• Title/Summary/Keyword: ACC

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IMMUNOHISTOCHEMICAL ASSAYS FOR THE EXPRESSION OF ANGIOGENIC SIGNALING MOLECULES AND MICROVESSEL DENSITY IN ADENOID CYSTIC CARCINOMAS OF HUMAN SALIVARY GLANDS (타액선 선양낭성암종에서 혈관형성 신호전달 물질의 발현과 미세혈관농도에 관한 면역조직화학적 연구)

  • Park, Young-Wook;In, Yeon-Soo
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.32 no.6
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    • pp.530-543
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    • 2006
  • Adeonoid cystic carcinoma (ACC) is one of the most common malignant tumors of salivary glands. It is characterized by a relentless regrowth especially around nerve tissues and a high rate of hematogenous distant metastasis. Clinically most deaths from salivary ACC are caused by delayed lung metastases that are resistant to conventional chemotherapy. So, knowledge of cellular and molecular properties that influence the dissemination of metastatic tumor cells, is important for new treatment strategies of metastatic lesions. We determined expressions of angiogenic signaling molecules microvessel density (MVD) using surgical specimens of human salivary ACC. Protein expressions of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-2, activated VEGFR-2, and human CD31 were assessed in 20 cases of salivary ACC by immunohistochemical staining. Most of the tumors, especially ACC with a tubulocribriform pattern, were positive for antibodies of VEGF, VEGFR-2, and activated VEGFR-2. The overall percentages of the 20 specimens expressing VEGF, VEGFR-2, activated VEGFR-2 were 90, 95, and 95%, respectively. Immunoreactivities of the biomarkers in salivary ACC were higher than those in normal salivary gland. Furthermore, immune-related cells as well as tumor cells expressed VEGF/VEGFR-2. Microvessel density of salivary ACC was higher than that of normal salivary gland (P<0.05). Taken together, angiogenic signaling molecules are actively expressed in salivary ACC. And we suggest that these molecules may have critical role in the hematogenous spread of salivay ACC, which has a propensity for delayed lung metastasis. Therefore, these biomarkers can be molecular targets for therapy of metastasis of salivary ACC.

Implementation of Integrated Controller of ACC/LKS based on OSEK OS (OSEK OS 기반 ACC/LKS 통합제어기 구현)

  • Choi, Dan-Bee;Lee, Kyung-Jung;Ahn, Hyun-Sik
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.13 no.5
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    • pp.1-8
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    • 2013
  • This paper implements an integrated vehicle chassis system of ACC(Adaptive Cruise Control) and LKS(Lane Keeping System) based on OSEK OS to vehicle operating system and analyzes its performance through experiments. In recent years active safety and advanced driver assistance system has discussed to improve safety of vehicle. Among the rest, We integrate ACC that controls longitudinal velocity of vehicle and LKS that assists a vehicle in maintaing its driving lane, then implement integrated control system in vehicle. Implemented control system uses OSEK/VDX proposed standard, which is aiming at reusability and safety of software for vehicle and removal hardware dependence of application software. Redesigned control system based on OSEK OS, which is supported by OSEK/VDX, can manage real-time task, process interrupt and manage shared resource. We show by results performed EILS(ECU-In-the-Loop Simulation) that OSEK OS-based integrated controller of ACC and LKS is equivalent conventional integrated controller of ACC and LKS.

Effectiveness of Rhizobacteria Containing ACC Deaminase for Growth Promotion of Peas (Pisum sativum) Under Drought Conditions

