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Genetic Change from Colorectal Carcinoma Patients Using Comparative Genomic Hybridization (비교유전자교잡법을 이용한 대장암환자에서의 유전자변화)

  • Lee, Jae Sik
    • Korean Journal of Clinical Laboratory Science
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    • v.47 no.4
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    • pp.209-215
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    • 2015
  • Colorectal carcinoma is one of the four major cancers in Korea, and it shows the tendency of increase every year due to economic development and changes to western styles. Accordingly, various diagnostic methods are needed and so comparative genomic hybridization (CGH) was performed. Deletion was detected on 5q (10%), 10q (17%), 17p (40%), 18p (23%), 18q (47%), 22q (23%), and higher deletion loci were 18q (12/30, 47%), 17p (12/30, 40%), and 22q (7/30, 23%). Amplification was shown on chromosomes 6pq (10%), 7p (17%), 7q (33%), 8q (13%), 9pq (10%), 12q (17%), 13q (37%), 20p (23%), and 20q (57%) respectively. The highest amplification was detected on chromosomes 20q (17/30, 57%), 13q (11/30, 37%), and 7q (10/30, 33%). The genetic change pattern with the locus of colorectal carcinoma was shown mean 3.1 (amplification 1.7, deletion 1.4) on the right colorectal carcinoma, while rectal carcinoma appeared high mean 6.3 (amplification 3.7, deletion 2.6) (p<0.001). The genetic change pattern with lymphatic gland metastasis, mean 3.5 (amplification 2.2, deletion 1.3) from "no metastasis" group, while high mean 6.3 (amplification 3.5, deletion 2.8) from metastasis group (p<0.003). The genetic change pattern with disease stages appeared mean 3.5 (amplification 2.1, deletion 1.4) from I-II stages, while high mean 6.0 (amplification 3.4, deletion 2.6) from III-IV stages (p<0.006). No significance was observed in comparing histological classification and serum CEA increased groups.

Interstitial deletion of 5q33.3q35.1 in a boy with severe mental retardation

  • Lee, Jin Hwan;Kim, Hyo Jeong;Yoon, Jung Min;Cheon, Eun Jung;Lim, Jae Woo;Ko, Kyong Og;Lee, Gyung Min
    • Clinical and Experimental Pediatrics
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    • v.59 no.sup1
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    • pp.19-24
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    • 2016
  • Constitutional interstitial deletions of the long arm of chromosome 5 (5q) are quite rare, and the corresponding phenotype is not yet clearly delineated. Severe mental retardation has been described in most patients who present 5q deletions. Specifically, the interstitial deletion of chromosome 5q33.3q35.1, an extremely rare chromosomal aberration, is characterized by mental retardation, developmental delay, and facial dysmorphism. Although the severity of mental retardation varies across cases, it is the most common feature described in patients who present the 5q33.3q35.1 deletion. Here, we report a case of a de novo deletion of 5q33.3q35.1, 46,XY,del(5)(q33.3q35.1) in an 11-year-old boy with mental retardation; to the best of our knowledge this is the first case in Korea to be reported. He was diagnosed with severe mental retardation, developmental delay, facial dysmorphisms, dental anomalies, and epilepsy. Chromosomal microarray analysis using the comparative genomic hybridization array method revealed a 16-Mb-long deletion of 5q33. 3q35.1(156,409,412-172,584,708)x1. Understanding this deletion may help draw a rough phenotypic map of 5q and correlate the phenotypes with specific chromosomal regions. The 5q33.3q35.1 deletion is a rare condition; however, accurate diagnosis of the associated mental retardation is important to ensure proper genetic counseling and to guide patients as part of long-term management.

q-COEFFICIENT TABLE OF NEGATIVE EXPONENT POLYNOMIAL WITH q-COMMUTING VARIABLES

  • Choi, Eunmi
    • Korean Journal of Mathematics
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    • v.30 no.3
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    • pp.433-442
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    • 2022
  • Let N(q) be an arithmetic table of a negative exponent polynomial with q-commuting variables. We study sequential properties of diagonal sums of N(q). We first device a q-coefficient table $\hat{N}$ of N(q), find sequences of diagonal sums over $\hat{N}$, and then retrieve the findings of $\hat{N}$ to N(q). We also explore recurrence rules of s-slope diagonal sums of N(q) with various s and q.

