• 대한의생명과학회지
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• 제20권3호
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• pp.103-110
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• 2014

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They are multidomain proteins and their activities are regulated by tissue inhibitor of metalloproteinases (TIMPs). The uncontrolled regulation of MMPs is involved in various pathologic processes, such as tumor invasion, migration, host immune escape, extravasation, angiogenesis, and tumor growth. Especially, matrix metalloproteinase-9 (MMP-9) is one of the metastasis-accelerating genes involved in metastasis of various types of human cancers. Here, we review the member of MMP family and discusses their domain structure and function, enzyme activation, the mechanism of inhibition by TIMPs. In particular, we focus the role of MMP-9 in relation to cancer metastasis.

• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.3119-3121
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• 2012

• Journal of Nutrition and Health
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• 제39권8호
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• pp.756-761
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• 2006

Curcumin has been known for its anti-proliferative and apoptotic effects on several cancer cells. We examined the inhibitory effects of curcumin on cancer cell adhesion, motility, invasion and matrix metalloproteinase-9 (MMP-9) activity in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured with 0, 5, 10 or $20{\mu}M$ of curcumin. Curcumin significantly inhibited the adhesion of cancer cells to the fibronectin at $20{\mu}M$ and suppressed the motility and invasion of cancer cells at all concentrations. Also, the MMP-9 activity was inhibited by curcumin, but MMP-9 protein amounts were not affected. Our data indicate that curcumin inhibits motility, invasion and MMP-9 activity of MDA-MB-231 cells. Therefore, curcumin may contribute to the potential beneficial food component to prevent the cancer metastasis in human breast cancer.

• 융복합기술연구소 논문집
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• 제9권1호
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• pp.1-6
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• 2019

Matrix multiplication is a fundamental mathematical operation that has numerous applications across most scientific fields. In this paper, we presents a parallel GPU computation algorithm for dense matrix-matrix multiplication using OpenGL compute shader, which can play a very important role as a fundamental building block for many high-performance computing applications. Experimental results on NVIDIA Quad 4000 show that the proposed algorithm runs about 208 times faster than previous CPU algorithm and achieves performance of 75 GFLOPS in single precision for dense matrices with matrix size 4,096. Such performance proves that our algorithm is practical for real applications.

• Journal of Yeungnam Medical Science
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• 제23권1호
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• pp.82-89
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• 2006

최근 여러 종양에서 단백분해효소의 분비와 암의 악성도에 대한 연구가 이루어져 왔으며, 이를 신세포암종 환자의 예후 측정인자로 사용하려는 시도가 진행되고 있다. 이에 저자들은 제 4형 collagenase 중 대표적인 MMP-9의 발현정도를 정상 신조직과 신세포암종 조직에서 비교하였고, 또 암의 침윤 및 전이정도와의 관계와 다른 임상적 인자들과의 상관성을 분석하여 암의 단계적 진행과정에서의 MMP-9의 발현변화에 대하여 조사하였다. 그 결과 정상 신 조직에 비해 신세포암종 조직에서 MMP-9의 발현이 증가되며 암의 크기가 크고 혈관침범이 있으며 병기가 높을수록 MMP-9의 발현이 증가됨을 관찰할 수 있었다. 이는 MMP-9 발현의 증가가 신세포암종의 발생과정 및 암의 후기 진행에 관여함을 시사하므로 향후 신세포암종의 예후척도로 사용되어 치료방침을 결정하는데 도움을 줄 수 있을 것으로 생각한다.

• 대한의생명과학회지
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• 제9권3호
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• pp.123-131
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• 2003

Inflammation appears to have a major role in the development of atherosclerosis. Cyclooxygenase-2 (COX-2) is involved in the inflammatory response via the generation of prostanoids that, in turn, are involved in the production of matrix metalloproteinases (MMPs). This study hypothesized that a vascular infection with cytomegalovirus (CMV) may induce a chronic inflammatory reaction and activated inflammatory cells may express inflammatory mediators such as cyclooxygenase-2 (COX-2) and matrix metalloproteinases-9 (MMP-9). To confirm the hypothesis, the immunohistochemical stains for CMV late antigen, COX-2, MMP-9, macrophage, and T-lymphocyte were performed on CMV-infected atherosclerotic lesions. The immunoreactivity for COX-2 and MMP-9 was evident in all cases of atherosclerosis along with plaques, mainly in macrophages/foamy cells, intimal and medial smooth muscle cells, and endothelial cells of the intima. Within the intima, the increased immunoreactivity for COX-2 and MMP-9 was colocalized to the area stained with CMV late antigen. Sections from control specimens showed no immunoreactivity for CMV late antigen, COX-2 and MMP-9. These data seem to support the hypothesis that CMV may participate in a pathogenetic mechanism for atherogenesis or progression of atherosclerosis.

