• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.3
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• pp.325-336
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• 2009

The purpose of this study was to investigate the eruption pattern of the mandibular first molar in sagittal, frontal and horizontal views using the cone beam CT scanning. CT images were obtained from healthy 83 children (42 boys, 41 girls) between 3 to 10 years of age with a normal dentition according to Nolla stage. 1. In the frontal and horizontal view, the intermolar width decreased continuously with stage and slightly increased at the last stage. 2. In the sagittal and frontal view, eruption distances from occlusal plane were observed the largest change between stage 5 and 7. 3. In the horizontal and sagittal view, mandibular first molar from distal surface of primary second molar moved distally between stage 4 and 6. 4. In the sagittal view, angle from occlusal plane to mesio-distal axis increased between stage 4 and 8. 5. In the frontal view, angle from occlusal plane to bucco-lingual axis increased continuously during all stage. 6. In the horizontal view, angle from midsagittal plane to long axis increased between stage 5 and 8.

• Journal of Gastric Cancer
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• v.19 no.3
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• pp.329-343
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• 2019

Purpose: Gastric cancer with lymph node metastasis (LNM) more than 15 (N3b) was defined as stage IV until the 6th AJCC system. However, it has been reclassified as a localized disease (stage IIb or III) since the 7th system. The aim of this study is to demonstrate that the survival of N3b is comparable to cytology-only positive (CY1-only) stage IV and to propose a new TNM system interpreting N3b as an eligibility criterion for receiving more intensive chemotherapy regimens. Materials and Methods: 1,430 patients who underwent gastric cancer surgery at Seoul National University Hospital from 2007 to 2012 were retrospectively analyzed. The 5-year survival rate (5YSR) and 3-year recurrence-free survival (RFS) were evaluated according to the 7th and 8th systems, as well as a new categorization based on N-classification; N0-2 (LNM<7), N3a (LNM 7-15), or N3b (LNM>15). Results: The survival of N3b is comparable to that of CY1-only stage IV (log rank test, P=0.671) and is distinct from that of grossly stage IV (log rank test, P<0.001). The survival of the remaining stage IIIc (T4bN3a) was comparable to those of N3b and CY1-only stage IV. Most N3b patients had significantly shorter 3-year RFS and mean RFS than those with IIb-IIIc, as if N3b itself was a higher TNM stage. Conclusions: In terms of survival, T4bN3a, N3b, and CY1-only stage IV were unified as stage IVa, while grossly stage IV was defined as stage IVb. N3b can be regarded as an eligibility criterion for undergoing more intensive chemotherapy regimens.

• The Journal of Korea Robotics Society
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• v.12 no.1
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• pp.78-85
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• 2017

This paper presents the development of a 3D printer based piezo-driven vertical micro-positioning stage. The stage consists of two flexure bridge structures which amplify and transfer the horizontal motion of the piezo-element into vertical motion of the end-effector. The stage is fabricated with ABS material using a precision 3D printer. This enables a one-body design eliminating the need for assembly, and significantly increases the freedom in design while shortening fabrication time. The design of the stage was optimized using response surface analysis method. Experimental results are presented which demonstrate 100nm stepping in the vertical out-of-plane direction. The results demonstrate the future possibilities of applying 3D printers and ABS material in fabricating linear driven motion stages.

• Journal of Embryo Transfer
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• v.12 no.1
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• pp.1-10
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• 1997