LOCAL PERMUTATION POLYNOMIALS OVER FINITE FIELDS

  • Lee, Jung-Bok;Ko, Hyoung-June
    • Communications of the Korean Mathematical Society
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    • v.9 no.3
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    • pp.539-545
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    • 1994
  • Let $q = p^r$, where p is a prime. A polynomial $f(x) \in GF(q)[x]$ is called a permutation polynomial (PP) over GF(q) if the numbers f(a) where $a \in GF(Q)$ are a permutation of the a's. In other words, the equation f(x) = a has a unique solution in GF(q) for each $a \in GF(q)$. More generally, $f(x_1, \cdots, x_n)$ is a PP in n variables if $f(x_1,\cdots,x_n) = \alpha$ has exactly $q^{n-1}$ solutions in $GF(q)^n$ for each $\alpha \in GF(q)$. Mullen ([3], [4], [5]) has studied the concepts of local permutation polynomials (LPP's) over finite fields. A polynomial $f(x_i, x_2, \cdots, x_n) \in GF(q)[x_i, \codts,x_n]$ is called a LPP if for each i = 1,\cdots, n, f(a_i,\cdots,x_n]$ is a PP in $x_i$ for all $a_j \in GF(q), j \neq 1$.Mullen ([3],[4]) found a set of necessary and three variables over GF(q) in order that f be a LPP. As examples, there are 12 LPP's over GF(3) in two indeterminates ; $f(x_1, x_2) = a_{10}x_1 + a_{10}x_2 + a_{00}$ where $a_{10} = 1$ or 2, $a_{01} = 1$ or x, $a_{00} = 0,1$, or 2. There are 24 LPP's over GF(3) of three indeterminates ; $F(x_1, x_2, x_3) = ax_1 + bx_2 +cx_3 +d$ where a,b and c = 1 or 2, d = 0,1, or 2.

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Analysis of Q Values on the Crust of the Kimcheon and Mokpo Regions, South Korea (남한 김천.목포 일대 지각의 Q 값 분석)

  • Do, Ji-Young;Lee, Yoon-Joong;Kyung, Jai-Bok
    • Journal of the Korean earth science society
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    • v.27 no.4
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    • pp.475-485
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    • 2006
  • The physical properties of the central and southwestern crust of South Korea were estimated by comparing values of ${Q_P}^{-1}\;and\;{Q_S}^{-1}$ in the Kimcheon and Mokpo areas. In order to get ${Q_P}^{-1}\;and\;{Q_S}^{-1}$ values, seismic data were collected from two stations of the KIGAM network (KMC and MUN) and four stations of the KMA network (CPN, KUC, MOP, and WAN). An extended coda-normalization method was applied to these data. Estimates of ${Q_P}^{-1}\;and\;{Q_S}^{-1}$ show variations depending on frequency. As frequencies vary from 3 Hz to 24 Hz, the estimates decrease from $(1.4{\pm}3.9){\times}10^{-3}\;to\;(2.3{\pm}3.5){\times}10^{-4}\;for\;{Q_P}^{-1}\;and\;(1.8{\pm}1.3){\times}10^{-3}\;to\;(1.9{\pm}1.5){\times}10^{-4}\;for\;{Q_S}^{-1}$ in central South Korea, and $(5.9{\pm}4.8){\times}10^{-3}\;to\;(2.2{\pm}3.8){\times}10^{-4}\;for\;{Q_P}^{-1}\;and\;(0.5{\pm}2.8){\times}10^{-3}\;to\;(1.8{\pm}1.6){\times}10^{-4}\;for\;{Q_S}^{-1}$ in southwestern South Korea. According that a frequency-dependent power law is applied to the data, the best fits of ${Q_P}^{-1}\;and\;{Q_S}^{-1}\;are\;0.003f^{-0.49}\;and\;0.005f^{-1.03}$ in central South Korea, and $0.026f^{-1.47}$ and $0.001f^{-0.49}$ in southwestern South Korea, respectively. These values almost correspond to those of seismically stable regions although ${Q_P}^{-1}$ values of southwestern South Korea are a little high due to lack of data used.

Synthesis and Optical Properties of Acrylic Copolymers Containing AlQ3 Pendant Group for Organic Light Emitting Diodes

  • Kim, Eun-Young;Myung, Sung-Hyun;Lee, Young-Hee;Kim, Han-Do
    • Clean Technology
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    • v.18 no.4
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    • pp.366-372
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    • 2012
  • Three acrylic copolymers containing tris(8-hydroxyquinoline) aluminum (AlQ3) pendant group (25 wt%), acrylateco-HEMA-$AlQ_3$ (25 wt%), were successfully synthesized by free radical polymerization from acrylates [methyl methacrylate (MMA), acrylonitrile (AN) or 2-hydroxyethyl methacrylate (HEMA)] with HEMA functionalized with AlQ3 pendant groups (HEMA-p-$AlQ_3$). The glass transition temperatures ($T_g$) of MMA-co-HEMA-p-$AlQ_3$ (copolymer 1), AN-co-HEMA-p-$AlQ_3$ (copolymer 2) and HEMA-co-HEMA-p-$AlQ_3$ (copolymer 3) were found to be 158, 150 and $126^{\circ}C$, respectively. They have good thermal stability: a very desirable feature for the stability of OLEDs. Their solubility, thermal properties, UV-visible absorption and photoluminescence behaviors were investigated. They were found to be soluble in various organic solvents such as tetrahydrofuran (THF), dimethylformamide (DMF), toluene and chloroform. It was also found that the UV-visible absorption and photoluminescence behaviors of these copolymers were similar to those of pristine $AlQ_3$. Green organic light-emitting diodes (OLEDs) have also been fabricated using these copolymers as light emission/electron transport components obtained easily by spin coating, and their current density voltage (J-V) curves were compared. The OLED device of the copolymer 3 had the lowest turn-on voltage of about 2 V compared to other copolymer types devices.

