• Title/Summary/Keyword: 4DT

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Effects of 2-Chloro-3-( 4-cyanophenylamino )-1,4-naphthoquinone( NQ-Y15 ) on Normal and Ischemical/reperfused Rat Hearts (정상 및 허혈/재관류 흰쥐 심장에 대한 2-클로로-3-(4-시아노페닐아미노 )-1,4-나프토퀴논 ( NQ-Y15 )의 작용)

  • Moon, Chang-Hyun;Kim, Ji-Young;Baik, Eun-Joo;Lee, Soo-Hwan;Ryu, Chung-Kyu
    • YAKHAK HOEJI
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    • v.41 no.6
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    • pp.829-836
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    • 1997
  • Studies on the effect of quinones on cardiac function has been conducted with normal hearts. But not with injured hearts, I.e. ischemia/reperfusion-injured heart. Quinone compounds are known to produce oxygen free radicals during metabolism, and for this reason, quinones are implicated in the aggravation of ischemia/reperfusion injury or cardioprotection, as in the case of ischemic preconditioning depending on the experimental conditions. The present study was carried out to examine the effect of 2-chloro-3-(4-cyanophenylamino)-1.4-naphthoquinone (NQ-Y15) on cardiac function of ischemic/reperfused and normal rat hearts. In isolated perfused hearts, various functional parameters such as left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (EDP) and maximum positive and negative dP/dt ($[\pm}dP/dt_{max}$), time to contracture, heart rate (HR) and coronary flow rate (CFR) were measured before and 30 min after dosing and following 25 min ischemia/30min reperfusion. NQ-Y15 increased LVDP, +dP/$d_{max}$and -dP/$dt_{min}$ by 18%. 30%, and 40%, respectively. There were no significant changes in other haemodynamic parameters. After ischemia/reperfusion injury, pretreatment with NQ-Y15 induced a significant decrease in LVDP and $[\pm}dP/dt_{max}$, but an increase in EDP. LDH-release was not significantly increased. These results suggested that NQ-Y15 may augment the ventricular contractility but it makes hearts more vulnerable to ischemia/reperfusion injury.

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Relationship between Deodorizing Condition and Production of Trans Fatty Acids in Soybean Oil (대두유의 탈취조건과 trans 지방산 생성의 상관관계)

  • Kim, Duk-Sook;Lee, Keun-Bo
    • Journal of the Korean Society of Food Culture
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    • v.21 no.2
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    • pp.166-170
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    • 2006
  • Soybean oil (SBO) was carried out deodorization at 4 factors as controlled maximum deodorizing temperature (DT), vacuum degree (VD), cycle time (CT) and treating amount of stripping steam (TASS). The results were as follows, acid value (AV), peroxide value (PV) and trans fatty acid content (TFAC) in produced deodorized SBO. Obtained deodorized SBO at high DT had the lower AV, PV, but TFAC was increased relatively. A suitable level of VD and TASS was 4.0 torr and 2.0%(w/w), than the longer CT was appeared a superior quality level. As a result, the best deodorizing conditions in SBO for lower TFAC were maximum DT; $235^{\circ}C$, VD;4.0torr, CT; $14{\sim}15min$ and TASS; 2.0% (w/w). Deodorizing conditions for lower TFAC in deodorizing of SBO was the major factor, more than lower DT was difficult because of the others quality factors.

Comparison of Multilevel with Single Level Injection during Lumbar Sympathetic Ganglion Block: Efficacy of Sympatholysis and Incidence of Psoas Muscle Injection

