• Korean Medical Education Review
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• v.22 no.1
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• pp.16-27
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• 2020

The accreditation process (AccP) is both an opportunity and a burden for medical schools-which one it becomes depends on how medical schools recognize and utilize the AccP. In other words, if a medical school recognizes the AccP only as a formal procedure or as a means for continuing medical education, it will be a burden for the medical school. However, if a medical school recognizes the real and positive value of the AccP, it can be both an opportunity and a tool for developing medical education. The educational value of the AccP is to improve the quality, equity, and efficiency of medical education, along with increasing the options of choice. In order for the AccP to contribute to the development of medical education, accrediting agencies and medical schools must first be recognized as part of an "educational alliance" working together towards common goals. Secondly, clear guidelines on the accreditation standards should be periodically reviewed and shared. Finally, a formative evaluation using self-evaluation as a system that can utilize the AccP as an opportunity to develop medical education must be introduced. This type of evaluation system could be developed through collaboration among medical schools, academic societies for medical education, and the accrediting authority.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.27 no.2
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• pp.110-122
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• 2005

Adenoid cystic carcinoma (ACC) of salivary glands has a protracted clinical course with perineural invasion, delayed onset of hematogenous metastasis, and poor responses to classical cytotoxic chemotherapic agents. Most deaths from salivary ACC are caused by lung metastases that are resistant to conventional therapy. Therefore, knowledge of cellular properties and tumor-host interactions that influence the dissemination of metastatic cells is important for the design of more effective therapy of salivary cancer. I determined in vitro expression of epidermal growth factor receptor (EGFR) and its downstream effectors and vascular endothelial growth factor receptor (VEGFR)-2 on a human salivary ACC cell line (ACC2). I also evaluated the expression of EGF and VEGF signaling molecules and metastasis-related proteins on human salivary ACC cells orthotopically growing in nude mice. In Western blot and immunohistochemical analyses, EGFR and VEGFR-2 were presented and phosphorylated in ACC2 cells. In human parotid cancer xenografts in nude mice, EGF and VEGF signaling molecules, IL-8, and MMP-9 were expressed at markedly higher levels than in normal parotid tissues. Moreover, tumor-associated endothelial cells of this orthotopic parotid tumor expressed phosphorylated VEGFR-2 and phosphorylated Akt, which is a cell-survival protein. These data show that those biomarkers can be molecular targets for therapy of salivary ACC, which has a propensity for delayed lung metastasis.

• Proceedings of the KIEE Conference
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• 2006.07c
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• pp.1564-1565
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• 2006

현재 전세계적으로 170kV급 이하의 초고압 지중케이블 접속함으로 기존의 현장몰드방식의 TMJ(Tape Molded Joint)와 부품조립방식의 PJ(Prefabricated Joint)보다 조립시간이 짧고 작업자의 숙련도가 높지 않아 경제적이며, 유지보수에 장점을 가진 고무몰드 접속함(PMJ)이 채용되고 있으며, 이러한 추세는 적용 전압급이 점차 상승하면서 230kV급까지 그 비중이 늘어나고 있는 경향을 보이고 있다. 당사에서는 이러한 추세에 발맞추어 154kV급 고무몰드접속함의 개발 당시의 Silicone의 기초물성시험 DATA 획득, 고무몰드 UNIT 및 금형 설계 기술 확립과 접속 공법 개발의 경험을 바탕으로 230kV급 고무몰드접속함의 개발에 성공하였다.

• Science of Emotion and Sensibility
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• v.23 no.2
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• pp.103-120
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• 2020

Using driving simulation, this study investigated the effects of driver's trust in the adaptive cruise control (ACC) system and road density on driver's workload and situation awareness. The drivers were allocated into one of four experimental conditions manipulated by ACC system trust level (trust-increased vs. trust-decreased) and road congestion (high vs. low). The workload and situational awareness of the participants were measured as dependent variables. The results showed followings. First, trust-decreased group for the ACC system had significantly lower trust scores for the system in all of the measurement items, including reducing the driving load and securing safe driving due to the use of this system, than the trust-increased group. Second, the trust-decreased group showed a slower reaction time in the secondary tasks and higher subjective workload than trust-increased group. Third, in contrast, the situational awareness for the driving situation was significantly higher in the trust-decreased group than trust-increased group. The results of this study showed that the driver's trust in the ACC system can affect the various information processing performed while driving. Also, these results suggest that trust in the user's system should be considered as an important variable in the design of an automated driving assistance system.

• Journal of the Korean Magnetic Resonance Society
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• v.12 no.1
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• pp.1-13
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• 2008

Acetyl-CoA carboxylase (ACC) catalyzes the first step in fatty acid biosynthesis: the synthesis of malonyl-CoA from acetyl-CoA. As essential regulators of fatty acid biosynthesis and metabolism, ACCs are regarded as therapeutic targets for the treatment of metabolic diseases such as obesity, In ACC, the biotinoyl domain performs a critical function by transferring an activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, followed by carboxyl transfer to malonyl-CoA. Despite the intensive research on this enzyme, only the bacterial and yeast ACC structures are currently available, To explore the mechanism of ACC holoenzyme function, we determined the structure of the biotinoyl domain of human ACC2 and analyze its characteristics using NMR spectroscopy. The 3D structure of the hACC2 biotinoyl domain has a similar folding topology to the previously determined domains from E. coli and P. Shermanii, however, the 'thumb' structure is absent in the hACC2 biotinoyl domain. Observations of the NMR signals upon the biotinylation indicate that the biotin group of hACC2 does not affect the structure of the biotinoyl domain, while the biotin group for E. coli ACC interacts directly with the thumb residues that are not present in the hACC2 structure. These results imply that, in the E. coli ACC reaction, the biotin moiety carrying the carboxyl group from BC to CT can pause at the thumb of the BCCP domain. The human biotinoyl domain, however, lacks the thumb structure and does not have additional non-covalent interactions with the biotin moiety; thus, the flexible motion of the biotinylated lysine residue must underlie the "swinging arm" motion. This study provides insight into the mechanism of ACC holoenzyme function and supports the "swinging arm" model in human ACCs.

