• 제목/요약/키워드: 3D dose model

검색결과 181건 처리시간 0.037초

흡수 선량 분포의 수송방정식을 이용한 10 MV X-선의 모델 (High Energy Photon Beam Modeling Using Transport Theory for Calculation of Absorbed Dose Distribution)

  • 최동락;전하정;이명자
    • Radiation Oncology Journal
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    • 제10권1호
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    • pp.115-120
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    • 1992
  • 물팬톰내에 조사된 10 MV X-선의 심부율을 입자의 수송이론을 근거로 한 1차원적인 모델을 이용하여 계산하였다. 계산된 이론식의 매개상수는 9개로 줄일 수 있었으며 실측치를 이용하여 비선형 회귀분석 방법으로 얻을 수 있다. 조사면과 선원간의 거리 및 깊이에따른 3차원적인 흡수선량분포의 계산식은 고에너지 광자선이 조사된 물팬톰내에서의 Beam Profile에 대한 시도함수를 이용하여 수송이론에의한 심부율계산을 3차원적으로 확장하였으며 흡수 선량 분포는 3차원적 위치의 함수로 널리 계산할 수 있다. 이 모델을 사용하여 계산된 이론값은 실험값과 $\pm12\%$ 이내의 만족할만큼 잘 일치하였다.

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Multiple isocenter를 이용한 뇌정위적 방사선 수술시 컴퓨터 자동 추적 방법에 의한 고속의 선량 최적화 (Rapid Optimization of Multiple Isocenters Using Computer Search for Linear Accelerator-based Stereotactic Radiosurgery)

  • 서태석;박찬일;하성환;윤세철;김문찬;박용휘;신경섭
    • Radiation Oncology Journal
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    • 제12권1호
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    • pp.109-115
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    • 1994
  • 본 연구의 목적은 뇌정위적 방사선수술시 최적 선량분포를 얻기 위하여 빠른 multiple isocenter 계획을 효과적으로 수행할 수 있는 방법을 개발하는 데 있다. 18cm 직경의 구형 머리 팬톰과 정확한 선량 알고리듬을 이용하여 선량값을 계산한 뒤 fltting 기술을 이용하여 빠른 구형선량 모델을 개발하였다. 구형선량 모델을 이용하여 single isocenter에 대한 선량값은 합산에 의하여 쉽게 얻어졌다. Isocenter들간의 이동에 따른 선량분포의 변화를 이용하여 컴퓨터 자동추적 방법이 개발되었으며, isocenter 간격 및 collimator 크기가 빠른 시간내에 결정될 수 있었다. 구형선량모델은 beam data에 의한 선량데이타와 같은 선량분포를 나타냈으며 고속으로 삼차원 선량계산을 가능하게 하였다. 컴퓨터 자동추적 방법은 지금까지의 시행착오적 방법에 비해 보다 빠르게 최적 isocenter setting을 제공할 수 있었다. 구형선량모델 및 컴퓨터 자동추적방법은 multiple isocenter를 이용한 수술 계획시 최적선량 분포를 보다 빨리 얻을 수 있었다.

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성숙 및 신생마우스에서 아포프토시스를 이용한 방사선 피폭의 생물학적 지표 (Biological indicator on radiation exposure using apoptosis in adult and newborn mice)

  • 오헌;이송은;양정아;정규식;현병화;김성호
    • 대한수의학회지
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    • 제38권4호
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    • pp.679-685
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    • 1998
  • We have studied, by a nonisotopic in situ DNA end-labeling (ISEL) technique, frequency of apoptosis in the external granular layer (EGL) of the cerebellum after whole-body irradiation of newborn mice and intestinal crypt cell of adult mice by gamma-rays from $^{60}Co$. The extent of changes following 2 Gy(10.9 Gy/min) was studied at 2, 4, 6, 8, 12, or 24h after exposure. The maximal frequency was found 4-8h after exposure. The mice that received 0.18, 0.36, 0.54, 1.08, 1.98, or 3.96 Gy were examined 6h after irradiation. Measurements performed after irradiation showed a dose-related increase in apoptotic cells in each of the mice studied. The dose-response curves were analyzed by a linear-quadratic model; frequency(%) of apoptotic cell in the newborn mice cerebellum was ($13.49{\pm}1.175$)D+$(-1.52{\pm}0.334)D^2$+0.048($r^2=0.981$, D = dose in Gy) and frequency(number per crypt) of apoptotic cell in the intestinal crypt of adult mice was ($3.857{\pm}0.420$)D+$(-0.535{\pm}0.120)D^2$+0.155($r^2=0.952$, D = dose in Gy). It provides the basis required for a better understanding of results which will be obtained in any further studies for biological responses of radiation using newborn and adult mice.