• Journal of Biosystems Engineering
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• 제30권4호
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• pp.202-209
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• 2005

The output of Stirling engine is influenced by the regenerator effectiveness. The regenerator effectiveness is influenced by heat transfer and flow friction loss of the regenerator matrix. In this paper, in order to provide a basic data for the design of regenerator matrix, characteristics of heat transfer and flow friction loss were investigated by a packed method of matrix in the oscillating flow as the same condition of operation in a Stirling engine. As matrices, 6 kinds of steel wires, 4 kinds of combined steel wires, 8 kinds of combined steel wires with screen meshes were used. The results are summarized as follows; Among 6 kinds of steel wires $({\phi}0.7\;mm,\;{\phi}0.9\;mm,\;{\phi}1.2\;mm,\;{\phi}\;1.6\;mm,\;{\phi}2.0\;mm,\;{\phi}2.7\;mm),$ the two steel wires $({\phi}0.7\;mm,\;{\phi}0.9\;mm)$ showed the highest in effectiveness. Among 4 kinds of combined steel wires $({\phi}l.6-{\phi}l.2\;mm,\;{\phi}1.2-{\phi}l.6\;mm,\;{\phi}0.9-{\phi}l.2\;mm,\;{\phi}l.2-{\phi}0.9\;mm),\;the\;{\phi}1.2-{\phi}0.9\;mm$ showed the highest in effectiveness. Among 8 kinds of combined steel wires with screen meshes $(150-{\phi}0.9\;mm,\;150-{\phi}l.2\;mm,\;{\phi}0.9\;mm-150,\;{\phi}1.2\;mm-150,\;150-{\phi}0.9\;mm-150,\;150-{\phi}1.2\;mm-150,\;150-{\phi}l.6\;mm-150,\;150-{\phi}2.0\;mm-150),\;the\;{\phi}l.2\;mm-150$ showed the highest in effectiveness.

• 한국위성정보통신학회논문지
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• 제11권4호
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• pp.107-113
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• 2016

본 논문에서는 5.9 GHz에서 동작하는 광대역의 Butler Matrix에 기반한 차량 간 통신(V2X)용 안테나의 설계법이 제시된다. V2X가, 교통 시스템의 지능화, 모바일 통신 기능의 다각화, 주파수 자원의 포화문제 해소, 신호 송수신의 효율성을 극대화를 위한 빔 형성 및 빔 조향 안테나를 필요로 함에 따라, 부피가 크지 않으면서 요구사항을 충족할 수 있는 Butler Matrix 급전부와 그에 연결된 방사체를 구현한다. 기본적인 Butler Matrix를 구성하는 협대역 부품들과 방사체가 먼저 설계된 다음, 안테나 시스템의 차량 장착시에 발생될 주파수 천이에 대해 영향을 크게 받지 않기 위한 광대역용 Butler matrix의 구성품들이 설계된다. 협대역과 광대역 구조들의 성능들이 서로 비교되어, 빔 형성 및 빔 조향의 공통된 성능을 보이는 동시에, 주파수 영역에서 대역폭 관점에서의 차별성이 도시된다.

• 대한기계학회논문집A
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• 제25권10호
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• pp.1583-1589
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• 2001

Metal matrix composites with whisker reinforcements have significant potentials for demanding mechanical applications including defense, aerospace, and automotive industries. Especially metal matrix composites, which are reinforced with aluminum borate whisker, have been used leer the part of piston head in automobile because of good specific strength and wear resistance. In this study, AC4CH-based metal matrix composites with $Al_{18}$B$_{4}$ $O_{33}$ reinforcement have been produced using squeeze casting method, after T6 heat treatment, we evaluated fatigue life property of matrix and MMC composite and investigated fracture mechanism.m.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7393-7400
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• 2015

Matrix metalloproteinase (MMP) 9, a key member of multifunctional family of zinc dependent endopeptidases has been found to be upregulated during inflammation and in some cancers. MMPs cleave extracellular matrix (ECM) proteins and play critical roles in cellular apoptosis, angiogenesis, tumor growth and metastasis. Several genetic polymorphisms have been identified that show allele specific effects on MMP9 regulation and are associated with gastric cancer, the fourth most common malignancy in the world. Besides Helicobacter pylori infection, genetic predisposition is another documented risk factor for gastric carcinoma. The single nucleotide polymorphism (SNP) at position -1562C/T of MMP9 results in the modulation for binding of transcription factors to the MMP9 gene promoter and thereby causes differences in protein expression and enzymatic activity. MMP9 transcriptional regulation during gastric cancer development remains poorly known although several studies have demonstrated associations between MMP9 -1562 C/T polymorphism with different diseases. Knowledge on mechanisms of MMP9 upregulation during gastric cancer may provide new paradigm in diagnostics and therapeutics.