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A Method for Estimating the Lung Clinical Target Volume DVH from IMRT with and without Respiratory Gating

  • J. H. Kung;P. Zygmanski;Park, N.;G. T. Y. Chen
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.53-60
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    • 2002
  • Motion of lung tumors from respiration has been reported in the literature to be as large as of 1-2 cm. This motion requires an additional margin between the Clinical Target Volume (CTV) and the Planning Target Volume (PTV). While such a margin is necessary, it may not be sufficient to ensure proper delivery of Intensity Modulated Radiotherapy (IMRT) to the CTV during the simultaneous movement of the DMLC. Gated treatment has been proposed to improve normal tissues sparing as well as to ensure accurate dose coverage of the tumor volume. The following questions have not been addressed in the literature: a) what is the dose error to a target volume without gated IMRT treatment\ulcorner b) what is an acceptable gating window for such treatment. In this study, we address these questions by proposing a novel technique for calculating the 3D dose error that would result if a lung IMRT plan were delivered without gating. The method is also generalized for gated treatment with an arbitrary triggering window. IMRT plans for three patients with lung tumor were studied. The treatment plans were generated with HELIOS for delivery with 6 MV on a CL2100 Varian linear accelerator with a 26 pair MLC. A CTV to PTV margin of 1 cm was used. An IMRT planning system searches for an optimized fluence map ${\Phi}$ (x,y) for each port, which is then converted into a dynamic MLC file (DMLC). The DMLC file contains information about MLC subfield shapes and the fractional Monitor Units (MUs) to be delivered for each subfield. With a lung tumor, a CTV that executes a quasi periodic motion z(t) does not receive ${\Phi}$ (x,y), but rather an Effective Incident Fluence EIF(x,y). We numerically evaluate the EIF(x,y) from a given DMLC file by a coordinate transformation to the Target's Eye View (TEV). In the TEV coordinate system, the CTV itself is stationary, and the MLC is seen to execute a motion -z(t) that is superimposed on the DMLC motion. The resulting EIF(x,y)is inputted back into the dose calculation engine to estimate the 3D dose to a moving CTV. In this study, we model respiratory motion as a sinusoidal function with an amplitude of 10 mm in the superior-inferior direction, a period of 5 seconds, and an initial phase of zero.

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Development and Application of a Mountain Village Revitalization Index Using Big Data (빅데이터를 활용한 산촌 활성화 지수 개발 및 적용)

  • Jang-Hwan Jo;Kyu-Dong Lee;Hye-Jung Cho;Sungki Jun;GwanPyeong Roh;Eunseok Jang
    • Journal of Korean Society of Forest Science
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    • v.113 no.3
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    • pp.292-307
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    • 2024
  • This study aimed to develop an index to assess the level of revitalization in mountain villages by utilizing big data and to verify its applicability in such areas. To achieve this, four key indices related to mountain villages were developed to evaluate the degree of revitalization, namely, Settlement Index, Workplace Index, Learning Index, and Leisure Index. These indices enable users to compare the revitalization levels of different mountain villages by establishing living zones, assigning data weights, extracting comparative data, and generating results in both map and report formats. The revitalization index developed in this study was applied to five mountain villages (A, B, C, D, E) located in Jeollabuk-do. Results showed that Village C had the highest comprehensive score of 320 points, while Village E had the lowest score of 141 points. In the mountain village indices of Jeollabuk-do, the Workplace Index generally showed higher scores, whereas the Learning Index had relatively lower scores on average. The development of these indices provides a practical means to identify which areas should be prioritized for support to enhance revitalization in specific mountain villages and offers a clear comparison of the revitalization levels across different regions and individual villages. The mountain village revitalization index developed in this study is expected to serve as valuable foundational information for formulating mountain village revitalization policies.

Analysis of Urban Heat Island Effect Using Information from 3-Dimensional City Model (3DCM) (3차원 도시공간정보를 이용한 도시열섬현상의 분석)

  • Chun, Bun-Seok;Kim, Hag-Yeol
    • Spatial Information Research
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    • v.18 no.4
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    • pp.1-11
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    • 2010
  • Unlike the previous studies which have focused on 2-dimensional urban characteristics, this paper presents statistical models explaining urban heat island(UHI) effect by 3-dimensional urban morphologic information and addresses its policy implications. 3~dimensional informations of Columbus, Ohio arc captured from LiDAR data and building boundary informations are extracted from a building digital map, Finally NDV[ and temperature data are calculated by manipulating band 3, band 4, and thermal hand of LandSat images. Through complicated data processing, 6 independent variables(building surface area, building volume, height to width ratio, porosity, plan surface area) are introduced in simple and multiple linear regression models. The regression models are specified by Box-Tidwell method, finding the power to which the independent variable needs to raised to be in a linearity. Porosity, NDVI, and building surface area are carefully chosen as explanatory variables in the final multiple regression model, which explaining about 57% of the variability in temperatures. On reducing UHI, various implications of the results give guidelines to policy-making in open space, roof garden, and vertical garden management.

