• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.4
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• pp.1941-1960
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• 2019

Unmanned aerial vehicles (UAVs), acting as mobile base stations (BSs), can be deployed in the typical fifth-generation mobile communications (5G) scenarios for the purpose of substantially enhancing the radio coverage. Meanwhile, UAV aided underlay device-to-device (D2D) communication mode can be activated for further improving the capacity of the 5G networks. However, this UAV aided D2D communication system is more vulnerable to eavesdropping attacks, resulting in security risks. In this paper, the D2D receivers work in full-duplex (FD) mode, which improves the security of the network by enabling these legitimate users to receive their useful information and transmit jamming signal to the eavesdropper simultaneously (with the same frequency band). The security communication under the UAV coverage is evaluated, showing that the system's (security) capacity can be substantially improved by taking advantage of the flexible radio coverage of UAVs. Furthermore, the closed-form expressions for the coverage probabilities are derived, showing that the cellular users (CUs)' secure coverage probability in downlink transmission is mainly impacted by the following three factors: its communication area, the relative position with UAV, and its eavesdroppers. In addition, it is observed that the D2D users or DUs' secure coverage probability is relevant to state of the UAV. The system's secure capacity can be substantially improved by adaptively changing the UAV's position as well as coverage.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.7
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• pp.3370-3392
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• 2017

Next Generation Beyond 4G/5G systems will rely on the deployment of small cells over conventional macrocells for achieving high spectral efficiency and improved coverage performance, especially for indoor and hotspot environments. In such heterogeneous networks, the expected performance gains can only be derived with the use of efficient interference coordination schemes, such as Fractional Frequency Reuse (FFR), which is very attractive for its simplicity and effectiveness. In this work, femtocells are deployed according to a spatial Poisson Point Process (PPP) over hexagonally shaped, 6-sector macro base stations (MeNBs) in an uncoordinated manner, operating in hybrid mode. A newly introduced intermediary region prevents cross-tier, cross-boundary interference and improves user equipment (UE) performance at the boundary of cell center and cell edge. With tools of stochastic geometry, an analytical framework for the signal-to-interference-plus-noise-ratio (SINR) distribution is developed to evaluate the performance of all UEs in different spatial locations, with consideration to both co-tier and cross-tier interference. Using the SINR distribution framework, average network throughput per tier is derived together with a newly proposed harmonic mean, which ensures fairness in resource allocation amongst all UEs. Finally, the FFR network parameters are optimized for maximizing average network throughput, and the harmonic mean using a fair resource assignment constraint. Numerical results verify the proposed analytical framework, and provide insights into design trade-offs between maximizing throughput and user fairness by appropriately adjusting the spatial partitioning thresholds, the spectrum allocation factor, and the femtocell density.

• Journal of Advanced Navigation Technology
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• v.26 no.2
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• pp.91-98
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• 2022

Unmanned aircraft system traffic management (UTM) service for the safe operation of unmanned aerial vehicles (UAV) such as drones using commercial communication networks such as long-term evolution (LTE) and 5G in low-altitude areas of 150m or less is being studied in several countries. In this paper, whether it is possible to secure three-dimensional (3D) coverage for UTM service using the existing LTE cellular network for terrestrial usersis analyzed through simulations. The practicality in the real environment is confirmed by performing performance analysis in the actual topographical environment and the LTE base station layouts in Korea. According to the analysis results, as the altitude increases, the number of line-of-sight (LOS) interference base stations increases, resulting in a worse signal to interference plus noise ratio (SINR), but coverage is secured except for the limited areas within 150m. was confirmed to be possible. In addition, it is confirmed that a significant proportion of outage areas could be reduced by placing a small number of additional base stations for the outage area.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.10
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• pp.4849-4864
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• 2019

Modern applications such as augmented reality, connected vehicles, video streaming and gaming have stringent requirements on latency, bandwidth and computation resources. The explosion in data generation by mobile devices has further exacerbated the situation. Mobile Edge Computing (MEC) is a recent addition to the edge computing paradigm that amalgamates the cloud computing capabilities with cellular communications. The concept of MEC is to relocate the cloud capabilities to the edge of the network for yielding ultra-low latency, high computation, high bandwidth, low burden on the core network, enhanced quality of experience (QoE), and efficient resource utilization. In this paper, we provide a comprehensive overview on different traits of MEC including its use cases, architecture, computation offloading, security, economic aspects, research challenges, and potential future directions.

