• Clinical Nutrition Research
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• 제11권3호
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• pp.159-170
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• 2022

Ischemic stroke and Alzheimer's disease (AD) are representative geriatric diseases with a rapidly increasing prevalence worldwide. Recent studies have reported an association between ischemic stroke neuropathology and AD neuropathology. Ischemic stroke shares some similar characteristics with AD, such as glia activation-induced neuroinflammation, amyloid beta accumulation, and neuronal cell loss, as well as some common risk factors with AD progression. Although there are considerable similarities in neuropathology between ischemic stroke and AD, no studies have ever compared specific genetic changes of brain cortex between ischemic stroke and AD. Therefore, in this study, I compared the cerebral cortex transcriptome profile of 5xFAD mice, an AD mouse model, with those of middle cerebral artery occlusion (MCAO) mice, an ischemic stroke mouse model. The data showed that the expression of many genes with important functional implications in MCAO mouse brain cortex were related to synaptic dysfunction and neuronal cell death in 5xFAD mouse model. In addition, changes in various protein-coding RNAs involved in synaptic plasticity, amyloid beta accumulation, neurogenesis, neuronal differentiation, glial activation, inflammation and neurite outgrowth were observed. The findings could serve as an important basis for further studies to elucidate the pathophysiology of AD in patients with ischemic stroke.

• 한국정보통신학회논문지
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• 제10권8호
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• pp.1401-1406
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• 2006

최근 산업 및 연구단체에서 이동 Ad-hoc망에 대한 관심이 높아지고 있다. 기존 연구들은 라우팅에 초점을 맞추고 있었던 것에 반해 본 논문에서는 이들 연구의 결과로 형성된 Ad-hoc망을 실제로 이용하기 위한 응용으로 가변지오캐스팅 방법을 제안한다. 지오캐스팅 프로토콜 목적은 특별한 지오캐스팅 영역에 위치한 노드들의 그룹에 패킷 데이터를 전송하는 것이다. 본 논문에서는 Ad-hoc기반의 이동 네트워크 환경에서 지오캐스트 서비스를 지원하는 기존연구에 데이터 전송경로의 비 최적화, 빈번한 지오캐스트 전송트리의 재구성으로 인한 오버헤드, 서비스단절의 문제를 해결하기 위해 이동형태기반의 가변지오캐스팅 기법을 제안한다. 가변지오캐스팅 기법은 서비스범위를 목적지 노드의 이동성에 따라 가변적으로 설정하고 자원예약기법과 다양한 실험을 통해 이동노드의 이동성에 따른 접근성 및 네트워크 오버헤드를 줄여 성능평가 하였다.

• 정보처리학회논문지C
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• 제12C권4호
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• pp.543-550
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• 2005

Ad-hoc 네트워크 환경에서의 많은 라우팅 알고리즘들은 소스 라우팅 기법을 기초로 설계되었으며 밀집된 ad-hoc 환경에서의 최단경로설정은 짧은 기간동안만 유지되는 제약사항이 존재한다 때문에 SSA와 ABR과 같은 라우팅 프로토콜은 링크 안정성을 고려하여 좀더 안정적인 경로를 탐색한다. 본 논문은 Ad-Hoc network 환경에 현실적으로 적합한 SSA 라우팅 알고리즘을 바탕으로 utilization 메트릭을 고려한 새로운 라우팅 기법에 대해 제안한다. 제안된 방식에서는 SSA의 특정 메트릭에 의한 병목현상을 해결하기 위해 연결을 위한 여러 경로들을 누적 utilization에 따라 분산시키도록 하여 네트워크상의 로드 밸런싱을 추구하였다. 성능 분석을 위해 기존의 라우팅 기법인 AODV와 SSA를 참고 비교 대상으로 하였다. ns-2 네트워크 시뮬레이션 결과 선택되어질 수 있는 안정적인 route가 많은 경우 전체 트래픽이 여러 경로들로 분산되어 경로 재설정(route reconstruction) 횟수를 현저히 줄이는 좋은 성능을 보였다

• 생물정신의학
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• 제16권4호
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• pp.238-245
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• 2009

