• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3287-3291
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• 2014

Background: The interesting preponderance of Chinese with colorectal carcinoma (CRC) amongst the three major ethnic groups in Malaysia prompted a study to determine DNA mismatch repair (MMR) status in our CRC and attempt correlation with patient age, gender and ethnicity as well as location, grade, histological type and stage of tumour. Histologically re-confirmed CRC, diagnosed between $1^{st} $January 2005 and $31^{st}$ December 2007 at the Department of Pathology, University of Malaya Medical Centre, were immunohistochemically stained with monoclonal antibodies to MMR proteins, MLH1, MSH2, MSH6 and PMS2 on the Ventana Benchmark XT autostainer. Of the 142 CRC cases entered into the study, there were 82 males and 60 females (M:F=1.4:1). Ethnically, 81 (57.0%) were Chinese, 32 (22.5%) Malays and 29 (20.4%) Indians. The patient ages ranged between 15-87 years (mean=62.4 years) with 21 cases <50-years and 121 ${\geq}50$-years of age. 14 (9.9%) CRC showed deficient MMR (dMMR). Concurrent loss of MLH1 and PMS2 occurred in 10, MSH2 and MSH6 in 2 with isolated loss of MSH6 in 1 and PMS2 in 1. dMMR was noted less frequently amongst the Chinese (6.2%) in comparison with their combined Malay and Indian counterparts (14.8%), and was associated with right sided and poorly differentiated tumours (p<0.05). 3 of the 5 (60.0%) dMMR CRC cases amongst the Chinese and 1 of 9 cases (11.1%) amongst the combined Malay and Indian group were <50-years of age. No significant association of dMMR was noted with patient age and gender, tumour stage or mucinous type.

• 대한지역사회영양학회지
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• 제3권3호
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• pp.380-388
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• 1998

This study was conducted to investigate the distribution of bone density according to age and the prevalence rate of osteoporosis I 613, middle-aged women who visited Saint Bundo Hospital in Pusan from June to December, 1997. Mean bone density of lumbar spine(L2L4), and femoral neck of 50-59 years of age was significantly lower than those of 40-49 years of age(p<0.05). At the 60years of age, mean bone density of two sites were less than those of 50-59 years of age. Mean bone density of lumbar spine tin the group of sixties were 20.7% lower than that of group aged under 40 ; For femoral neck, women in their sixties showed 22.6% lower density compared to the women aged under forty. Bone density of ward's triangle of sixties were the least, which was 34.2% lower than that of group aged under 40. Bone density in lumbar spine, femoral neck, trochanter and ward's triangle correlates strongly with each other(p<0.001). The proportion of osteoporosis was 3.6% in the group of forties, 10.9% in the group of fifties and 33.8% for the group aged over 60, which was assessed by bone density of lumbar spine. Bone density of lumbar spine, femoral neck and ward's triangle were positively correlated with height, weight and BMI(p<0.001∼p<0.01), and weight showed highest correlation with the bone density. Forty-four percent of variation in lumbar spine bone density was explained by age and weight.

• Journal of Nutrition and Health
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• 제30권9호
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• pp.1109-1115
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• 1997

The present study was aimed to investigated whether there are age-and sex-related differences in serum levels of lipid peroxides, retinol , and $\alpha$-tocopherol in Korean adults. The subjects were 441 persons , including 268 men and 173 women. Those of each sex were divided into four age group : 20-29, 30-39, 40-49 and 50-65 years, and their lifestyles and serum levels were compared . Men smoked and drank less as age increased , but 99.9% of women of did not smoke and only 11% drank more than once a month. Lipid peroxides of males increased gradually with age, while those of females showed greater levels in the 50-65 years group thon younger groups. Lipid peroxides, retinol and $\alpha$-tocopherol concentrations, which were adjusted for age, were significantly higher in males than in females. Lipid peroxide levels adjusted for total lipid were positively correlated with age in males than in females. Serum levels of $\alpha$-tocopherol adjusted for total lipid were positively correlated with age both in males and in females , while retinol was neither. The results indicate that serum levels of lipid peroxides, retinol , and $\alpha$-tocopherol are affected by age and that the response could be different between males and females.

