• 한국수학교육학회지시리즈B:순수및응용수학
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• 제25권4호
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• pp.229-241
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• 2018

In the present study, we derive the problem of constructing a hypersurface family from a given isogeodesic curve in the 4D Galilean space $G_4$. We obtain the hypersurface as a linear combination of the Frenet frame in $G_4$ and examine the necessary and sufficient conditions for the curve as a geodesic curve. Finally, some examples related to our method are given for the sake of clarity.

• 복식문화연구
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• 제14권2호
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• pp.271-285
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• 2006

The purpose of this study was to develop a new basic skirt pattern for 4 lower body types of Plus-sized women. To reduce a time and economic loss about putting it on, This study applied a 3D sample module in the course to develop a basic skirt pattern which is fit, functional and beautiful. A data analysis used the SPSS 11.0 statistics program. To verify the difference, This study used the variance analysis and Duncan's test for the postmortem verification. The result was as follows. To reflect a feature according to an abdomen projection and hip projection, we added the maximum hip circumference to the waist circumference and hip circumference for necessary for a skirt draft item. The front hip circumference sets to the H/4+1cm(ease)+D/4. The back hip circumference set to the H/4+0.5cm(ease)+D/4. The D is the hip circumference in the maximum hip circumference to subtract. The front waist circumference sets to the W/4+0.5cm(ease)+0.5cm(A front and back's difference)+D/4. The back waist circumference sets to the W/4+0.5cm(ease)-0.5cm(A front and back's difference)-D/4. Compare with 4 lower body types of Plus-sized Women, A type 2 and type 4 abdomen projections are bigger. We raised a front waistline of skirt pattern to a 0.3cm upside, and take about 1.3cm down the skirt length from a developed skirt pattern. Consequently, the appearance of a front skirt length was improved with a side skirt length.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2883-2887
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• 2015

Background: The calcium-binding S100A4 protein is involved in epithelial to mesenchymal transition, oncogenic transformation, angiogenesis, cytoskeletal integrity, mobility and metastasis of cancer cells. This study aimed to clarify the roles of S100A4 in genesis and progression of glioma. Materials and Methods: S100A4 expression was examined by real-time RT-CPR and Western blot in glioma and paired normal brain tissue (n=69), and compared with clinicopathological parameters of tumors. In addition, glioma U251 cells transfected with an S100A4-expressing plasmid were examined for proliferation by MTT, apoptosis by Annexin V-FITC, and migration and invasion with Transwell chambers. Results: Increased S100A4 mRNA expression was found in gliomas, compared with paired non-tumor tissue (p<0.001). Gradual elevation of overexpression of S100A4 was observed with increasing glioma grade (p<0.001). Astrocytoma showed lower S100A4 mRNA expression than oligodendrogliomas, with glioblastomas having highest values (p<0.001). Similar results were obtained for S100A4 protein, a positive link being found between mRNA and protein expression in gliomas (p<0.001). There was higher growth, lower apoptosis, stronger migration and invasion of S100A4 transfectants than control and mock transfected cells (p<0.001). Conclusions: These findings indicate that up-regulated S100A4 expression is positively linked to pathogenesis, progression and histogenesis of glioma by modulating proliferation, apoptosis, migration and invasion.

• Bulletin of the Korean Chemical Society
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• 제18권11호
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• pp.1192-1195
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• 1997

A divergent approach to 2-(hydroxymethyl)pyrrolidine-3,4-diols has been studied with 1,4-dideoxy-1,4-imino-D-arabinitol (D-AB1), a potent glycosidase inhibitor. D-AB1 was efficiently synthesized from 2,3-epoxyalcohol 6a in overall 11% yield.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2002년도 Proceedings of International Symposium on Remote Sensing
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• pp.844-849
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• 2002

A provision of spatial information is expected to make a market explosion in various fields. A distribution of spatial data on wireless mobile environments indicates a huge expansion of mobile technology as well as a spread of geospatial applications. For high quality spatial information, 4S technology project integrating 4 kinds of spatial systems is currently being executed with the goal of nationwide integration of spatial data and spatial information systems. In terms of network environments, a mobile ad hoc network where mobile terminals communicate with each other without any infrastructures has been standardized for the next generation mobile wireless network. With respect to the future technologies for spatial information, it is necessary to design 4S applications on mobile ad hoc networks. This paper addresses the issue, which is proposing design points for distributing 4S spatial data on mobile ad hoc networks and ad hoc styled 4S applications.

• Journal of Microbiology and Biotechnology
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• 제15권6호
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• pp.1397-1401
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• 2005

Bone morphogenetic protein-4 (BMP-4) is a signaling homodimeric molecule that acts as a morphogen to influence cell fate in a concentration-dependent manner. The limited supply of a pure preparation of BMP-4, due to very low level of their expression in vivo, makes it difficult not only to study the biological activities of BMPs, but also to use them as a clinical tool. For a large-scale production of BMP-4, human BMP-4 cDNA was expressed in Chinese hamster ovary (CHO) cells by a recently development vector system, which confers position-independent stable expression of the foreign genes. The CHO cell line expressing recombinant human BMP-4 (rhBMP-4) at the level of $7\;{\mu}g/ml$ could be obtained after stepwise selection with methotrexate. This level of expression is about 70 times higher than those previously reported. The partially processed form of BMP-4 as well as mature form could be detected, when the aliquots of culture media were analyzed by Western blot. The glycosylation pattern and biological activity of the rhBMP-4 were determined by glycosidase treatment and the induction rate of alkaline phosphatase in mouse osteoblastic cells.