Objectives : Mild Alzheimer's disease(AD) is uncertain to be related to visuospatial working memory subsystem dysfunction. We used the self ordered pointing test(SOPT) to find the characteristics of visuospatial working memory in mild AD. Methods : We compared the visuospatial working memory abilities of 20 patients with mild AD and 20 normal elderly controls(NC) using SOPT, of which stimuli consisted of two stimuli types(A : abstract, C : concrete) and two stimuli numbers(8 and 12). Therefore, working memory was tested using C8, C12, A8, and A12 stimuli conditions in SOPT. Mixed-model ANOVA was conducted with the AD and NC groups as between-subjects factor, with stimuli types and stimuli numbers as the within-subjects factors and with SOPT error rates as the dependent variable. Results : The AD group showed higher error rates in SOPT than the NC group. The NC group showed low error rates in concrete stimuli than in abstract stimuli and in small stimuli numbers than in large stimuli numbers. And the AD group showed no differences between stimuli types or stimuli numbers. Conclusion : AD patients showed a poor performance in visuospatial working memory using concrete stimuli. The result suggests that there is a non-transformation from visual input to phonological working memory in AD. Patients with AD showed a poor performance although in small stimuli number condition of SOPT. It suggests that in AD, visuospatial working memory is not working well although in low central executive loads.

• Journal of Nutrition and Health
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• 제39권8호
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• pp.795-800
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• 2006

In order to examine nutritional and behavioral risk factors of atopic dermatitis (AD) in Korean preschoolers, we analyzed data on 144 children aged 3-6 years with AD and their 434 healthy counterparts. The data included breast-feeding history, current weight, food behaviors assessed by the Mini Dietary Assessment (MDA), food intake by a semi-quantitative food frequency questionnaire, and behavior problems by the Preschool and Kindergarten Behavior Scale (PKBS). Multivariate logistic regression analyses were performed after controlling for preschool location and child's age, gender and total energy intake, as appropriate. There was no group difference of child and household characteristics. Breastfeeding history was related to lower AD risk (OR = 0.63, 95% Cl = 0.40-0.99), yet no statistically significant association was found with overweight status. Regarding food behaviors, AD risk was lower in children who drank milk at least one cup per day (OR = 0.52, 95% Cl = 0.35-0.78) and had regular meals (OR = 0.62, 95% Cl =0.42-0.92). Moreover, there were lower risks of AD in the second (OR =0.48, 95% Cl = 0.28-0.82) and the highest (OR = 0.55, 95% Cl = 0.32-0.94) intake quartiles as compared with the lowest quartile of kimchi intake. Similarly, AD risk was lower in the highest quartile of rice (OR = 0.51 Cl = 0.28-0.93) and the second quartile of fruit (OR =0.45, 95% Cl = 0.25-0.82) intakes. AD children had more problems in social interaction (OR = 1.97,95% Cl = 1.26-3.07) and independence (OR = 1.60, 95% Cl = 1.01 -2.54) measures than the healthy controls. Likewise, AD children tended to show more problem behaviors such as anxiety (OR = 1.63, 95% Cl = 0.99-2.69). Our results suggest that nutritional and behavioral dimensions are related to AD risk, yet the case control study design may preclude generalization of these results.

• Journal of Acupuncture Research
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• 제22권5호
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• pp.1-10
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• 2005

Objectives : The Present study was carried out to investigate the preventive effect of Anti-diabetic prescription 1(AD-1) on streptozotocin(STZ)-induced diabetic nephropathy. Methods : AD-1 consists of eleven herbs that have an effect on diabetes mellitus. AD-1 was given to rats with the combination of oral administration and herbal-acupuncture stimulation. The experimental animals were divided into 3 groups : normal group of rats, control group of STZ-induced diabetic rats, sample group with AD-1 treatment. Experimental diabetes was induced by the injection of STZ(60mg/kg) to e rat via the peritoneum. The effect of AD-1 on STZ-induced diabetic nephropathy was observed by measuring the serum level of creatinine and BUN. Urine secretion of albumin for 24 hours and urine level of glucose measures too. Anti-oxidative stress of AD-1 administration in living body was estimated by measuring lipid peroxide and GSH content in cortex of kidneys. Results : STZ induced increase of serum creatinine, BUN and albumin secretion were lowered by AD-1 treatment. Conclusion : The AD-1 treatment showed protective effect on rat diabetic nephropathy model, and action mechanism of the effect was thought to be concerned with anti-oxidative stress.

