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Continuous wound infiltration of ropivacaine for reducing of postoperative pain after anterior lumbar fusion surgery: a clinical retrospective comparative study

  • Lee, Sang-Min;Yun, Dong-Ju;Lee, Sang-Ho;Lee, Hyung-Chang;Joeng, Kyung Ho
    • The Korean Journal of Pain
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    • v.34 no.2
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    • pp.193-200
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    • 2021
  • Background: Local anesthetic infiltration at the site of a surgical wound is commonly used to control postoperative pain. In this study, we examined the effectiveness of continuous local infiltration at an abdominal surgical site in patients undergoing anterior lumbar interbody fusion (ALIF) surgery. Methods: Sixty-one patients who underwent ALIF surgery were enrolled. For thirtyone of them, a continuous local anesthetics infiltration system was used at the abdominal site. We collected data regarding the patients' sleep quality; satisfaction with pain control after surgery; abilities to perform physical tasks and the additional application of opioids in the postoperative 48 hours. Results: The On-Q system group showed reduced visual analogue scale scores for pain at the surgical site during rest and movement at 0, 12, 24, and 48 hours; and more was satisfied with pain control management at the first postoperative day (7.0 ± 1.2 vs. 6.0 ± 1.4; P = 0.003) and week (8.1 ± 1.6 vs. 7.0 ± 1.8; P = 0.010) than the control group. The number of additional patient-controlled analgesia (PCA) bolus and pethidine injections was lower in the On-Q group (PCA: 3.67 ± 1.35 vs. 4.60 ± 1.88; P = 0.049 and pethidine: 2.09 ± 1.07 vs. 2.73 ± 1.38; P = 0.032). Patients who used the On-Q system performed more diverse activity and achieved earlier ambulation than those in the control group. Conclusions: Continuous wound infiltration with ropivacaine using an On-Q system may be effective for controlling postoperative pain after ALIF surgery.

Methodology for segmentation of rating curve (수위-유량관계곡선식 구간분리 방법론 제안)

  • Hwang-Bo, Jong Gu
    • Journal of Korea Water Resources Association
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    • v.55 no.7
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    • pp.557-563
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    • 2022
  • The rating curve is required to convert measured stage into a discharge and is developed using the measurement. In the development of the rating curve, the segmentation position is determined by considering the hydraulic characteristic and channel shape, and subjective judgment of the Hydrographer may intervene in this process. The segmentation position is so important that it determines the overall form of the rating curve, and the incorrect segmentation can cause errors in the rating curve, especially in extrapolation. In order to develop an accurate rating curve with a small number of measurements, the sections must be divided by considering hydraulic characteristic such as the cross-sectional shape. In this study, hydraulic examination methods such as stage-mean velocity, stage-area, stage-${\sqrt{Q}}$ investigated and supplemented to eliminate subjectivity in segmental positioning. Appropriateness for the segmentation position was verify in consideration of the physical meaning of the rating curve index (c).

Relationship between metabolic syndrome and intake of ultra-processed foods in Korean adults: based on 6th and 7th Korea National Health and Nutrition Examination Survey (2013-2018)

  • Chaeryeon Kim ;Woori Na ;Seunghee Choi ;Seo Hyeon Hwang ;Cheongmin Sohn
    • Nutrition Research and Practice
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    • v.17 no.4
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    • pp.735-746
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    • 2023
  • BACKGROUND/OBJECTIVES: Metabolic syndrome is closely associated with lifestyle factors, including diet and nutritional intake. Modern trends show a shift in food consumption from healthy home-cooked meals to processed and instant foods. Therefore, this study analyzed the association between ultra-processed food intake and the development of metabolic syndrome in Korean adults based on the data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2013-2018. SUBJECTS/METHODS: The subjects of this study were 17,414 adults aged 19-80 years who participated in the 6th-7th KNHANES. Processed food was classified into four categories, NOVA1 to NOVA4, using 24-h recall data. The higher the NOVA category, the more processed the food. Statistical analysis was conducted using logistic regression to investigate the prevalence of metabolic syndrome according to the consumption of ultra-processed foods. RESULTS: Among the diagnostic criteria for metabolic syndrome, hypertension (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.62-0.85; Q4 vs. Q1, P-trend < 0.001) and high triglycerides (OR, 0.83; 95% CI, 0.72-0.94; Q4 vs. Q1, P-trend < 0.001) showed a correlation with the percentages of energy consumed from ultra-processed foods. The OR for metabolic syndrome, according to the percentages of energy consumed from ultra-processed foods, is shown only for men. The OR showed that the percentages of energy consumed from ultra-processed foods were associated with increased metabolic syndrome. CONCLUSIONS: This study suggests that consumption of ultra-processed foods raises the risk of metabolic syndrome especially among men. To prevent metabolic syndrome, it is necessary to prepare appropriate dietary guidelines for Korean adults.

