• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.11
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• pp.101-106
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• 2014

This paper presents a wide dynamic range radio-frequency (RF) root-mean-square (RMS) power detector using an automatic gain control (AGC) loop. The AGC loop consists of a variable gain amplifier (VGA), RMS conversion block and gain control block. The VGA exploits dB-linear gain characteristic of the cascade VGA. The proposed circuit utilizes full-wave squaring and generates a DC voltage proportional to the RMS of an input RF signal. The proposed RMS power detector operates from 500MHz to 5GHz. The detecting input signal range is from 0 dBm to -70 dBm or more with a conversion gain of -4.53 mV/dBm. The proposed RMS power detector is designed in a 65-nm 1.2-V CMOS process, and dissipates a power of 5 mW. The total active area is $0.0097mm^2$.

• Bulletin of the Korean Chemical Society
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• v.34 no.4
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• pp.1212-1220
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• 2013

The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.

• Korean Journal of Pharmacognosy
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• v.40 no.1
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• pp.77-81
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• 2009

Abies nephrolepis(Pinaceae) extracts were tested for determined immune system regulating activity based on antiinflammatory activity, antioxidant activity and anti-proliferative effect on HeLa cell line. The A. nephrolepis extracts increased dose-dependently anti-proliferation of HeLa cell line. The DM fraction of the extracts having anti-proliferatative effects of HeLa cell line was fractionalized four subfractions($D1{\sim}D4$). Inflammation-induced NO production was inhibited by D2 and D4 in LPS-activated RAW264.7 macrophages. And also, this fractions showed antioxidant activity examined by DPPH radical scavenging effects. These results suggest that the potential use of DM fraction of A. nephrolepis in chemoprevention and regulation overproduction of NO on pathogenic conditions. The mechanism of the inflammatory effects, however, must be evaluated through various parameters in the induction cascade of NO production.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.6
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• pp.195-200
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• 2018

A W-band frequency octupler is implemented on 100-nm GaAs pHEMT process. The fabricated octupler can be used as a local oscillator or a signal source of W-band transceivers. Three common-source doublers are connected in cascade to multiply an input signal of 10.75 GHz to 83 GHz. A common-source amplifier is followed for each doubler to improve the conversion gain and suppress the unwanted harmonics. The fabricated octupler showes high output of more than 6 dBm in the 80 - 84 GHz band and achieved excellent spurious suppression performance over 20 dBc.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.379-386
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• 2021

This study was undertaken to develop a cascade-type continuous culture system (CCCS) that combines both ICT and biotechnology (BT), for the mass production of microalgae. This system is capable of maintaining the essential culture conditions of pH, temperature, carbon dioxide, and illuminance control, which are key parameters for the growth of microalgae, and is economical for producing microalgae regardless of the season or location. It has the added advantage of providing stable and high productivity. In the current study, this system was applied to culture microalgae for 71 days, with subsequent analysis of the experimental data. The initial O.D. of the culture measured from incubator 1 was 0.006. On the 71st day of culture, the O.D.s obtained were 0.399 (incubator 1), 0.961 (incubator 2), 0.795 (incubator 3), and 0.438 (incubator 4), thereby confirming the establishment of continuous culture. Thus, we present a smart-farm based on ISMC (in-situ monitoring and control) for a mass culture method. We believe that this developed technology is suitable for commercialization, and has the potential to be applied to hydroponics-based cultivation of microalgae and cultivation of high-value-added medicinal plants as well as other plants used in functional foods, cosmetics, and medical materials.

• BMB Reports
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• v.43 no.7
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• pp.485-490
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• 2010

Neurotrophins regulate many aspects of neuronal function through activation of the high affinity Trk receptors. Shc family proteins are implicated in the coupling of RTK to the Ras/mitogen-activated protein kinase signaling cascade. Here we report that the fourth Shc family member, ShcD, associates with TrkB receptor and regulates BDNF-induced MAPK activation. Yeast two-hybrid assay and Co-IP experiments demonstrate ShcD interacts with TrkB in a kinase-activity-dependent manner. Confocal analysis shows ShcD cololizes well with TrkB in transfected 293T cells. Subsequent mapping experiments and mutational analysis indicate that both PTB and SH2 domains are capable of binding to TrkB and PTB domain binds to TrkB NPQY motif. Furthermore, ShcD is involved in BDNF-induced MAPK activation. In summary, we demonstrate that ShcD is a substrate of TrkB and mediates TrkB downstream signaling pathway.