Molecular Cloning and Characterization of Bovine HMGA1 Gene

  • Yu, S.L.;Chung, H.J.;Sang, B.C.;Bhuiyan, M.S.A.;Yoon, D.;Kim, K.S.;Jeon, J.T.;Lee, J.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.11
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    • pp.1662-1669
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    • 2007
  • The high mobility group AT-hook1 (HMGA1) proteins are known to be related to the regulation of gene transcription, replication and promotion of metastatic progression in cancer cells. The loss of expression by disrupting the HMGA1 gene affects insulin signaling and causes diabetes in the mouse. Previously identified single nucleotide polymorphism (SNP) of HMGA1 was significantly associated with fat deposition traits in the pig. In this study, we identified 3,935 bp nucleotide sequences from exon 5 to exon 8 of the bovine HMGA1 gene and its mRNA expression was observed by quantitative real-time PCR. Six single nucleotide polymorphisms in the bovine HMGA1 gene were detected and the allele frequencies of these SNPs were investigated using the PCR-RFLP method in nine cattle breeds including Limousin, Simmental, Brown Swiss, Hereford, Angus, Charolais, Hanwoo, Brahman and Red Chittagong cattle. The map location showed that the bovine HMGA1 gene was also closely located with a previously identified meat quality QTL region indicating this gene is the most likely positional candidate for meat quality traits in cattle.

Comparison of reproducibility of prepared tooth impression scanning utilized with white and blue light scanners (백색광과 청색광 스캐너를 이용한 지대치 인상체 스캐닝의 반복재현성 비교)

  • Jeon, Jin-Hun;Sung, Hwan-Kyung;Min, Byung-Kuk;Hwang, Jae-Sun;Kim, Ji-Hwan;Kim, Woong-Chul
    • Journal of Technologic Dentistry
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    • v.37 no.4
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    • pp.213-218
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    • 2015
  • Purpose: The purpose of this study compared of reproducibility of prepared tooth impression scanning utilized with white and blue light scanners. Methods: To evaluate reproducibility with white and blue light scanners, the impression of premolar were rotated by $10^{\circ}{\sim}20^{\circ}$ and scanned. These data were compared with the first 3-D data (STL file), and the error sizes were measured (n=5). Independent t test was used to evaluation the reproducibility of impression of premolar with white versus blue light scanners through discrepancies of mean, RMS (${\alpha}=0.05$). Results: Discrepancies of mean with regard to reproducibility were $11.2{\mu}m$, $5.8{\mu}m$, respectively, with white and blue light scanners (p<0.047). And discrepancies of RMS with regard to reproducibility were $33.4{\mu}m$, $18.8{\mu}m$, respectively, with white and blue light scanners (p<0.045). Conclusion: Our results indicate a good reproducibility of prepared tooth impression digitized with blue light scanner more than that with white light scanner.

Edge-Directional Joint Disparity-Motion Estimation of Stereoscopic Sequences (경계 방향성을 고려한 스테레오 동영상의 움직임-변이 동시추정 기법)

  • 김용태;서형갑;박창섭;이재호;손광훈
    • Journal of Broadcast Engineering
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    • v.9 no.3
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    • pp.196-206
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    • 2004
  • This paper presents an efficient joint disparity-motion estimation algorithm for stereo sequence CODEC. Disparity vectors are estimated by the left and right motion vectors and previous disparity vectors for every frame. In order to obtain more accurate disparity vectors. we include a spatial prediction Process after the feint estimation. From joint estimation and spatial prediction, we can obtain accurate disparity vectors and then Increase coding efficiency. Finally, we proposed the backward quadtree decomposition. which helps the encoder to have a more detailed disparity vector map without transmitting additional coding bits for quadtree information. We confirmed superior performance of the proposed method through computer simulation.

