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Bioequivalence of Levopid Tablet to Levopride Tablet (Levosulpiride 25 mg) (레보프라이드 정(레보설피리드 25 mg)에 대한 레보피드 정의 생물학적 동등성)

  • Cho, Hea-Young;Kang, Hyun-Ah;Moon, Jai-Dong;Lee, Yong-Bok
    • Journal of Pharmaceutical Investigation
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    • v.32 no.2
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    • pp.127-133
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    • 2002
  • Levosulpiride is the 1evo-enantiomer form of racemic sulpiride, a benzamide derivative selectively inhibiting dopaminergic $D_2$ receptors at the trigger zone both in the central nervous system and in the gastrointestinal tract. The purpose of the present study was to evaluate the bioequiva1ence of two levosulpiride tablets, Levopride (SK Pharmaceutical Co., Ltd.) and Levopid (Dae Won Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The levosulpiride release from the two levosulpiride tablets in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty eight normal male volunteers, $23.82{\pm}3.26$ years in age and $69.13{\pm}8.58$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 25 mg of levosulpiride was orally administered, blood was taken at predetermined time intervals and the concentrations of levosulpiride in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two levosulpiride tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Levopride were -1.17%, 1.20% and -1.09%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.93){\sim}log(1.07)\;and\;log(0.90){\sim}log(1.14)\;for\;AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${\pm}20%$ $(e.g.,\;-19.47{\sim}16.20\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Levopid tablet is bioequivalent to Levopride tablet.

The Effect of snatch technique improvement for men weightlifter of feedback support through quantity analysis by periods (주기적 정성적분석을 통한 훈련목표 제공이 남자 역도 인상기술 향상에 미치는 영향)

  • Moon, Young-Jin;Ryu, Jung-Hyun;Lee, Soon-Ho
    • Korean Journal of Applied Biomechanics
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    • v.14 no.2
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    • pp.69-83
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    • 2004
  • The purpose of this study is searching for technical merits and demerits of each weight lifting player through qualitative motion analysis system. Moreover, It is also analysis the repeating the establishment of exercise purpose and studying for the effect of the field adaptation. The subject of this study was five male weight lifting players who have been engaged in Korean Delegation Team. The institution of exercise target was made through two times qualitative analysis and the result of studying for the effect of the field adaptation was produced before offering feedback. Moreover, two time analysis added after offering feedback. All analysis was based on 2-D visual analysis. The results of this study are as follows: 1. Maximal barbell moving speed in starting phase was decreased after offering feedback. This result implies advancement of technical skills after offering feedback. 2. From starting posture to 앉아받기, forward and backward moving distance of hip joint was decreased after offering feedback in all subjects. This result represents advancement of technical skills after offering feedback. 3. In terms of pull phase, forward and backward moving distance of hip and shoulder joint was decreased after offering feedback in all subjects. This result represents advancement of technical skills after offering feedback. 4. In terms of pull phase, the difference of horizontal value of coordinates was decreased after offering feedback in all subjects. This result represents advancement of technical skills after offering feedback. 5. In terms of pull phase, the motion range of hip joint was decreased after offering feedback in three of five subjects and this represents advancement of technical skills after offering feedback. However, the rest of them were not variable or narrow decreasing. This result represents that feedback system could not brought tremendous effects. 6. From apex point of barbell to 앉아받기, the difference of barbell height was decreased after offering feedback in three of five subjects and this represents advancement of technical skills after offering feedback. However, the rest of them weren't variable or narrow increasing. This result represents that feedback system could not brought tremendous effects. 7. In terms of last-pull phase, the angular velocity of knee joint was increased after offering feedback in four of five subjects and this represents advancement of technical skills after offering feedback. However, the rest of them, only one subject, decreased. This result represents that feedback system could not brought tremendous effects. 8. In terms of last-pull, the conversional tendency of maximal extension to flextion came out all but simultaneously without offering feedback in four of five subjects. This is well-performed technique. Only one subject, however, could not use power effectively because the fact that his maximal extension came out in serial, from ankle to knee and waist means dispersion of power. In addition to, after offering feedback, only one subject made increasing the maximal extension of knee in last-pull and this result represents advancement of skills after offering feedback. However, the rest of them could not make meaningful development after offering feedback. 9. It might be assumed that searching for technical merits and demerits of each weight lifting player through qualitative motion analysis system could improve player's skill.