D. H. LEHMER PROBLEM OVER HALF INTERVALS

  • Xu, Zhefeng
    • Journal of the Korean Mathematical Society
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    • v.46 no.3
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    • pp.493-511
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    • 2009
  • Let $q\;{\geq}\;3$ be an odd integer and a be an integer coprime to q. Denote by N(a, q) the number of pairs of integers b, c with $bc\;{\equiv}\;a$ (mod q), $1\;{\leq}\;b$, $c\;{\leq}\;{\frac{q-1}{2}}$ and with b, c having different parity. The main purpose of this paper is to study the sum ${\sum}^{'q}_{a=1}\;\(N(a,\;q)\;-\;\frac{{\phi}(q)}{8}\)^2$ and obtain a sharp asymptotic formula.

An Experimental Study for Estimation of Head Loss Coefficients at Surcharged Combining Junction Manholes (과부하 합류맨홀에서의 손실계수 산정을 위한 실험적 연구)

  • Kim, Jung-Soo;Choi, Hyun-Soo;Yoon, Sei-Eui
    • Journal of Korea Water Resources Association
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    • v.43 no.5
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    • pp.445-453
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    • 2010
  • Energy loss at manholes, often exceeding friction loss of pipes under surcharged flow, is considered as one of the major causes of inundation in urban area. Therefore, it is necessary to analyze head losses at manholes, especially in case of surcharged flow. Hydraulic experimental apparatus which can change the manhole shape (square, circular) were installed for this study. In the experiments, two inflows ($Q_1,\;Q_2$) were varied from 0 to $4{\ell}$/sec and 15 combinations were tested in total. The flow ratios $Q_2/Q_3$ were varied from 0 to 1 for a total flow $Q_3$ ($Q_3=Q_1+Q_3$) of 2, 3, and $4{\ell}$/sec, respectively. The variation of head losses were strongly influenced by the lateral inflow because the head loss coefficient increases as the flow ratio $Q_2/Q_3$ increases. There was no significant difference of head loss between square manhole and circular one, and also no large variation of head loss as discharges change. The relation equations between K and $Q_2/Q_3$ were suggested in this paper.

nth-order q-derivatives of Srivastava's General Triple q-hypergeometric Series with Respect to Parameters

  • Sahai, Vivek;Verma, Ashish
    • Kyungpook Mathematical Journal
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    • v.56 no.3
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    • pp.911-925
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    • 2016
  • We obtain q-derivatives of Srivastava's general triple q-hypergeometric series with respect to its parameters. The particular cases leading to results for three Srivastava's triple q-hypergeometric series $H_{A,q}$, $H_{B,q}$ and $H_{C,q}$ are also considered.

Comparative Analysis of the Q Value between the Crust of the Seoul Metropolitan Area and the Eastern Kyeongsang Basin (수도권과 경상 분지 동부 지역 지각의 Q 값 비교 분석)

  • Park, Yoon-Jung;Kyung, Jai-Bok;Do, Ji-Young
    • Journal of the Korean earth science society
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    • v.28 no.6
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    • pp.720-732
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    • 2007
  • For the Seoul metropolitan area and the eastern Kyeongsang Basin, we simultaneously calculated $Q_P^{-1}$ and $Q_S^{-1}$ by applying the extended coda-normalization method for 98 seismograms of local Earthquakes. As frequency increases from 1.5 Hz to 24 Hz, the result decreased from $(4.0{\pm}9.2){\times}10^{-3}$ to $(4.1{\pm}4.2){\times}10^{-4}$ for $Q_P^{-1}$ and $(5.5{\pm}5.6){\times}10^{-3}$ to $(3.4{\pm}1.3){\times}10^{-4}$ for $Q_S^{-1}$ in Seoul Metropolitan Area. The result of eastern Kyeongsang basin also decreased from $(5.4{\pm}8.8){\times}10^{-3}$ to $(3.7{\pm}3.4){\times}10^{-4}$ for $Q_P^{-1}$ and $(5.7{\pm}4.2){\times}10^{-3}$ to $(3.5{\pm}1.6){\times}10^{-4}$ for $Q_S^{-1}$. If we fit a frequency-dependent power law to the data, the best fits of $Q_P^{-1}$ and $Q_S^{-1}$ are $0.005f^{-0.89}$ and $0.004f^{-0.88}$ in Seoul metropolitan Area, respectively. The value of $Q_P^{-1}$ and $Q_S^{-1}$ in the eastern Kyeongsang basin are $0.007f^{-1.02}$ and $0.006f^{-0.99}$, respectively. The $Q_S^{-1}$ value of the eastern Kyeongsang basin is almost similar to Seoul metropolitan area. But the $Q_P^{-1}$ value of the eastern Kyeongsang basin is a little higher than that of Seoul metropolitan area. This may be that the crustal characteristics of the eastern Kyeongsang basin is seismologically more heterogeneous. However, these $Q_P^{-1}$ values in Korea belong to the range of seismically stable regions all over the world.