• Title/Summary/Keyword: A new host

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A New Approch for Catalyst Optimization: Host/Guest Complexes of Chiral Bisphosphine Bearing Imidazolidinone and Their Application in Rh-Catalyzed Asymmetric Hydrogenation

  • Park, Jung-Hwan;Shin, Hyun-Ik;Park, Doo-Han;Lee, Sang-Gi
    • Bulletin of the Korean Chemical Society
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    • v.31 no.3
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    • pp.635-638
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    • 2010
  • As a new strategy for the optimization of a chiral catalyst, the catalytic activity of the host-guest complexes of chiral bisphosphine bearing imidazolidinone was investigated in Rh-catalyzed asymmetric hydrogenation of enamide. Marginal enhancement in enantioselectivity was observed and the nature of interaction between host-guest was experimentally elucidated.

Vitamin A: a key coordinator of host-microbe interactions in the intestine

  • Ye-Ji Bang
    • BMB Reports
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    • v.56 no.3
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    • pp.133-139
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    • 2023
  • The human intestine is home to a dense community of microbiota that plays a key role in human health and disease. Nutrients are essential regulators of both host and microbial physiology and function as key coordinators of host-microbe interactions. Therefore, understanding the specific roles and underlying mechanisms of each nutrient in regulating the host-microbe interactions will be essential in developing new strategies for improving human health through microbiota and nutrient intervention. This review will give a basic overview of the role of vitamin A, an essential micronutrient, on human health, and highlight recent findings on the mechanisms by which it regulates the host-microbe interactions.

Synthesis and Characterization of New Anthracene-Based Blue Host Material

  • So, Ki-Ho;Park, Hyun-Tae;Shin, Sung-Chul;Lee, Sang-Gyeong;Lee, Dong-Hui;Lee, Kyeong-Hoon;Oh, Hyeong-Yun;Kwon, Soon-Ki;Kim, Yun-Hi
    • Bulletin of the Korean Chemical Society
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    • v.30 no.7
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    • pp.1611-1615
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    • 2009
  • We designed new anthracene-based host material to increase color purity as well as device efficiency. The new blue host, 9,10-bis(2,4-dimethylphenyl)anthracene (BDA), has highly twisted structure and wide band gap due to ortho interaction between anthracene and introduced 2,4-dimethylphenyl substituents. BDA exhibited deep blue fluorescence in solution (${\lambda}_{max}$ = 410 nm) and in solid state (${\lambda}_{max}$ = 429 nm), respectively, with the wide optical band gap (E = 3.12 eV). Blue-light-emitting OLEDs using obtained host and 2% Flu-DPAN as emitter showed 8 cd/A of high efficiency as well as high color purity [CIE coordinates = (0.15, 015)].

The study of new host materials for solution-processed green organic electrophosphorescence

  • Jung, Sung-Hyun;Lee, Ho-Jae;Kim, Young-Hoon;Kim, Hyung-Sun;Yu, Eun-Sun;Chae, Mi-Young;Chang, Tu-Won
    • 한국정보디스플레이학회:학술대회논문집
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    • 2008.10a
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    • pp.454-457
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    • 2008
  • We report the syntheses, photophysical properties and device performances of solution processible host material for green-phosphorescent OLEDs. The butterfly-shaped new host materials with nonconjugated linkage of carbazole and fluorene moieties have large triple energy band gap around 2.8 eV. All of the EL devices exhibited turn-on voltages in the range of 4.8-5.0 V. GH-4 exhibited the best performance with a maximum current efficiency and power efficiency of 21.1 cd/A and 7.9 lm/W.