Design & Performance of the Solar Energy Research & Test Center (태양에너지 연구 시험센타 설계 및 효율에 관한 연구)

  • Auh, Paul Chung-Moo;Lee, Jong-Ho;Choi, Byung-Owan;Cho, Yil-Sik
    • Solar Energy
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    • v.2 no.2
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    • pp.29-36
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    • 1982
  • The Solar Energy R&D Department of KIER under the auspice of the Korean government is pushing hard on the development of the passive solar technology with high priority for the expeditious widespread use of solar energy in Korea, since the past few years of experiences told us that the active solar technology is not yet ready for massive commercialization in Korea. KIER has completed the construction of the Solar Energy Research & Test Center in Seoul, which houses the major facilities for its all solar test programs. The Center was designed as a passive solar building with great emphasis on the energy conserving ideas. The Center is not only the largest passive building in Korea, but also the exhibit center for the effective demonstration of the passive heating and cooling technology to the Korean public. The Center was designed to satisfy the requirements based on the technical and economical criteria set by the KIER. Careful considerations, therefore, were given in depth in the following areas to meet the requirements. 1) Passive Heating Concepts The Center employed the combination of direct and indirect gain system. The shape of the Center is Balcomb House style, and it included a large built-in sunspace in front. A partition, consists of transparent and translucent glazings, separates the sunspace and the living space. Since most activities in the Center occur during the day time, direct utilization of the solar energy by the living spaces was emphasized with the limited energy storage capacity. 2) Passive Cooling Concepts(for Summer) Natural ventilation concept was utilized throughout the building. In the direct gain portion of the system, the front glazing can be openable during the cooling season. Natural convection scheme was also applied to the front sunspace for the Summer cooling. Reflective surfaces and curtains were utilized wherever needed. 3) Auxiliary Heat ing and Cooling System As an auxiliary cooling system, mechanical means(forced convection system) were adopted. Therefore forced air heating system was also used to match the duct work requirements of the auxiliary cool ing system. 4) Effect ive Insulation & Others These included the double glazed windows, the double entry doors, the night glazing insulation, the front glazing-frame insulation as well as the building skin insulation. All locally available construction materials were used, and natural lightings were provided as much as possible. The expected annual energy savings (compared to the non-insulated conventional building)of the Center was estimated to be about 80%, which accounts for both the energy conservation and the solar energy source. The Center is being instumented for the actual performance tests. The experimental results of the simplified tests are discussed in this paper.

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Analysis of Pollution Characteristics in the Mainstream and Its Tributaries of Gongneung Stream Using Water Quality Index and Pollution Load Data (통합수질지수 및 오염부하자료를 이용한 공릉천 유입지천과 본류의 오염특성 분석)

  • Yu, Jae-Hyun;Lee, Han-Saem;Lim, Byung-Ran;Kang, Joo-Hyoung;Ahn, Tae-Ung;Shin, Hyun-Sang
    • Journal of Korean Society on Water Environment
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    • v.36 no.2
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    • pp.125-136
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    • 2020
  • In this study, we identified the major pollution-zones of the mainstream and its tributaries of Gongneung stream and investigated their pollution sources based on water quality, flowrate and pollution-load data of the stream having the characteristics of the urban-rural complex to examine the effect of the tributaries on the water quality changes in the mainstream. The water quality and flowrate data were collected for 10 months (2018 ~ 2019) at 3 points of mainstream and ten tributaries. Water quality index (WQI), load duration curve (LDC), discharge load density (DLD)and delivery ratios for each tributary were obtained so as to investigate the pollution characteristics and some of the information visualized on GIS. The main pollution-zone in the Gongneung stream was in the middle and lower streams, and the tributaries that may affect the pollution of the area were JS, JY, SL and SM. JS and SL had low WQI levels (34.7/37.5) and DLD (kg/d/㎢) of BOD and T-P were relatively high in JY (99.2/6.00) and SL (60.0/2.07). BOD and T-P delivery ratios in JS were high (0.94/0.83), suggesting that JS had significant influence on the water quality of the main pollution-zone in the Gongneung stream. Meanwhile, SM having a high T-P delivery ratio (0.97) was found to be more affected by the non-point source due to the higher LDC excess rate (%) in the low flow compared to high flow. This study provides basic data on the water quality and pollution characteristics of the Gongneung stream, and the analysis results are expected to be used as examples for identifying the main pollution-zone and tributaries of stream and their pollution sources.

