• Journal of Pharmaceutical Investigation
• /
• 제27권1호
• /
• pp.15-22
• /
• 1997

The mucosal route of administration(nasal, buccal, conjunctival and vaginal) has recently been considered as an alternative to parenteral delivery for many peptide drugs because enzymatic degradation of these agents may be partly avoided. The objective of these study was to establish the optimal mucosal administration dosage form of $LHRH/[D-Ala^6]LHRH$, based on presystemic metabolism. We reported previously the peptidase inhibition effect of medium chain fatty acid salts(sodium caprylate, soadium caprate and sodium laurate), EDTA and STDHF on the proteolysis of $LHRH/[D-Ala^6]LHRH$ in rabbit mucosal homgenates. We also reported that EDTA, STDHF and sodium laurate markedly increased the potency of $LHRH/[D-Ala^6]LHRH$ solution applied vaginally. In the present study, by administration of polycarbophil hydrogel containing LHRH the ovulation inducing activity was 3.3 times greater than solution. These results indicate not only peptidase inhibitor but also polycarbophil hydrogel significantly improved the absorption of this drug. The results of this study would provide the feasibility as a rational dosage form for improving bioavailability and self administration of this hydrogel by the vaginal application.

• 대한화학회지
• /
• 제57권4호
• /
• pp.461-471
• /
• 2013

Optimized geometrical structure, atomic charges, molecular electrostatic potential, nonlinear optical (NLO) effects and thermodynamic properties of the title compound N-(2,5-methylphenyl)salicylaldimine (I) have been investigated by using ab initio quantum chemical computational studies. Calculated results showed that the enol form of (I) is more stable than keto form. The solvent effect was investigated for obtained molecular energies, hardneses and the atomic charge distributions of (I). Natural bond orbital and frontier molecular orbital analysis of the title compound were also performed. The total molecular dipole moment (${\mu}$), linear polarizability (${\alpha}$), and first-order hyperpolarizability (${\beta}$) were calculated by B3LYP method with 6-31G(d), 6-31+G(d,p), 6-31++G(d,p), 6-311+G(d) and 6-311++G(d,p) basis sets to investigate the NLO properties of the compound (I). The standard thermodynamic functions were obtained for the title compound with the temperature ranging from 200 to 450 K.

• Journal of Multimedia Information System
• /
• 제8권4호
• /
• pp.277-284
• /
• 2021

Despite skepticism about commercial potential, the stereoscopic 3D cinema is still a form that any filmmaker can choose to employ for its aesthetics and its immersive potential. Based on a haptic illusion, the stereoscopic media content requires a new perspective different from the principle of 2D media content in terms of creation and acceptance. This paper examines the technical and aesthetic issues of stereoscopic 3D film production from the perspective of today's emerging realistic and immersive media through a case study. One of the key factors for successful content creation and research and development in stereoscopic 3D cinema is the combination of artistic principles together with technical mastering of the new image technology. The purpose of this paper is to outline the principal challenges and research topics in stereoscopic 3D cinema through a case study of stereoscopic 3D pilot film production for the 'User-Selective UHD Stereoscopic Media Service Platform' of the ETRI (Electronics and Telecommunications Research Institute). This paper intends to examine stereoscopic 3D filmmaking workflow and production methodologies, as well as technical elements and aesthetic issues.

• 한국생산제조학회지
• /
• 제19권4호
• /
• pp.427-433
• /
• 2010

With recent increased demand for reverse engineering in dental machining, the 3D laser scanner is widely used for inspection of artificial pontic. In order to overcome the optical drawback of laser scanner, such as irregular scatter, direction of beam, and the influence of surface integrity, it is developed in this study a new 3D measuring system for artificial pontic using spherical coordinate system mechanism by point laser sensor, which keeps the direction of beam normal to surface consistently. The comprehensive integrated system is established to evaluate the improvement of accuracy with data acquisition system. The experimental results for measuring a master ball and pontic models shows the excellent form accuracy and repeatability compared with conventional apparatus. Also, these results shows the possibility to apply this system for the measuring purpose within 0.05mm accuracy of pontic at the sharp edge or margin contour, which was difficult to measure at the conventional systems.