The present study was conducted to investigate the influence of embryo cell stage at 18h post-fusion and oocyte preactivation on sebsequent in vitro developmental potential in the nuclear transplant rabbit embryos. The embryos of 16-cell stage were collected and synchronized to G$_1$ phase of 32-cell stage. The recipient cytoplasms were obtained by removing the first polar body and chromosome rnass from the oocytes collected by non-dis-ruptive microsurgery procedure. The separated G$_1$ phase blastomeres of 32-cell stage were injected into non-preactivated recipient cytoplasms. Otherwise, the enucleated recipient cytoplasms were preactivated by electrical stimulation at 18h post-hCG injection and the separated G$_1$ phase blastomeres of 32-cell stage were injected. Mter culture until 20h post-hOG injection, the nuclear transplant oocytes were electrofused by electrical stimulation. The fused nuclear transplant embryos were classified into 3~4-cell, 2-cell and 1-cell stage at 18 hrs post-fusion and cultured until the embryos reached blastocyst stage. The developmental rate to blastocyst stage was significantly (P <0.05) higher in all the reconstituted embryos of 3~4-cell stage(58.0%) than in 2 and icell stage. The developmental rate to blastocyst stage in the embryos of 3~4-cell stage at 18 hrs post-fusion was significantly (P<0.05) higher in the reconstituted without oocyte preactivation(77.8%) than in the oocyte-preactivated embryos (33.3%). These results indicated that the higher rate of in the in vitro development to blastocyst stage might be obtained form the embryos which were reconstituted with nuclear donor of G$_1$ phase and non-preactivated oocyte, and developed more rapidly for 18 hrs post-fusion.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1207-1210
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• 2003

This paper deals with experiments for dynamic characteristics and performance evaluation of the 3-axis fine positioning stage developed in [1]. The features of the developed fine positioning stage are the long stroke due to the magnetically preloaded PZT actuators, the minimum motion crosstalk due to the use of a ball contact mechanism and the compact design. The dynamic characteristics of the actuator and the stage are tested with the preload changed in order to validate the actuator and the stage design. Performance evaluation is also made for the PZT actuators as well as the stage positioning accuracy. Experimental results show that the developed stage is accurate enough to be used for nanometer positioning.

• International Journal of Advanced Culture Technology
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• v.7 no.4
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• pp.96-103
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• 2019

In this paper, we propose two-stage multichannel architecture for oyster product management system, called cloud stage and agent stage. There are two communication channels at each stage. In cloud stage, the embedded system in the smart scale communicates with the server through two channels, Ethernet or 3G/LTE mobile communication. In agent stage, PCs and smart phones called agents communicate with the server also through Internet and 3G/LTE mobile communication. Compared with previous system in which the amount of the oyster produced in oyster workplaces could be monitored only at the console of only one oyster main server, developed system makes it possible to monitor the amount of produced oyster at several PCs (or smart phones). In addition to the amount of oysters produced at all oyster workplaces the environment of oyster workplaces such as temperature and humidity can be monitored on agents to judge the freshness. Two-stage architecture with multiple channels makes it possible to monitor the amount of oyster product and environment of the oyster workplace at any place in real time.

• Journal of Korean Academy of Nursing Administration
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• v.1 no.2
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• pp.268-284
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• 1995

This study was designed to test effects of nursing ethics education (NEE) on moral reasoning and ethical decision making of subjects. This NEE that was teached for 10 hours course was composed of these : Nurses' ethical code, moral responsibility, Moral value and professional accountability, Respect for human life, General ethics, Theory and Norms of biomedical ethics, Ethical decision making model and Discussion about hypothetical ethical dilemmas Twenty-five senior student nurses were sampled from four year college of nursing from Nov. 3rd, 1993 to Nov. 24th, 1993. Data were collected through self-reported questionnaires included two kinds of tests. Rest's Defining Issues Test was adopted to measure the stage of moral development, which was classified with the stage 2 (instrumental relativist orientation), the stage 3 (interpersonal concordance), the stage 4 (law and order), the stage 5A (societal consensus), and the stage 5B (intuitional humanism), the stage 6 (universal ethical practice). In particular, the level of principled thinking (P) was measured by summing these scores of the stages 5A, 5B, and 6. The possible range of P is 0 to 95. As for measuring the levels of morality and nursing dilemma, Crisham's Nursing Dilemma Test was adopted. This test generated the morality score(MS) and the dilemma score (DS). The data were analyzed by t-test, ANOVA, Kruskal-Wallis test, Mc Nemar's test and Pearson correlation coefficients. The results were as follows ; 1. For the Moral Reasoning both before and after NEE, The Mean score of the stage 5A was significantly higher than that of other stages.(P=0.0001) Before NEE, the mean score of the stage 4 was significantly different from stage 2, 3, 5A, and after NEE, different from stage 2, 5B,6. 2. The analysis of change of moral development level revealed that the score of stage 4 increased after NEE.(P=0.0004) 3. The Effect of NEE for the mean score of 5A, 6, P after education was significantly different by birth place. 4. With regard to the five dilemmas postulated such as forcing medication performing cardiac pulmonary resuscitation, reporting a medication error, informing diagnosis to terminally ill adult, and providing new-nurse orientation, the mean score of the MS and the DS was no significant difference with general characteristics of the students. Effect of NEE morality score and dilemma score after education was no significant difference. 5. As for the correlations between moral reasoning and decision making, the score of the stage 2, 5A, 6, DS was positively correlated with the scores of before and after. Positive correlation was also observed between the scores of stage 2 and stage 4, stage 3 and 6. On the other hand, the score of P was negatively correlated with the scores of stage 2 and of stage 4 and of stage 5A. The score of the stage 5A was also negatively correlated with the score of the sge 6.

