• Analytical Science and Technology
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• v.36 no.1
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• pp.53-58
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• 2023

2'-Hydroxy-3',4'-methylenedioxy-3,4,5-trimethoxychalcone (HMTC) is a newly synthesized chalcone that affects proliferation, cytotoxic potential and apoptosis in human leukemia cells. However, no validated determination method has been described so far for HMTC in biological samples. Thus, we developed a liquid chromatographic method using a tandem mass spectrometry to determine HMTC in rat plasma. Liquid-liquid extraction with ethyl acetate was used for the clean-up procedure. The analyte was separated on a reversedphase column with mobile phase of distilled water and acetonitrile (2:8, v/v, including 0.1 % formic acid). The ion transition of the precursor to the product ion was principally deprotonated ions [M-H]^- at m/z 356.8 → 327.2 for HMTC. This analytical method was successfully applied in pharmacokinetic study of HMTC after intravenous administration in rats.

• Geophysics and Geophysical Exploration
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• v.4 no.3
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• pp.70-79
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• 2001

The integral equation method is a powerful tool for numerical electromagnetic modeling. But the difficulty of this technique is the size of the linear equations, which demands excessive memory and calculation time to invert. This limitation of the integral equation method becomes critical in inverse problem. The conventional Born approximation, where the electric field in the anomalous body is approximated by the background field, is very rapid and easy to compute. However, the technique is inaccurate when the conductivity contrast between the body and the background medium is large. Quasi-linear, quasi-analytical and extended Born approximations are novel approaches to 3-D EM modeling based on the linearization of the integral equations for scattered EM field. These approximation methods are much less time consuming than full integral equation method and more accurate than conventional Born approximation. They we, however, still approximate methods for 3-D EM modeling. Iterative series methods such as modified Born, quasi-linear and quasi-analytical can be used to increase the accuracy of various approximation methods. Comparisons of numerical performance against a full integral equation and various approximation codes show that the iterative series methods are very accurate and almost always converge. Furthermore, they are very fast and easy to implement on a computer. In this study, extended Born series method is developed and it shows more accurate result than that of other series methods. Therefore, Iterative series methods, including extended Born series, open principally new possibilities for fast and accurate 3-D EM modeling and inversion.

• Analytical Science and Technology
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• v.36 no.5
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• pp.205-215
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• 2023

In the present study, an analytical method was proposed for detecting trifluralin in aquatic products at trace concentrations. The method employed QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) and gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) as the sample preparation and measurement, respectively. The effect of the aqueous phase volume used in the QuEChERS was demonstrated, and the ratio of 10:10 (mL) between water and acetonitrile phase was used for 5 g of sample. Besides, dSPE using C18 and primary-secondary amine (PSA) was applied to remove the potential interferences from the food matrices, indicating no remarkable analyte loss. The linear range was built up from 0.50 ㎍ L^-1 to 3.0 ㎍ L^-1 (R² = 0.9993). Other criteria, i.e., repeatability (RSD_r = 0.86-1.96 %), reproducibility (RSD_R = 1.09-2.01 %), and recovery (over 90 %), were in accordance with Appendix F of AOAC (2016) for method performance. Although no trifluralin was detected for the commercial samples (fish, shrimp, and breaded shrimp), the spiked samples performed favorable recoveries and precision.

• Journal of the Korean Society of Tobacco Science
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• v.33 no.1
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• pp.28-38
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• 2011

This experiment was conducted as a part of Asia collaborative study on purpose of verifying the difference between CM6 and CM7 including 3R4F for reference. It carried out using various analytical categories for example, main stream, sidestream and Av. smoke. Additional analysis such as physical properties, blending ratio, combustibility and general leaf component analysis also implemented in order to investigate the difference. We complied with ISO standard and CORESTA recommended method during analytical operating procedures. In this study, we described that comparative analytical result for CM6 and CM7 known as reference or monitoring cigarettes including 3R4F for reference. All sample cigarettes were conditioned at $22^{\circ}C$, 60% relative humidity for 48 hours. Av. Smoke, MS and SS smoke analysis were performed over five times with two smoking condition, ISO and Health Canada with the exception of Av. smoke analysis. We complied with ISO standard method during analytical operating procedures. And, we conducted additional analysis, such as physical properties, blending ratio, combustibility and leaf component analysis also in order to investigate the difference. In conclusion, we found out some differences between CORESTA monitoring cigarette No. 6 and No 7. The smoke components such as total particulate matters, NFDPM, nicotine and carbon monoxide contents of CM7 were a little lower than CM6. And, these phenomena were the same as not only main stream smoke but also side stream smoke and Av. smoke. This tendency was consistent with ISO and Health Canada smoking condition. Besides, leaf constituents' color of CM7 was darker than CM6. In case of combustibility, it showed short combustion time approximately 30 seconds.

• Analytical Science and Technology
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• v.12 no.5
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• pp.355-359
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• 1999

Trace cadmium was determined in urine by flame and nameless AAS. Inflame method, cadmium was extracted into MIBK from Cd-DDTC complex. In flameless method, samples were pretreated with 1%, Triton X-100. 1% $HNO_3$ and matrix modifier $Pd(NO_3)_2$. Analysis of cadmium was, performed at $450-750^{\circ}C$ ashing temperature by use of pyrocoated tubes. Results of analysis, flameless method superior in sample treatment and reproducibility to flame method and highest absorbance was obtained at $550^{\circ}C$ ashing temperature. 100 mg/L $Pd(NO_3)_2$ concentration. Proposed method were applied to the determination of cadmium in standard urine Lononorm-Metalle 3.