  • Zahir, Z.A.;Munir, A.;Asghar, H.N.;Shaharoona, B.;Arshad, M.
    • Journal of Microbiology and Biotechnology
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    • v.18 no.5
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    • pp.958-963
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    • 2008
  • A series of experiments were conducted to assess the effectiveness of rhizobacteria containing 1-aminocyclopropane-1-carboxylate (ACC) deaminase for growth promotion of peas under drought conditions. Ten rhizobacteria isolated from the rhizosphere of different crops (peas, wheat, and maize) were screened for their growth promoting ability in peas under axenic condition. Three rhizobacterial isolates, Pseudomonas fluorescens biotype G (ACC-5), P. fluorescens (ACC-14), and P. putida biotype A (Q-7), were selected for pot trial on the basis of their source, ACC deaminase activity, root colonization, and growth promoting activity under axenic conditions. Inoculated and uninoculated (control) seeds of pea cultivar 2000 were sown in pots (4 seeds/pot) at different soil moisture levels (25, 50, 75, and 100% of field capacity). Results revealed that decreasing the soil moisture levels from 100 to 25% of field capacity significantly decreased the growth of peas. However, inoculation of peas with rhizobacteria containing ACC deaminase significantly decreased the "drought stress imposed effects" on growth of peas, although with variable efficacy at different moisture levels. At the lowest soil moisture level (25% field capacity), rhizobacterial isolate Pseudomonas fluorescens biotype G (ACC-5) was found to be more promising compared with the other isolates, as it caused maximum increases in fresh weight, dry weight, root length, shoot length, number of leaves per plant, and water use efficiency on fresh and dry weight basis (45, 150, 92, 45, 140, 46, and 147%, respectively) compared with respective uninoculated controls. It is highly likely that rhizobacteria containing ACC deaminase might have decreased the drought-stress induced ethylene in inoculated plants, which resulted in better growth of plants even at low moisture levels. Therefore, inoculation with rhizobacteria containing ACC deaminase could be helpful in eliminating the inhibitory effects of drought stress on the growth of peas.

Studies on Physiological Action of Ethylene in Rice Plant IV. Effect of Methionine and ACC on Ethylene Evolution Seedling and Leaf Blade of Rice (벼에 대한 Ethylene의 생리작용에 관한 연구 IV. 벼 유묘와 엽의 Ethylene 생성량에 미치는 Methionine 및 1-Aminocyelopropane-1-Carboxylic Acid의 영향)

  • Lee, Moon-Hee;Ota, Yasuo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.30 no.2
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    • pp.184-189
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    • 1985
  • The experiments were carried out to know the effect of methionine (precursor) and l-aminocyclopropane-1-carboxylic acid (ACC, direct precursor) on ethylene evolution in rice plant. Wher rice seedlings and leaves were incubated with various concentrations of methionine and ACC, the amount of ethylene evolution increased, but at high nitrogen levels the ethylene evolution decreased.

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Mode identifiability of a multi-span cable-stayed bridge utilizing stabilization diagram and singular values

  • Goi, Y.;Kim, C.W.
    • Smart Structures and Systems
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    • v.17 no.3
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    • pp.391-411
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    • 2016
  • This study investigates the mode identifiability of a multi-span cable-stayed bridge in terms of a benchmark study using stabilization diagrams of a system model identified using stochastic subspace identification (SSI). Cumulative contribution ratios (CCRs) estimated from singular values of system models under different wind conditions were also considered. Observations revealed that wind speed might influence the mode identifiability of a specific mode of a cable-stayed bridge. Moreover the cumulative contribution ratio showed that the time histories monitored during strong winds, such as those of a typhoon, can be modeled with less system order than under weak winds. The blind data Acc 1 and Acc 2 were categorized as data obtained under a typhoon. Blind data Acc 3 and Acc 4 were categorized as data obtained under wind conditions of critical wind speeds around 7.5 m/s. Finally, blind data Acc 5 and Acc 6 were categorized as data measured under weak wind conditions.

Inhibitory Effect of Mannose on Auxin-Induced Ethylene Production in Corn (Zea mays L.) Coleoptiles (옥수수 자엽초에서 오옥신 유발 에틸렌 생성에 대한 Mannose의 억제작용)

  • 조성혜
    • Journal of Plant Biology
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    • v.33 no.4
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    • pp.309-314
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    • 1990
  • Effect of mannose on auxin-induced ethylene production in corn (Zea mays L.) coleoptiles was studied. Auxin induced ethylene production decreased in proportion to mannose concentrations. The inhibitory effect of mannose appeared after 2 h of incubation. Ethylene production was significantly depressed by mannose at high concentration (10-5M-10-4M) of indole acetic acid (IAA), but not at low concentrations (10-8M-10-6M). The inhibition of auxin-induced ethylene production by mannose was specific, since other sugars such as galactose, glucose, sucrose and mannitol did not have an inhibitory effect. In an effort to elucidate mechanisms of mannose the effect on the auxin induced ethylene production, effect of the sugar on ACC synthase activity and ACC induced ethylene production was studied. Mannose failed to inhibit ACC mediated ethylene production, but decreased both the ACC content and ACC synthase activity in the tissue. These results suggest that the inhibitory effect of mannose on auxin induced ethylene production results from suppression of auxin induction of ACC synthase.