• The Journal of Engineering Geology
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• v.28 no.3
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• pp.349-365
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• 2018

The strain and acoustic emission (AE) signals of Pocheon granite were measured during uniaxial compression tests to investigate microcrack formation and damage. Crack closure, initiation, and damage stresses of each sample were determined through an analysis of the crack volumetric strain and stiffness. The samples experienced four damage stages according to stress levels: stage 1 = crack closure stage; stage 2 = elastic stage; stage 3 = crack initiation stage; stage 4 = crack damage stage. At least 75% of all AE signals occurred in stages 3 and 4, and different AE parameters were detected in the four stress stages. Rise time, count, energy, and duration clearly showed a tendency to gradually increase with the damage stress stage. In particular, the rise time, energy, and duration increased by at least 95% in stage 4 as compared with stage 1. However, the maximum amplitude showed a smaller increase, and the average frequency decreased slightly at higher stages. These results indicate that as the degree of rock damage increases, the crack size grows larger. The crack types corresponding to the AE signals were determined using the relationship between RA (Rise time / Amplitude) values and average frequencies. Tension cracking was dominant in all stress stages. Shear cracking was rare in stages 1 and 2, but increased in stages 3 and 4. These results are consistent with previous studies that reported cracking begins after samples have already been damaged. Our study shows that the state of rock damage can be investigated solely through an analysis of AE parameters when rocks are under compressive stress. As such, this methodology is suitable for understanding and monitoring the stress state of bedrock.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.5
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• pp.211-217
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• 2007

A nano-imprinting stage has been widely used in various fields of nanotechnology. In this study, an analysis method of a nano-imprinting stage machine using FEM and flexible multi-body kinematics and dynamics has been presented. We have developed a virtual imprinting machine to evaluate the prototype design in the early design stage. The simulation using CAE for the imprinting machine is not only to analyze static and dynamic characteristics of the machine but also to determine design parameters of the components for the imprinting machine, such as dimensions and specifications of actuators and sensors. Structural components as the upper plate, the rotator, the shaft and the translator have been modeled with finite elements to analyze flexibility effects during the precision stage motion. In this paper flexible multi-body dynamic simulation is executed to support robust design of the precision stage mechanism. In addition, we made the 4-axis stage model to compare the dynamic behavior with that of 3-axis stage model.

• Applied Microscopy
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• v.47 no.4
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• pp.242-250
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• 2017

The purpose of this study was to characterize the prenatal and postnatal development of the mouse parotid salivary gland and tooth, and to investigate the relationship between the developmental timing of the two organs. Development of parotid salivary gland begins on embryonic day 15 (E15), which is the prebud stage; E17 is the initial bud stage; E21 to postnatal day 3 (PN3) is the pseudoglandular stage; PN5 to PN10 is the canalicular stage; and PN21 is the terminal bud stage. At E15, the developing maxillary molar tissue is at the bud stage; at E17, it is at the cap stage; at E21, it is at the early bell stage; PN3 to PN5 comprises the advanced bell stage; at PN10, it is at the crown stage; at PN21, it is at the functional stage. Therefore, unlike the other major salivary glands, the development of mouse parotid salivary gland is completed through a process of prenatal and postnatal morphogenesis and becomes functional at about the same time as the developing tooth. The developmental completion times of the parotid salivary gland and tooth are closely related to the weaning time of animal.