• 천문학회지
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• 제40권4호
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• pp.123-125
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• 2007

NGC 1333 is a nearby star forming region, and IRAS 4A and IRAS 4BI are low-mass Class 0 protostars. IRAS 4A is a protobinary system. The NGC 1333 IRAS 4 region was observed in the 22 GHz water maser with a high resolution (0.08") using the Very Large Array. Two groups of masers were detected: one near A2 and the other near BI. Most of the masers associated with A2 are located very close (< 100 AU) to the radio continuum source. They may be associated with the circumstellar disk. Since no maser was detected near AI, the A2 disk is relatively more active than the Al disk. Most of the masers in the BI region are distributed along a straight line, and they are probably related with the outflow. As in many other water maser sources, the IRAS 4 water masers seem to trace selectively either the disk or the outflow. Considering the outflow lifetimes, the disk-outflow dichotomy is probably unrelated with the evolutionary stage of protostars. A possible explanation may be that both the outflow-maser and the disk-maser are rare phenomena and that detecting both kinds of maser around a single protostar may be even rarer.

• Molecules and Cells
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• 제45권10호
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• pp.718-728
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• 2022

Splicing factor B subunit 4 (SF3B4), a component of the U2-pre-mRNA spliceosomal complex, contributes to tumorigenesis in several types of tumors. However, the oncogenic potential of SF3B4 in lung cancer has not yet been determined. The in vivo expression profiles of SF3B4 in non-small cell lung cancer (NSCLC) from publicly available data revealed a significant increase in SF3B4 expression in tumor tissues compared to that in normal tissues. The impact of SF3B4 deletion on the growth of NSCLC cells was determined using a siRNA strategy in A549 lung adenocarcinoma cells. SF3B4 silencing resulted in marked retardation of the A549 cell proliferation, accompanied by the accumulation of cells at the G0/G1 phase and increased expression of p27, p21, and p53. Double knockdown of SF3B4 and p53 resulted in the restoration of p21 expression and partial recovery of cell proliferation, indicating that the p53/p21 axis is involved, at least in part, in the SF3B4-mediated regulation of A549 cell proliferation. We also provided ubiquitination factor E4B (UBE4B) is essential for p53 accumulation after SF3B4 depletion based on followings. First, co-immunoprecipitation showed that SF3B4 interacts with UBE4B. Furthermore, UBE4B levels were decreased by SF3B4 depletion. UBE4B depletion, in turn, reproduced the outcome of SF3B4 depletion, including reduction of polyubiquitinated p53 levels, subsequent induction of p53/p21 and p27, and proliferation retardation. Collectively, our findings indicate the important role of SF3B4 in the regulation of A549 cell proliferation through the UBE4B/p53/p21 axis and p27, implicating the therapeutic strategies for NSCLC targeting SF3B4 and UBE4B.

• Molecules and Cells
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• 제25권2호
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• pp.205-210
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• 2008

To develop molecular markers linked to the $L^4$ locus conferring resistance to tobamovirus pathotypes in pepper plants, we performed AFLP with 512 primer combinations for susceptible (S pool) and resistant (R pool) DNA bulks against pathotype 1.2 of pepper mild mottle virus. Each bulk was made by pooling the DNA of five homozygous individuals from a T10 population, which was a near-isogenic $BC_4F_2$ generation for the $L^4$ locus. A total of 19 primer pairs produced scorable bands in the R pool. Further screening with these primer pairs was done on DNA bulks from T102, a $BC_{10}F_2$ derived from T10 by back crossing. Three AFLP markers were finally selected and designated L4-a, L4-b and L4-c. L4-a and L4-c each underwent one recombination event, whereas no recombination for L4-b was seen in 20 individuals of each DNA bulk. Linkage analysis of these markers in 112 $F_2$ T102 individuals showed that they were each within 2.5 cM of the $L^4$ locus. L4-b was successfully converted into a simple 340-bp SCAR marker, designated L4SC340, which mapped 1.8 cM from the $L^4$ locus in T102 and 0.9 cM in another $BC_{10}F_2$ population, T101. We believe that this newly characterized marker will improve selection of tobamovirus resistance in pepper plants by reducing breeding cost and time.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2011년도 춘계학술대회
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• pp.129-131
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• 2011

Hight speed memory application을 위하여 6.4-Gb/s/channel 4-PAM transceiver가 제안된다. Voltage margin과 time margin용 증가시키기 위하여 asymmetric 4-PAM scheme과 이를 위한 회로를 제안한다. 제안된 asymmetric 4-PAM scheme은 기존 회로에 비하여 송신단에서 33%의 기준전압 노이즈 영향을 줄인다. Channel의 ISI를 줄이기 위해서 transmitter의 1-tap pre-emphasis가 사용된다. 제안된 asymmetric 4-PAM transceiver는 1.2V supply 0.13um 1-poly 6-metal CMOS 공정에서 구현되었다. PLL을 포함한 1-channel transceiver의 면적과 전력소모는 각각 $0.294um^2$와 6mW이다.