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한우 및 한국재래산양 유래 말초혈액 림프구의 미소핵을 이용한 방사선 피폭의 생물학적 선량측정 (Use of Frequencies of Micronuclei as Biological Dosimetry in Korean Native Cattle and Goat Lymphocytes after Irradiation in vitro)

  • 류시윤;김민주;김호준;조성환;김태환;정규식;이해준;김성호
    • 한국임상수의학회지
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    • 제19권3호
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    • pp.290-294
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    • 2002
  • The frequencies of gamma-ray-induced micronuclei (MN) in cytokinesis-blocked (CB) lymphocytes at several doses were measured in three donors of Korean native cattle and Korean native goat. Measurements performed after irradiation showed a dose-related increases in MN frequency in each of the donors studied. When analysed by linear-quadratic model the line of best fit was cattle : y : 0.1016D +$0.0118D^2$+0.0147, goat : y = 0.1353D +$0.0043D^2$+0.0087 (y : number of MN/CB cells and D = irradiation dose in Gy). The relative sensitivity of goat lymphocytes compared with cattle lymphocytes was estimated by best fitting linear-quadratic model based on the radiation-induced MN data over the range from 0 Gy to 4 Gy. In the case of MN frequency with 0.05, 0.1, 0.2, 0.4 and 0.8, the relative sensitivities of goat lymphocytes were 1.106. 1.166. 1.140, 1.069 and 0.976 respectively. Our in vitro radiobiological study confirmed that the cytogenetic response obtained in blood from cattle and goat can be utilized for application in environmental studies.

방사선 치료용 고에너지 전자선의 조직 내 선량분포 특성에 관한 연구 (Study on Characteristics of Dose Distribution in Tissue of High Energy Electron Beam for Radiation Therapy)

  • 나수경
    • 대한방사선치료학회지
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    • 제14권1호
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    • pp.175-186
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    • 2002
  • The purpose of this study is directly measure and evaluate about absorbed dose change according to nominal energy and electron cone or medical accelerator on isodose curve, percentage depth dose, contaminated X-ray, inhomogeneous tissue, oblique surface and irradiation on intracavitary that electron beam with high energy distributed in tissue, and it settled standard data of hish energy electron beam treatment, and offer to exactly data for new dote distribution modeling study based on experimental resuls and theory. Electron beam with hish energy of $6{\sim}20$ MeV is used that generated from medical linear accelerator (Clinac 2100C/D, Varian) for the experiment, andwater phantom and Farmer chamber md Markus chamber und for absorbe d dose measurement of electron beam, and standard absorbed dose is calculated by standard measurements of International Atomic Energy Agency(IAEA) TRS 277. Dose analyzer (700i dose distribution analyzer, Wellhofer), film (X-OmatV, Kodak), external cone, intracavitary cone, cork, animal compact bone and air were used for don distribution measurement. As the results of absorbed dose ratio increased while irradiation field was increased, it appeared maximum at some irradiation field size and decreased though irradiation field size was more increased, and it decreased greatly while energy of electron beam was increased, and scattered dose on wall of electron cone was the cause. In percentage depth dose curve of electron beam, Effective depth dose(R80) for nominal energy of 6, 9, 12, 16 and 20 MeV are 1.85, 2.93, 4.07, 5.37 and 6.53 cm respectively, which seems to be one third of electron beam energy (MeV). Contaminated X-ray was generated from interaction between electron beam with high energy and material, and it was about $0.3{\sim}2.3\%$ of maximum dose and increased with increasing energy. Change of depth dose ratio of electron beam was compared with theory by Monte Carlo simulation, and calculation and measured value by Pencil beam model reciprocally, and percentage depth dose and measured value by Pencil beam were agreed almost, however, there were a little lack on build up area and error increased in pendulum and multi treatment since there was no contaminated X-ray part. Percentage depth dose calculated by Monte Carlo simulation appeared to be less from all part except maximum dose area from the curve. The change of percentage depth dose by inhomogeneous tissue, maximum range after penetration the 1 cm bone was moved 1 cm toward to surface then polystyrene phantom. In case of 1 cm and 2 cm cork, it was moved 0.5 cm and 1 cm toward to depth, respectively. In case of air, practical range was extended toward depth without energy loss. Irradiation on intracavitary is using straight and beveled type cones of 2.5, 3.0, 3.5 $cm{\phi}$, and maximum and effective $80\%$ dose depth increases while electron beam energy and size of electron cone increase. In case of contaminated X-ray, as the energy increase, straight type cones were more highly appeared then beveled type. The output factor of intracavitary small field electron cone was $15{\sim}86\%$ of standard external electron cone($15{\times}15cm^2$) and straight type was slightly higher then beveled type.

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Dose Dependency of Earthworm Powder on Antithrombotic and Fibrinolytic Effects

  • Kim, Yeong-Shik;Pyo, Mi-Kyung;Park, Kyung-Mi;Hahn, Bum-Soo;Yang, Kyung-Youl;Choi, Hye-Sook Yun
    • Archives of Pharmacal Research
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    • 제21권4호
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    • pp.374-377
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    • 1998
  • The freeze-dried powder of Lumbricus rubellus earthworm was administered orally to rats and its fibrinolytic and antithrombotic effects were investigated. The fibrinolytic activity of plasma was determined by measuring the plasmin activity of the euglobulin fraction and was increased to two-folds of the control at a dose of 0.5 g/kg/day and five times with 1 g/kg/day after 4-day administration. The antithrombotic effect was studied in an arterio-venous shunt model of rats. The thrombus weight decreased significantly from 43.2 mg to 32.4 mg at a dose of 0.5 g/kg/day after 8-day treatment. The level of fibrinogen/fibrin degradation product (FDP) in serum was elevated in a dose-dependent manner during the treatment period. On the 8th day after administration, the FDP value was increased to 7.7 $\mu\textrm{g}$g/ml compared with the control value of 3.3 $\mu\textrm{g}$g/ml. These results support that earthworm powder is valuable for the prevention and/or treatment of thrombotic conditions.

