• Toxicological Research
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• v.11 no.1
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• pp.81-89
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• 1995

A teratogenicity study of KTC-1, a new semisynthetic rifamycin antituberculous drug, was conducted in Sprague-Dawley rats. Dosages of KTC-1 0, 7, 21, and 63 mg/kg/day were administered to darns orally gayage from day 7 to day 17 of gestation. Two-third of dams per group were subjected to cesarean section on day 21 of pregnancy for examination of their fetuses, and the remaining one-third of darns per group were allowed to deliver naturally for postnatal examination of their offspring. At 21 mg/kg/day, an increase in the skeletal variations of F1 fetuses and a decrease in the body weight of F1 offspring were seen. At 63 mg/kg/day, a loss in body weight was observed in darns. An increase in fetal death rate, a decrease in litter size and body weight, and an increase in the incidence of visceral malforrnations and skeletal variations were found in F1 fetuses. In particular, lumar rib occurred at an incidence of 31%. In addition, an increase in the dead newborns at birth and neonatal deaths during the lactation period, a loss in body weight, and a decrease in spleen weight were observed in F1 offspring. There were no signs of maternal toxicity or embryotoxicity at 7 mg/kg/day. The results suggest that the no-effect dose level(NOEL)for dams is 21 mg/kg/day, and NOELs for F1 fetuses and offspring are 7 mg/kg/day.

• Journal of Astronomy and Space Sciences
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• v.40 no.2
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• pp.45-57
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• 2023

This study examined the effect of solar flux (F10.7) and sunspots number (R) on the daily variation of equatorial electrojet (EEJ) and morning/afternoon counter electrojet (MCEJ/ACEJ) in the ionospheric E region across the eight longitudinal sectors during quiet days from January 2008 to December 2013. In particular, we focus on both minimum and maximum solar cycle of 24. For this purpose, we have collected a 6-year ground-based magnetic data from multiple stations to investigate EEJ/CEJ climatology in the Peruvian, Brazilian, West & East African, Indian, Southeast Asian, Philippine, and Pacific sectors with the corresponding F10.7 and R data from satellites simultaneously. Our results reveal that the variations of monthly mean EEJ intensities were consistent with the variations of solar flux and sunspot number patterns of a cycle, further indicating that there is a significant seasonal and longitudinal dependence. During the high solar cycle period, F10.7 and R have shown a strong peak around equinoctial months, consequently, the strong daytime EEJs occurred in the Peruvian and Southeast Asian sectors followed by the Philippine regions throughout the years investigated. In those sectors, the correlation between the day Maxima EEJ and F10.7 strengths have a positive value during periods of high solar activity, and they have relatively higher values than the other sectors. A predominance of MCEJ occurrences is observed in the Brazilian (TTB), East African (AAE), and Peruvian (HUA) sectors. We have also observed the CEJ dependence on solar flux with an anti-correlation between ACEJ events and F10.7 are observed especially during a high solar cycle period.

• Journal of IKEEE
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• v.28 no.1
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• pp.110-115
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• 2024

This paper analyzed the V_th (Threshold Voltage) variations in 3D NAND Flash memory with tapered O/N/O (Oxide/Nitride/Oxide) structure and O/N/F (Oxide/Nitride/Ferroelectric) structure, where the blocking oxide is replaced by ferroelectric material. With a tapering angle of 0°, the O/N/F structure exhibits lower resistance compared to the O/N/O structure, resulting in reduced V_th variations in both the upper and lower regions of the WL (Word Line). Tapered 3D NAND Flash memory shows a decrease in channel area and an increase in channel resistance as it moves from the upper to the lower WL. Consequently, as the tapering angle increases, the V_th decreases in the upper WL and increases in the lower WL. The tapered O/N/F structure, influenced by V_fe proportional to the channel radius, leads to a greater reduction in V_th in the upper WL compared to the O/N/O structure. Additionally, the lower WL in the O/N/F structure experiences a greater increase in V_th compared to the O/N/O structure, resulting in larger V_th variations with increasing tapering angles.

• Bulletin of the Korean Mathematical Society
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• v.17 no.1
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• pp.9-19
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• 1980

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.10
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• pp.1394-1406
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• 2015

The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammalian growth and development. The goal of this study was to detect novel nucleotide variations and haplotypes structure of the ATBF1 gene, as well as to test their associations with growth-related traits in goats. Herein, a total of seven novel single nucleotide polymorphisms (SNPs) (SNP 1-7) within this gene were found in two well-known Chinese native goat breeds. Haplotypes structure analysis demonstrated that there were four haplotypes in Hainan black goat while seventeen haplotypes in Xinong Saanen dairy goat, and both breeds only shared one haplotype (hap1). Association testing revealed that the SNP2, SNP5, SNP6, and SNP7 loci were also found to significantly associate with growth-related traits in goats, respectively. Moreover, one diplotype in Xinong Saanen dairy goats significantly linked to growth related traits. These preliminary findings not only would extend the spectrum of genetic variations of the goat ATBF1 gene, but also would contribute to implementing marker-assisted selection in genetics and breeding in goats.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.2
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• pp.122-130
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• 1996

