• 제목/요약/키워드: A1BC3

검색결과 609건 처리시간 0.033초

임의의 경계조건을 갖는 철근 콘크리트 사판의 해석 (An Analysis of the R/C Skew-Plates With Arbitrary Boundary Conditions)

  • 조현영;조진구
    • 한국농공학회지
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    • 제28권4호
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    • pp.49-56
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    • 1986
  • This study was carried out to investigate mechanical characteristics of the uniformly loaded skew-plate at 4 kinds of boundary condition : i) all edges are clamped (BC-1) , ii) all edges are simply supported (BC- 2), iii) two opposite edges are clamped and the other two edges are free (BC-3), and iv )two opposite edges are simply supported and the other two edges are free (BC-4). Various skew angles, 0$^{\circ}$, 10$^{\circ}$, 15$^{\circ}$, 30$^{\circ}$, 40: 45: and 60, of the plate were tested for the above boundary conditions. Resutts obtained from the study are summarized as follows ; 1.The lateral displacement at the center of a skew- plate was decreased as the skewangle increased at all of the boundary conditions. The decrements of the conditions of BC-3 and BC-4 were considerable. And, difference of the displacement between the boundary conditions was decreased as the skew-angle was increased. 2. X-moments (to the Y-axis) at the center of a skew- plate and the minimum principal moments were shown as a similar pattern of change with respect to the skew-angle variation between BC-i and BC-2 and between BC-3 and BC-4, and the pattern of change at the conditions of BC-3 and BC-4 were shown higher rates than those for the conditions of BC-i and BC-2 3.Y-moments (to the X- axis) at the center of a skew-plate and the maximum principal moment were decreased as the skew-angle increased in a similar pattern at all of the boundary conditions. 4.X-moments at the obtuse angle side of a skew-plate were shown as a parabolic pattern of change (frist increased after then decreased) as the skew-angle increased, and a skew-angle resulting the maximum absolute moment was depended on the boundary conditions. 5.Y-moments at the obtuse angle side of a skew-plate were affected by the skewangle much more at the boundary condtions of BC-2 and BC-4 than at the conditions of BC-i and BC-3. 6.Maximum principal moments at the obtuse angle side of a skew-plate at the skew angle of 40$^{\circ}$- 45$^{\circ}$ were resulted almost the same value at all of the boundary conditions .

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BC3H-1 분화세포에서의 (Na,K)ATPase ${\alpha}_2$ isoform의 표현증대 (Increased Expression of the ${\alpha}_2$ Isoform of (Na,K)ATPase in the Differentiated Murine Muscle Cell Line BC3H-1)

  • 이경림
    • 약학회지
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    • 제40권6호
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    • pp.734-738
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    • 1996
  • The development of the alpha2 isoform of (Na,K)ATPase which is high affinity ouabain receptors was studied in the differentiating nonfusing muscle cell line BC3H-1. T he differentiation process of BC3H-1 cell line was confirmed by 2-dexy-D-[$^3$H] glucose uptake experiment and the quantity of the expression of ${\alpha}_2$ isoform was measured using a whole cell [$^3$H] ouabain-binding assay. Undifferentiated growing BC3H-1 cells, myoblasts, exhibited low levels of insulin-stimulated glucose uptake and [$^3$H] ouabain-binding sites. In contrast, differentiated BC3H-1 cells, myocytes, had a 5.6-fold increase in insulin-stimulated glucose uptake and 5-fold increase in [$^3$H] ouabain-binding sites. Scatchard analysis showed that myocytes developed more [$^3$H] ouabain-binding sites than myoblasts vath a dissociation constant (kd) of 6${\times}10^{-8}$M and capacity of 6.l${\times}10^{-5}$ sites/cell. Therefore. it seems that myoblasts express low levels of ${\alpha}_2$ subunit and probably the majority of ${\alpha}_1$ subunit, whereas myocytes express high levels of ${\alpha}_2$ isoform. The results indicate that the expression of ${\alpha}_2$ isoform is developmentally regulated during differentiation and that BC3H-1 culture system provides an excellent model for the study of differentiation and mechanism of (Na,K)ATPase action in muscle which requires electrical excitability.