Development of mass spectrometric analysis of $\alpha_1$(I) and $\alpha_2$(I) chain Collagen ($\alpha_1$(I)및 $\alpha_2$(I)사슬 콜라겐의 질량분석법 개발 연구)

  • Kim, Kwang-Yon;Cho, Seon-Young;Lee, Sang-Han;Nnm, Hae-Seon;Kim, Sung-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.6 no.2
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    • pp.134-143
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    • 2005
  • Collagen is the important structural proteins in mammals with various peptide composition and cross-linkings. The direct analysis of collagen protein was not suitable because of its structural complexity and diversity. In this study, we suggest the simple way of collagen analysis by introducing matrix-assisted laser desorption/ionization time-of flight mass spectrometry (MALDI-TOF MS) to identify the collagen and its trypsin-digested fragments, and by subsequent time-of-flight tandem mass spectrometry(Q-TOF MS/MS) to analyze the amino acid sequences of identified fragments. Using the collagen samples extracted from the tail of mouse, 10 separated bands were found in SDS-PAGE, and the masses of most bands could be more finely determined by MALDI-TOF MS. When each 10 separated proteins was tryptic digested and introduced to MALDI-TOF, the Gly1056-Arg1073 fragment from $\alpha_1$-chain was identified in four bands, and the Gly1056-Arg1073 fragment from $\alpha_2$-chain was identified in five bands, both in type I collagen. Although few fragments were found because of the cross-linkings left in digested collagen sample, it could be determined that the type I collagen existed at least in 7 separated bands. When the amino acid sequences of two identified fragments were analyzed by Q-TOF MS/MS, both sequences were identical with those determined by MALDI-TOF MS. It suggested that the two peaks in MALDI-TOF MS caused by the fragments identified in this work could be used as the fingerprint to simply identify type I collagen in protein samples.

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Vegetation Structures of Stewartia koreana Forest in Mt. Jirisan (지리산 노각나무(Stewartia koreana)림의 식생구조)

  • Kwon, Hye-Jin;Gwon, Jae-Hwan;Jeong, Hye-Ran;Lee, Ji-Hye;Song, Ho-Kyung
    • Korean Journal of Environment and Ecology
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    • v.25 no.5
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    • pp.725-735
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    • 2011
  • This study was carried out to analyze the vegetation properties, soil characteristics, and ordination of Stewartia koreana community of Mt. Jirisan in Korea. The S. koreana community was classified into S. koreana-Quercus mongolica serrata community, S. koreana-Quercus mongolica community, and Typical community. In specific, S. koreana-Q. serrata community was classified into two subgroups such as Carpinus laxiflora subcommunity and typical subcommunity. The S. koreana community was found out to be located at an elevation of 409m to 1,604m. The Results of importance value on the S. koreana community consisted of the following in order: 75.47% of S. koreana, the highest, 21.83% of Q. serrata, 18.65% of Q. mongolica, 18.19% of Acer pseudosieboldianum, 10.56% of Rhododendron schlippenbachii, 10.36% of Styrax japonicus. In the targeted study sites, soil organic matter, total nitrogen, available phosphate, exchangeable potassium, soil moisture and soil pH were 3.15~39.1%, 0.37~11.7%, 0.9~45.4mg/kg, $0.09{\sim}1.48cmol^+/kg$, 19.28~55.47% and 4.08~5.65, respectively. The results of the correlation between communities and soil conditions of S. koreana community by DCCA ordination method are as follows: S. koreana-Q. serrata community was found in the highest elevation and followed in order S. koreana typical community, S. koreana-Q. serrata typical subcommunity, and C. laxiflora subcommunity.

