• Proceedings of the Korean Magnetic Resonance Society Conference
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• 2002.08a
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• pp.90-90
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• 2002

Syndecans, transmembrane heparan sulfate proteoglycans, are coreceptors with integrin in cell adhesion process. It forms a ternary signaling complex with protein kinase C and phosphatidylinositol 4,5 bisphosphate (PIP2) for integrin signaling. NMR data indicates that cytoplasmic domain of syndecan-4 (4L) undergoes a conformational transition in the presence of PIP2, forming oligomeric conformation. The structure based on NMR data demonstrated that syndecan-4L itself forms a compact intertwined symmetric dimer with an unusual clamp shape for residues Leu$^{186}$ -Ala$^{195}$ . The molecular surface of the syndecan-4L dimer is highly positively charged. In addition, no inter-subunit NOEs in membrane proximal amino acid resides (Cl region) has been observed, demonstrating that the Cl region is mostly unstructured in syndecan-4L dimmer. However, the complex structure in the presence of PIP2 induced a high order multimeric conformation in solution. In addition, phosphorylation of cytoplasmic domain induces conformational change of syndecan-4, resulting inhibition of PKC signaling. The NMR structural data strongly suggest that PIP2 promotes oligomerization of syndecan-4 cytoplasmic domain for PKC activation and further induces structural reorganization of syndecan for mediating signaling network in cell adhesion procedure.

• Communications for Statistical Applications and Methods
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• v.19 no.4
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• pp.547-558
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• 2012

Social network analysis is a graphical technique to search the relationships and characteristics of nodes (people, companies, and organizations) and an important node for positioning a visualized social network figure; however, it is difficult to characterize nodes in a social network figure. Therefore, their relationships and characteristics could be presented through an application of correspondence analysis to an affiliation matrix that is a type of similarity matrix between nodes. In this study, we provide the relationships and characteristics around authors and keywords in the JKSS(Journal of the Korean Statistical Society) of the Korean Statistical Society through the use of social network analysis and correspondence analysis.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.4
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• pp.510-519
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• 2015

Concerning the issue of high-dimensions, hybrid uncertainties of randomness and intervals including implicit and highly nonlinear limit state function, reliability analysis based on the hybrid uncertainty reliability mode combining with back propagation neural network (HU-BP neural network) is proposed in this paper. Random variables and interval variables are as input layer of the neural network, after the training and approximation of the neural network, the response variables are obtained through the output layer. Reliability index is calculated by solving the optimization model of the most probable point (MPP) searching in the limit state band. Two numerical cases are used to demonstrate the method proposed in this paper, and finally the method is employed to solving an engineering problem of the aerospace friction plate. For this high nonlinear, small failure probability problem with interval variables, this method could achieve a good analysis result.

• Reproductive and Developmental Biology
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• v.37 no.4
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• pp.185-192
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• 2013

Many countries have implemented genetic evaluation for fertility traits in recent years. In particular, reproductive trait is a complex trait and need to require a system-level approach for identifying candidate genes related to the trait. To find the candidate gene associated with reproductive trait, we applied a weighted gene co-expression network analysis from expression value of bovine genes. We identified three co-expressed modules associated with reproductive trait from bovine microarray data. Hub genes (ZP4, FHL2 and EGR4) were determined in each module; they were topologically centered with statistically significant value in the gene co-expression network. We were able to find the highly co-expressed gene pairs with a correlation coefficient. Finally, the crucial functions of co-expressed modules were reported from functional enrichment analysis. We suggest that the network-based approach in livestock may an important method for analyzing the complex effects of candidate genes associated with economic traits like reproduction.

• Health Policy and Management
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• v.16 no.4
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• pp.68-85
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• 2006

With the competitive environment accelerating in healthcare industry, the hospital network system is considered as one of the strategies for clinical and managerial efficiency. This study was intended to offer a theoretical view on the hospital network system and to analyze the current network status of hospitals in Korea. Specifically, network types were classified based on the criteria modified from previous studies, and were used to describe and compare the scope and intensity of associated activities. The questionnaire survey was conducted with 237 hospitals during the period of December 27 2005 to January 25 2006. Above 90% of tertiary and secondary care hospitals were under the network system, while only 20% of primary care clinics were affiliated. In general, the scope and intensity of network activities was limited. Vertical and/or clinical integration was more common than horizontal and/or managerial integration. Three most frequent types of hospital network systems were clinical-vertical integration (Type A), clinical/managerial-vertical integration(Type B), and clinical/managerial-horizontal /vertical integration (Type C). Such network types differentiated significantly different features of affiliated hospitals and network systems. The affiliation duration to the network system was the only significant factor influencing on the network type. The strategic approach to the network system was emphasized for hospitals to increase the potential advantage of hospital network systems.

