• Title/Summary/Keyword: 4P모델

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The Search of Pig Pheromonal Odorants for Biostimulation Control System Technologies: A 2D-QSAR Model for Binding Affinity between 2-Cyclohexyloxytetrahydrofurane Analogues and Porcine Odorant Binding Protein (생물학적 자극 통제 수단으로 활용하기 위한 돼지 페로몬성 냄새 물질의 탐색: 2-Cyclohexyloxytetrahydrofurane 유도체와 Porcine Odorant Binding Protein 사이의 결합 친화력에 관한 2D-QSAR 모델)

  • Park, Chang-Sik;Choi, Yang-Seok;Sung, Nack-Do
    • Reproductive and Developmental Biology
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    • v.31 no.1
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    • pp.15-20
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    • 2007
  • To search of a new porcine pheromonal odorant for biostimulation control system technologies to offer a potentially useful and practical way to improve reproductive efficiency in livestock species, the two dimensional quantitative structure-activity relationship (QSAR) models between physicochemical parameters as descriptors of 2-cyclohexyloxytetrahydrofurane (A), 2-phenoxytetrahydrofurane (B) analogues and binding affinity constant ($p[Od.]_{50}$) for porcine odorant-binding protein (pOBP) as receptor of pig pheromones were derived and disscused. The statistical quality of the optimized 2D-QSAR model is good ($r^{2}=0.964$) and accounts for 96.4% of the variance in the binding affinity constants. It was found that the binding affinity constants were dependent upon the optimal value, $(SL)_{opt.}=1.418$ of substituent lipole (SL) in molecules. Therefore, the SL constant was very important factor for binding affinity.

WORKGLOW: A P2P-based Web Service Orchestration Supporting Complex Workflow Patterns (복잡한 워크플로우 패턴들을 지원하는 P2P 기반 웹 서비스 오케스트레이션)

  • Tran, Doan Thanh;Hoang, Nam Hai;Choi, Eun-Mi
    • Journal of the Korea Society for Simulation
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    • v.16 no.4
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    • pp.77-86
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    • 2007
  • Web services are considered as the critical component in the business plans of corporations as they offers the potential for creating highly dynamic and versatile distributed applications that span across business boundaries. Web Service Orchestration studies composition of already-existing web services to create new value-added services. The composite web services could be executed in a centralized or peer-to-peer(P2P) orchestration model. Compared with centralized-orchestration model, the P2P-based orchestration model provides better scalability, reliability, and performance for the overall services. However, recent P2P-orchestration solutions have limitation in supporting complex workflow patterns. Therefore, they could not effectively handle sophisticated business workflow, which contains complex workflow patterns. In this paper, we propose the WORKGLOW system, which can deal with complex workflow patterns while it is able to perform composite services in P2P orchestration manner. Comparing with centralized orchestration systems, the WORKGLOW brings up more business logic advantages, better performance, and higher flexibility with only a little overhead.

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검색서비스 시장 분석- ‘P4P 방식의 검색광고’ 시장점령 초읽기

  • Sin, Seon-Ja
    • Digital Contents
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    • no.6 s.133
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    • pp.88-91
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    • 2004
  • 올해 포털사이트들의 최대 화두는 키워드 검색이다. 국내 검색광고 시장은 연간 100% 이상의 고성장을 거듭하며 포털사이트의 가장 확실한 수익모델로 자리매김했을 뿐 아니라 기업들도 검색을 가장 효율적인 광고 수단으로 인식하고 있어서다. 이에 따라 최근 검색서비스 기업간 경쟁이 치열해지고 있으며, 보다 합리적인 검색서비스들도 속속 등장하고 있다. 검색서비스의 새로운 장을 열며 합리적인 비즈니스 모델로서 인터넷 시장부활을 견인한 검색광고의 성장동인을 살펴보며 검색광고 시장을 진단해본다.

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Application of Montmorillonite as Capping Material for Blocking of Phosphate Release from Contaminated Marine Sediment (해양오염퇴적물 내 인산염 용출차단을 위한 피복소재로서의 몬모릴로나이트 적용)

