• Korean Journal of Clinical Pharmacy
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• v.23 no.4
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• pp.344-364
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• 2013

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune-complex-mediated hypersensitivity reactions that predominantly involve skin and mucous membranes. Despite the low incidence, both are considered medical emergencies as the mortality rate has been estimated at 30-50%. Although as many as half of cases are idiopathic, several drugs have been implicated as main cause of SJS/TEN. This review therefore aimed to identify drugs that were potentially associated with SJS/TEN and compare the relative risk of the medications. Method: A comprehensive search was performed using MEDLINE, EMBASE and 5 Korean databases. We defined study drugs as non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, antiepileptics, and allopurinol. Only epidemiologic studies investigating associations between the above drugs and drug-induced SJS/TEN were included. Two reviewers independently selected and evaluated candidate papers and extracted odds ratios or incidence rates. Meta-analysis was performed only for drugs that were reported from 4 or more studies. Results: We found 8 case-control studies, 3 cohort studies and 1 RCT. The ranges of adjusted ORs were 0.6-34.0 for NSAIDs, 1.6-302.0 for antiepileptics, 0.3-10.0 for antibiotics and 1.0-187.0 for allopurinol. The drug with the highest incidence of SJS/TEN was carbamazepine (40 persons/1,000 DDD). Conclusion: Finally, the risk was highest in first 8 weeks after onset of treatment in all drugs.

• The korean journal of orthodontics
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• v.48 no.4
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• pp.268-280
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• 2018

Resistance to sliding (RS) between the bracket, wire, and ligature has been largely debated in orthodontics. Despite the extensive number of published studies, the lack of discussion of the methods used has led to little understanding of this phenomenon. The aim of this study was to discuss variables affecting RS in orthodontics and to suggest an operative protocol. The search included $PubMed^{(c)}$, $Medline^{(c)}$, and the Cochrane $Library^{(c)}$. References of full-text articles were manually analyzed. English-language articles published between January 2007 and January 2017 that performed an in vitro analysis of RS between the bracket, wire, and ligature were included. Study methods were analyzed based on the study design, description of materials, and experimental setup, and a protocol to standardize the testing methods was proposed. From 404 articles identified from the database search and 242 records selected from published references, 101 were eligible for the qualitative analysis, and six for the quantitative synthesis. One or more experimental parameters were incompatible and a meta-analysis was not performed. Major factors regarding the study design, materials, and experimental setup were not clearly described by most studies. The normal force, that is the force perpendicular to the sliding of the wire and one of the most relevant variable in RS, was not considered by most studies. Different variables were introduced, often acting as confounding factors. A protocol was suggested to standardize testing procedures and enhance the understanding of in vitro findings.

• The Journal of Korean Academy of Prosthodontics
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• v.34 no.2
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• pp.335-348
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• 1996

Retention is one of the major factors deciding the success and longevity of resin bonded restorations. The purpose of this study was to find a better resin cement and metal surface treatment method that would enhance the bonding strength. The bonding surfaces of Verabond, one of Ni-Cr-Be alloys, were treated with sandblasting(Group 1), sandblasting and EZ-Oxisor(Group 2), sandblasting and silicoating(Group 3), and than thay were bonded with All-Bond C & B, Panavia 21, Superbond C & B. The specimens were thermocycled, and the tensile bond strength was measured using the unive-rsal testing machine. Also the mode of bond failure was observed. The results were as folows. 1. The Superbond C & B showed the highest bond strength among the three resin cements and decreased in the order of Panavia 21, All-Bond C & B. There was significant differe-nce among them(p<0.05). 2. Group 3 showed the highest bond strength among the three metal surface treatment methods, and there was significant difference compared with Group 1 and Group 2(p<0.05). But there was no significant difference between Group 1 and Group 2. 3. Observing the mode of bond failure, Superbond C & B and Panavia 21 showed mostly cohesive failure in all groups. All-Bond C & B showed all types of bond failure in Group 3, but Group 1 and Group 2 showed only adhesive failure. 4. According to the results of this study, the silicoating method and 4-META containing resin cement were considered to be more acceptable for resin bonded restoration.

• CELLMED
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• v.1 no.1
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• pp.6.1-6.4
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• 2011

For cancer patients undergoing radiation therapy (RT) or systemic chemotherapy (CHT), cancer-related fatigue (CRF) is a common problem that can negatively impact their quality of life. Guarana (Paullinia cupana) is a plant native to the Amazon basin that has been used as a stimulant since pre-Columbian times. PURPOSE: To evaluate the effectiveness of guarana extract on fatigue in BC patients undergoing either CHT or RT. A total of 137 cancer patients (85% with Breast Cancer) undergoing either CHT (101) or RT (36) were randomized to receive either a placebo or guarana. In all 3 studies, the guarana was given as an unmanipulated dry extract at a dose of 75 mg PO QD in the first two studies or 50 mg PO BID in the third study. Patients were crossed over to the other experimental arm, and we evaluated fatigue with the Chalder Scale in all three studies. Guarana significantly improved the The Chalder Scale Global Scores (- 0.85; 95% CI:-1.31 to -0.40; p = 0.0002); Physical Fatigue Scores (-0.44; 95% CI: - 0.74 to - 0.13; p = 0.005) and Mental Fatigue Scores (-0.93; 95% CI: - 1.14 to - 0.72; p < 0.00001). Guarana did not produce any CTCAE grades 3 or 4 toxicities in any of the studies. Guarana is an effective, cheap and non-toxic alternative for the treatment of fatigue in cancer patients undergoing treatment.

