• 분석과학
• /
• 제36권1호
• /
• pp.53-58
• /
• 2023

2'-Hydroxy-3',4'-methylenedioxy-3,4,5-trimethoxychalcone (HMTC) is a newly synthesized chalcone that affects proliferation, cytotoxic potential and apoptosis in human leukemia cells. However, no validated determination method has been described so far for HMTC in biological samples. Thus, we developed a liquid chromatographic method using a tandem mass spectrometry to determine HMTC in rat plasma. Liquid-liquid extraction with ethyl acetate was used for the clean-up procedure. The analyte was separated on a reversedphase column with mobile phase of distilled water and acetonitrile (2:8, v/v, including 0.1 % formic acid). The ion transition of the precursor to the product ion was principally deprotonated ions [M-H]^- at m/z 356.8 → 327.2 for HMTC. This analytical method was successfully applied in pharmacokinetic study of HMTC after intravenous administration in rats.

• 지구물리와물리탐사
• /
• 제4권3호
• /
• pp.70-79
• /
• 2001

적분방정식법은 매우 강력한 3차원 전자탐사 모델링 기법이다. 그러나 이 방법은 이상체내의 전기장 계산시 대형 선형방정식의 해를 구해야 하므로 계산시간이 많이 소요된다는 단점이 있다. 특히 3차원 역산의 경우에는 이러한 적분방정식의 단점은 치명적이 될 수밖에 없다. 이상체내의 전기장을 1차장으로 가정하는 통상적인 Born 근사법은 계산이 용이하고 속도가 빠르다는 장점이 있다. 그러나 이 방법은 이상체와 모암간의 전기전도도비가 너무 클 경우에는 정확성에 문제가 있다. 준선형, 준해석 및 확장된 Born 근사는 이상체내의 전기장 계산을 위한 적분방정식을 선형화한 방법으로 적분방정식법에 비하여 계산시간이 빠르고 통상의 Born 근사에 비해서는 정확성이 높은 매우 훌릉한 3차원 전자탐사 모델링 기법이다. 그러나 이들 또한 근본적으로 근사법에 해당되므로 정확성을 향상시킬 필요가 있다. 근사법의 정확성을 높이기 위한 방법으로 반복적 방법을 사용하는 급수 전개법이 동원되며, 이 방법에는 수정 Born 급수, 준선형 급수 및 준해석 급수 등이 있다. 이들 급수 전개법은 적분방정식법 및 여러 근사법과 비교해 볼 때 매우 정확하고 비교적 빠르며, 항상 수렴하여 그 효율성이 높은 것으로 나타났다. 또한 급수 전개법은 전산프로그램의 작성이 용이하다는 장점도 있다. 본 연구에서는 이를 확장된 Born 급수 전개법으로 화장하여 보다 정확한 결과를 얻을 수 있었다. 따라서 확장된 Born 급수법을 포함하는 각종 급수 전개법은 향후 3차원 전자탐사 모델링 및 역산에 적용 가능한 빠르고 정확한 모델링 기법으로 기대된다.

• 분석과학
• /
• 제36권5호
• /
• pp.205-215
• /
• 2023

In the present study, an analytical method was proposed for detecting trifluralin in aquatic products at trace concentrations. The method employed QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) and gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) as the sample preparation and measurement, respectively. The effect of the aqueous phase volume used in the QuEChERS was demonstrated, and the ratio of 10:10 (mL) between water and acetonitrile phase was used for 5 g of sample. Besides, dSPE using C18 and primary-secondary amine (PSA) was applied to remove the potential interferences from the food matrices, indicating no remarkable analyte loss. The linear range was built up from 0.50 ㎍ L^-1 to 3.0 ㎍ L^-1 (R² = 0.9993). Other criteria, i.e., repeatability (RSD_r = 0.86-1.96 %), reproducibility (RSD_R = 1.09-2.01 %), and recovery (over 90 %), were in accordance with Appendix F of AOAC (2016) for method performance. Although no trifluralin was detected for the commercial samples (fish, shrimp, and breaded shrimp), the spiked samples performed favorable recoveries and precision.

