• Microbiology and Biotechnology Letters
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• v.44 no.4
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• pp.497-503
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• 2016

This study aimed to optimize the culture conditions of recombinant Escherichia coli expressing otsBA using crude glycerol for the enhanced production of trehalose. The effects of culture temperature and isopropyl ${\beta}$-D-1-thiogalactopyranoside (IPTG)-induction were investigated. Trehalose production and cell growth were highest when cells were cultured at $37^{\circ}C$ and induced with IPTG. The concentrations of IPTG, validamycin A, and NaCl were optimized using Box-Behnken design. Statistical analyses of the experimental data revealed that the concentrations of IPTG and NaCl had significant effects on trehalose production, but that of validamycin A did not. Contour plot analysis and model calculation showed that the highest amount of trehalose could be produced at 298 mM NaCl and 0.1 mM IPTG. Under these optimal conditions, the optical density at 600 nm and trehalose production were $5.4{\pm}0.2$ and $304{\pm}15mg/l$, respectively.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.8 no.3
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• pp.673-681
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• 2007

The integration of Quality Circles and Six-Sigma has gained attentions for the attainment of enhanced customer satisfaction, costs reduction, and improved business performance. The purpose of this paper is to verify the benefit from the integration of Quality Circles and Six-Sigma by applying the integrated process for an alcohol manufacturing line. In the integrated process, we used the first three steps of Six-Sigma of Define, Measure, and Analyze(D-M-A) and then applied the concept of Quality Circle, which has good performance in the Improvement and Control(I-C) process. For the selection of the theme of quality circles, Analytic Hierarch Process(AHP) is used, and we also employed the experimental design, which is designed to find an optimal operating condition. Furthermore, the results of the economic analysis confirm that the integration process would be successful in reducing the incidence of defects and the quality cost.

• Journal of Korea Technology Innovation Society
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• v.11 no.2
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• pp.171-193
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• 2008

Every country of the world in the 21st century is going to push forward the policy protecting their intellectual property right, and international movement to protect their intellectual right is still more strengthened. Under these situations, the firm is required to seek for more efficient methods of technology security and business management while the existence of business itself is at risk. The control of intellectual properties in business should be considered in the patent management. In the company, the industrial property right should be into one of the management resource, and its importance has great influence on the existence of the company. The information in patent data can be used for strategic planning purposes. This study systematically evaluates the patenting behaviour of sample of 27 business firms within the Korean metal industry. Utilizing the patent application data between 2000 and 2005, the relationship between these patenting management and company performance is analysed. This study showed that patent activity per employee and labor productivity are positive relationship, but patent activity per employee and firm size are negative relationship. Since a positive relationship between patenting and company performance could be shown, patent activity gains important as a instrument for R&D planning.

• Applied Chemistry for Engineering
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• v.29 no.5
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• pp.503-509
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• 2018

In this study, we used the ultrasonic extraction process as a method to extract antioxidant substances from kudzu, and measured the content of iso-flavonoids puerarin, daidzein, daidzin contained in kudzu. The response surface methodology which is a statistical analysis method for optimizing the extraction amount of iso-flavonoids from the kudzu and the process condition for maximizing the yield was applied. It is the final objective of this study to effectively derive the condition of the process that matches the target response with a minimum number of experiments and analyze the effect of each process condition on the response. In the response surface methodology, the central composite design was applied and the optimum condition was analyzed, and the three independent variables were set to ultrasonic irradiation time, volume ratio of ethanol/ultrapure water, ultrasonic irradiation power. Using the response surface methodology, the optimum conditions with the maximum extraction yield and the content of iso-flavonoids were evaluated as ultrasonic irradiation time (24.75 min), ethanol / ultrapure water volume ratio (39.75 vol%), ultrasonic irradiation power (592.36 W). The overall satisfaction level appears as high as 0.8938, which is recognized at a significance level within 5%. As a result of analyzing the optimization process, it was confirmed that the ultrasonic irradiation time is the factor that most affects the responses.

• Investigative Magnetic Resonance Imaging
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• v.16 no.1
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• pp.67-75
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• 2012

Purpose : We studied enhanced method to view the vessels in the brain using Magnetic Resonance Angiography (MRA). Noticing that Maximum Intensity Projection (MIP) image is often used to evaluate the arteries of the neck and brain, we propose a new method for view brain vessels to stereo image in 3D space with more superior and more correct compared with conventional method. Materials and Methods: We use 3T Siemens Tim Trio MRI scanner with 4 channel head coil and get a 3D MRA brain data by fixing volunteers head and radiating Phase Contrast pulse sequence. MRA brain data is 3D rotated according to the view angle of each eyes. Optimal view angle (projection angle) is determined by the distance between eye and center of the data. Newly acquired MRA data are projected along with the projection line and display only the highest values. Each left and right view MIP image is integrated through anaglyph imaging method and optimal stereoscopic MIP image is acquired. Results: Result image shows that proposed method let enable to view MIP image at any direction of MRA data that is impossible to the conventional method. Moreover, considering disparity and distance from viewer to center of MRA data at spherical coordinates, we can get more realistic stereo image. In conclusion, we can get optimal stereoscopic images according to the position that viewers want to see and distance between viewer and MRA data. Conclusion: Proposed method overcome problems of conventional method that shows only specific projected image (z-axis projection) and give optimal depth information by converting mono MIP image to stereoscopic image considering viewers position. And can display any view of MRA data at spherical coordinates. If the optimization algorithm and parallel processing is applied, it may give useful medical information for diagnosis and treatment planning in real-time.