• IMMUNE NETWORK
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• v.8 no.3
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• pp.67-74
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• 2008

Background: The effects of the dietary administration of two heat-inactivated whole bacteria from the Vibrionaceae family, singly or combined, on innate immune response of the rainbow trout were studied. The two bacteria (Pdp11 and 51M6), which were obtained from the skin of rainbow trout, showed in vitro characteristics that suggested they could be considered as potential fish probiotics. Methods: The fish were fed four different diets: control (non-supplemented), or diets supplemented with heat-inactivated bacteria at $10^8$ cfu/g Pdp11, $10^8$ cfu/g 51M6 or with $0.5{\times}10^8$ cfu/g Pdp11 plus $0.5{\times}10^8$ cfu/g 51M6 for 4 weeks. Six fish were sampled at weeks 1, 2, 3 and 4, and then the main humoral (natural haemolytic complement activity and serum peroxidase content) and cellular innate immune responses (leucocyte peroxidase content, phagocytosis, respiratory burst and cytotoxicity) were evaluated. Results: The serum peroxidase content and the natural haemolytic complement activity increased with time, reaching the highest values in the third and fourth weeks of feeding, respectively. The phagocytic ability of specimens fed the mixture of the two inactivated bacteria was significantly higher than in the controls after 2 and 3 weeks of treatment. The same activity increased significantly in rainbow trout fed the Pdp11 diet for 2 weeks or the 51M6 diet for 3 weeks. Respiratory burst activity was unaffected by all the experimental diets at all times assayed. Cytotoxic activity had significantly increased after 3 weeks in fish fed the 51M6 diet. Conclusion: Our results demonstrated the usefulness of incorporating inactivated probiotic bacteria into fish diets.

• IMMUNE NETWORK
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• v.11 no.5
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• pp.268-280
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• 2011

Background: Dengue virus, which belongs to the Flavivirus genus of the Flaviviridae family, causes fatal dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) with infection risk of 2.5 billion people worldwide. However, approved vaccines are still not available. Here, we explored the immune responses induced by alternating prime-boost vaccination using DNA vaccine, adenovirus, and vaccinia virus expressing E protein of dengue virus type 2 (DenV2). Methods: Following immunization with DNA vaccine (pDE), adenovirus (rAd-E), and/or vaccinia virus (VV-E) expressing E protein, E protein-specific IgG and its isotypes were determined by conventional ELISA. Intracellular CD154 and cytokine staining was used for enumerating CD4+ T cells specific for E protein. E protein-specific CD8+ T cell responses were evaluated by in vivo CTL killing activity and intracellular IFN-${\gamma}$ staining. Results: Among three constructs, VV-E induced the most potent IgG responses, Th1-type cytokine production by stimulated CD4+ T cells, and the CD8+ T cell response. Furthermore, when the three constructs were used for alternating prime-boost vaccination, the results revealed a different pattern of CD4+ and CD8+ T cell responses. i) Priming with VV-E induced higher E-specific IgG level but it was decreased rapidly. ii) Strong CD8+ T cell responses specific for E protein were induced when VV-E was used for the priming step, and such CD8+ T cell responses were significantly boosted with pDE. iii) Priming with rAd-E induced stronger CD4+ T cell responses which subsequently boosted with pDE to a greater extent than VV-E and rAd-E. Conclusion: These results indicate that priming with live viral vector vaccines could induce different patterns of E protein-specific CD4+ and CD8+ T cell responses which were significantly enhanced by booster vaccination with the DNA vaccine. Therefore, our observation will provide valuable information for the establishment of optimal prime-boost vaccination against DenV.