• 한국연초학회지
• /
• 제33권1호
• /
• pp.28-38
• /
• 2011

This experiment was conducted as a part of Asia collaborative study on purpose of verifying the difference between CM6 and CM7 including 3R4F for reference. It carried out using various analytical categories for example, main stream, sidestream and Av. smoke. Additional analysis such as physical properties, blending ratio, combustibility and general leaf component analysis also implemented in order to investigate the difference. We complied with ISO standard and CORESTA recommended method during analytical operating procedures. In this study, we described that comparative analytical result for CM6 and CM7 known as reference or monitoring cigarettes including 3R4F for reference. All sample cigarettes were conditioned at $22^{\circ}C$, 60% relative humidity for 48 hours. Av. Smoke, MS and SS smoke analysis were performed over five times with two smoking condition, ISO and Health Canada with the exception of Av. smoke analysis. We complied with ISO standard method during analytical operating procedures. And, we conducted additional analysis, such as physical properties, blending ratio, combustibility and leaf component analysis also in order to investigate the difference. In conclusion, we found out some differences between CORESTA monitoring cigarette No. 6 and No 7. The smoke components such as total particulate matters, NFDPM, nicotine and carbon monoxide contents of CM7 were a little lower than CM6. And, these phenomena were the same as not only main stream smoke but also side stream smoke and Av. smoke. This tendency was consistent with ISO and Health Canada smoking condition. Besides, leaf constituents' color of CM7 was darker than CM6. In case of combustibility, it showed short combustion time approximately 30 seconds.

• 분석과학
• /
• 제12권5호
• /
• pp.355-359
• /
• 1999

뇨중 미량 카드뮴 분석에 흑연로 장치가 부착된 원자흡수분광광도계(GFAAS)를 사용하였다. 불꽃분광법에서 시료는 회화하여 Na-DDTC로 착물을 형성한 후 MIBK로 추출하였으며, 비불꽃분광법에서는 1% Triton X-100과 1% $HNO_3$으로 5배 희석시킨 후 $Pd(NO_3)_2$를 매트릭스 개선제로 농도를 변화시키면서 회화 온도 $450-750^{\circ}C$에서 pyrocoated 흑연 튜브를 사용하여 분석하였다. 그 결과 불꽃분광법보다는 비불꽃분광법이 전처리가 간단하고 재현성있게 나타났으며, 비불꽃분광법을 이용한 경우 $Pd(NO_3)_2$ 100 mg/L을 사용하여 회화온도 $550^{\circ}C$에서 분석시 가장 높은 흡광도를 나타냈다. 본 분석법을 표준뇨인 Lononorm-Metalle 3 중의 카드뮴 분석에 적용하였다.

• 한국축산식품학회지
• /
• 제32권5호
• /
• pp.571-577
• /
• 2012

This study was carried out to develop an analytical method for the determination of vitamin D in infant formula. Vitamin D was determined by column-switching high-performance liquid chromatography (HPLC) equipped with a reversed phase column and UV detector after saponification and extraction of the formula with an organic solvent. A preseparation column ($C_8$), focusing column ($C_{18}$), analytical column ($C_{18}$) and UV-Vis detector (254 nm) were used. The limits of detection (LOD) and the limits of quantification (LOQ) for vitamin D were estimated to be $1.51{\mu}g/kg$ and $4.95{\mu}g/kg$, respectively. The linearity, recovery, precision and accuracy of the analytical method for vitamin D were evaluated through the application of a SRM (Standard Reference Material) 1846 (National Institute of Standard & Technology, USA). The linearity of this method was calculated with a value of the coefficient of determination ($r^2$) ${\geq}0.9999$. The recovery of vitamin D was $85.20{\pm}3.00%$. The intra-assay precision for vitamin D was between $1.68{\pm}0.03%$ and $5.75{\pm}0.33%$, and the inter-assay precision for vitamin D ranged from $1.73{\pm}0.03%$ to $2.96{\pm}0.09%$. The intra-assay accuracy for vitamin D was between $100.03{\pm}2.77%$ and $102.01{\pm}0.59%$, and the inter-assay accuracy for vitamin D ranged from $99.00{\pm}1.53%$ to $102.01{\pm}3.04%$. The proposed method is optimal for the separation and quantification of vitamin D from infant formula.

