• Journal of Sensor Science and Technology
• /
• v.18 no.4
• /
• pp.280-285
• /
• 2009

In this paper, we designed a 2-stage CMOS operational amplifier with temperature compensation function using 2-poly 4-metal 0.35 $\mu$m standard CMOS technology. Using two bias circuits, the positive temperature coefficient(PTC) and the negative temperature coefficient(NTC) of the bias circuit are canceled out each other. When reference current circuit is simulated that it has a temperature coefficient of -150 ppm/$^{\circ}C$ with a temperature change from 0 $^{\circ}C$ to 120 $^{\circ}C$. Also the proposed circuit has a temperature coefficient of -0.011 dB/$^{\circ}C$ of DC open loop gain with the same temperature range.

• Bulletin of the Korean Chemical Society
• /
• v.26 no.2
• /
• pp.285-291
• /
• 2005

The nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is the viral RNA-dependent RNA polymerase (RdRp), which is the essential catalytic enzyme for the viral replication and is an appealing target for the development of new therapeutic agents against HCV infection. A small amount of serum from a single patient with hepatitis C was used to get the genome of a Korean HCV isolate. Sequence analysis of NS5B 1701 nucleotides showed the genotype of a Korean isolate to be subtype 1b. The soluble recombinant HCV NS5B polymerase lacking the C-terminal 24 amino acids was expressed and purified to homogeneity. With the highly purified NS5B protein, we established in vitro systems for RdRp activity to identify potential polymerase inhibitors. The rhodanine family compounds were found to be potent and specific inhibitors of NS5B from high throughput screening (HTS) assay utilizing the scintillation proximity assay (SPA) system. The binding mode of an inhibitor was analyzed by measuring various kinetic parameters. Lineweaver-Burk plots of the inhibitor suggested it binds not to the active site of NS5B polymerase, but to an allosteric site of the enzyme. The activity of NS5B in in vitro polymerase reactions with homopolymeric RNA requires interaction with multiple substrates that include a template/primer and ribonucleotide triphosphate. Steady-state kinetic parameter, such as Km, was determined for the ribonucleotide triphosphate. One of compounds found interacts directly with the viral polymerase and inhibits RNA synthesis in a manner noncompetitively with respect to UTP. Furthermore, we also investigated the ability of the compound to inhibit NS5B-directed viral RNA replication using the Huh7 cell-based HCV replicon system. The investigation is potentially very useful for the utility of such compounds as anti-hepatitic agents.

• Journal of the Korean Ceramic Society
• /
• v.32 no.3
• /
• pp.359-365
• /
• 1995

The grain boundary effect on the ionic conductivity was investigated using a.c. admittance analysis in (Bi2O3)0.715(CaO)0.285 oxygen-ion conducting solid electrolyte. As a separated arc representing grain boundary polarization was not observed in the admittance plane, bulk conductivity was measrued for samples with various grain sizes in the temperature range from 48$0^{\circ}C$ to 72$0^{\circ}C$ and the conductivity distribution between grain interior and grain boundary was determined by the reported analytical methods. In the above temperature range, grain boundary worked as a high conductive path instead of blocking layer and ionic conduction through grain boundary was significant. The activation energy for conduction through grain and grain boundary was 78 and 106 kJ/mol, respectively.

• The KIPS Transactions:PartC
• /
• v.14C no.3 s.113
• /
• pp.285-292
• /
• 2007

In the adaptable bandwidth allocation technique, a transmission plan for variable rate video data is made by the CBA algorithm and the data is transmitted by considering network traffic. But the CBA algorithm produces a transmission plan where the size of the increasing interval of transmission rate is generally larger than the size of the decreasing interval. And the transmission rate in CBA algorithm is changed in overflow curve during the increasing interval of transmission rate. This ぉy cause many frames to be discarded when available transmission rate is small. In this paper, a smoothing algorithm is proposed, where transmission rate is changed in the middle of underflow curve and overflow curve, but the transmission rate increases at the minimum. In order to show the performance, the proposed algorithm and a CBA algorithm were applied to a transmission plan in the adaptable bandwidth allocation technique, and the minimum frame rates, the average frame rates, the variation of frame rates, and the numbers of discarded frames were compared in both algorithms.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.11 no.8
• /
• pp.2935-2941
• /
• 2010

This study used 3 kinds of experimental toothpaste with different contents(0%, 1.1%,2.2% of SLS. A total of 150 young adults in their 20's without any systemic disease were recruited for the study. These 150 subjects were subdivided into three groups(each having 50 subjects) according to the results of preliminary oral examination.After 4 weeks application of the three groups of toothpaste, Group C showed the highest halitosis index, followed by Groups A and B which had similar halitosis indices. Both oral sulfur compound and aerobic sulfur compound were measured at high content possibly because higher SLS content which is associated with the lower salivary flow rate is causing the xerostomia. SLS content was correlated with oral sulfur compound (r=0.412) and aerobic sulfur compound (r=0.285).