• Journal of Microbiology and Biotechnology
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• v.7 no.3
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• pp.212-214
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• 1997

A new isolate, Bacillus sp. ALK-7 can synthesize ethylene from l-aminocyclopropane-l-carboxylic acid (ACC) as well as from methionine. The ACC has only been recognized as a key intermediate found in the metabolic pathway leading to ethylene formation in various plants. The efficiency of ethylene formation from the ACC by Bacillus sp. ALK-7 was about 2 times as high as that from the methionine. The reaction from ACC to ethylene formation was also shown to be mediated by the cell-free extracts of Bacillus sp. ALK-7.

• Proceedings of the SAREK Conference
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• 2003.07a
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• pp.109-109
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• 2003

• Journal of Life Science
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• v.18 no.2
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• pp.148-153
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• 2008

Phytochrome double mutant (PhyAB) showed the delayed root gravitropic response compared to the wild type (WT) in Arabidopsis. After 8 hr of gravistimulation, the gravitropic response of mutant showed 48% of the WT. The delayed response started at 1.5 hr after gravistimulation. And we measured the ethylene production in the root segments of WT and mutant for 12 hr. Ethylene production of mutant decreased about 40% of the WT at 12 hr. This result suggested that the phytochrome might be linked with ethylene production in some way. Generally, ethylene inhibits the growth of plant organs including roots. We measured the root growth rate in the presence of ACC (1-aminocyclopropane-1-carboxylic acid), a precursor of ethylene. And WT showed the inhibition of root growth with ACC, but mutant did not show the inhibition as WT did. To confirm the relationship between the ethylene and gravitropic response, we measured the gravitropic response with ACC. In the presence of $10^{-6}$ M ACC, WT showed the 37.4% inhibition compared to the control (no ACC), whereas mutant showed the only 6.6% inhibition of control (no ACC). This research suggested the relationship between phytochrome and gravitropic response through an ethylene production.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• v.61 no.11
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• pp.573-579
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• 2018

Background and Objectives Cochlear dead region (CDR) is a region in the cochlear where hearing loss has occurred due to damage to the inner hair cells and/or neurons. Recently, a subjective test involving a pure-tone test in the presence of threshold-equalizing noise (TEN) was introduced to identify CDR. However, for uncooperative patients, such a subjective method would be unsuitable and objective methods would be needed instead to detect CDR. The acoustic change complex (ACC) is an evoked potential elicited by changes in the ongoing sound. In this study, we developed an objective method of identifying CDR by combining ACC response with a TEN test, namely the TEN-ACC test, and investigated its feasibility in normal-hearing listeners. Subjects and Method Ten normal-hearing subjects participated in this study. All subjects underwent both behavioral TEN test and electrophysiological TEN-ACC test. The stimuli for the TEN-ACC test consisted of TEN and embedded pure tones with different frequencies/signals to noise ratios (SNRs). To identify the thresholds, the range SNR of stimulation was varied from 0 to 20 dB, in stages of 4 dB. Results The ACC responses of all subjects who participated in this study were well elicited by stimuli developed for the TEN-ACC test. We confirm that the pure-tones embedded in TEN elicited the objective ACC response. Conclusion The results of this study suggest that the novel TEN-ACC test can be applied to evoke ACC in normal-hearing listeners. Future research should incorporate hearing-impaired listeners to determine the feasibility of the TEN-ACC test as an objective method to identify CDR.

• Journal of Auto-vehicle Safety Association
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• v.9 no.4
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• pp.38-47
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• 2017

With automobiles sharply increasing worldwide, we are faced with serious social problems such as traffic accidents, traffic jams, environmental pollution, and economic inefficiency. In response, research on ITS is promoted mainly by regions with advanced automotive industry such as the US, Europe, and Japan. While Korea is working to get ahead to take global market through developing and turning into global standards systems related to ASV(Advanced Safety Vehicle), the country is not excellently prepared for such projects. The purpose of ACC is to control the vehicle's longitudinal speed and distance and minimize driver workload. Such a system should be useful in preventing accidents, as it reduces driver workload in the 21st-century world of telematics created by the development of automobile culture industry. In this light, the thesis presents a method to test and evaluate ACC system and a mathematical method to assess distance. Furthermore, for the proposed test and evaluation, theoretical values are tested with vehicle test and a database is acquired, by using vehicles equipped with an ACC system. We proposed the scenarios suitable for the domestic environment and conducted the actual road test. Theoretical evaluation criteria for developing ACC system may be employed and scenario-specific evaluation methods may find their useful application through testing the formula proposed by comparing the database and the mathematical method. and, many companies are expected to utilize the scenario in the developing stage of ACC, and be able to employ as a verification method by harnessing theoretical formula before a road test.