• 산업경영시스템학회지
• /
• 제35권4호
• /
• pp.48-54
• /
• 2012

In this paper, quantitative and systematic procedures for establishing Key Performance Indicators (KPI's) of R&D departments are presented. The proposed methodology is composed of 4 steps : 1) identification of critical success factors, 2) identification of potential KPI's, 3) determination of KPI's and 4) monitoring and execution. A Strategy Map has been presented to better align KPI's with a company's competitive strategies. Also, Analytical Hierarchy Planning (AHP) is used to determine weights of KPI's and Data Envelopment Analysis (DEA) is used to analyze the effectiveness of R&D departments. To demonstrate its validity of the proposed method, it has been applied to the R&D divisions of a semiconductor company.

• Structural Engineering and Mechanics
• /
• 제87권5호
• /
• pp.461-473
• /
• 2023

This study aims to solve for nonlinear cylindrical shell systems with a semi-analytical and numerical approach implementing the P-T method. The procedures and conditions for such a study are presented in practically solving and analyzing the cylindrical shell systems. An analytical model for a nonlinear thick cylindrical shell (TCS) is established on the basis of the stress function and Reddy's higher-order shear deformation theory (HSDT). According to Reddy's HSDT, Hooke's law in three dimensions, and the von-Kármán equation, the stress-strain relations are developed for the thick cylindrical shell systems, and the three coupled nonlinear governing equations are thus established and discretized as per the Galerkin method, for implementing the P-T method. The solution generated with the approach is continuous everywhere in the entire time domain considered. The approach proposed can also be used to numerically solve and analyze the nonlinear shell systems. The procedures and recurrence relations for numerical solutions of shell systems are presented. To demonstrate the application of the approach in numerically solving for nonlinear cylindrical shell systems, a specific nonlinear cylindrical shell system subjected to an external excitation is solved numerically. In numerically solving for the system, the present approach shows higher efficiency, accuracy, and reliability in comparison with that of the Runge-Kutta method. The approach with the P-T method presented is practically sound especially when continuous and high-quality numerical solutions for the shell systems are considered.

• Computers and Concrete
• /
• 제25권5호
• /
• pp.461-470
• /
• 2020

This paper presents a numerical study on structural behavior of hammer head pier cap beams, extended on verges and reinforced with carbon fiber reinforced polymer (CFRP) plates. A 3-D finite element (FE) model along with a simplified analytical model are presented. Concrete damage plasticity (CDP) was adapted in the FE model and an analytical approach predicting the CFRP anchor strength was adapted in both FE and analytical model. Total five quarter-scaled pier cap beams with various CFRP reinforcing schemes were experimentally tested and analyzed with numerical approaches. Comparison between experimental results, FE results, analytical results and current ACI guideline predictions was presented. The FE results showed good agreement with experimental results in terms of failure mode, ultimate capacity, load-displacement response and strain distribution. In addition, the proposed strut-and-tie based analytical model provides the most accurate prediction of ultimate strength of extended cap beams among the three numerical approaches.

• Geomechanics and Engineering
• /
• 제30권4호
• /
• pp.363-372
• /
• 2022

One of the most frequent issues in tunnel excavation is the collapse of rock blocks and the dropping of rock fragments from the tunnel face. The tunnel face can be reinforced using a number of techniques. One of the most popular and affordable solutions is the use of face longitudinal dowels, which has benefits including high strength, flexibility, and ease of cutting. In order to examine the reinforced face, this work shows the longitudinal deformation profile and ground response curve for a tunnel face. This approach is based on assumptions made during the analysis phase of problem solving. By knowing the tunnel face response and dowel behavior, the interaction of two elements can be solved. The rock element equation derived from the rock bolt method is combined with the dowel differential equation to solve the reinforced ground response curve (GRC). With a straightforward and accurate analytical equation, the new differential equation produces the reinforced displacement of the tunnel face at each stage of excavation. With simple equations and a less involved computational process, this approach offers quick and accurate solutions. The FLAC3D simulation has been compared with the suggested analytical approach. A logical error is apparent from the discrepancies between the two solutions. Each component of the equation's effect has also been described.