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http://dx.doi.org/10.12749/RDB.2013.37.4.185

Gene Co-Expression Network Analysis of Reproductive Traits in Bovine Genome  

Lim, Dajeong (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA)
Cho, Yong-Min (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA)
Lee, Seung-Hwan (Hanwoo Experiment Station, National Institute of Animal Science, RDA)
Chai, Han-Ha (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA)
Kim, Tae-Hun (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA)
Publication Information
Reproductive and Developmental Biology / v.37, no.4, 2013 , pp. 185-192 More about this Journal
Abstract
Many countries have implemented genetic evaluation for fertility traits in recent years. In particular, reproductive trait is a complex trait and need to require a system-level approach for identifying candidate genes related to the trait. To find the candidate gene associated with reproductive trait, we applied a weighted gene co-expression network analysis from expression value of bovine genes. We identified three co-expressed modules associated with reproductive trait from bovine microarray data. Hub genes (ZP4, FHL2 and EGR4) were determined in each module; they were topologically centered with statistically significant value in the gene co-expression network. We were able to find the highly co-expressed gene pairs with a correlation coefficient. Finally, the crucial functions of co-expressed modules were reported from functional enrichment analysis. We suggest that the network-based approach in livestock may an important method for analyzing the complex effects of candidate genes associated with economic traits like reproduction.
Keywords
Reproduction; Gene Co-expression Network (GCN); Cattle;
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