Effects of Photoperiod and Water Temperature on the Reproductive cycle of the Spring-Spawning Bitterling, Rhodeus uyekii (Pisces : Cyprinidae) (각시붕어, Rhodeus uyekii의 생식주기에 미치는 광주기 및 수온의 영향)

  • An, Cheul-Min
    • Korean Journal of Ichthyology
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    • v.7 no.1
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    • pp.43-55
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    • 1995
  • Based on the reproductive cycle of Rhodeus uyekii, the reproductive control mechanism was examined under the several combinations of photoperiod and temperature regimes at different phases of their reproductive cycle. In early spring, the gonads developed rapidly under the warm temperature condition(above $8^{\circ}C$), regardless of the photoperiod. In late spring or early summer, gonads intensely regressed under the high temperature condition(above $24^{\circ}C$), regardless of the photoperiod. Thus, it is concluded that the spawning period of R. uyekii is initiated by the rising of water temperature in spring and is terminated by the high temperature in early summer. In autumn, the gonadal recrudescence occurs under the conditions of artificial long daylength with warm temperature(15L/9D, $12^{\circ}C{\sim}20^{\circ}C$), whereas the gonads remain in the existing condition under the short daylength. Therefore, in autumn the gonadal recrudescence is prevented by the short daylength although the temperature is still in favorable condition. In bitterling, the responsiveness of the gonads to photoperiod varies clearly with seasons, which was declined during the winter but increased during the autumn. The critical photoperiod for maturation ranges 12~13 hours of light per day. The results indicate that the proper ranges of temperature and photoperiod for gonadal maturation of this species are from $8^{\circ}C$ to $8^{\circ}C$ and from 13L to 15L, respectively.

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Release Behavior of 5-FU from 5-FU/PLGA Wafer using Recrystallized PLGA and Monomer (재결정 PLGA와 단량체를 이용한 5-FU/PLGA 웨이퍼의 방출거동)

  • Park, Jung Soo;Choi, Myoung Kyu;Kim, Yun Tae;Lee, Jun Hee;Mo, Jong Hyun;Khang, Gilson;Rhee, John Moon;Shin, Hyung Shik;Lee, Hai Bang
    • Korean Chemical Engineering Research
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    • v.46 no.2
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    • pp.205-210
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    • 2008
  • Poly(D,L-lactide-co-glycolide) (PLGA) has been widely used as carriers in controlled release delivery systems due to its biodegradability and relatively good biocompatibility. However, Release pattern of carriers fabricated using PLGA have disadvantage an initial burst within a few days, lag time several days and then sudden release changes. To solve these problems of PLGA, we fabricated PLGA wafer including monomer. Also, drug release behavior restraint sudden burst effect using recrystallization of PLGA. Recrystallized PLGA was characterized the morphological difference by SEM and in vitro release behavior measured by HPLC. The PLGA molecular weight analyzed to recognize monomer influence during degradation process of polymer using GPC. In this study, drug release duration cut short up to three days and was eliminated the lag time based on the bulk erosion.

Effects of Preoperative Psychological fare on Postoperative Recovery - An Exploratory Experiment - (수술 전 심리간호가 회복에 미치는 효과에 관한 실험적 연구)