• 대한기관식도과학회지
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• 제16권2호
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• pp.115-120
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• 2010

Background: Pediatric deep neck infection can cause critical complications in that they are seldom able to verbalize symptoms or cooperate with physical examination. The objective of this study is to identify the clinical characteristics according to age. Material and Method: A retrospective study was performed on 26 cases with pediatric deep neck infection during 12 years. Patients were classified infancy group (1-7 yr, 19.2%), preschool age group (7-15 yr, 30.8%) and school age group (15 yr-, 50%). We analyzed the age, sex, sites of abscess, predisposing factors, symptoms and compared onset, hospital date, laboratory and outcomes at each group. Results: In pediatric patients with deep neck infection, the age distribution was 18 males (69.2%) and 8 females (30.8%), the mean age was 7.4 years. The most common infection site was the anterior cervical triangle and submandibular space (19.2%). The most commonly known associated preceding disease was upper viral infection (34.6%), but we could not find the preceding diseases in most of cases (50%). Neck swelling (69.2%) was the most frequent symptom. The mean age of patients who performed neck CT was 8.23 years and neck US was 2.75 years. The younger patients were preferred to perform the neck US than the neck CT (p=0.022). The mean time from disease onset to admission was 9 days in the infancy, 5.5 days in the preschool aged and 5 days in the school aged group. The surgical treatment was performed in 30.8% of school aged, 62.5% of preschool aged and 100% of infancy group. Surgical treatment was preferred to younger patients (p=0.026). Conclusion: Abscess sites, size, and antibiotics susceptibility and especially patient age should be carefully considered in treating pediatric deep neck infection.

• Journal of Chest Surgery
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• 제21권4호
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• pp.641-648
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• 1988

Between April 9, 1986 and September 2, 1987, 134 patients underwent open heart surgery with hypothermic cardiopulmonary bypass and cold blood cardioplegia. There were 65 patients[48.5%] of acyanotic congenital cardiac anomalies, 19 patients[14.2%] of cyanotic congenital cardiac anomalies, and 50 patients[37.3%] of acquired heart diseases, which included 49 valvular diseases and 1 myxoma. In 84 congenital cardiac anomalies, 44 patients were male and 40 patients were female ranged in age from 2 years to 57 years. In 50 acquired heart diseases, 18 patients were male and 32 patients were female ranged in age from 10 years to 65 years. The common congenital defects operated were VSD in acyanotic cardiac patients, and Tetralogy of Fallot in cyanotic cardiac patients. Among 50 acquired heart diseases, 49 patient underwent operation for cardiac valvular lesions. 33 patients had mitral valve replacement and 7 patients had aortic valve replacement. 1 patient underwent aortic valvuloplasty and 8 patients had double valve replacement. The operative mortality rate was 3.1%[2 out of 65 patients] in acyanotic cardiac patients, 5.3%[1 out of 17 patients] in cyanotic cardiac patients, and 12.0%[6 out of 50 patients] in acquired cardiac patients, with overall mortality rate of 6.7%[9 out of 134 patients].

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.671-676
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• 2014

Objective: The objective of this study was to establish a program model for use in wide-spread cervical cancer screening. :Methods: Cervical cancer screening was conducted in Zhongshan city in Guangdong province, China through a coordinated network of multiple institutes and hospitals. A total of 43,567 women, 35 to 59 years of age, were screened during regular gynecological examinations using the liquid-based ThinPrep cytology test (TCT). Patients who tested positive were recalled for further treatment. Results: The TCT-positive rate was 3.17%, and 63.4% of these patients returned for follow-up. Pathology results were positive for 30.5% of the recalled women. Women who were younger than 50 years of age, urban dwelling, low-income, had a history of cervical disease, began having sex before 20 years of age, or had sex during menstruation, were at elevated risk for a positive TCT test. The recall rate was lower in women older than 50 years of age, urban dwelling, poorly educated, and who began having sex early. Ahigher recall rate was found in women 35 years of age and younger, urban dwelling, women who first had sex after 24 years of age, and women who had sex during menstruation. The positive pathology rate was higher in urban women 50 years of age and younger and women who tested positive for human papillomavirus. Conclusion: An effective model for large-scale cervical cancer screening was successfully established. These results suggest that improvements are needed in basic education regarding cervical cancer screening for young and poorly educated women. Improved outreach for follow-up is also necessary to effectively control cervical cancer.

• 대한임상검사과학회지
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• 제51권2호
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• pp.265-269
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• 2019

엡스타인 기형은 삼첨판엽이 삼첨판륜에 붙지 않고 아래쪽 우심실 첨부 쪽으로 내려가 우심실 안에 붙는 심장 기형으로 대부분에서 20대까지 생존하는 것으로 되어 있으며 25세 이상에서는 심부전과 급사의 발생이 비슷하였으며 약 70%에서 2세까지 생존하고, 50%에서 3세까지, 5%이하에서 50세 이상까지 생존한다. 본 예를 통해 엡스타인 기형은 다양한 형태로 존재함을 경험하였고, 22세의 WPW 증후군이 동반된 예와 77세까지도 생존하고 있는 예를 보고하는 바이다. 아울러 심첨 4강 단면도에서 정상적인 심장구조는 승모판륜보다 삼첨판륜이 심첨 쪽으로 약간 내려가 있기는 하나 거의 비슷한 선에서 관찰되어야 하는데 그렇지 않다면 반드시 이 기형을 의심해 봐야 한다. 더 나아가 선천성 심장기형의 진단 및 예후를 파악하는데 심장초음파는 중요한 역할을 하고 있으며 필수검사로 임상에서 활용되어지고 있다.