Object Recognition and Target Tracking Using Motion Synchronization between Virtual and Real Robots (가상로봇과 실제로봇 사이의 운동 동기화를 통한 물체 인식 및 목표물 추적방안)

  • Ahn, Hyeo Gyeong;Kang, Hyeon Jun;Kim, Jin Beom;Jung, Ji Won;Ok, Seo Won;Kim, Dong Hwan
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.26 no.1
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    • pp.20-29
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    • 2017
  • Motion synchronization between developed real and virtual robots for object recognition and target tracking is introduced. ASUS's XTION PRO Live is implemented as a sensor and configured to recognize walls and obstacles, and perceive objects. In order to create virtual reality, Unity 3D is adopted to be associated with the real robot, and the virtual object is controlled by using an input device. A Bluetooth serial communication module is used for wireless communication between the PC and the real robot. The motion information of a virtual object controlled by the user is sent to the robot. Then, the robot moves in the same way as the virtual object according to the motion information. Through motion synchronization, two scenarios, which map the real space and current object information with virtual objects and space, were demonstrated, yielding good agreement between the two spaces.

Estimation of Disparity for Depth Extraction in Monochrome CMOS Image Sensors with Offset Pixel Apertures (깊이 정보 추출을 위한 오프셋 화소 조리개가 적용된 단색 CMOS 이미지 센서의 디스패리티 추정)

  • Lee, Jimin;Kim, Sang-Hwan;Kwen, Hyeunwoo;Chang, Seunghyuk;Park, JongHo;Lee, Sang-Jin;Shin, Jang-Kyoo
    • Journal of Sensor Science and Technology
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    • v.29 no.2
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    • pp.123-127
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    • 2020
  • In this paper, the estimation of the disparity for depth extraction in monochrome complementary metal-oxide-semiconductor (CMOS) image sensors with offset pixel apertures is presented. To obtain the depth information, the disparity information between two different channel data of the offset pixel apertures is required. The disparity is caused by the difference in the response angle between the left- and right-offset pixel aperture images. A depth map is implemented by the generated disparity. Therefore, the disparity is the most important factor for realizing 3D images from the designed CMOS image sensor with offset pixel apertures. The disparity is influenced by the pixel height and offset value of the offset pixel aperture. To confirm this correlation, the offset value is set to maximum within the pixel area, and the disparity values corresponding to the difference in the heights are calculated and compared. The disparity is derived using the camera-lens formula. Two monochrome CMOS image sensors with offset pixel apertures are used in the disparity estimation.

A Study on the Research Trend of Surveying in Korea (국내 측량분야의 연구동향에 관한 연구)

  • Kim, Youn-Hee;Choi, Yun Soo;Kang, Moon Kwon
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.26 no.5
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    • pp.475-483
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    • 2008
  • The purpose of this study is to figure out the research trend of surveying in Korea through the analyses of research field and the published year of surveying related papers in journals and theses of master and Ph. D. The papers and theses published since 1957 were collected and analyzed to find out the major research topics and trends with time. The analyses of research trends in terms of time showed certain correlation between research areas, for example, remote sensing is highly correlated with GIS (98%), GPS correlated with GIS(95%). Through the regression analysis, it was found that the trends of the most fields were well-fitted with a third-order polynomial except the field of Geodesy. Furthermore, it was predicted that the number of studies in general surveying, photogrammetry, remote sensing and land information will be increasing while those in GPS, GIS, digital map and Geodesy will be decreasing.

Bis Is Involved in Glial Differentiation of PI9 Cells Induced by Retinoic Acid

  • Yoon, Jung-Sook;Lee, Mun-Yong;Lee, Jae-Seon;Park, Chan-Sun;Youn, Ho-Joong;Lee, Jeong-Hwa
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.3
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    • pp.251-256
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    • 2009
  • Previous observations suggest that Bis, a Bcl-2-binding protein, may playa role the neuronal and glial differentiation in vivo. To examine this further, we investigated Bis expression during the in vitro differentiation of P19 embryonic carcinoma cells induced by retinoic acid (RA). Western blotting and RT-PCR assays showed that Bis expression was temporarily decreased during the free floating stage and then began to increase on day 6 after the induction of differentiation. Double immunostaining indicated that Bis-expressing cells do not express several markers of differentiation, including NeuN, MAP-2 and Tuj-1. However, some of the Bis-expressing cells also were stained with GFAP-antibodies, indicating that Bis is involved glial differentiation. Using an shRNA strategy, we developed bis-knock down P19 cells and compared them with control P19 cells for the expression of NeuroD, Mash-1 and GFAP during RA-induced differentiation. Among these, only GFAP induction was significantly attenuated in Pl9-dnbis cells and the population showing GFAP immunoreactivity was also decreased. It is noteworthy that distribution of mature neurons and migrating neurons was disorganized, and the close association of migrating neuroblasts with astrocytes was not observed in P19-dnbis cells. These results suggest that Bis is involved in the migration-inducing activity of glial cells.