms of blood deficiency and Wind-Dryness. Conclusion : We need to establish a new severity scoring system which reflects pattern identifications and treatments with Korean medicine, and we should assess the validity, reliability, and sensitivity of the new scoring system.

• 한국위성정보통신학회논문지
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• 제6권2호
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• pp.60-65
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• 2011

이동 Ad-hoc 네트워크 (MANET: Mobile Ad-hoc Network)는 기존의 통신 인프라의 구축 여부와 무관하게 무선 단말기간의 통신이 가능한 네트워크이다. Ad-hoc 네트워크는 음영지역, 재난지역, 전쟁 시와 같은 통신 인프라가 구축되기 어려운 상황에서 유용하게 사용 될 수 있다. 그러나 음성 및 데이터 서비스 등과 같은 무선 서비스의 제공을 위해 많은 양의 네트워크 용량이 필요하게 되지만 기존의 제한된 주파수 자원에 따른 주파수 부족 상황 및 주파수 자원정책의 규제에 따라 원활한 주파수 사용이 어려운 상황이다. 이에 따라 높은 주파수 활용을 제공하는 인지 무선 시스템을 ad-hoc네트워크에 적용하여 보다 다양하고 확장된 네트워크 서비스를 제공할 수 있다. 따라서 본 논문에서는 인지 무선 기반 ad-hoc 네트워크에서 주로 사용되는 에너지 검출 기법의 성능 향상을 위해, 다중 안테나를 이용한 인지 무선 기반 ad-hoc 네트워크 시스템을 제안하여 신호 검출 성능을 보였다.

• 한국컴퓨터산업학회논문지
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• 제2권9호
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• pp.1219-1224
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• 2001

실제 이동 Ad Hoc 네트워크상의 단말기 혹은 무선 환경의 비대칭성에는 단방향 링크가 존재한다. 이에 현재 기존의 이동 Ad Hoc 라우팅 프로토콜을 양방향 링크만을 지원할 수 있도록 구현하였으며, 본 논문에서는 새로운 라우팅 프로토콜을 구현하기 위하여 기존의 동적 소스라우팅 프로토콜을 확장하여 단방향 링크를 가지고 있는 이동 Ad Hoc 네트워크에 적용하였다. 성능평가를 위하여 이동시나리오 파일의 결합과 카네기멜론 대학의 연결 패턴파일을 사용하였다. 또한 수신 데이터율과 평균경로발견시간을 평가 요소로 고려하였으며, 제안된 세 가지 경로 설정 방법을 비교 평가하였다.

• 한국통신학회논문지
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• 제34권8B호
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• pp.768-776
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• 2009

본 논문에서는 TDMA ad hoc MAC 프로토콜들의 메시지 복잡도를 분석한다. Ad hoc 네트워크의 자원은 간섭과 경쟁 기반 무선 통신 채널로 제한되기 때문에 ad hoc 알고리즘을 개발하는 데 있어 노드 수의 증가에 따른 유연한 확장성(Scalability) 문제는 주요한 연구 과제 중의 하나이다. 분석 기법을 적용한 결과, MAC 프로토콜들 중에서 TMMAC가 가장 높은 메시지 복잡도를 가졌으며, SMACS 프로토콜이 가장 낮은 메시지 복잡도를 보였다. 네트워크의 크기가 커질수록 유니캐스트에 의한 메시지 복잡도의 영향이 증가함으로, $N^2$항목을 가지고 있는 Z-MAC, BMA, TMMAC에서 Z-MAC은 노드 수의 증가에 따라 복잡도가 선형적으로 상승하는 반면, BMA와 TMMAC의 복잡도는 지수 형태로 상승함을 밝혔다.