• 한국산학기술학회논문지
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• 제14권8호
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• pp.3933-3940
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• 2013

본 연구의 목적은 연령별 난시빈도를 알아보고 굴절난시와 각막난시, 내부난시의 연령에 따른 변화와 변화요인을 알아보고자 하였다. 2010년 7월에 만5~59세의 청주지역 거주자 1,017명을 대상으로 굴절력과 각막전면굴절력을 자동굴절검사기로 측정하였다. 난시빈도는 전체적으로 22.7%이었고, 5~9세에 8.9%에서 20대에 36.8%로 증가하였다. 40대에는 19.2%로 감소하였다가 50대에 28.6%로 다시 증가하였다. 굴절난시와 각막난시, 내부난시의 $J_{45}$성분은 연령군에 상관없이 거의 일정하였으나 굴절난시와 각막난시의 J0성분은 30대 이후 감소하는 경향성을 보였다. 또한 $J_0$성분 중에서 수직방향 굴절력은 연령에 따라 변화가 없이 일정하였지만 수평방향 굴절력은 연령에 따라 큰 변화가 있었다. 연령에 따른 난시빈도의 변화는 수평방향 굴절력의 변화에 기인하는 것으로 판단된다.

• 한국의류산업학회지
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• 제12권3호
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• pp.310-317
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• 2010

Middle aged women these days not only consider themselves as younger than actual, maintain figures and looks of younger women, but also show a big interest to fashion goods as younger generations. The TV media has a big influence on this trend. This study is conducted to figure out how the TV media involvement of middle aged women affects their difference age, youth-pursuing clothing behavior and fashion leadership. After the survey, a total of 326 questionnaires completed by women of their 40s and 50s were used to this analysis. The results are as follows, 1. The highest cognitive age of middle aged women was the look age, and the lowest was the feel age in the 40s, and the interest age in the 50s. And it was shown that the difference age were 7.05 years for the 40s and 9.10 years for the 50s. 2. The TV media involvement had a significant influence on the difference age as its antecedent. And the TV media involvement affected directly the youth-pursuing clothing behavior and fashion leadership. The higher the TV media involvement was, the higher difference age and fashion leadership were shown. 3. The difference age was shown as mediating the TV media involvement and the youth-pursuing clothing behavior, and the TV media involvement and fashion leadership only partially. 4. The youth-pursuing clothing behaviors were influenced by TV media involvement and difference age. Conclusionally, this study revealed that the TV media had a great influence on middle-aged women's clothing behavior, supporting the cultivation theory of TV media.

• Journal of Nutrition and Health
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• 제35권5호
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• pp.558-570
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• 2002

This study was performed to develop an index assessing the overall diet quality for Korean. The study subjects consisted of preschool children (PC), elementary school children (EC), high school students (HS), college students (CS), and adults over 30 years old living Seoul and the surrounding areas. The subjects over 30 years old were classified to 30-49 years, 50-69 years, and over 70 years. A dietary survey was conducted using 24-hour recall method and data were collected from 2392 people. Newly developed Korean diet quality index (KDQI) was an index assessing the overall diet quality from the view point of balance. KDQI was based on the nutritional problems of Koreans, dietary risk factors for chronic degenerative diseases, 5 major food groups, and dietary guidelines. The ten components of KDQI were vegetables, fruits, dairy products, dietary variety score, calcium intake, iron intake, energy intake, fat intake, and cholesterol intake. The full score of each component was 10 points and the score of KDQI was calculated by summing the scores of the 10 components. When the KDQI was applied to this study subjects, the distribution of subjects KDQI scores was similar to normal distribution. Mean score of KDQI was 56.0 and the range of the mean by age was from 45.7 for the subjects over 70 years old to 60.7 for the elementary school children. The components which composed the lowest three means were dairy intake, fruit intake, Ca intake in most age groups. Mean score of DVS was one of the highest three but not for the subjects over 50 years old. After subjects with KDQI score over 70 were classified to higher poop and those with KDQI score under 40, to lower group, nutritional characteristics were compared. Energy contributions of carbohydrate, proteins, and fit, percentages of RDA for major nutrients, and dietary diversity scores were more adequate in the higher poop than in the lower group. The lower poop had more risks for chronic degenerative diseases. According to the results, KDQI was valid index to assess the overall diet quality and it could be used to detect risk group for malnutrition and chronic degenerative diseases.