• Journal of the Korean Association of Geographic Information Studies
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• v.13 no.1
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• pp.74-88
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• 2010

In this study, the points of LiDAR were modified in order to generate various DEM resolutions by applying LiDAR data in Ulsan. Since the LiDAR data have points with 1m intervals, the number of points for each resolution was modified to the size of 1, 5, 10, 30, 50, 100m by uniformly eliminating the points. A runoff analysis was performed on Taehwa river and its tributary, Dongcheon, with 200 year rainfall exceedance probability. 2-dimensional inundation analysis was performed based on the density of LiDAR data using FLUMEN, which was used to establish domestic flood risk map. Once DEM data obtained from LiDAR survey are used, it is expected that the study results can be used as data in determining optimal grid spacing, which is economical, effective and accurate in establishing flood defence plans including the creation of flood risk map.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.9
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• pp.681-688
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• 2013

Several problems caused by inevitable increment of airplane have been issued. The most effective solution to solve the issues is considered as establishing appropriate Air Traffic Management (ATM) that reduces aircraft's delay at an airport and intensify the airport's capacity. The purpose of this paper is to produce the optimum aircraft schedules that maximize the aircraft throughput by smooth air traffic flow near terminal area of an airport In this paper, mathematical formulations of the scheduling problem are firstly specified. Based on the mathematical modelling, an Optimization-Based Flight Scheduler that provides the optimum flight schedules for arriving aircraft is developed by introducing the Mixed Integer Linear Programming(MILP) and the Genetic Algorithms(GA). With this scheduler, we calculated the optimum schedules to compare to real schedule data from an Incheon Airport. As a result, it is validated that aircraft throughput produced by the optimum schedule is much better than that of the schedule from the Incheon airport. The optimization-based flight scheduler is expected to deal with problems due to the aircraft saturation in near future.

• Progress in Medical Physics
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• v.16 no.1
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• pp.24-31
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• 2005

The stereotactic radiosurgery (SRS) describes a method of delivering a high dose of radiation to a small tar-get volume in the brain, generally in a single fraction, while the dose delivered to the surrounding normal tissue should be minimized. To perform automatic plan of the SRS, a new method of multi-isocenter/shot linear accelerator (linac) and gamma knife (GK) radiosurgery treatment plan was developed, based on a physical lattice structure in target. The optimal radiosurgical plan had been constructed by many beam parameters in a linear accelerator or gamma knife-based radiation therapy. In this work, an isocenter/shot was modeled as a sphere, which is equal to the circular collimator/helmet hole size because the dimension of the 50% isodose level in the dose profile is similar to its size. In a computer-aided system, it accomplished first an automatic arrangement of multi-isocenter/shot considering two parameters such as positions and collimator/helmet sizes for each isocenter/shot. Simultaneously, an irregularly shaped target was approximated by cubic structures through computation of voxel units. The treatment planning method by the technique was evaluated as a dose distribution by dose volume histograms, dose conformity, and dose homogeneity to targets. For irregularly shaped targets, the new method performed optimal multi-isocenter packing, and it only took a few seconds in a computer-aided system. The targets were included in a more than 50% isodose curve. The dose conformity was ordinarily acceptable levels and the dose homogeneity was always less than 2.0, satisfying for various targets referred to Radiation Therapy Oncology Group (RTOG) SRS criteria. In conclusion, this approach by physical lattice structure could be a useful radiosurgical plan without restrictions in the various tumor shapes and the different modality techniques such as linac and GK for SRS.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.37 no.1
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• pp.43-53
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• 2011

The conditions in fluid-bed processor for nanoencapsulation of azelaic acid-milk nano powder for acne nanocosmetics were optimized by response surface methodology (RSM). The maximum value of yield was 70.97 %. The yield was appreciably influenced by inlet air temperature, atomizing pressure, and feeding speed. The particle size increased with an increase in the feeding speed and a decrease in the atomizing pressure. The elution rate in saline solutions was appreciably influenced by inlet air temperature and atomizing pressure. The moisture content increased with higher atomizing pressure, which was demonstrated to be similar to the nanoencapsulation characteristics related to water activity. The Hunter's L and b values increased with an increase in the inlet air temperature. The optimum conditions estimated by RSM for the maximized values of yield, moisture content, particle size and elution rate in skin suitability were $67{\sim}73^{\circ}C$ of inlet air temperature, 0.6 ~ 0.8 mL/min feeding speed and 1.8 ~ 2.0 kg/$cm^2$ of atomizing pressure, respectively. These estimated values were in agreement with those measured by real experiments.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.7
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• pp.935-945
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• 2009

This study was performed to find the optimum ratio of ingredients in the Chinese quince jam. The experiment was designed according to the D-optimal design of mixture design, which included 14 experimental points with 4 replicates for three independent variables (Chinese quince paste $45{\sim}60%$, pectin $1.5{\sim}4.5%$, sugar $45.5{\sim}63.5%$). A mathematical analytical tool was employed for the optimization of typical ingredients. The canonical form and trace plot showed the influence of each ingredient in the mixture against final product. By use of F-test, sweetness, pH, L, b, ${\Delta}E$, and firmness were expressed by a linear model, while the spreadmeter value, a, and sensory characteristics (appearance, color, smell, taste, and overall acceptability) were by a quadratic model. The optimum formulations by numerical and graphical method were similar: Chinese quince paste 54.48%, pectin 2.45%, and sugar 53.07%. Optimum ingredient formulation is expected to improve use of Chinese quince and contribute to commercialization of high quality Chinese quince jam.