• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.12
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• pp.136-145
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• 2009

This paper proposes control methods and simulation models of a driving system, which consists of converters and inverters, for high speed trains employing multi-level power converters. The control method of a single phase three-level converter for high-speed trains is designed to use DC values instead of instantaneous current values which are usually used in single-phase application, so that it results in a fast and robust voltage control response. In addition, simulation models of Space Vector Pulse Width Modulation (SVPWM) for single phase three-level converters as well as three level inverters are proposed. Experimental results demonstrate the validity of the simulation model for three-level inverters.

• Food Science of Animal Resources
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• v.35 no.3
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• pp.398-405
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• 2015

Egg allergy has been shown to be the most common food allergy in children with atopic dermatitis. Allergic reactions to proteins derived from egg white (EW) are more common than those derived from egg yolk. Ovomucoid, ovalbumin, ovotransferrin, and lysozyme have been identified as major allergens in EW. This study was conducted to evaluate the effect of EW on immune modulation in an induced allergy mouse model. A total of 50 five-week-old BALB/c male mice were treated with trimellitic anhydride (TMA) for three weeks to induce allergy-like symptoms. The TMA-treated mice were rested for one week and then divided into five groups and fed 0, 10, 50, and 100 mg/d EW for four weeks. All EW consumption groups showed no significant increase or decrease in the populations of white blood cells; however, a significant increase in B-lymphocyte activity was observed in the fourth week. Furthermore, EW consumption did not influence serum immunoglobulin G and immunoglobulin E levels. Taken together, these data demonstrate that the consumption of EW by TMA-treated mice did not increase allergic parameters such as serum IgE level, but enhanced the lymphocyte activities against pathogens. Therefore, this study suggests that the consumption of EW promotes Th2 immune modulation, and EW could be an excellent candidate for maintaining health.

• The Journal of the Acoustical Society of Korea
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• v.36 no.3
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• pp.179-185
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• 2017

The problem that occurred in the design/fabrication/testing of the wideband transmitting power amplifier for an embedded active SONAR (Sound Navigation and Ranging) system operating underwater was analyzed and the solution of the problem was proposed in this paper. Wideband acoustic SONAR systems had been developed in order to improve the underwater detection performance. The underwater acoustic transmission system had been also developed to achieve the wideband SONAR system. In this paper, the wideband acoustic transmission signal was generated using a 2 Level sawtooth type Class D PWM (Pulse Width Modulation) which was not complicated to implement. When the sonar signals having two or more frequencies were simultaneously generated, parasitic frequencies were added to the original signals by integer multiples of the frequency difference of the original signal. To cope with this problem, we proposed a way to remove the parasitic frequency from the source signal through modeling and simulation of the implemented power amplifier and PWM control hardware using MATLAB and Simulink.

• Journal of Power Electronics
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• v.14 no.3
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• pp.478-487
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• 2014

This study presents a new interleaved three-level zero-voltage switching (ZVS) converter for high-voltage and high-current applications. Two circuit cells are operated with interleaved pulse-width modulation in the proposed converter to reduce the current ripple at the input and output sides, as well as to decrease the current rating of output inductors for high-load-current applications. Each circuit cell includes one half-bridge converter and one three-level converter at the primary side. At the secondary side, the transformer windings of two converters are connected in series to reduce the size of the output inductor or switching current in the output capacitor. Based on the three-level circuit topology, the voltage stress of power switches is clamped at $V_{in}/2$. Thus, MOSFETs with 500 V voltage rating can be used at 800 V input voltage converters. The output capacitance of the power switch and the leakage inductance (or external inductance) are resonant at the transition interval. Therefore, power switches can be turned on under ZVS. Finally, experiments verify the effectiveness of the proposed converter.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.11
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• pp.2021-2026
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• 2016