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Preclinical application of 188Re-Tin colloid for treatment of mouse tumor model with peritoneal effusion

  • Jin, Yong Nan;Lee, Yong Jin;Kim, Young Joo;Lee, Yun-Sang;Jeong, Jae Min
    • 대한방사성의약품학회지
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    • 제3권2호
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    • pp.80-84
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    • 2017
  • Re-188 is an excellent and practical radioisotope produced by W-188/Re-188-generator for therapy. We prepared Re-188-tin colloid for therapy of various diseases and tried to treat peritoneal effusion in animal model. Sarcoma-180 cells were injected into ICR mice to induce peritoneal effusion and the mice were grown for 3 d. Re-188-tin colloids (0.25, 0.5, and 1 mCi/mL per 30 g body weight) were injected into the mice and the mice were grown for 90 d. Planar gamma scintigraphy showed even distribution of Re-188-tin colloid radioactivity. Bax expression was found to be dose dependent to Re-188-tin colloid. Normal saline treated group showed the shortest survival time. Among the treated groups, 0.5 mCi dose group showed the longest survival time. In conclusion, Re-188-tin colloid was prepared successfully and showed the feasibility to use as a peritoneal effusion treatment in mice.

Oxytetracycline을 근육 주사한 넙치 (Paralichthys olivaceus)의 약물동태학적 특성 (Pharmacokinetics of oxytetracycline in olive flounder (Paralichthys olivaceus) by intramuscular injection)

  • 정승희;최동림;김진우;조미라;서정수;지보영
    • 한국어병학회지
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    • 제22권1호
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    • pp.91-95
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    • 2009
  • 옥시테트라사이클린 (OTC)을 넙치 (평균체중 600 g)에 1회 근육 주사 (12.5, 25 및 50 ㎎/㎏ body weight)한 다음, 경시적 (3시간-360시간) 인 혈장내 OTC의 잔류농도를 분석하였다. 25 및 50 ㎎/㎏ 시험구에서 투여 5시간째 각각 0.99 및 1.49 $\mu{g}/m\ell$로 최대혈중농도를 나타내었으나, 12.5 ㎎/㎏ 시험구는 투여 10시간째 0.35 $\mu{g}/m\ell$로 최대혈중농도를 나타내었다. 모든 시험구는 투여 360시간째 혈중에서 OTC가 검출되지 않 았다. OTC의 넙치 체내 약물 혈중농도 측정결과를 바탕으로 1- compartment model로 Win-Nonlin program을 이용하여 OTC의 흡수, 배설,반감기 등 약물동태학적 매개변수 (parameter)를 조사하였다. 12.5, 25 및 50 ㎎/㎏을 근육 주사한 경우, 혈장농도-시간곡선하 면적 (AUC)은 각각 24.9, 44.67 및 50.45 $\mu{g}$ $h/m\ell$, 약물의 반감기 ($T_{1/2}$)는 각각 0.42, 0.59 및 0.41 h, 혈중최고농도의 도달시간 ($T_{max}$)은 8.46, 6.34 및 2.66 h, 혈중 최고농도 ($C_{max}$)는 0.30, 0.63 및 1.13 $\mu{g}/m\ell$로 계산되었다.

A GPU-based point kernel gamma dose rate computing code for virtual simulation in radiation-controlled area

  • Zhihui Xu;Mengkun Li;Bowen Zou;Ming Yang
    • Nuclear Engineering and Technology
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    • 제55권6호
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    • pp.1966-1973
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    • 2023
  • Virtual reality technology has been widely used in the field of nuclear and radiation safety, dose rate computing in virtual environment is essential for optimizing radiation protection and planning the work in radioactive-controlled area. Because the CPU-based gamma dose rate computing takes up a large amount of time and computing power for voxelization of volumetric radioactive source, it is inefficient and limited in its applied scope. This study is to develop an efficient gamma dose rate computing code and apply into fast virtual simulation. To improve the computing efficiency of the point kernel algorithm in the reference (Li et al., 2020), we design a GPU-based computing framework for taking full advantage of computing power of virtual engine, propose a novel voxelization algorithm of volumetric radioactive source. According to the framework, we develop the GPPK(GPU-based point kernel gamma dose rate computing) code using GPU programming, to realize the fast dose rate computing in virtual world. The test results show that the GPPK code is play and plug for different scenarios of virtual simulation, has a better performance than CPU-based gamma dose rate computing code, especially on the voxelization of three-dimensional (3D) model. The accuracy of dose rates from the proposed method is in the acceptable range.