• Food Science of Animal Resources
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• v.32 no.5
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• pp.571-577
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• 2012

This study was carried out to develop an analytical method for the determination of vitamin D in infant formula. Vitamin D was determined by column-switching high-performance liquid chromatography (HPLC) equipped with a reversed phase column and UV detector after saponification and extraction of the formula with an organic solvent. A preseparation column ($C_8$), focusing column ($C_{18}$), analytical column ($C_{18}$) and UV-Vis detector (254 nm) were used. The limits of detection (LOD) and the limits of quantification (LOQ) for vitamin D were estimated to be $1.51{\mu}g/kg$ and $4.95{\mu}g/kg$, respectively. The linearity, recovery, precision and accuracy of the analytical method for vitamin D were evaluated through the application of a SRM (Standard Reference Material) 1846 (National Institute of Standard & Technology, USA). The linearity of this method was calculated with a value of the coefficient of determination ($r^2$) ${\geq}0.9999$. The recovery of vitamin D was $85.20{\pm}3.00%$. The intra-assay precision for vitamin D was between $1.68{\pm}0.03%$ and $5.75{\pm}0.33%$, and the inter-assay precision for vitamin D ranged from $1.73{\pm}0.03%$ to $2.96{\pm}0.09%$. The intra-assay accuracy for vitamin D was between $100.03{\pm}2.77%$ and $102.01{\pm}0.59%$, and the inter-assay accuracy for vitamin D ranged from $99.00{\pm}1.53%$ to $102.01{\pm}3.04%$. The proposed method is optimal for the separation and quantification of vitamin D from infant formula.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.4
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• pp.48-54
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• 2012

In this paper, quantitative and systematic procedures for establishing Key Performance Indicators (KPI's) of R&D departments are presented. The proposed methodology is composed of 4 steps : 1) identification of critical success factors, 2) identification of potential KPI's, 3) determination of KPI's and 4) monitoring and execution. A Strategy Map has been presented to better align KPI's with a company's competitive strategies. Also, Analytical Hierarchy Planning (AHP) is used to determine weights of KPI's and Data Envelopment Analysis (DEA) is used to analyze the effectiveness of R&D departments. To demonstrate its validity of the proposed method, it has been applied to the R&D divisions of a semiconductor company.

• Structural Engineering and Mechanics
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• v.87 no.5
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• pp.461-473
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• 2023

This study aims to solve for nonlinear cylindrical shell systems with a semi-analytical and numerical approach implementing the P-T method. The procedures and conditions for such a study are presented in practically solving and analyzing the cylindrical shell systems. An analytical model for a nonlinear thick cylindrical shell (TCS) is established on the basis of the stress function and Reddy's higher-order shear deformation theory (HSDT). According to Reddy's HSDT, Hooke's law in three dimensions, and the von-Kármán equation, the stress-strain relations are developed for the thick cylindrical shell systems, and the three coupled nonlinear governing equations are thus established and discretized as per the Galerkin method, for implementing the P-T method. The solution generated with the approach is continuous everywhere in the entire time domain considered. The approach proposed can also be used to numerically solve and analyze the nonlinear shell systems. The procedures and recurrence relations for numerical solutions of shell systems are presented. To demonstrate the application of the approach in numerically solving for nonlinear cylindrical shell systems, a specific nonlinear cylindrical shell system subjected to an external excitation is solved numerically. In numerically solving for the system, the present approach shows higher efficiency, accuracy, and reliability in comparison with that of the Runge-Kutta method. The approach with the P-T method presented is practically sound especially when continuous and high-quality numerical solutions for the shell systems are considered.

• Computers and Concrete
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• v.25 no.5
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• pp.461-470
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• 2020

This paper presents a numerical study on structural behavior of hammer head pier cap beams, extended on verges and reinforced with carbon fiber reinforced polymer (CFRP) plates. A 3-D finite element (FE) model along with a simplified analytical model are presented. Concrete damage plasticity (CDP) was adapted in the FE model and an analytical approach predicting the CFRP anchor strength was adapted in both FE and analytical model. Total five quarter-scaled pier cap beams with various CFRP reinforcing schemes were experimentally tested and analyzed with numerical approaches. Comparison between experimental results, FE results, analytical results and current ACI guideline predictions was presented. The FE results showed good agreement with experimental results in terms of failure mode, ultimate capacity, load-displacement response and strain distribution. In addition, the proposed strut-and-tie based analytical model provides the most accurate prediction of ultimate strength of extended cap beams among the three numerical approaches.

• Geomechanics and Engineering
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• v.30 no.4
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• pp.363-372
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• 2022

One of the most frequent issues in tunnel excavation is the collapse of rock blocks and the dropping of rock fragments from the tunnel face. The tunnel face can be reinforced using a number of techniques. One of the most popular and affordable solutions is the use of face longitudinal dowels, which has benefits including high strength, flexibility, and ease of cutting. In order to examine the reinforced face, this work shows the longitudinal deformation profile and ground response curve for a tunnel face. This approach is based on assumptions made during the analysis phase of problem solving. By knowing the tunnel face response and dowel behavior, the interaction of two elements can be solved. The rock element equation derived from the rock bolt method is combined with the dowel differential equation to solve the reinforced ground response curve (GRC). With a straightforward and accurate analytical equation, the new differential equation produces the reinforced displacement of the tunnel face at each stage of excavation. With simple equations and a less involved computational process, this approach offers quick and accurate solutions. The FLAC3D simulation has been compared with the suggested analytical approach. A logical error is apparent from the discrepancies between the two solutions. Each component of the equation's effect has also been described.