• Journal of Korea Multimedia Society
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• v.2 no.3
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• pp.231-242
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• 1999

Generally, either caption-based search method or content-based search methods is used to retrieve video information. However, each search method has its limitations. Caption-based search is apt to lose consistency as for user's subjects, and content-based search is hard to extract general means. To enhance efficiency and correctness as for complementing each other, we propose the Integrated Video Data Model(IVDM) which integrates the two search methods, to device the model, we analyze video data and construct the structure of video information hierarchically. IVDM supports caption-based search as assigning meta-data by analyzing thematic-unit in the higher level, and also supports content-based search as extracting feature data by analyzing the content of video data in the lower level. We design Object-Oriented database schema of news video, based-on the IVDM. And we provide 4-type of queries and query processing algorithm to retrieve news video information.

• Journal of Advanced Navigation Technology
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• v.17 no.1
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• pp.39-46
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• 2013

If a file system is damaged because of the unusual system close, the system performs the consistency test using fsch and it takes long time. Especially, if it is a big file system, it will take a lot of time. The journaling file system that uses journaling technique, can reduce the restoring time because it uses meta data and it may increase the chance of restoration when restoring. The goal of this paper compared performance evaluation journaling file systems focused on the reading and writing using Iozone tool which is the kernel based benchmarking tool in linux operating system. In this paper, Ex4 which is the current basic Linux file system. is 1.28x faster than XFS file system in terms of file read performance and 1.22x faster than Ext3 file system in terms of file write performance.

• Applied Biological Chemistry
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• v.42 no.3
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• pp.252-255
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• 1999

Inhibition activities$(pI_{50})$ of chalcone derivatives as substrate with farnesyl protein transferase(FPTase) were determined in vitro. The structure activity relationships(SAR) between the activity and physicochemical parameters of X & Y-substituents on the phenyl groups were analyzed by Free-Wilson and Hansch method. X-substituents on the benzoyl group have the more important role to inhibition activity than Y-substituents on the styryl group. Among them, none substituent, 8 showed the highest FPTase inhibition activity$(pI_{50}=4.30)$. Particularly, the SAR equation could be formulated, showing a parabolic relationship between the activity and hydrophobicity(logP) where the optimal value$({\Sigma}logP)_{opt}$ was 3.915. And also the activity depends on the steric effect(Es > 0) with X-substituent and the resonance effect(R < 0) with electron donating Y-substituents. Based on the results of SAR analyses, the interactions between substrates and receptor, FPTase, could be assumed.

• Transactions of the Korean Society of Automotive Engineers
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• v.20 no.4
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• pp.46-51
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• 2012

Injection pressure, an important factor in filling process, should be minimized to enhance injection molding quality. Injection pressure can be controlled by valve gate open timing. In this work, we decided the valve gate open timing to minimize the injection pressure. To solve this design problem, we integrated MAPS-3D (Mold Analysis and Plastic Solution-3Dimension), a commercial injection molding CAE tool, to PIAnO (Process Integration, Automation and Optimization), a commercial PIDO (Process Integration, and Design Optimization) tool using the file parsing method. In order to reduce computational cost, we performed an approximate optimization using meta-models that replaced expensive computer simulations. At first, we carried out DOE (Design of Experiments) using OLHD (Optimal Latin Hypercube Design) available in PIAnO. Then, we built Kriging models using the simulation results at the sampling points. Finally, we used micro GA (Genetic Algorithm) available in PIAnO. Using the proposed design approach, the injection pressure has been reduced by 13.7% compared to the initial one. This design result clearly shows the validity of the proposed design approach.

• Journal of the Korea Computer Industry Society
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• v.4 no.4
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• pp.633-646
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• 2003

Using the self-contained characteristics of XML, in various areas the XML is widely used to a meta language which can describe information and is recognized to a standard language to present information on the web. In this paper, we point out many difficult problems when we are going to a serial activity of software engineering like that we analyze, reuse, and maintenance source programs. Then we describe whether the existed studies about documentation provide the solutions for the problems above mentioned or not. Finally, we propose the JML(Java Markup Language) that can effectively support solutions about these difficulties. Then we analyze the sample program and present the generated JML docuement using the results. explain the result that The JML is an XML DTD to describe software information written by Java language. Also, we describe the meaning of elements that are parts of whole JML, and explain how to represent the information of Java source codes using each element.

• Structural Engineering and Mechanics
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• v.17 no.3_4
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• pp.527-537
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• 2004

Consequence-Based Engineering (CBE) is a new paradigm proposed by the Mid-America Earthquake Center (MAE) to guide evaluation and rehabilitation of building structures and networks in areas of low probability - high consequence earthquakes such as the central region of the U.S. The principal objective of CBE is to minimize consequences by prescribing appropriate intervention procedures for a broad range of structures and systems, in consultation with key decision makers. One possible intervention option for rehabilitating unreinforced masonry (URM) buildings, widely used for essential facilities in Mid-America, is passive energy dissipation (PED). After the CBE process is described, its application in the rehabilitation of vulnerable URM building construction in Mid-America is illustrated through the use of PED devices attached to flexible timber floor diaphragms. It is shown that PED's can be applied to URM buildings in situations where floor diaphragm flexibility can be controlled to reduce both out-of-plane and in-plane wall responses and damage. Reductions as high as 48% in roof displacement and acceleration can be achieved as demonstrated in studies reported below.