In this paper, a system model for transmission of 3-dimensional (3-D) signals is presented and its performance is analyzed. Unlike 2-D signals, no quadrature form expression for the 3-D signals is available. Exploiting a set of orthogonal basis functions, the 3-D signals are transmitted. As a result of computer simulation using very higher-level signal constellations, the 3-D transmission system has significantly improved error performance as compared with the 2-D system. It is considered that the principal reason for such performance improvement is much increased minimum Euclidean distance (MED) of the 3-D lattice constellations compared with the corresponding 2-D ones. When the MEDs of 2-D and 3-D lattice constellation are compared to confirm the analysis, the MED of 3-D 1024-ary constellation is around 2.6 times larger than that of the quadrature amplitude modulation (QAM). Expanding the constellation size to 4096, the MED of 3-D lattice constellation is increased by 3.2 times of the QAM.

• Preventive Nutrition and Food Science
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• v.22 no.2
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• pp.118-123
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• 2017

This study was conducted to investigate the anti-adipogenic activity of esculetin (ECT) which is reported to be attributable to the modulation of antioxidant enzymes during adipogenesis. After six days of ECT treatment of 3T3-L1 cells, lipid accumulation was determined by Oil red O staining. The levels of glutathione (GSH) and reactive oxygen species (ROS), and the activities of antioxidant enzymes including glutathione reductase, glutathione peroxidase (GPx), and catalase were examined. In addition, the protein expression of glutamate-cysteine ligase catalytic subunit (GCLC) and heme oxygenase-1 (HO-1) was measured by Western blot. ECT significantly inhibited lipid accumulation by approximately 80% and ROS production in a concentration-dependent manner. GSH level and GPx activity were increased by ECT by approximately 1.3-fold and 1.7-fold compared to the control group, respectively. GCLC and HO-1 expression were elevated by ECT. These results showed that ECT treatments strongly inhibit adipogenesis, increase GSH level, and upregulate the expression of GCLC and HO-1, possibly by decreasing ROS production in 3T3-L1 cells during adipogenesis.

• Proceedings of the IEEK Conference
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• 2002.06b
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• pp.165-168
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• 2002

As the demand for higher data-rate chip-to-chip communication such as memory-to-controller, processor-to-processor increases, low cost high-speed serial links\ulcorner become more attractive. This paper describes a 0.25-fm CMOS 1.6Gbps/pin 4-level transceiver using Stub Series Terminated Logic for high Bandwidth. For multi-gigabit/second application, the data rate is limited by Inter-Symbol Interference (ISI) caused by channel low pass effects, process-limited on-chip clock frequency, and serial link distance. The proposed transceiver uses multi-level signaling (4-level Pulse Amplitude Modulation) using push-pull type, double data rate and flash sampling. To reduce Process-Voltage-Temperature Variation and ISI including data dependency skew, the proposed high-speed calibration circuits with voltage swing controller, data linearity controller and slew rate controller maintains desirable output waveform and makes less sensitive output. In order to detect successfully the transmitted 1.6Gbps/pin 4-level data, the receiver is designed as simultaneous type with a kick - back noise-isolated reference voltage line structure and a 3-stage Gate-Isolated sense amplifier. The transceiver, which was fabricated using a 0.25 fm CMOS process, performs data rate of 1.6 ~ 2.0 Gbps/pin with a 400MHB internal clock, Stub Series Terminated Logic ever in 2.25 ~ 2.75V supply voltage. and occupied 500 * 6001m of area.

• The Transactions of the Korean Institute of Power Electronics
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• v.19 no.4
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• pp.376-382
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• 2014

This paper proposes the pulse width modulation (PWM) control strategy for low-speed operation in the three-level neutral-point-clamped (NPC) inverters based on the bootstrap gate drive circuit. As a purpose of the cost reduction, several papers have paid attention to the bootstrap circuit applied to the three-level NPC inverter. However, the bootstrap gate driver IC cannot generate the gate signal to the IGBT for low-speed operation, because the bootstrap capacitor voltage decreases under the threshold level. For low-speed operation, the dipolar and partial-dipolar modulations can be the effective solution. However, these modulations have drawbacks in terms of the switching loss and THD. Therefore, this paper proposes the PWM control strategy to operate the inverter at low-speed and to minimize the switching loss and harmonics. The experimental results are presented to verify the validity on the proposed method.