• 한국콘텐츠학회논문지
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• 제11권9호
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• pp.76-84
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• 2011

본 논문에서는 인터랙티브 미디어 작품 제작에 적용 가능한 개념을 제안하고 개념이 적용된 미디어 아트작품에 대한 사용자 경험과 그것에 대한 결과물을 통해 개념의 타당성과 그 가능성을 시험해보고자 한다. 이를 위해 사용자 인터랙션 흔적을 아날로그와 디지털 형태로 남기도록 하는 '에이디-트레이스(AD-Trace)'라는 개념을 세우고, 이를 적용한 다양한 인터랙티브 미디어 아트 작품 창작을 시도하였다. 에이디-트레이스는 디자인 요소로서 '아날로그 흔적(Analogue Trace)', '디지털 흔적(Digital Trace)', 그리고 두 요소를 연결하면서 사용자의 인터랙션을 유도하여 보다 의미 있는 흔적을 남길 수 있도록 지원하는 '인터랙션 메타포(Interaction Metaphor)'를 갖는다. 이 세 가지 요소는 본 연구자의 세 개 작품인 '에이디-피디(AD-PD)', '에이디-스타(AD-Star)', 그리고 '에이디-맵(AD-Map)'에서 각 작품의 콘셉트에 맞게 디자인 되었으며, 사용자 참여 후 얻어진 결과물을 통해 에이디-트레이스가 가질 수 있는 특성을 분석하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2006년도 Spring Conference
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• pp.139-149
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• 2006

Amyloid beta (A$\beta$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of A$\beta$ is considered a primary therapeutic target. Immunization with A$\beta$ can reduce A$\beta$ burden and pathological features in transgenic AD model mouse. This means anti-A$\beta$ autoantibodies may have a role in AD pathology. Recent findings suggest anti-A$\beta$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma. The level of anti-A$\beta$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower anti-A$\beta$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of anti-A$\beta$ autoantibodies in the serum may be used to diagnose the presence of AD.

• 대한전자공학회논문지SD
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• 제45권12호
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• pp.22-28
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• 2008

본 논문은 SOC 응용을 위한 효율적인 8비트 AD 변환기(Analog-to-Digital Converter)를 설계하였다. 이 구조는 2개의 수정된 4 비트 플래시 AD 변환기로 구성되었고, 그것은 기존의 플래시 AD 변환기 보다 더 효율적인 구조를 가지고 있다. 이것은 입력신호에 연결된 저항들의 일정 범위를 예측하고 초기 예측을 기반으로 입력신호에 가까운 위치를 정한다. 입력신호의 예측은 전압예측기에 의하여 가능하다. 4비트 해상도를 가진 경우 수정된 플래시 AD 변환기는 단지 6개의 비교기가 필요하다. 그러므로 8비트 AD 변환기는 12개의 비교기와 32개의 저항을 사용한다. 이 AD 변환기의 변환속도는 기존의 플래시 AD 변환기와 거의 같지만 비교기와 저항의 수가 줄어들기 때문에 다이의 면적의 소모를 현저하게 줄일 수 있다. 이것은 반 플래시 AD 변환기보다 더 적은 비교기를 사용한다, 본 논문에서 구현한 회로들은 LT SPICE 컴퓨터 소프트웨어 툴을 이용하여 시뮬레이션 하였다.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2006년도 Spring Conference
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• pp.137-149
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• 2006

Amyloid beta ($A{\beta}$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of $A{\beta}$ is considered a primary therapeutic target. Immunization with $A{\beta}$ can reduce $A{\beta}$ burden and pathological features in transgenic AD model mouse. This means $anti-A{\beta}$ autoantibodies may have a role in AD pathology. Recent findings suggest $anti-A{\beta}$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring $anti-A{\beta}$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring $anti-A{\beta}$ autoantibodies in the plasma. The level of $anti-A{\beta}$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower $anti-A{\beta}$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of $anti-A{\beta}$ autoantibodies in the serum may be used to diagnose the presence of AD.