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대구지역 택배서비스업 종사자의 디젤엔진배출물 노출 평가 (Exposure Assessment of Diesel Engine Exhaust among Door-to-door Deliverers in Daegu)

  • 이가현;김승원
    • 한국산업보건학회지
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    • 제27권4호
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    • pp.361-370
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    • 2017
  • Objectives: This study evaluated the diesel engine exhaust (DEE) exposure levels of door-to-door deliverers in Daegu from July to September. Methods: We measured exposure levels of DEE surrogates for the same door-to-door deliverers who joined the particulate matter 2.5 exposure study previously published in this journal. Black carbon(BC) concentrations were measured using real-time BC monitoring devices with 1 minute interval. $NO_2$ concentrations were monitored using passive badges. DEE exposure data were analyzed using the same characteristics and GPS information as the first study. Results: A total of 40 measurements of BC concentrations and $NO_2$ concentrations were collected during delivery of parcels. The average exposure levels to BC, and $NO_2$ were $2.23{\mu}g/m^3$ ($0.001-350.85{\mu}g/m^3$) and 21.26 ppb(3.3-61.37 ppb), respectively. Exposure levels to BC according to the day of a week and coverage areas were not significantly different(p>0.05). Delivery trucks manufactured before 2006 caused significantly higher exposure to BC than the trucks manufactured after 2006(p<0.05). Exposure levels of BC integrated for each time in residential area and roadsides were $1.96{\mu}g/m^3$ and $3.46{\mu}g/m^3$, respectively, and the difference was statistically significant(p<0.001). The Pearson correlation coefficients between the ambient $PM_{2.5}$ and BC was significant, r=0.26(p<0.01); however, the correlations between $PM_{2.5}$ and ambient $PM_{2.5}$, and between BC of DEE and $PM_{2.5}$ of DEE did not show a significant correlation Conclusions: BC and $NO_2$ exposure levels were significantly lower when door-to-door deliverers drove newer trucks. BC exposure levels of deliverers were higher in roadsides than in residential area. DEE from nearby vehicles through open windows might be the main source of BC exposure.

Isolation and Cultivation Characteristics of Acetobacter xylinum KJ-1 Producing Bacterial Cellulose in Shaking Cultures

  • Son, Chang-Jin;Chung, Seon-Yong;Lee, Ji-Eun;Kim, Seong-Jun
    • Journal of Microbiology and Biotechnology
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    • 제12권5호
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    • pp.722-728
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    • 2002
  • Eight strains producing bacterial cellulose (BC) were isolated from rotten fruits and traditionally fermented vinegars. One of the isolated strains from the rotten grape in Gwangju, Korea, maintained a relatively stable BC production in shaking cultures. This isolated strain proved to be Acetobacter xylinum, based on several biochemical and morphological tests. It was shown that the slant-baffled flask was more efficient than the conventional flask for the BC production in shaking cultures. To determine the most suitable carbon and nitrogen sources for the production of BC, various compounds were examined. Fructose was found to be the most effective carbon source with an optimal concentration of 2%. Mixed carbon source (glucose:fructose=1:3) was also better than glucose or fructose alone. Optimal nitrogen source, when basal medium was used, was 10% (v/v) com steep liquor (CSL). When com steep liquor was used with a mixed carbon source (glucose:fructose=1 :3),4% CSL exhibited the best BC production. Based on these results, a defined medium was developed for the BC production by Acetobacter xylinum KJ-1. When this medium was used under optimal culture conditions, the BC production was 7.2 g/1, which was approximately 3 times higher than that with the traditional HS medium.

Anti-apoptotic effect by Bcl-2 in UVB-irradiated keratinocytes.