  • Hong, Ji-Hee;Oh, Min-Ju
    • The Korean Journal of Pain
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    • v.23 no.2
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    • pp.131-136
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    • 2010
  • Background: We prospectively evaluated the incidence and possible factors causing intramuscular injection during lumbar sympathetic ganglion block and compared the multiple needle technique to the single technique to obtain a profound and complete block effect. Methods: Among 83 patients, 58 patients (group A, n = 27, multiple needle technique and group B, n = 31, single needle technique) were reevaluated for the changes of skin temperature (Ts) and mean segment of longitudinal contrast spread. After injecting the contrast agent, the incidence of psoas muscle injection and the change of Ts was compared between two groups. Results: The incidence of psoas muscle injection was 21.3% (46/216) and it was associated with the level of injection (L2) significantly (${\chi}_2$ = 14.773, P = 0.001). $DT^{post}$ (postblock temperature difference between ipsilateral and contralateral great toe, $4.6{\pm}2.8^{\circ}C$, $1.8{\pm}1.6^{\circ}C$, P < 0.001 for group A and B) and $DT^{net}$ ($DT^{post}$ - $DT^{pre}$, $3.9{\pm}2.7^{\circ}C$, $1.5{\pm}1.5^{\circ}C$, P < 0.001 for group A and B) was significantly higher in group A. The mean segment of longitudinal contrast spread was $8.1{\pm}0.9$ for group A and $3.2{\pm}1.6$ for group B (P < 0.001). Conclusions: The LSGB at the L2 level showed the lowest incidence of psoas muscle injection of contrast. Multiple needle approach showed more significant increase of $DT^{net}$ and $DT^{post}$.

Optimization of Ramen Flour Formulation by Mixture Experimental Design (혼합물실험설계법에 의한 라면 밀가루 혼합비의 최적화)

  • Park, Hye Ryong;Lee, Seung Ju
    • Food Engineering Progress
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    • v.15 no.4
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    • pp.297-304
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    • 2011
  • Ramen flour formulation was optimized by applying a mixture experimental design. In the optimization, the overall palatability (OP) of cooked ramen and the rheological properties of selected dough were maximized or minimized. Blended ratios of the ingredients such as Dark Northern Spring (DNS), Hard Red Winter (HRW), and Soft White (SW) were designed on a simplex-lattice. Dough rheological properties were measured by Rapid Visco Analyser (RVA), Farinograph, and Extensograph, and the overall palatability by sensory evaluation. Several principal dough rheological properties such as RVA peak viscosity (PV), Farinograph development time (DT), and Extensograph resistance/extensibility after 45 min (R/E 45 min) were selected to influence the overall palatability by canonical correlation analysis (CCA). Goals of the optimization were given as OP maximized, PV maximized, DT minimized, and R/E at 45 min maximized. The optimization results were found to be DNS 33.3%, HRW 33.3%, and SW 33.3% with OP, 5.825; PV, 587.9 cP; DT, 3.1 min; R/E at 45 min, 2.339 BU/mm.

Temporary Persistance of Pesticide Residue of Diazinon, Iprodione and Chlorfenapyr during the Cultivation Periods in Shallot (Allium ascalonicum L.) (쪽파(Allium ascalonicum L.) 재배기간 중 Diazinon, Iprodione 및 Chlorfenapyr의 잔류량 변화)

  • Ko, Kwang-Yong;Na, Eun-Sik;Kim, Sung-Hun;Kim, Sang-Jun;Jang, Young-Hee;Lee, Kye-Seung
    • Korean Journal of Agricultural Science
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    • v.32 no.2
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    • pp.223-231
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    • 2005
  • In order to know the residual pattern of pesticides and predict to the degradation period until below MRL, we experimented diazinon, iprodinon and chlorfenapyr for shallot. They were the most detected pesticide in shallot by NAQS (National Agricultural product Quality management Service) survey. In this experiment, we sprayed those pesticides 15days before harvest and analyzed 0, 1, 2, 3, 5, 7, 10, 14 day sample to establish logical equation and to calculate $DT_{50}$. During the cultivating period, the residue amount of diazinon was changed from 1.02 mg/kg (0 day) to 0.01 mg/kg (14 day), $DT_{50}$ was 2.19 days, and iprodione was changed from 1.45 mg/kg (0 day) to 0.14 mg/kg (14 day), $DT_{50}$ was 4.15 days, and chlorfenapyr was changed from 1.5 mg/kg (0 day) to 0.01 mg/kg (14 day), $DT_{50}$ was 1.97 days. The $DT_{50}$ of double amount in those pesticides, diazinon was 2.24 days, iprodione was 4.82 days, and chlorfenapyr was 2.24 days, respectively.