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1-Aminocyclopropane-1-Carboxylate Deaminase from Pseudomonas stutzeri A1501 Facilitates the Growth of Rice in the Presence of Salt or Heavy Metals

  • Han, Yunlei;Wang, Rui;Yang, Zhirong;Zhan, Yuhua;Ma, Yao;Ping, Shuzhen;Zhang, Liwen;Lin, Min;Yan, Yongliang
    • Journal of Microbiology and Biotechnology
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    • v.25 no.7
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    • pp.1119-1128
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    • 2015
  • 1-Aminocyclopropane-1-carboxylate (ACC) deaminase, which is encoded by some bacteria, can reduce the amount of ethylene, a root elongation inhibitor, and stimulate the growth of plants under various environmental stresses. The presence of ACC deaminase activity and the regulation of ACC in several rhizospheric bacteria have been reported. The nitrogen-fixing Pseudomonas stutzeri A1501 is capable of endophytic association with rice plants and promotes the growth of rice. However, the functional identification of ACC deaminase has not been performed. In this study, the proposed effect of ACC deaminase in P. stutzeri A1501 was investigated. Genome mining showed that P. stutzeri A1501 carries a single gene encoding ACC deaminase, designated acdS. The acdS mutant was devoid of ACC deaminase activity and was less resistant to NaCl and NiCl2 compared with the wild-type. Furthermore, inactivation of acdS greatly impaired its nitrogenase activity under salt stress conditions. It was also observed that mutation of the acdS gene led to loss of the ability to promote the growth of rice under salt or heavy metal stress. Taken together, this study illustrates the essential role of ACC deaminase, not only in enhancing the salt or heavy metal tolerance of bacteria but also in improving the growth of plants, and provides a theoretical basis for studying the interaction between plant growth-promoting rhizobacteria and plants.

An Implementation on the XOR-ACC of Multimedia Fingerprinting using Neural Network (신경망을 이용한 멀티미디어 핑거프린팅의 XOR-ACC 구현)

  • Rhee, Kang-Hyeon
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.48 no.6
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    • pp.1-8
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    • 2011
  • In multimedia fingerprinting field, it is many used a code based on BIBD, which has a strong resiliency of anti-collusion. When a collusion-attack code is generated with a logical XOR operation using the code based on BIBD, then some cases are occurred that a colluded code could be generated to the same fingerprint of non-colluder on the other hand, the colluder is decided to the non-colluder so that he would be excepted in the colluder tracing. For solving the serious problem of the wrong decision of the colluder tracing in this paper, XOR-ACC is implemented using multi-layer perceptron neural network among (AND, OR, XOR and Averaging)-ACC by the measured correlation coefficient. Through the experiment, it confirms that XOR-ACC efficiency of multimedia fingerprinting code{7,3,1} based on BIBD is improved to 88.24% from the conventional 41.18%, so that a ratio of the colluder tracing is also improved to 100% from the conventional 53%. As a result, it could be traced and decided completely a sectional colluder and non-colluder about the collusion attacks.

Performance Improvement of SCAM Climate Model using PGI Compiler with OpenACC (SCAM 기상모델의 성능향상을 위한 PGI Compiler의 OpenACC 활용)

  • Lee, Chang-Hyun;Kang, Bol-Kyung;Chung, Sung-Wook
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.15 no.3
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    • pp.189-197
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    • 2022
  • With the development of high-performance computing technology and the advancement of numerical model, it is possible to predict the better weather forecasting. The purpose of this paper is the performance improvement for the SCAM climate model for the model running time excluding the compilation time. Therefore, the model previously performed using the Intel Fortran Compiler was changed to PGI Fortran Compiler. To this end, we reconfigure system environment variables, reset compilation options, install dependencies SW and library, and modify source code. In addition, we proposed and applied the 'PGI Compile with OpenACC' method. As a result, when the compiler was changed from intel to PGI, it led to an improvement of 6.08% in running time and when the openACC method was applied, it led to an improvement of 43.05% in running time. This demonstrates that the PGI Compile with OpenACC method proposed in this paper leads to excellent performance.