• Journal of information and communication convergence engineering
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• v.9 no.4
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• pp.396-400
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• 2011

P2P(peer to Peer) network is a distributed network architecture composed of participants that make a portion of their resources directly available to other network participants, without the need for a central server. Currently, convergence network industry using wired and mobile are grows rapidly. So P2P protocols will be used between mobile and wired network. But current P2P protocols are focused on the wired networks only and there are no simulators for performance analysis of mobile P2P. In this paper, we design a P2P simulation system for performance analysis of P2P protocols in mobile, wired and convergence networks. It is constructed by a well-known mobile network simulator and wired based P2P protocol simulator. Finally we have implemented a smart TV test-bed using our P2P test-bed for convergence networks.

• Smart Structures and Systems
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• v.4 no.1
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• pp.99-102
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• 2008

• 제어로봇시스템학회:학술대회논문집
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• 1991.10b
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• pp.1805-1810
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• 1991

This paper derives the upper and the lower bound of the mean cycle time and the mean service time of the class 6 and the class 4, within which the minimum utilization constrain of the class 4 is guaranteed. Also, derived are conditions under which the token bus network is stable or unstable. These bounds and stable conditions are represented in terms of the high priority token hold time, the token rotation time and the arrival rate and the total station number etc. This paper suggest a parameter tuning algorithm in a partially symmetric token bus network with two classes, which maximizes the token rotation time for a suitable high priority token hold time and at the same time meets the stability condition of the network, the real time constraint and the minimum utilization constraint of the class 4.

• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.3
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• pp.246-256
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• 2020

In the future Network Centric Warfare(NCW), changing to IPv6 based network environment is required to enable various future technologies such as the Internet of Things(IoT) and cloud technology which are expected to be introduced to the tactical network evolution. With the change to the IPv6 network, an ID/LOC(Identifier/Location) separation protocol that decomposes context of the IP address to location and identifier can enhance network capacity of increasing number of device and provide efficient mobility management in the tactical network that changes topology dynamically. In this paper, we choose ILNP(Identifier-Locator Network Protocol) as an ID/LOC separation for tactical network environment. In addition to ILNP-based tactical network design, this paper proposes a network-based mobility management scheme for providing efficient mobility management. Through numerical performance analysis, we show that the proposed scheme can reduce network loads more effectively than the conventional IP-based mobility management scheme and common handover procedure in ILNP.

• 한국정보통신설비학회:학술대회논문집
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• 2004.08a
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• pp.328-333
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• 2004

SK Telecom은 2000년 10월 세계 최초로 기존 IS-95A/B망에서 지원하였던 속도인 14.4Kbps나 56Kbps 보다 훨씬 빠른 최고 144Kbps로 무선인터넷이 가능한 CDMA2000 IX를 상용화 하였다. 또한, 2002년 1월에는 CDMA2000 IX보다 15배 이상 빠른 최대 2.4Mbps가 가능한 동기식 3세대 망인 CDMA2000 IxEV-DO를 세계 최초로 상용화 하였다. 이러한 초고속 무선 인터넷 서비스를 위해서 패킷 데이터 처리에 필수적인 PDSN(Packet Data Serving Node), HA(Home Agent), AAA(Authentication, Authorization and Accounting) 등의 노드들로 구성된 Packet Core Network(이하 PCN)이 도입되었으며, 이에 대한 운용 및 관리 방안이 중요한 issue로 등장하였다. 본 논문에서는 기존의 음성 서비스 관리를 위한 망관리 시스템(Network Management System)과는 다른 개념으로 관리되어야 할 패킷 서비스를 위한 NMS 구축 방안을 제시하고, 필수적인 관리 정보 및 서비스 관리를 위한 방향을 제시한다.