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Low-area Dual mode DC-DC Buck Converter with IC Protection Circuit (IC 보호회로를 갖는 저면적 Dual mode DC-DC Buck Converter)

  • Lee, Joo-Young
    • Journal of IKEEE
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    • v.18 no.4
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    • pp.586-592
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    • 2014
  • In this paper, high efficiency power management IC(PMIC) with DT-CMOS(Dynamic threshold voltage Complementary MOSFET) switching device is presented. PMIC is controlled PWM control method in order to have high power efficiency at high current level. The DT-CMOS switch with low on-resistance is designed to decrease conduction loss. The control parts in Buck converter, that is, PWM control circuit consist of a saw-tooth generator, a band-gap reference(BGR) circuit, an error amplifier, comparator circuit, compensation circuit, and control block. The saw-tooth generator is made to have 1.2MHz oscillation frequency and full range of output swing from supply voltage(3.3V) to ground. The comparator is designed with two stage OP amplifier. And the error amplifier has 70dB DC gain and $64^{\circ}$ phase margin. DC-DC converter, based on current mode PWM control circuits and low on-resistance switching device, achieved the high efficiency nearly 96% at 100mA output current. And Buck converter is designed along LDO in standby mode which fewer than 1mA for high efficiency. Also, this paper proposes two protection circuit in order to ensure the reliability.

Molecular genetic characterization of multiple antimicrobial resistant Salmonella spp. isolated from pigs and cattle (소와 돼지유래 다제내성 Salmonella속 균의 분자유전학적 특성)

  • Lee, Woo-Won;Jung, Byeong-Yeal;Lee, Gang-Rok;Lee, Dong-Soo;Kim, Yong-Hwan
    • Korean Journal of Veterinary Service
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    • v.32 no.1
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    • pp.61-76
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    • 2009
  • At the present study, it was aimed to explore the molecular genetic characterization of multiple antimicrobial resistant Salmonella spp. isolates from pigs and cattle. A total of 138 Salmonella Typhimurium (S. Typhimurium) isolates were typed with phage, among them, 83.3% of S. Typhimurium tested could divide into a 10 phage types. Definitive type 193 (DT193) (25.4%) and DT195 (24.6%) were exhibited as the dominant types. DT104 and U302 were found from pigs and cattle. On the other hand, S. Enteritidis had 6 phage types, of them, phage type 21 (PT21) and PT11b were the popular types. In the plasmid profiles, 135 of S. Typhimurium isolates were exhibited 1 to 6 plasmid bands which molecular weight ranged from 90 to 2kb. 35 isolates (25.4%) harbored a 90kb plasmid which is thought to be the serotype specific virulence plasmid. Two of twenty five S. Enteritidis had common plasmids at 2 and 1.5kb. With multiplex polymerase chain reaction, virulence genes (invA and spvC) were detected from all Salmonella spp. from 167 of S. Typhimurium, S. Enteritidis and chloramphenicol resistant S. Schwarzengrund, but some drug resistant genes, such as PSE-1, cml/tetR and flo were not determined but other drug resistant genes, for example TEM and int were found. The detection rates of spvC, TEM and int gene was 35.3%, 29.3% and 72.5%, respectively. The TEM gene was highly popular in S. Typhimurium, which was detected from ampicillin and amoxicillin resistant strains as 95.9%. int gene was able to detect from all the isolates identified as multidrug resistsnt (MDR), particularly DT193 was thought as the most prevalent virulence and multidrug resistance isolate. The major plasmid profile and drug resistance pattern of DT193 were 90, 40, 10.5, 6.3, 3.0kb and ACCbDNaPSSuT, respectively. MDR was commonly found in other phage types, particularly DT104, U302 and DT203.