Differences in Emergence and Growth of an Exotic Weed Quamoclit coccinea Moench under Different Environment Conditions (환경조건에 따른 외래잡초 둥근잎유홍초의 출현과 생육 차이)

  • Jang, Se Ji;Lee, In-Yong;Kuk, Yong In
    • Weed & Turfgrass Science
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    • v.7 no.2
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    • pp.111-119
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    • 2018
  • This study was carried out to investigate the differences in germination and growth of Quamoclit coccinea Moench under various temperatures, seeding depths, and levels of shading and soil moisture for effective weed management. Seed dormancy of Q. coccinea Moench was over 1 year; best results were obtained when seeds were soaked in sulfuric acid for 15 minutes in order to break the dormancy. Germination rates of Q. coccinea Moench ranged from 69 to 73% at $25-35^{\circ}C$ and 26% at $15^{\circ}C$. The germination rates ranged from 70-84% at 2, 3, 5, 7, and 8 cm of seeding depths. In addition, the germination rates were 7% and 13% at 12 cm and 15 cm of seeding depths, respectively, and showed normal growth at the both seeding depths. Q. coccinea Moench showed a high germination rate regardless of shading levels, but shoot fresh weight varied depending on the level of shading as follows: 20%>no shading=shading 35%>shading 50%>shading 75%=shading 90%. Q. coccinea Moench did not germinate when soil had a saturation rate of either 30% or 100%. However, 60-83% of seeds germinated with optimal growth when soil had saturation rates of 60% and 80%.

THE FIXED POINT INDEX FOR ACCRETIVE MAPPINGS WITH K-SET CONTRACTION PERTURBATIONS IN CONES

  • Chen, Y.Q.;Ha, K.S.;Cho, Y.J.
    • Journal of the Korean Mathematical Society
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    • v.34 no.1
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    • pp.237-245
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    • 1997
  • The fixed point index plays an important role in solving the positive solutions of nonlinear equations in ordered Banach spaces ([7], [10], [11], [14], [15]). Many authors have studied the existence problems of positive solutions of nonlinear equations for nonlinear mappings ([1]-[5], [7], [9], [10], [14], [15]).

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Enzymatic Properties of Cytidine Deaminase from Aspergillus fumigatus IFO 5840 (Aspergillus fumigatus IFO 5840이 생산하는 Cytidine Deaminase의 효소학적 성질)

  • Kim, Jae-Keun;Ha, Young-Duck
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.21 no.3
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    • pp.279-285
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    • 1992
  • Cytidine deaminase (EC 3.5.4.5) from Aspergillus fumigatus IFO 5840, which was the first cytidine deaminase to be found in a mold, was fractionated with ammonium sulfate (35-60%). When the enzyme solution in 0.25M of Tris-HCI buffer (pH 7.2) was preincubated at $37^{\circ}C$ for 25min, the enzyme activity was reached to maximum state. The optimum pH and temperature for the enzyme activity were found to be 6.8 to 7.2 and near $37^{\circ}C$, respectively. The enzyme was stable in a pH 7.2 to 9.0, and was generally stable at 4$0^{\circ}C$, but after treating at 6$0^{\circ}C$ for 20min at the optimal pH, 17% of the enzyme activity was inactivated, and disappeared completely by treating at 1$0^{\circ}C$ for 25min. Activation energy (Ea) of fungal cytidine deaminase was calculated as 14.190 Kcal /mol by the Arrhenius plot, and temperate coeffient ($Q_{10}$ ) of the enzyme was calculated as 2.163.