  • 김조자
    • Journal of Korean Academy of Nursing
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    • v.2 no.1
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    • pp.97-113
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    • 1971
  • The purpose of this study was to investigate the preoperative anxiety of surgical patients and to observe the effects of an experimental nursing process on the incidence of vomiting, the number of analgesics used and the voiding ability of surgical patients within a 48 hour postoperative period and also the number of postoperative days in the hospital. This study me based on a sample of 51 patients who were scheduled for abdominal surgery. They were assigned alternately to experimental and control groups. Patients assigned to the experimental group were given nursing care by the writer, using an experimental nursing process. This is a process directed toward helping the patient obtain a suitable psychological state for surgery. This process was performed by use of the following steps: 1. The nurse approached the patient with interest and concern, and observed the patient's behavior to determine the presence of anxiety. 2. The nurse explored further to find out what was causing the anxiety and what was needed too relieve it. 3. The nurse listened carefully lo the patient. 4. The nurse gave an opportunity for expression of individuality. 5. The nurse showed friendliness and reassured the patient 6. The nurse gave instruction about deep berating, turing and coughing and gave an explanation of routine preoperative preparation which decreased the unknown and so decreased the patient's anxiety- The findings of this study are as follows: 7. The investigation of preoperative anxiety through observing and interviewing revealed patients were concerned about the following: a. Length of stay in the hospital 69.7% (31 cases) b. Condition unimproved o. worse 48.,8% (30 cases) c. Postoperative pain and discomfort .56.8% (29 cases) 2. The results of the study regarding the four hypothesis were as follows: a. Preoperative psychological care not reduce the number of analysis needed during the 48 hour period following surgery. b. Preoperative psychological care did not reduce the Postoperative incidence of vomiting c. Preoperative psychological care had no influence on voiding ability following surgery. d. Preoperative psychological care significantly reduced the number of postoperative days in tile hospital. The experimental nursing process proved to be successful in decreasing the length of postoperative hospitalization (improving rate of healing). This study has demonstrated further that the relief of anxiety (emotional distress) is part of the nurse's professional role. In order to be sure psychological care is given it is important to make a nursing care plan which .includes a plan for the psychological care needed by the patient. As this care is given it can be charted off by each nurse just as medication and treatments are checked after they are given.

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Tele-metering

  • Hearte, L.O.
    • 전기의세계
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    • v.2
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    • pp.6-14
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    • 1949
  • Telemetering may be described as the art of metering at a considerable distance those quantities which are ordinarily encountered in industry, and in the generation of electric power. It is in the production of electric power that telemetering is particularly important, for it permits the system operator, or load dispatcher, to have before him at all times a continuous graphic record of the power output of each individual generating station together with an automatically made continuous graphic record of the total system output. There desired individual graphic records may be obtained showing power flow in or out, on important tie lines, etc. Such arrangements have the very great advantage that loads may be assigned to each generating station so that the best over-all system economy may be obtained and the system operator at all times may see with his own eyes that loads scheduled are actually held at the various stations. Moreover, with such equipment, in the event of system or station trouble the load dispatcher can see exactly what station, or stations, are affected and to what extent, without having to get in touch with anyone by telephone. Decisions can, therefore, be quickly reached for rescheduling the load. One of the most accurate and reliable telemetering systems is based on the use of potentiometric circuits, the fundamentals of which are discussed below. A member of such telemetering systems have been installed for the Boston Edicon Co., Boston, Massachusetts, the Consolidated Edison Co. of New York City. The Public Service Gas & Electric Co. of Newark, new Jersey. The Philadelphia Electric Co. for Philadelphia, Pennsylvania, and the Pennsylvania Railroad Co. for their electrified zone between New York and Washington a distance of over 200 miles. The scale of the totalizing recorder for the New York area is 3,000,00 KW. That of the totalizing recorder for the Philadelphia area is 2,000,000 KW. The initial installation using this type of equipment described was placed in service for the Philadelphia Electric Co. in 1923. All of the original recording instruments are still in service, later instruments have been added to take care of additions to the power system and naturally these later recorders have incorporated in those refinements in design made since the earlier ones were manufactured. Many other installations of similar equipment have been made in the United States in various locations such as at St. Louis, on the West Coast, at Baltimore and in Washington, D.C. While the use of these basic potentiometric circuits involves the use of continuous metallic circuits of good insulation resistance and free of grounds, nevertheless, intermediate transmission links, involving and impulse method suitable for use on telephone Morse carrier channels is available. This same method may be employed on power line carrier systems and is also suitable for use on beam type microwave transmission. Many impulse type units are also used as a link in these potantiometric methods. For the sake of brevity a description is given only of these basic potentiometric circuits. If there is sufficient interest in Korea, a further paper can be given covering those impulse circuits also.