• Journal of Korean Neurosurgical Society
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• v.65 no.1
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• pp.4-12
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• 2022

Objective : We reported the differentially methylated genes in patients with subarachnoid hemorrhage (SAH) using bioinformatics analyses to explore the biological characteristics of the development of delayed cerebral ischemia (DCI). Methods : DNA methylation profiles obtained from 40 SAH patients from an epigenome-wide association study were analyzed. Functional enrichment analysis, protein-protein interaction (PPI) network, and module analyses were carried out. Results : A total of 13 patients (32.5%) experienced DCI during the follow-up. In total, we categorized the genes into the two groups of hypermethylation (n=910) and hypomethylation (n=870). The hypermethylated genes referred to biological processes of organic cyclic compound biosynthesis, nucleobase-containing compound biosynthesis, heterocycle biosynthesis, aromatic compound biosynthesis and cellular nitrogen compound biosynthesis. The hypomethylated genes referred to biological processes of carbohydrate metabolism, the regulation of cell size, and the detection of a stimulus, and molecular functions of amylase activity, and hydrolase activity. Based on PPI network and module analysis, three hypermethylation modules were mainly associated with antigen-processing, Golgi-to-ER retrograde transport, and G alpha (i) signaling events, and two hypomethylation modules were associated with post-translational protein phosphorylation and the regulation of natural killer cell chemotaxis. VHL, KIF3A, KIFAP3, RACGAP1, and OPRM1 were identified as hub genes for hypermethylation, and ALB and IL5 as hub genes for hypomethylation. Conclusion : This study provided novel insights into DCI pathogenesis following SAH. Differently methylated hub genes can be useful biomarkers for the accurate DCI diagnosis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.9
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• pp.1001-1009
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• 2016

In LTE networks, the base station transmits control information over the physical downlink control channel (PDCCH) including scheduling grants, which are used to indicate the resources that the user equipment uses to send data to the base station. Because the size of the PDCCH message and the number of the PDCCH transmissions increase in proportion to the number of user equipments, the overhead of the PDCCH may cause serious network congestion problems in the narrowband LTE (NB-LTE) system. This paper proposes the compact PDCCH information bit allocation to reduce the size of the PDCCH message and evaluates the performance of the semi-persistent scheduling (SPS) in the NB-LTE system. The simulation results show that the SPS can significantly reduce the signaling overhead of the PDCCH and therefore increase the system utilization.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.5
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• pp.917-926
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• 2019

At present, TICN has been developed and distributed for military command control. TICN is known as the 3.5G mobile communication technology based on WiBro, which shows technical limitation in the field operation situation. Accordingly, the drone-type base station platform is attracting attention as an alternative to overcome technical limitations such as difficulty in securing communication LoS and limiting expeditious network configuration. In this study, we performed simulation performance evaluation of drone-type base station operation in 28 GHz that is considered most suitable for cellular communication within mmWave frequency band. Specifically, we analyzed the changes in throughput and fairness performance according to radio resource management policies such as frequency reuse and scheduling in multi-cell topology. Through this, we tried to provide insights on the operation philosophy on drone-type base station.

• IMMUNE NETWORK
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• v.5 no.2
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• pp.68-77
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• 2005

Background: Costimulation is a critical process in Ag-specific immune responses. Both B7.1 and CD28 molecules have been reported to stimulate T cell responses during antigen presentation. Therefore, we tested whether Ag-specific immune responses as well as protective immunity are influenced by coinjecting with B7.1 and CD28 cDNAs in a mouse HSV-2 challenge model system. Methods: ELISA was used to detect levels of antibodies, cytokines and chemokines while thymidine incorporation assay was used to evaluate T cell proliferation levels. Results: Ag-specific antibody responses were enhanced by CD28 coinjection but not by B7.1 coinjection. Furthermore, CD28 coinjection increased IgG1 production to a significant level, as compared to pgD+pcDNA3, suggesting that CD28 drives Th2 type responses. In contrast, B7.1 coinjection showed the opposite, suggesting a Th1 bias. B7.1 coinjection also enhanced Ag-specific Th cell proliferative responses as well as production of Th1 type cytokines and chemokines significantly higher than pgD+pcDNA3. However, CD28 coinjection decreased Ag-specific Th cell proliferative responses as well as production of Th1 types of cytokines and chemokine significantly lower than pgD+pcDNA3. Only MCP-1 production was enhanced by CD28. B7.1 coimmunized animals exhibited an enhanced survival rate as well as decreased herpetic lesion formation, as compared to pgD+pcDNA3. In contrast, CD28 vaccinated animals exhibited decreased survival from lethal challenge. Conclusion: This study shows that B7.1 enhances protective Th1 type cellular immunity against HSV-2 challenge while CD28 drives a more detrimental Th2 type immunity against HSV-2 challenge, supporting an opposite role of B7.1 and CD28 in Ag-specific immune responses to a Th1 vs Th2 type.