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Studies on the fungicidal action and its physico-chemical properties of phenylmercuric 8-oxyquinolinate (Phenylmercuric 8-oxyquinolinate의 살균작용 및 이의 이화학적 성질에 관한 연구)

  • Sohn C. Y.;Kang I. M.;Lee S. H.
    • Korean journal of applied entomology
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    • v.4
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    • pp.11-18
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    • 1965
  • In order to investigate the fungicidal activities against various plant pathogenes, diminishing effect of plant transpiration, phytotoxicities, vapor effect and the rate of reduction by ultraviolet rays of phenylmercuric 8-oxyquinolinate(P.M.Q), this experiments were undertaken under various laboratory conditions. 1. Inhibitory activity on the spore germination of this chemical was shown less effective than that of P.M.A..(Table 2, Table 3, Table 4, Table 5 and Table 6) Also, P.M.Q. was resulted a somewhat higher inhibitory activity on the hyphae growth than P.M.A. (Table 7). 2. In the diminishing effect of plant transpiration, 8-hydroxyquinoline sulfate(oxine sulfate) was more strong inhibitory at first than P.M.Q., while, at last, P.M.Q. was more strong inhibitory in comparison with oxine sulfate(Table 8, Fig. 1 and Table 9). 3. P.M.Q. was shown less injury on the germination of rice plant seeds and the emergence of their roots than P.M. A.(Table 10). Injuries was not observed on the rice seedlings and soy-bean seedlings sprayed with 40 ppm of this chemical. 4. P.M.A. had more inhibitory effects on the mycelial growth of phytopathogenes than P.M.Q. on the vapor effect (Table 11, Fig. 2). 5. Biological activity and chemical decomposition rate of P.M.A. were greatly reduced by exposure of this compound to ultraviolet rays. But, P.M.Q. was only slightly affected by similar treatment(Table 12, Fig. 3, Table 13 and Fig. 4). From the above results, this chemical will be a promising fungicide adding fungitoxicities against various phytopatho genes, diminishing effect of plant transpiration and physico-stability.

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Locating QTLs controlling overwintering seedling rate in perennial glutinous rice 89-1 (Oryza sativa L.)

  • Deng, Xiaoshu;Gan, Lu;Liu, Yan;Luo, Ancai;Jin, Liang;Chen, Jiao;Tang, Ruyu;Lei, Lixia;Tang, Jianghong;Zhang, Jiani;Zhao, Zhengwu
    • Genes and Genomics
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    • v.40 no.12
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    • pp.1351-1361
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    • 2018
  • A new cold tolerant germplasm resource named glutinous rice 89-1 (Gr89-1, Oryza sativa L.) can overwinter using axillary buds, with these buds being ratooned the following year. The overwintering seedling rate (OSR) is an important factor for evaluating cold tolerance. Many quantitative trait loci (QTLs) controlling cold tolerance at different growth stages in rice have been identified, with some of these QTLs being successfully cloned. However, no QTLs conferring to the OSR trait have been located in the perennial O. sativa L. To identify QTLs associated with OSR and to evaluate cold tolerance. 286 $F_{12}$ recombinant inbred lines (RILs) derived from a cross between the cold tolerant variety Gr89-1 and cold sensitive variety Shuhui527 (SH527) were used. A total of 198 polymorphic simple sequence repeat (SSR) markers that were distributed uniformly on 12 chromosomes were used to construct the linkage map. The gene ontology (GO) annotation of the major QTL was performed through the rice genome annotation project system. Three main-effect QTLs (qOSR2, qOSR3, and qOSR8) were detected and mapped on chromosomes 2, 3, and 8, respectively. These QTLs were located in the interval of RM14208 (35,160,202 base pairs (bp))-RM208 (35,520,147 bp), RM218 (8,375,236 bp)-RM232 (9,755,778 bp), and RM5891 (24,626,930 bp)-RM23608 (25,355,519 bp), and explained 19.6%, 9.3%, and 11.8% of the phenotypic variations, respectively. The qOSR2 QTL displayed the largest effect, with a logarithm of odds score (LOD) of 5.5. A total of 47 candidate genes on the qOSR2 locus were associated with 219 GO terms. Among these candidate genes, 11 were related to cell membrane, 7 were associated with cold stress, and 3 were involved in response to stress and biotic stimulus. OsPIP1;3 was the only one candidate gene related to stress, biotic stimulus, cold stress, and encoding a cell membrane protein. After QTL mapping, a total of three main-effect QTLs-qOSR2, qOSR3, and qOSR8-were detected on chromosomes 2, 3, and 8, respectively. Among these, qOSR2 explained the highest phenotypic variance. All the QTLs elite traits come from the cold resistance parent Gr89-1. OsPIP1;3 might be a candidate gene of qOSR2.