• Journal of Life Science
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• v.20 no.9
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• pp.1324-1331
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• 2010

Mifepristone (MIF) and Tamoxifen (TAM) have been used in the treatment of prostate cancer and breast cancer for more than a decade. MIF can induce apoptosis in both AR-positive and negative prostate cancer cells. Because of its pleiotropic ligand-receptor properties, TAM exerts cytotoxic activity in estrogen (ER)-positive and various ER.negative cancer cells. However, the molecular mechanisms of these two substances are not yet clear. In the present work, we report that the cytotoxic effects of MIF and TAM are due to the modulation of intracellular $Ca^{2+}$ level in DU-145, androgen-insensitive cells. When the cells were treated with micromolar concentrations of either MIF or TAM, the growth and viability were significantly decreased in a dose- and time-dependent manner. The apoptosis induced by MIF or TAM was further proved and analyzed by confocal laser scanning microscopy (CLSM) and fluorescence-activated cell sorting (FACS). In the cells cultivated in a normal 1.5 mM $Ca^{2+}$ medium, both MIF and TAM also induced an increase of the intracellular $Ca^{2+}$ level in a dose-dependent fashion. Since a change in calcium level could not be found in cells of the $Ca^{2+}$-free medium, the increase of intracellular $Ca^{2+}$ level might be due to an increase in extracellular calcium uptake. Our results show that the apoptotic effect was more prominent in TAM treatment compared to MIF treatment in DU-145 cells. The above findings might be due to the difference in the uppermost pathways of apoptosis induced by either MIF or TAM. When we checked the level of procaspase-8 activation, TAM showed minor level of activation, as opposed to MIF, which exerted strong activation. In both treatments, the levels of anti-apoptotic protein Bcl-2 decreased, and pro-apoptotic protein Bax level increased more than 2-fold. The activation of caspase-3, a key protease enzyme in the downstream pathway of apoptosis, was much higher in the cells treated with TAM, compared to the MIF treatment. The overall apoptotic activity shown in the present work was closely related to intracellular $Ca^{2+}$ concentration levels. Therefore, the cytotoxic activity induced by MIF and TAM might have been due to intracellular calcium modulation.

• Journal of Ginseng Research
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• v.27 no.3
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• pp.120-128
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• 2003

Alternative medicines such as herbal products are increasingly being used for preventive and therapeutic purposes. Ginseng is the best known and most popular herbal medicine used worldwide. In spite of some beneficial effects of ginseng on the nervous system, little scientific evidence shows at the cellular level. In the present study, I have examined the direct modulation of ginseng total saponins and individual ginsenosides on the activation of $Ca^{2+}$ channels and NMDA-gated channels in cultured rat dorsal root ganglion (DRG) and hippocampal neurons, respectively. In DRG neurons, application of ginseng total saponins suppressed high-voltage-activated $Ca^{2+}$ channel currents and ginsenoside Rg$_3$, among the 11 ginsenosides tested, produced the strongest inhibition on $Ca^{2+}$ channel currents. Occlusion experiments using selective $Ca^{2+}$ channel blockers revealed that ginsenoside Rg$_3$ could modulate L-, N-, and P/Q-type currents. In addition, ginsenoside Rg$_3$ also proved to be an active component of ginseng actions on NMDA receptors in cultured hippocampal neurons. Application of ginsenoside Rg$_3$ suppressed NMDA-induced [Ca$^{2+}$]$_{i}$ increase and -gated channels using fura-2-based digital imaging and patch-clamp techniques, respectively. These results suggest that the modulation of $Ca^{2+}$ channels and NMDA receptors by ginsenoside Rg$_3$ could be part of the pharmacological basis of ginseng actions in the peripheral and central nervous systems.ous systems.