• 한국자원식물학회지
• /
• 제19권5호
• /
• pp.592-597
• /
• 2006

광릉숲 양치식물을 중심으로 한 집중적인 조사를 통하여 이 지역에 분포하는 양치식물을 정확히 밝히고자 하였다. 광릉숲에는 9과 17속 43종 3변종 총 46종류의 양치식물이 분포하고 있으며, 지역별 출현식물을 보면, 쇠뜨기, 고사리삼 등 26종류가 광릉숲 전지역에 걸쳐 분포하는 것으로 나타났으며, 꿩고비, 지리개관중 등 5종류가 소리봉 일대를 중심으로 하여 한정 분포하는 것으로 나타났다. 또, 산림동물원 계곡부를 중심으로 낚시고사리, 광릉족제비고사리 등이 분포하였고, 왕지네고사리, 참새발고사리 등은 외국수목원 일대에 국한된 분포역을 형성하고 있었다. 생활형을 보면, 휴면형(Domancy form)은 H(Hemicryptophyte)의 비율이 56.5%로 가장 높았으며, HH(Hydatophyte)가 2.2%로 가장 낮은 값을 보였다. 번식형(Propagation form)의 지하기관형(Radicoid form)은 대부분이 근경이 짧게 분지하고 가장 좁은 범위의 연결체를 갖는 $R_3$으로 39.1%이며, 근경이 옆으로 벋고 약간 넓은 범위의 연결체를 갖는 $R_2$가 2.2%이었고, 산포기관형(Disseminule form)은 모두 포자가 바람이나 물에 의해 운반되는 $D_1$이었다. 생육형(Growth form)은 t(Tussock)와 e(Erect)가 각각 67.4%와 32.6%로 나타나 광릉숲 양치식물의 대표적인 생활형은 $H-R_{3}-D_{1}-t$로 정리되었다. 광릉숲의 양치식물계수(Ptph.-Q.)는 1.28로 한반도 중부지역과 비교하였을 때 상대적으로 다소 높은 수치를 보이고 있어, 이 지역이 학술림으로서 안정적으로 보전 관리되고 있음을 알수 있다.

• Asian Journal of Innovation and Policy
• /
• 제3권1호
• /
• pp.94-116
• /
• 2014

The technological innovation is considered as an important factor and there is a positive externality in developing technology in the form of technology spillover. In this context, it is argued that government should play an active role in advancing technology development and several means have been introduced. This study attempts to analyze manufacturing firms' evaluation for the performance of government assistance programs to their R&D activities. Considering that the performance evaluation takes the form of a count outcome, we apply several kinds of count data models. Some interesting findings emerge from the analysis. For example, we found that a firm's sales amount, dummy for the firm's having an R&D department, dummy for the firm's being a venture one, and the number of the firm's innovative activities have positive relationships with the degree that the firm evaluates government assistance as being useful.

• 한국디자인학회:학술대회논문집
• /
• 한국디자인학회 2005년도 춘계 학술발표대회 논문집
• /
• pp.228-229
• /
• 2005

• 방송공학회논문지
• /
• 제24권7호
• /
• pp.1237-1245
• /
• 2019

Most of the blind are low vision blinds due to injury or disease. As their vision decreases, they are experiencing inconvenience in their normal life and forgetting their memories with their family. The purpose of this study is to use Lithophane printing technology to help their normal life and to remember their family. Also, the manufactured 3D plates are to study the conditions that can be optimal understood through the tactile sense of low vision blind. When the low vision blind person understood the 3D plates, they chose three parameters that affect their tactile sense. And by comparing their tactile sense, the optimal condition results were found. This paper was concluded with (1) the round form that perceived as 3D objects, (2) the thin thickness similar to Braille, and (3) the high resolution that can be expressed in detail.

• 대한수학회지
• /
• 제31권3호
• /
• pp.401-416
• /
• 1994

We study the existence of an intermediate solution of nonlinear elliptic boundary value problems (BVP) of the form $$ (BVP) {\Delta u = f(x,u,\Delta u), in \Omega {Bu(x) = \phi(x), on \partial\Omega, $$ where $\Omega$ is a smooth bounded domain in $R^n, n \geq 1, and \partial\Omega \in C^{2,\alpha}, (0 < \alpha < 1), \Delta$ is the Laplacian operator, $\nabla u = (D_1u, D_2u, \cdots, D_nu)$ denotes the gradient of u and $$ Bu(x) = p(x)u(x) + q(x)\frac{d\nu}{du} (x), $$ where $\frac{d\nu}{du} denotes the outward normal derivative of u on $\partial\Omega$.

• 약학회지
• /
• 제39권1호
• /
• pp.78-84
• /
• 1995

Based on Computer graphics molecular modeling method, quinolone derivatives as DNA-gyrase inhibitors formed stable DNA-intercalation complex with deoxycytidilyl-3',5'-deoxy guanosine[d($C_{p}G)_{2}$] dinucleotide. When d($C_{p}G)_{2}$ and d($A_{p}T)_{2}$, were compared in order to find out which DNA could form more stable DNA-Drug complex based on interaction energy($\Delta$E) and DNA-Drug complex energy, d($C_{p}G)_{2}$ resulted in lower energy than d($A_{p}T)_{2}$.