High-Level Expression of Recombinant Human Bone Morphogenetic Protein-4 in Chinese Hamster Ovary Cells |
PARK JUNHO
(Institute of Life Sciences and Resources, and Graduate School of Biotechnology, Kyung Hee University)
YU SUNGRYUL (Institute of Life Sciences and Resources, and Graduate School of Biotechnology, Kyung Hee University) YOON JAESEUNG (Institute of Life Sciences and Resources, and Graduate School of Biotechnology, Kyung Hee University) BAEK KWANGHEE (Institute of Life Sciences and Resources, and Graduate School of Biotechnology, Kyung Hee University) |
1 | Hogan, B. L. 1996. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes Dev. 10: 1580-1594 DOI PUBMED ScienceOn |
2 | Aono, A., M. Hazama, K. Notoya, S. Taketomi, H. Yamasaki, R. Tsukuda, S. Sasaki, and Y. Fujisawa. 1995. Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer. Biochem. Biophys. Res. Commun. 210: 670-677 DOI ScienceOn |
3 | Israel, D. I., J. Nove, K. M. Kern, I. K. Moutsatsos, and R. J. Kaufman. 1992. Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells. Growth Factors 7: 139-150 DOI ScienceOn |
4 | Cui, Y., R. Hackenmiller, L. Berg, F. Jean, T. Nakayama, G. Thomas, and J. L. Christian. 2001. The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. Genes Dev. 15: 2797-2802 |
5 | Kozak, M. 1984. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res. 4: 857-872 |
6 | Suzuki, A., S. Nishimatsu, A. Shoda, K. Takebayashi, and K. Murakami. 1993. Biochemical properties of amphibian bone morphogenetic protein-4 expressed in CHO cells. Biochem. J. 291: 413-417 DOI |
7 | Hammonds, R. G. Jr., R. Schwall, A. Dudley, L. Berkemeier, C. Lai, J. Lee, N. Cunningham, A. H. Reddi, W. I. Wood, and A. J. Mason. 1991. Bone-inducing activity of mature BMP-2b produced from a hybrid BMP-2a/2b precursor. Mol. Endocrinol. 5: 149-155 DOI ScienceOn |
8 | Kim, J.-M., J.-S. Kim, D.-H. Park, H. S. Kang, J. Yoon, K. Baek, and Y. Yoon. 2004. Improved recombinant gene expression in CHO cells using matrix attachment regions. J. Biotechnol. 107: 95-105 DOI ScienceOn |
9 | Kim, E., D. Kim, H.-Y. Hwang, J. Yoon, Y. Yoon, and K. Baek. 2004. High-level expression of recombinant human interleukin-2 in Chinese hamster ovary cells using the expression system containing transcription terminator. J. Microbiol. Biotechnol. 14: 810-815 |
10 | Degnin, C., F. Jean, G. Thomas, and J. L. Christian. 2004. Cleavage within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4. Mol. Biol. Cell 15: 5012-5020 DOI ScienceOn |
11 | Christian, J. L. and T. Nakayama. 1999. Can't get no SMADifaction: Smad proteins as positive and negative regulators of TGF- family signals. BioEssays 21: 382-390 DOI ScienceOn |
12 | Ciudad, C. K., G. Urlaub, and L. A. Chasin. 1988. Deletion analysis of the Chinese hamster dihydrofolate reductase gene promoter. J. Biol. Chem. 263: 16274-16282 |
13 | Nakayama, T., Y. Cui, and J. L. Christian. 2000. Regulation of BMP/Dpp signaling during embryonic development. Cell. Mol. Life Sci. 57: 943-956 DOI ScienceOn |
14 | Chung, J. Y., H. K. Ahn, S. W. Lim, Y. H. Sung, Y. W. Koh, S. K. Park, and G. M. Lee. 2003. Development of recombinant Chinese hamster ovary cell lines producing human thrombopoietin or its analog. J. Microbiol. Biotechnol. 13: 759-766 |
15 | Cho, K. W. and I. L. Blitz. 1998. BMPs, Smads and metalloproteases: Extracellular and intracellular modes of negative regulation. Curr. Opin. Genet. Dev. 8: 443-449 DOI ScienceOn |
16 | Shi, Y. and J. Massague. 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700 DOI PUBMED ScienceOn |