• ETRI Journal
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• v.31 no.3
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• pp.254-262
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• 2009

This paper presents a novel simple filter design method based on a parallel short-ended coupled-line structure with capacitive loading for size reduction and ultra-broad rejection of spurious passbands. In addition, the introduction of a cross-coupling capacitor into the miniaturized coupled-line can create a transmission zero at the second harmonic frequency for better frequency selectivity and attenuation level. The aperture compensation technique is also applied to achieve a strong coupling in the coupled-line section. The influence of using the connecting transmission line to cascade two identical one-stage filters is studied for the first time. Specifically, such a two-stage bandpass filter operating at 2.3 GHz with a fractional bandwidth of 10% was designed and realized with low-temperature co-fired ceramic technology for application in base stations that need high power handling capability. It achieved attenuation in excess of -40 dB up to $4f_0$ and low insertion loss of -1.2 dB with the size of 10 mm ${\times}$ 7 mm ${\times}$ 2.2 mm. The measured and simulated results showed good agreement.

• Journal of information and communication convergence engineering
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• v.8 no.5
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• pp.575-580
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• 2010

Eye gaze as a form of input was primarily developed for users who are unable to use usual interaction devices such as keyboard and the mouse; however, with the increasing accuracy in eye gaze detection with decreasing cost of development, it tends to be a practical interaction method for able-bodied users in soon future as well. This paper explores a low-cost, robust, rotation and illumination independent eye gaze system for gaze enhanced user interfaces. We introduce two brand-new algorithms for fast and sub-pixel precise pupil center detection and 2D Eye Gaze estimation by means of deformable template matching methodology. In this paper, we propose a new algorithm based on the deformable angular integral search algorithm based on minimum intensity value to localize eyeball (iris outer boundary) in gray scale eye region images. Basically, it finds the center of the pupil in order to use it in our second proposed algorithm which is about 2D eye gaze tracking. First, we detect the eye regions by means of Intel OpenCV AdaBoost Haar cascade classifiers and assign the approximate size of eyeball depending on the eye region size. Secondly, using DAISMI (Deformable Angular Integral Search by Minimum Intensity) algorithm, pupil center is detected. Then, by using the percentage of black pixels over eyeball circle area, we convert the image into binary (Black and white color) for being used in the next part: DTBGE (Deformable Template based 2D Gaze Estimation) algorithm. Finally, using DTBGE algorithm, initial pupil center coordinates are assigned and DTBGE creates new pupil center coordinates and estimates the final gaze directions and eyeball size. We have performed extensive experiments and achieved very encouraging results. Finally, we discuss the effectiveness of the proposed method through several experimental results.

• Journal of the Korean Chemical Society
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• v.34 no.1
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• pp.1-9
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• 1990

Cholesteryl pentanoate $(C_{32}O_2H_{54})$ is orthorhombic, space group $P2_12_12_1$, with a = 21.930(3), b = 21.404(3), c = 6.419(5) $\AA$, Z = 4, V = 3012.8(5)$\AA$$^3$, $D_c$ = 1.04 g$cm^{-3}$, ${\lambda}(Mo\; K{\alpha}$ = 0.71069 $\AA$, $\mu$ = 0.58 $cm^{-1}$, F(000) = 1048, T = 298, R = 0.086 for 1502 unique observed reflections with I > 1.0 $\sigma$ (I). The structure was solved by direct methods and refined by cascade diagonal least-squares refinement. The C-H bond lengths and the methyl groups are fixed and refined as their ideal geometry. A comparison with other cholesteryl esters gives normal structure for the tetracyclic ring, while the tail regions of the side chain and the ester group which stands on end, show a variation from their normal values, presumably due to thermal effects. The molecules are stacked together by non-bonded van der Waals forces with the shortest intermolecular distance of 3.529 $\AA$.

• The KSFM Journal of Fluid Machinery
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• v.7 no.2 s.23
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• pp.14-20
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• 2004

In this study, the overall performance and the local flow field of the centrifugal compressor with the refrigerant HFC-l34a were numerically studied using CFX-TASCflow. The thermodynamic and transport properties of the refrigerant gas were modeled by REFPROP which is NIST refrigerant properties database. The impacts of a grid qualify, discretization scheme, turbulent model and interaction between a impeller and a cascade diffuser were analyzed comparatively. The results were compared with experimental data and 1-D design results using COMPAL and agreed well with others. The numerical method and data obtained in this study can be applied to the design and modification of centrifugal compressors with real gases