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Finite Element Stress Analysis of Implant Prosthesis according to Position and Direction of Load (하중의 위치 및 경사에 따른 임플랜트 보철의 유한요소법적 응력분석)

  • Bae, Sook-Jin;Chung, Chae-Heon;Jeong, Seung-Mi
    • Journal of Dental Rehabilitation and Applied Science
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    • v.19 no.4
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    • pp.257-268
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    • 2003
  • The purpose of this study was to assess the loading distributing characteristics of implant prosthesis according to position and direction of load, under vertical and inclined loading using FEA analysis. The finite element model was designed according to standard fixture (4.1mm restorative component x 11.5mm length). The crown for mandibular first molar was made using UCLA abutment. Each three-dimensional finite element model was created with the physical properties of the implant and surrounding bone. This study simulated loads of 200N at the central fossa in a vertical direction (loading condition A), 200N at the outside point of the central fossa with resin filling into screw hole in a vertical direction (loading condition B), 200N at the centric usp in a $15^{\circ}$ inward oblique direction (loading condition C), 200N at the in a $30^{\circ}$ inward oblique direction (loading condition D) or 200N at the centric cusp in a $30^{\circ}$ outward oblique direction (loading condition E) individually. Von Mises stresses were recorded and compared in the supporting bone, fixture, and abutment screw. The following results have been made based on this study: 1. Stresses were concentrated mainly at the ridge crest around implant in both vertical and oblique loading but stresses in the cancellous bone were low in both vertical and oblique loading. 2. Bending moments resulting from non-axial loading of dental implants caused stress concentrations on cortical bone. The magnitude of the stress was greater with the oblique loading than with the vertical loading. 3. An offset of the vertical occlusal force in the buccolingual direction relative to the implant axis gave rise to increased bending of the implant. 4. The relative positions of the resultant line of force from occlusal contact and the center of rotation seems to be more important. 5. The magnitude of the stress in the supporting bone, fixture and abutment screw was greater with the outward oblique loading than with the inward oblique loading and was the greatest under loading at the centric cusp in a $30^{\circ}$ outward oblique direction. Conclusively, this study provides evidence that bending moments resulting from non-axial loading of dental implants caused stress concentrations on cortical bone. But it seems to be more important that how long is the distance from center of rotation of the implant itself to the resultant line of force from occlusal contact(leverage). The goal of improving implants should be to avoid bending of the implant.

Finite Element Stress Analysis of Implant Prosthesis of Internal Connection System According to Position and Direction of Load (임플랜트-지대주의 내측연결 시스템에서 하중의 위치 및 경사에 따른 임플랜트 보철의 유한요소 응력분석)

  • Jang, Jong-Seok;Jeong, Yong-Tae;Chung, Chae-Heon
    • Journal of Dental Rehabilitation and Applied Science
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    • v.21 no.1
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    • pp.1-14
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    • 2005
  • The purpose of this study was to assess the loading distributing characteristics of implant prosthesis of internal connection system(ITI system) according to position and direction of load, under vertical and inclined loading using finite element analysis (FEA). The finite element model of a synOcta implant and a solid abutment with $8^{\circ}$ internal conical joint used by the ITI implant was constructed. The gold crown for mandibular first molar was made on solid abutment. Each three-dimensional finite element model was created with the physical properties of the implant and surrounding bone. This study simulated loads of 200N at the central fossa in a vertical direction (loading condition A), 200N at the outside point of the central fossa with resin filling into screw hole in a vertical direction (loading condition B), 200N at the centric cusp in a $15^{\circ}$ inward oblique direction (loading condition C), 200N at the in a $30^{\circ}$ inward oblique direction (loading condition D) or 200N at the centric cusp in a $30^{\circ}$ outward oblique direction (loading condition E) individually. Von Mises stresses were recorded and compared in the supporting bone, fixture, and abutment. The following results have been made based on this study: 1. Stresses were concentrated mainly at the ridge crest around implant under both vertical and oblique loading but stresses in the cancellous bone were low under both vertical and oblique loading. 2. Bending moments resulting from non-axial loading of dental implants caused stress concentrations on cortical bone. The magnitude of the stress was greater with the oblique loading than with the vertical loading. 3. An offset of the vertical occlusal force in the buccolingual direction relative to the implant axis gave rise to increased bending of the implant. So, the relative positions of the resultant line of force from occlusal contact and the center of rotation seems to be more important. 4. In this internal conical joint, vertical and oblique loads were resisted mainly by the implant-abutment joint at the screw level and by the implant collar. Conclusively, It seems to be more important that how long the distance is from center of rotation of the implant itself to the resultant line of force from occlusal contact (leverage). In a morse taper implant, vertical and oblique loads are resisted mainly by the implant-abutment joint at the screw level and by the implant collar. This type of implant-abutment connection can also distribute forces deeper within the implant and shield the retention screw from excessive loading. Lateral forces are transmitted directly to the walls of the implant and the implant abutment mating bevels, providing greater resistance to interface opening.