  • Takahashi, Hidetoshi;Honma, Masaru;Ishida-Yamamoto, Akemi;Namikawa, Kazuhiko;Miwa, Akiko;Okado, Haruo;Kiyama, Hiroshi;Iizuka, Hajime
    • Journal of Photoscience
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    • 제9권2호
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    • pp.225-228
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    • 2002
  • Bcl-2 is a member of large bcl-2 family and protects cells from apoptosis. Using bcl-2-expressing adenovirus vector (Ad-bc1-2), we investigated the effect of bc1-2 on UVB-induced apoptosis. Adenovirus vector efficiently introduced bc1-2 gene in cultured normal mouse keratinocytes (NMK cells); almost all NMK cells (lx10$^{6}$ ) were transfected at Ixl0$^{8}$ PFU/ml. Bcl-2-transfected NMK cells were significantly resistant to UVB-induced apoptosis with the suppressive effect dependent on bcl-2-expression level. Following UVB irradiation caspase 8, 3, 9 activities were stimulated in NMK cells, while in bc1-2-transfected cells, only caspase 8, but not caspase 3 or 9 activities were stimulated. In order to investigate the effect of bc1-2 in vivo, topical application of Ad-bc1-2 on tape-stripped mouse skin was performed. Following the application, Bc1-2 was efficiently overexpressed in almost all viable keratinocytes. The expression was transient with the maximal expression of Bc1-2 at 1st day following the application of lxl0$^{9}$ PFU in 200ml. The introduced Bc1-2 remained at least for 6 days. UVB irradiation (1250 J/m$^2$) induced apoptosis within 12 h and the maximal effect was observed at 24 h in control mouse skin. Bc1-2-transfected mice skin were resistant to UVB-induced apoptosis. Topical application of empty adenovirus vector alone had no effect on Bc1-2 expression or UVB-induced apoptosis. These results indicate that adenovirus vector is an efficient gene delivery system into keratinocytes and that Bcl-2 is a potent inhibitor of UVB-induced apoptosis both in vitro and in vivo.

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양파와 파간의 종간잡종 F1과 여교잡계통의 핵 DNA 함량 (Variation of Nuclear DNA Content in Interspecific Allium cepa L.×A. fistulosum L. hybrids and Their Successive Backcross Lines)

  • 김철우;김화영;이을태;최인후;방진기
    • 한국육종학회지
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    • 제41권4호
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    • pp.463-467
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    • 2009
  • Allium 속 근연종인 파와 양파간 종간교잡을 이용하여 양파로부터 새로운 형질을 도입하는 과정에서 유래되는 종간교잡 F1과 여교잡 세대들의 게놈크기의 변화를 flow cytometry를 이용하여 측정한 결과 다음과 같은 결과를 얻었다. 1. 양파와 파의 종간교잡 F1의 식물학적 특성은 양친의 중간형을 보였으나 여교잡이 진전됨에 따라 반복친인 파의 표현형이 우세하였다. flow cytometry를 이용하여 2C nuclear DNA content을 측정한 결과 $F_1$은 양친에 비해 오히려 증가하였으나 여교잡이 진행됨에 따라 급속히 감소하여 $BC_2F_1$에서는 반복친과 비슷한 수준으로 감소하였다. 여교잡세대의 자식인 $BC_1F_2$은 반복친과 비슷한 $23.1{\pm}1.0pg$으로 측정되었으나 $BC_2F_2$$22.9{\pm}0.4pg$으로 반복친의 2C nuclear DNA content인 $23.2{\pm}0.2pg$ 보다 오히려 감소하였다.

A Multicenter Matched Case Control Study of Breast Cancer Risk Factors among Women in Karachi, Pakistan

  • Shamsi, Uzma;Khan, Shaista;Usman, Sheheryar;Soomro, Saleem;Azam, Iqbal
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권1호
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    • pp.183-188
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    • 2013
  • Background: Breast cancer (BC), the most common female cancer in Pakistan, is associated with a very high mortality. However, the roles of individual risk factors for BC among Pakistani women are still controversial. To assess potential risk factors for BC, a matched case-control study was conducted in two tertiary care hospitals of Karachi, Pakistan. Materials and Methods: The study population included 297 pathologically confirmed incident cases of BC patients diagnosed between January 2009 and December 2010. 586 controls without any history of BC were matched on hospital and ${\pm}5$ years of ages. Results: Positive family history of BC (MOR=1.72; 95%CI: 1.10, 2.80 for first degree vs. none), single marital status (MOR=1.55; 95%CI: 1.10, 2.39 for single/divorced/widowed women vs. married women), older age at menopause (MOR=3.92; 95%CI: 2.52, 6.18 for menopausal women aged below 45 years, MOR=6.42; 95%CI: 3.47, 11.98 for menopausal women above 45 years of age compared with premenopausal women) conferred an increased risk of BC for women. Increasing parity decreased the risk of BC (MOR=0.90; 95%CI: 0.85, 0.97 for each live birth). Intake of Vitamin D supplements (MOR=0.30; 95%CI: 0.12, 0.81 for ${\leq}3$ years and MOR=0.27; 95%CI: 0.13, 0.56 for >3 years) was protective compared to non-users of Vitamin D. Conclusions: This study confirmed only few of the recognized risk factors in Pakistani women. The protective effect of Vitamin D is important from public health perspective and needs to be further explored through a randomized controlled trial.