Proteome analysis between diverse phenotypes of Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium)

  • Shin, Gee-Wook;Cha, In-Seok;Lee, Woo-Won;Nho, Seong-Won;Park, Seong-Bin;Jang, Ho-Bin;Kim, Yong-Hwan;Jung, Tae-Sung
    • Korean Journal of Veterinary Research
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    • v.50 no.4
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    • pp.285-295
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    • 2010
  • Protein expression patterns in Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium) strains with diverse phenotypes, such as phage type, antibiotic resistance pattern and plasmid profiles were examined. For detailed analysis of proteins expressed by different S. Typhimurium strains, protein fractions were divided into detergent-rich phase (DP) and aqueous phase (AP) using triton X-114 detergent. The two phases were subjected to two-dimensional gel electrophoresis (2-DE), followed by protein identification using peptide mass fingerprinting (PMF). In the results, PMF showed that DP fractions consisted mainly of outer membrane proteins, whereas the AP fractions included cytosolic proteins. Comparison of 2-DE profiles of DP did not show any distinct protein spots which could be correlated with phage type, antibiotic resistance pattern or plasmid profile. However, comparisons of 2-DE profiles of the AP revealed differences in the protein spots, which could be correlated with the plasmid profile and phage types. Among these protein spots, flagellin was specific for strains containing a 90 kb plasmid. Compared to DT193 phage type, three protein spots in the range of pI 5.0-5.5 and MW 8-15 kDa of AP 2-DE profiles were absent in the DT104 phage types. Additionally, a protein spot with PI in the range of 4.5-5.0 and molecular weight (MW) between 51-69 kDa was specific for phage type DT104, while a protein spot with pI in the range of 4.0-4.8 and MW between 18-20 kDa was specific for DT193 phage type. These protein spots may be useful for discriminating phage types of S. Typhimurium.

Flexible quantum dot solar cells with PbS-MIx/PbS-BuDT bilayers

  • Choe, Geun-Pyo;Yang, Yeong-U;Yun, Ha-Jin;Im, Sang-Gyu
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.347.2-347.2
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    • 2016
  • Recently, in order to improve the performance of the colloidal quantum dot solar cells (CQDSCs), various efforts such as the modification of the cell architecture and surface treatment for quantum dot (QD) passivation have been made. Especially, the incorporation of halides into the QD matrix was reported to improve the performances significantly via passivating QD trap states that lower the life-time of the minority-carrier. In this work, we fabricated a lead sulfide (PbS) QD bilayer treated with different ligands and utilized it as a photoactive layer of the CQDSCs. The bottom and top PbS layer was treated using metal iodide ($MI_x$ and butanedithiol (BuDT), respectively. All the depositions and ligand treatments were carried out in air using layer-by-layer spin-coating process. The fabrication of the active layers as well as the n-type zinc oxide (ZnO) layer was successfully carried out on the bendable indium-tin-oxide (ITO)-coated polyethylene terephthalate (PET) substrate, which implies that this technique can be applied to the fabrication of flexible and/or wearable solar cells. The power conversion efficiency (PCE) of the CQDSCs with the architecture of $PET/ITO/ZnO/PbS-MI_x/PbS-BuDT/MoO_x/Ag$ reached 4.2 %, which is significantly larger than that of the cells with single QD (PbS-BuDT) layer.

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THE DENTAL CARIES EXPERIENCE RATE IN THE CEREBRAL PALSIED CHILDREN (뇌성마비 환자의 치아우식 경험도에 관한 조사 보고)

  • Han, Chang-Kyu;Lee, Keung-Ho
    • Journal of the korean academy of Pediatric Dentistry
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    • v.21 no.2
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    • pp.463-468
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    • 1994
  • The purpose of this study was evaluation of the oral health of cerebral palsied children by considering the DMFT index. The 31 cerebral palsied children(Male 20, Female 11) participated in the study, and mean age was 11.3 years. All patient were examined for determination of decayed tooth, missing tooth, filled tooth. For children with only deciduous dentition, the dmf system was used; for children with only permanent dentition, the DMF system was used; for children with mixed dentition, a combination of two systems(dmf and DMF) was used. The results were as follows: 1. In the deciduous dentition, dmft index was 11.60.(dt rate ; 83.62%, mt rate ; 12.07%, ft rate ; 4.31 %) 2. In the mixed dentition, DMFT index was 12.25 and dmft index was 10.75.(DT rate ; 90.00 %, MT rate ; 0 %, FT rate ; 10.00 %, dt rate ; 60.53 %, mt rate ; 28.95 %, ft rate ; 10.52 % ) 3. In the permanent dentition, DMFT index was 8.16.(DT rate ; 87.77 %, MT rate ; 11.51 %, FT rate ; 0.72 %)

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