In an effort to learn more about the reaction mechanisms which lead to the compound nucleation at the interface of cobalt and silicon, electrical noise properties has been investigated for cobalt thin films deposited on silicon substrates by the electron beam evaporation and rf sputtering techniques. Microstructural variations at the Co/Si interfaces have been observed by transmission electronmicroscopy. Amorphous structures are observed at the Co/Si interfaces for samples whose cobalt thicknesses are less than 4nm and a polycrystalline compound nucleation has been occurred for thicker films. 1/f noise power same samples, and the spetral density has been normalized. The amplitude of 1/f noise power spectral density shows a gradual increase as the cobalt thickness is increased, and the amplitude has dropped abruptly after the compound nucleation. The variations of the noise parameters areassumed to be an indiction of the phase transformation along the nucleation reaction path, and amplitude has been interpreted as instabilities of the Co/Si interfacial structures.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.4
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• pp.39-46
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• 2009

In this paper, we propose a full digital capacitive sensing touch key reducing the effects due to the variations of resistance and clock frequency. The proposed circuit consists of two capacitive loads to measure and a resistor between the capacitive loads. The method measures the delays of the resistor and two capacitive loads, respectively. The ratio of the two delays is represented as the ratio of the two capacitive loads and is irrelative to the resistance and the clock frequency if quantization error is disregarded. Experimental results show the proposed scheme efficiently reduces the effects due to the variations of clock frequency and resistance. Further more the method has l.04[pF] resolution and can be used as a touch key.

• Phonetics and Speech Sciences
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• v.9 no.2
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• pp.53-59
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• 2017

The present study examined if individual listeners' perceptual variations were associated with their cognitive characteristics indexed by the Autistic Spectrum Quotient (AQ). This study first investigated the perception of the lexical pitch accent contrast in the Kyungsang Korean currently undergoing a sound change, and then tested if listeners' perceptual variations were correlated with their AQ scores. Eighteen Kyungsang listeners in their 20s participated in the perception experiment where they identified two contrastive accent words for auditory stimuli systematically varying F0 scaling and timing properties; the participants then completed the AQ questionnaire. In the results, the acoustic parameters reporting reduced phonetic differences across accent contrasts for younger Kyungsang generation played a reliable role in perceiving the HH word from HL, suggesting the discrepancy between the perception and the production in the context of sound change. This study also observed that individuals' perceptual variations were negatively correlated with their AQ sub scores. The present findings suggested that the sound change might appear differently between production and perception with a different time course, and deviant percepts could be explained by individuals' cognitive measure.

• BMB Reports
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• v.30 no.3
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• pp.216-221
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• 1997

Changes in pathogenicity of old and successively-cultured isolates of Fusarium oxysporum f. sp. niveum have been observed and the concept that such cultures will become attenuated is generally accepted. However, the genetic basis for this phenomenon has not been studied. In an effort to identify a DNA marker closely linked to variations, DNA methylation was investigated both before and after the successive transfers of F. o. f. sp. niveum isolates on artificial media. A sector of mycelium in F. o. f. sp. niveum race 2 isolate (TXXID) which showed variation in pigmentation and colonial morphology occurred after 18 successive weekly transfers on potato dextrose agar (PDA). The sector characteristics were stable and did not change after more successive transfers. It was shown that DNA methylation preexists in ribosomal RNA gene (rDNA) of F. o. f. sp. niveum and that additional changes in DNA methylation occurred during successive culturing.

• Archives of Pharmacal Research
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• v.27 no.5
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• pp.547-553
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• 2004

The pyrrolizidine alkaloids (PAs), contained in a number of traditional remedies in Africa and Asia, show wide variations in metabolism between animal species but little work has been done to investigate differences between animal strains. The metabolism of the PA senecionine (SN) in Fischer 344 (F344) rats has been studied in order to compare to that found in the previously investigated Sprague-Dawley (SO) rats (Drug Metab. Dispos. 17: 387, 1989). There was no difference in the formation of ($\pm$) 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP, bioactivation) by hepatic microsomes from either sex of SO and F344 rats. However, hepatic microsomes from male and female F344 rats had greater activity in the Noxidation (detoxication) of SN by 88% and 180%, respectively, when compared to that of male and female SD rats. Experiments conducted at various pH showed an optimum pH of 8.5, the optimal pH for flavin-containing monooxygenase (FMO), for SN N-oxidation by hepatic microsomes from F344 females. In F344 males, however, a bimodal pattern was obtained with activity peaks at pH 7.6 and 8.5 reflecting the possible involvement of both cytochrome P450 (CYP) and FMO. Use of specific inhibitors (SKF525A, 1-benzylimidazole and methimazole) showed that the N-oxide of SN was primarily produced by FMO in both sexes of F344 rats. In contrast, SN N-oxide formation is known to be catalyzed mainly by CYP2C11 rather than FMO in SD rats. This study, therefore, demonstrated that there were substantial differences in the formation of SN N-oxide by hepatic microsomes from F344 and SD rats and that this detoxification is catalyzed primarily by two different enzymes in the two rat strains. These findings suggest that significant variations in PA biotransformation can exist between different animal strains.