BC-B Type150K DWT Class Bulk carrier 구조적 특성에 관한 고찰 (A study of Analysis for 150K DWT Class Bulk carrier(BC-B type))

  • 서향덕;김도군;안형준
    • 대한조선학회 특별논문집
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    • 대한조선학회 2015년도 특별논문집
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    • pp.79-84
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    • 2015
  • A BC-B type bulk carrier is rarely built, so the structural characteristics is not reported and familiar so far. The biggest difference between BC-B and BC-A type vessel is applying alternate cargo loading, which density is over $1.0ton/m^3$. In this paper, 150K DWT class BC-B type bulk carrier is calculated and compared with BC-A type vessel, which has same condition such as main dimension and deadweight, about prescriptive rule and FEA based on CSR. And aspect ratio of target vessel is smaller than typical capsize bulk carrier, so 150K and 180K bulk carrier, which applied BC-A type, are also compared to find feature of wide beam vessel.

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3BC와 F2mECC를 이용한 MDIT(Mobile Digital Investment Trust) 에이전트 설계 및 보안 강화 (A MDIT(Mobile Digital Investment Trust) Agent design and security enhancement using 3BC and E2mECC)

  • 정은희;이병관
    • 인터넷정보학회논문지
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    • 제6권3호
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    • pp.1-16
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    • 2005
  • 본 논문은 모바일 전자 상거래 환경에서 투자 신탁을 위한 MDIT(Mobile Digital Investment Trust) 에이전트 설계를 제안하고 또한 이 MDIT에서 모바일 전자 상거래 환경이 가지고 있는 기억 장치 용량, CPU 처리 속도 문제, 그리고 보안 강화 문제점을 해결하기 위해, 비밀키 암호 알고리즘인 3BC(Bit, Byte end Block Cypher)와 공개키 알고리즘인 F2mECC 설계를 제안한다. 특히, MDIT는 모바일 전자상거래에 투자 신탁의 개념을 도입한 은행 업무 보안 프로토콜로서 공개키 알고리즘인 ECC를 이용해 공유 비밀키를 생성한 후, 이 값을 공유 비밀키를 대칭키로 사용하는 블록 암호화 기법인 3BC에 사용하여, 보안 기능을 강화시키고, 처리속도를 감소시킨 MDIT 보안 에이전트를 구축하였다.

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Risk Factors for Premenopausal Breast Cancer: A Case-control Study in Uruguay

  • Ronco, Alvaro L.;Stefani, Eduardo De;Deneo-Pellegrini, Hugo
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권6호
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    • pp.2879-2886
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    • 2012
  • In order to thoroughly analyze risk factors of breast cancer (BC) in premenopausal Uruguayan women, a case-control study was carried out at the Pereira Rossell Women's Hospital, Montevideo, where 253 incident BC cases and 497 frequency-matched healthy controls were interviewed on menstrual and reproductive story, were administered a short food frequency questionnaire and undertook a series of body measurements necessary to calculate body composition and somatotype. Odds ratio (OR) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Among the classical risk factors, only the family history of BC in first degree relatives was significantly associated with risk of premenopausal BC (OR=2.20, 95% CI 1.33-3.62). Interestingly, this risk factor was found to be stronger in women of ages >40 (OR=4.05, 95% CI 2.10-7.81), late menarche (OR= 2.39, 95% CI 1.18-4.85), early age for their first delivery (OR=3.02, 95% CI 1.26-7.22), short time between menarche and first delivery (OR=3.22, 95% CI 1.29-8.07), and with high parity (OR=4.10, 95% CI 1.79-9.36), although heterogeneity was detected only for age and parity. High consumption of red meat was positively associated with the disease risk (OR=2.20, 95% CI 1.35-3.60), in the same way as fried foods (OR=1.79, 95% CI 1.12-2.84). Conversely, a high intake of plant foods displayed a protective effect (OR=0.41, 95% CI 0.26-0.65). Except for hypertension (OR=1.55, 95% CI 1.03-2.35), none of the analyzed components of metabolic syndrome were associated to BC risk. Particular increases of risk for premenopausal BC were found for family history in first degree relatives in certain subsets derived from the menstrual-reproductive history. Preventive strategies could broaden their scope if new studies confirm the present results, in view of the limited prevention measures that premenopausal BC currently has.