  • Kang, Ku;Kim, Young-Kee;Hong, Seong-Gu;Kim, Han-Joong;Park, Seong-Jik
    • Journal of Korean Society of Environmental Engineers
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    • v.36 no.8
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    • pp.554-560
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    • 2014
  • To investigate the applicability of montmorillonite to capping material for the remediation of contaminated marine sediment, adsorption characteristics of $PO{_4}{^{3-}}$ onto montmorillonite were studied in a batch system with respect to changes in contact time, initial concentration, pH, adsorbent dose amount, competing anions, adsorbent mixture, and seawater. Sorption equilibrium reached in 1 h at 50 mg/L but 3 h was required to reach sorption equilibrium at 300 mg/L. Freundlich model was more suitable to describe equilibrium sorption data than Langmuir model. The $PO{_4}{^{3-}}$ adsorption decreased as pH increased, due to the $PO{_4}{^{3-}}$ competition for favorable adsorption site with OH- at higher pH. The presence of anions such as nitrate, sulfate, and bicarbonate had no significant effect on the $PO{_4}{^{3-}}$ adsorption onto the montmorillonite. The use of the montmorillonite alone was more effective for the removal of the $PO{_4}{^{3-}}$ than mixing the montmorillonite with red mud and steel slag. The $PO{_4}{^{3-}}$ adsorption capacity of the montmorillonite was higher in seawater than deionized water, resulting from the presence of calcium ion in seawater. The water tank elution experiments showed that montmorillonite capping blocked well the elution of $PO{_4}{^{3-}}$, which was not measured up to 14 days. It was concluded that the montmirillonite has a potential capping material for the removal of the $PO{_4}{^{3-}}$ from the aqueous solutions.

Simulation and model validation of Biomass Fast Pyrolysis in a fluidized bed reactor using CFD (전산유체역학(CFD)을 이용한 유동층반응기 내부의 목질계 바이오매스 급속 열분해 모델 비교 및 검증)

  • Ju, Young Min;Euh, Seung Hee;Oh, Kwang cheol;Lee, Kang Yol;Lee, Beom Goo;Kim, Dae Hyun
    • Journal of Energy Engineering
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    • v.24 no.4
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    • pp.200-210
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    • 2015
  • The modeling for fast pyrolysis of biomass in fluidized bed reactor has been developed for accurate prediction of bio-oil and gas products and for yield improvement. The purpose of this study is to analyze and to compare the CFD(Computational Fluid Dynamics) simulation results with the experimental data from the CFD simulation results with the experimental data from the reference(Mellin et al., 2014) for gas products generated during fast pyrolysis of biomass in fluidized bed reactor. CFD(ANSYS FLUENT v.15.0) was used for the simulation. Complex pyrolysis reaction scheme of biomass subcomponents was applied for the simulation of pyrolysis reaction. This pyrolysis reaction scheme was included reaction of cellulose, hemicellulose, lignin in detail, gas products obtained from pyrolysis were mainly $CO_2$, CO, $CH_4$, $H_2$, $C_2H_4$. The deviation between the simulation results from this study and experimental data from the reference was calculated about 3.7%p, 4.6%p, 3.9%p for $CH_4$, $H_2$, $C_2H_4$ respectively, whereas 9.6%p and 6.7%p for $CO_2$ and CO which are relatively high. Through this study, it is possible to predict gas products accurately by using CFD simulation approach. Moreover, this modeling approach should be developed to predict fluidized bed reactor performance and other gas product yields.

4PBL model proposal for education of Game Design (게임 교과목 교육을 위한 4PBL모델 제안 연구)

  • Lee, Dong-Eun
    • Journal of Korea Game Society
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    • v.18 no.5
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    • pp.93-102
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    • 2018
  • This article aims to present an effective and systematic learning methodology of game curriculum which is oriented convergence education. In particular, I will present the 4PBL model reflecting the trend of the changing times from teacher-centered learning to learner-centered learning environment. The 4PBL model consists of Personal based Learning, Problem based Learning, Project based learning and Performance based Learning. In this article, I will explain the concepts and characteristics of PBLs at each stage by providing concrete examples of game education courses. Such an attempt may have a meaningful value in that it can suggest a learning environment in which knowledge can be structured subjectively in a changing educational paradigm.

Optimization of Cookie Preparation by Addition of Polygonum multiflorum Radix Powder using Response Surface Methodology (반응표면분석법을 이용한 하수오 가루를 첨가한 쿠키의 제조조건 최적화)

  • Yu, Hyeon Hee;Oh, Jong Chul
    • The Korean Journal of Food And Nutrition
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    • v.27 no.4
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    • pp.539-550
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    • 2014
  • The purpose of this study was to determine the optimal mixing ratios of three different ingredients of Polygonum multiflorum Radix powder, butter, and sugar for the development of recipe for cookies with Polygonum multiflorum Radix powder. Response surface methodology based on a five level and three variables by central composite design was employed to obtain the best possible combination for the ratios of Polygonum multiflorum Radix powder ($X_1$), butter ($X_2$), and sugar ($X_3$). The analytical results of the physical and mechanical properties for each sample including color L (P<0.01), color a (P<0.01), color b (P<0.01), spread ratio (P<0.001), and hardness (P<0.001) showed significant differences. The sensory measurements were significantly different in color (P<0.05), appearance (P<0.05), texture (P<0.001), flavor (P<0.01), taste (P<0.01), and overall quality (P<0.001). The optimal compositional ratios were determined to be 4.00 g for the Polygonum multiflorum Radix powder, 75.42 g for the butter, and 45.67 g for the sugar.