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Nutritional Modulation of Resistance and Resilience to Gastrointestinal Nematode Infection - A Review

  • Walkden-Brown, Stephen W.;Kahn, Lewis P.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.6
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    • pp.912-924
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    • 2002
  • Disease susceptibility is linked to nutritional status for a wide range of human and animal diseases. Nutritional status can influence both resistance (ability to resist the pathogen) and resilience (ability to tolerate or ameliorate the effects of the pathogen). This review focuses on the nutritional modulation of gastro-intestinal nematode infection in domestic ruminants, primarily sheep. It highlights the duality of the adverse consequences of infection on host nutritional status and the adverse consequences of poor host nutritional status on resistance to infection. Central to both phenomena is the complex, gut-based immune response to gastrointestinal nematode infection. The potential for strategic nutritional supplementation to enhance host resistance and resilience is reviewed together with recent findings on responses to increased ME supply, and long term effects on host immunity of short term protein supplementation.

Secretome Analysis of Host Cells Infected with Toxoplasma gondii after Treatment of Human Epidermal Growth Factor Receptor 2/4 Inhibitors

  • Kim, Hye-Jung;Ahn, Hye-Jin;Kang, Hyeweon;Park, Jaehui;Oh, Seul gi;Choi, Saehae;Lee, Won-Kyu;Nam, Ho-Woo
    • Parasites, Hosts and Diseases
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    • v.58 no.3
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    • pp.249-255
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    • 2020
  • Toxoplasma gondii, a ubiquitous, intracellular parasite of the phylum Apicomplexa, infects an estimated one-third of the human population as well as a broad range of warm-blooded animals. We have observed that some tyrosine kinase inhibitors suppressed the growth of T. gondii within host ARPE-10 cells. Among them, afatinib, human epithermal growth factor receptor 2 and 4 (HER2/4) inhibitor, may be used as a therapeutic agent for inhibiting parasite growth with minimal adverse effects on host. In this report, we conducted a proteomic analysis to observe changes in host proteins that were altered via infection with T. gondii and the treatment of HER2/4 inhibitors. Secreting proteins were subjected to a procedure of micor basic reverse phase liquid chromatography, nano-liquid chromatography-mass spectrometry, and ingenuity pathway analysis serially. As a result, the expression level of heterogeneous nuclear ribonucleoprotein K, semaphorin 7A, a GPI membrane anchor, serine/threonine-protein phosphatase 2A, and calpain small subunit 1 proteins were significantly changed, and which were confirmed further by western blot analysis. Changes in various proteins, including these 4 proteins, can be used as a basis for explaining the effects of T. gondii infections and HER2/4 inhibitors.

Studies on the Laboulbeniomycetes in Korea (I) (한국산(韓國産) 충생균류(蟲生菌類)에 대한 연구(硏究) (I))

  • Lee, Yong-Bo;Lee, Ji-Yul
    • The Korean Journal of Mycology
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    • v.9 no.4
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    • pp.177-192
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    • 1981
  • From a large number of insects collected by the athours, in Korea. various species of the Laboulbeniales have been obtained Seven species in four genera of these fungi which were found on several beetles of the. families Carabidae, Endomychidae, Staphylinidae are reported as new to Korea. They are as follows: Dichomyces biformis (Host: Philonthus micanticolis), D. furcifer (Host: Philonthus sp.), Enathromyces indicus (Host: Pheropsophus jessoensis), Laboulbenia exigus (Host: Chlaenius varricornis), L. flagellata (Host: Anisodactylus punctatipennis), L. vularis (Host: Bembidion oxyglimma, B. thermarum) and Rickia ancylopi (Ancylopus) melanocephalus). All the specimens studied are deposited in the Biological Laboratory of Educational College, Cho Sun University.

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Electroluminescence Properties of New Spiro(fluorene-benzofluore)-Type Blue Host Materials (새로운 Spiro[fluorene-benzofluore]계 청색 호스트 물질의 유기전계발광 특성)

  • Jeon, Young-Min;Lee, Hyun-Seok;Lee, Chil-Won;Kim, Jun-Woo;Chang, Gi-Geun;Gong, Myoung-Seon
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2008.04a
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    • pp.29-30
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    • 2008
  • New spiro-type host materials, 5'-phenylnaphthyl-spiro[fluorene-7,9'-benzofluorene](BH-lPN) and 5',6-bis(phenylnaphthyl)-spiro[fluorene-7,9'-benzofluorene](BH-6PN) were designed and successfully prepared by the Suzki reaction. The EL characteristics of BH-1PN as blue host material doped with blue dopant materials, BD-1 were evaluated and compared with the existing host MADN:dopant BD-1 system. The structure of the device is ITO/DNTPD/NPB/Host:5% dopant/Alq3/Al-LiF. The device obtained from BH-lPN doped with BD-1 showed a good color purity and efficiency, on the other hand luminance and current-density characteristics are worse than that of MADN doped with BD-1.