• Asian-Australasian Journal of Animal Sciences
• /
• v.5 no.2
• /
• pp.285-294
• /
• 1992

Biochemical polymorphisms of sow's milk proteins, $\beta$-casein ($\beta$-CN), $\beta$-lactoglobulin ($\beta$-LG), post-lactoglobulin (post-LG), $\alpha$-lactalbumin ($\alpha$-LA) and X-protein, as genetic markers for major pig breeds (Landrace, Yorkshire, Duroc, Hampshire and cross bred) in Korea were determined by starch gel electrophoresis. Phenotype and gene frequencies at all marker loci were estimated and genetic differences among breed populations were analyzed. Three $\beta$-CN phenotypes (AA, AB and BB) controlled by two codominant alleles (${\beta}-CN^A$ and ${\beta}-CN^B$), four $\beta$-LG phenotypes (AA, AC, $AC^{\pm}$ and CC) controlled by two codominant alleles (${\beta}-LG^A$ and ${\beta}-LG^C$) and ten X-protein phenotypes (AA, BB, CC, DD, AB, AC, AD, BC, BD and CD) controlled by four codominant alleles ($X^A,\;X^B,\;X^C\;and\;X^D$) were identified. In addition, a genetically controlled polymorphism of post-LG was found for the first time in sow's milk protein. Three different phenotypes (AA, AB and BB) were designated $post-LG^A$ and $post-LG^B$. Of the five marker loci examined, $\alpha$-LA locus was observed to lack any individual variation in all breeds studied. All populations were in Hardy-Weinberg equilibrium for all loci. There were marked breed differences for phenotype and gene frequencies in the post-LG and X-protein marker loci. However, there were little differences between breeds in the gene frequencies at the $\beta$-CN and $\beta$-LG marker loci.

• Journal of Convergence for Information Technology
• /
• v.8 no.6
• /
• pp.75-84
• /
• 2018

Objects: This study is a descriptive study to identify the factors influencing the glycated hemoglobin control in type 2 diabetes patients. Methods: This study used raw data from the third year of the National Health and Nutrition Examination Survey performed from 2015. The subjects were 285 people who were classified as type 2 diabetes patients among the 7,380 participants of the National Health and Nutrition Examination Survey. Findings: The factors influencing the glycated hemoglobin control in type 2 diabetes patients were found to be age, education level, prevalence period and sleeping time. Improvements: In type 2 diabetes patients, it is very important to have appropriate education on diabetes when they discovered the disease morbidity in the middle age rather than in the aged period and to have enough sleeping time. A practical program to help this education and training should be developed.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.32 no.6C
• /
• pp.285-293
• /
• 2012

The surface tension, which is generated in the unsaturated soils, increases the stiffness of the soils. The objective of this study is to estimate the effect of the surface tension, which varies according to the temperature, on the shear wave velocity. Nine specimens, which have the different degree of saturation (0%, 2.5%, 5%, 10%, 20%, 40%, 60%, 80%, 100%), are prepared by using sand-silt mixtures. Experiments are carried out in a nylon cell designed for the measurement of shear waves. A pair of bender elements, which are used for the generation and detection of shear waves, is installed as a cross-hole type. The shear waves are continuously monitored and measured as the temperature of specimens decreases from $15^{\circ}C$ to $1^{\circ}C$. The results show that shear wave velocities of the fully saturated and fully dried specimens change a little bit as the temperatures of specimens decrease. However, the shear wave velocities of the specimens with the degree of saturations of 2.5%, 5%, 10%, 20%, 40%, 60% and 80% continuously increase as temperature decreases from $15^{\circ}C$ to $1^{\circ}C$. Furthermore, a fully saturated specimen is dried at the temperature of $70^{\circ}C$ in order to observe the shear waves according to degree of saturation. The shear wave velocities measured at the temperature of $70^{\circ}C$ are generally lower than those measured at temperature of $15^{\circ}C$. This study demonstrates that the dependence of shear wave velocities on the temperature according to the degree of saturation should be taken into account in both laboratory and field tests.

• Proceedings of the IEEK Conference
• /
• summer
• /
• pp.285-288
• /
• 2004

In this paper, we present a design and experiment of PCI Express core verification model. The model targeting Endpoint core based on Verilog HDL is designed by newly-emerging SystemC, which is a new C++ class library based system design approach. In the verification model, we designed and implemented a SystemC host system model which acted as Root Complex and device driver dedicated to the PCI Express Endpoint RTL core. The verification process is scheduled by scenarios which are implemented in host model. We show that the model is useful especially for verifying the RTL model which has dependencies on system software.

• Korean Journal of Poultry Science
• /
• v.40 no.2
• /
• pp.91-96
• /
• 2013

FABPs, 15 kDa organic substances, are small intracellular proteins which have a primary role to regulate fatty acid uptake and intracellular transport. This study was conducted to identify SNPs in the two FABP family genes and their associations with the body weight traits in Korean native chicken (KNC). Two SNPs, namely g.508C>T of FABP3 gene and g.285C>T of FABP4 gene, have been genotyped by using PCR-RFLP method. The results showed that FABP3 was significantly associated with body weight at birth, body weights at 12 to 20 weeks, and also slaughter weight. Moreover, the g.285C>T SNP of FABP4 gene was not associated with any body weight traits. These results suggested that the g.508C>T SNP of FABP3 genes can be used as molecular markers to select KNC having desirable body weights.