Active Transport Characteristics of K+-Na+ Pumping System in Cell Membrane Model which Irradiated by High Energy X-ray (고에너지 엑스선을 조사한 세포막모델에서 K+-Na+ 펌프 시스템의 능동적 전달 특성)

  • Ko, In-Ho
    • Journal of the Korean Society of Radiology
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    • v.11 no.2
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    • pp.157-165
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    • 2017
  • The active transport characteristics of $K^+$ and $Na^+$ pumping system of cell membrane model which irradiated by high energy x-ray(linac 6MeV) was investigated. The cell membrane model used in this experiment was a $Na^+$ type sulfonated copolymerized membrane of styrene and divinylbenezene. The initial flux of the ion was increased with increase of both $H^+$ ion concentration. In this experiment range(pH 1.5-5, temperature $36.5^{\circ}C$), the initial flux of $K^+$ which was not irradiated by radiation was found to be from $2.09{\times}10^{-4}$ to $1.32{\times}10^{-3}mole/cm^2{\cdot}h$ and that of $Na^+$ from $7.09{\times}10^{-4}$ to $1.09{\times}10^{-3}mole/cm^2{\cdot}h$. the initial flux of $K^+$ which was irradiated by radiation was found to be from $21.0{\times}10^{-4}$ to $16.7{\times}10^{-3}mole/cm^2{\cdot}h$ and that of $Na^+$ from $62.0{\times}10^{-4}$ to $20.6{\times}10^{-3}mole/cm^2{\cdot}h$. The ratio $K^+$/$Na^+$ of membrane was about 1.10. And the driving force of pH of irradiated membrane was significantly increased about 9-20 times than membrane which was not irradiated. As active transport of $K^+$ and $Na^+$ of cell membrane model were abnormal, cell damages were appeared at cell.

Precision Validation of Electromagnetic Physics in Geant4 Simulation for Proton Therapy (양성자 치료 전산모사를 위한 Geant4 전자기 물리 모델 정확성 검증)

  • Park, So-Hyun;Rah, Jeong-Eun;Shin, Jung-Wook;Park, Sung-Yong;Yoon, Sei-Chul;Jung, Won-Gyun;Suh, Tae-Suk
    • Progress in Medical Physics
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    • v.20 no.4
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    • pp.225-234
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    • 2009
  • Geant4 (GEometry ANd Tracking) provides various packages specialized in modeling electromagnetic interactions. The validation of Geant4 physics models is a significant issue for the applications of Geant4 based simulation in medical physics. The purpose of this study is to evaluate accuracy of Geant4 electromagnetic physics for proton therapy. The validation was performed both the Continuous slowing down approximation (CSDA) range and the stopping power. In each test, the reliability of the electromagnetic models in a selected group of materials was evaluated such as water, bone, adipose tissue and various atomic elements. Results of Geant4 simulation were compared with the National Institute of Standards and Technology (NIST) reference data. As results of comparison about water, bone and adipose tissue, average percent difference of CSDA range were presented 1.0%, 1.4% and 1.4%, respectively. Average percent difference of stopping power were presented 0.7%, 1.0% and 1.3%, respectively. The data were analyzed through the kolmogorov-smirnov Goodness-of-Fit statistical analysis test. All the results from electromagnetic models showed a good agreement with the reference data, where all the corresponding p-values are higher than the confidence level $\alpha=0.05$ set.

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The Effect of Stress and Sense of Coherence on Health Behavior Compliance in Outpatients with Stroke (뇌졸중 환자의 스트레스와 통합성이 건강행위 이행에 미치는 영향)

  • Lee, Won Joo;Lee, Ji Won
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.1
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    • pp.232-239
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    • 2020
  • The purpose of this study was to identify the effect of stress and sense of coherence on health behavior compliance in patients with stroke. The subjects were 124 outpatients with stroke at a general hospital in Ulsan from May to July, 2019. The data were analyzed using descriptive statistics, t-test, one-way ANOVA, Scheffé test, Pearson's correlation coefficient and hierarchical multiple regression analysis by using SPSS 25.0. In the results, the health behavior compliance showed a significantly positive correlation with sense of coherence(r=.71, p<.001) and a negative correlation with stress(r=-.53, p<.001). The predictors of model 1 were gender(t=4.07, p<.001), education level(t=4.18, p<.001), and monthly income(t=-2.34, p=.021) and the statistical power was 39.6%. The predictors of model 2 were gender(t=4.65, p<.001), education level(t=43.24, p<.001), and sense of coherence(t=4.33, p<.001) and the statistical power was 60.4%. Thus, a nursing intervention program which is focused on a sense of coherence could promote health behavior compliance in patients with stroke.