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Verification of aecial host ranges of four Gymnosporangium species based on artificial inoculation.

  • Yun, Hye-Young;Lee, Seung-Kyu;Lee, Kyung-Joon
    • Proceedings of the Korean Society of Plant Pathology Conference
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    • 2003.10a
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    • pp.134.1-134
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    • 2003
  • Aecial host ranges of four Gymnosporangium species causing cedar-apple rust diseases, G. asiaticum, G. cornutum, 5. japonicum and G. yamadae, were investigated through artificial inoculation. Thirteen species of nine genera among Rosaceous plants, which have been reported as social hosts in Korea, were inoculated with fresh teliospores spores in early days of May of 2000 and of 2001, respectively. In the results, we re-confirmed that there was highly specific relationship between the rust species and aecial hosts and report new aecial hosts of four Gymnosporangium species. Teliospores of G. cornutum collected from Juniperus rigida successively produced spermogonia and aecia only on Sorbus alntifolia, the first report on host alteration of G. cornutum in Korea. Positive responses by teliospores of G. japonicum from J. chinenis of Suwon and from J. chinenis var. horizontalis of Jeju island were obtained only on P. villosa. Crataegus pinnatifida was confirmed as a new aecial host of G. viatium. Until this time, G. ymadae was believed to have Malus as the aecial host. However, teliospores of G. yamadae collected from J. chinensis var. kaizuka successively formed spermogonia and aecia on the leaves of Chaenomeles lagenaria, C. sinensis, Pyrus pyrtifolia var, culta, P. ussuriensis, Malus pumila and M. sileboldii. The date for maturation of spermogonia and aecia, and symptom development varied according to the rust fungi and aecial host plants, respectively.

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Biological Control Strategy of Uzi Fly in Sericulture

  • Singh, R.N.;Saratchandra, Beera
    • International Journal of Industrial Entomology and Biomaterials
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    • v.6 no.2
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    • pp.125-132
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    • 2003
  • Uzi fly (Exorista bombycis Louis) is one of the major larval endo-parasitoid of silkworm (Bombyx mori). It causes extensive damage to sericulture industry. The application of synthetic organic pesticides has tremendous impact on minimizing pest population but their overuse and frequent misuse and high sensitivity towards the silkworms, has forced the entomologists to search for alternatives to chemical control, which is safe to silkworm, environment and farm workers. Biological control continues to offer exciting possibilities for the control of fly pest population. It is environmentally safe alternative to chemical control and offering a long-term protection. Several potential hymenopteran parasitoids have been screened. Among successful natural enemies, Nesolynx thymus, Trichomalopsis apanteloctena, Trichopria sp., Brachymeria lasus, Pediobius sp., Spalangia sp., Spilomicrus karnatakensis and Dhirhinus sp. are important. It is essential to predict accurately the efficacy of these natural enemies in a new habitat prior to its introduction. The important desirable attributes of these potential parasitoids viz., host searching capacity, specificity, power of increase and fitness and adaptability of the parasitoid in new environment has been recorded. Results of the host parasitoid interaction indicate that the aging of the host function as a factor that influence the host finding efficiency of the parasitoid. It is highly scored with 15-20 hrs old pupa of the host. However, aging of the parasitoid does not significantly affect it. The sex ratio is female biased which is advantageous from biological control point of view, Biological suppression methods involving conservation and utilization of natural enemies have been discussed in detail.