• 한국해안·해양공학회논문집
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• 제20권2호
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• pp.168-175
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• 2008

군장 국가산업단지(장항지구) 조성공사 후 단지를 가로지르는 솔리천 하구에 새로 건설될 배수갑문 설계안에 대해 축척모형을 제작하고 현장과 동일한 수리조건을 적용한 수리모형실험을 수행하여 통수능력을 검토함과 동시에 결과의 신뢰도 확보를 위해 상용 3차원 전산유체역학 코드인 FLOW-3D를 이용하여 수치모의를 실시하였다. 수리모형실험과 수치모의에서는 얻어진 통수능은 유사한 결과를 보여주었다.

• 한국물환경학회지
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• 제31권1호
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• pp.35-41
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• 2015

This study focuses on whether a physical habitat model, River2D, is useful to assess and design stream restoration. To achieve the aim, the habitat suitability for Zacco Platypus was analyzed using River2D at midstream of the Anyang-Cheon through modifying the low flow channel and changing the flow discharge. The River2D simulation results show that the inhabited environment for Zacco Platypus is improved by increasing the sinuosity of the low flow channel, and vice versa. Also the inhabited environment for Zacco Platypus gets worse when there is no additional flow for maintenance water supply at the stream flowing through cities. In this respect, the physical habitat simulation study based on the River2D model is useful because it provides a practical guidance in designing stream restoration.

• Ocean Systems Engineering
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• 제7권2호
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• pp.107-120
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• 2017

Spud-can is used for fixing jack-up rig on seabed. It needs to be inserted up to the required depth during the installation process to secure enough soil reaction and prevent overturning accidents. On the other hand, it should be extracted from seabed soils as fast as possible during the extraction process to minimize the corresponding operational cost. To achieve such goals, spud-can may be equipped with water-jetting system including monitoring and control. To develop such a smart spud-can, a reliable numerical simulation tool is essential and it has also to be validated against physical model tests. In this regard, authors developed a numerical simulation tool by using a commercial program ANSYS with extended Drucker-Prager (EDP) formula. Authors also conducted small-scale (1/100) physical model tests for verification and calibration purpose. By using the numerical model, a systematic parametric study is conducted both for sand and K(kaolin)-clay with varying important soil parameters and the best estimated soil properties of the physical test are deduced. Then, by using the selected soil properties, the numerical and experimental results for a sand/K-clay multi-layer case are cross-checked to show reasonably good agreement. The validated numerical model will be useful in the next-stage study which includes controllable water-jetting.

• Geomechanics and Engineering
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• 제2권2호
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• pp.89-106
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• 2010

Sliding within the dam foundation is one of the key failure modes of a gravity dam. A two-dimensional (2-D) physical model test has been conducted to study the sliding failure of a concrete gravity dam under overloading conditions. This model dam was instrumented with strain rosettes, linear variable displacement transformers (LVDTs), and embedded fiber Bragg grating (FBG) sensing bars. The surface and internal displacements of the dam structure and the strain distributions on the dam body were measured with high accuracy. The setup of the model with instrumentation is described and the monitoring data are presented and analyzed in this paper. The deformation process and failure mechanism of dam sliding within the rock foundation are investigated based on the test results. It is found that the horizontal displacements at the toe and heel indicate the dam stability condition. During overloading, the cracking zone in the foundation can be simplified as a triangle with gradually increased height and vertex angle.

• 한국해안·해양공학회논문집
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• 제20권2호
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• pp.184-193
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• 2008

아산호 상류지역의 도시화 진행과 이상 기후 등에 따른 강수량 증가로 아산만 방조제 배수갑문 확장의 필요성이 제기됨에 따라 배수갑문 확장으로 인한 방류량 증가가 아산만 및 주변 해역에 미치는 영향을 수리모형실험과 범용 수치모의 코드인 Delft3D, FLOW-3D를 이용하여 검토하였다. 그 결과 아산만 방조제 배수갑문확장에 의한 영향은 미흡한 것으로 확인되었다.

• 대한의생명과학회지
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• 제29권4호
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• pp.263-273
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• 2023

This study aimed to investigate effect of scalp acupuncture (SA) and repetitive transcranial magnetic stimulation (rTMS) intervention on neuromotor function in photothrombotic cerebral infarction (PCI) rat model. Sixty male SD rats were used. PCI was induced on M1 cortex of right frontal lobe. SA was performed at the Qianding (GV21), Xuanli (GB6) acupoints of ipsilesional M1. Low-frequency rTMS was delivered to contralesional M1. All rats were randomly divided into 4 groups: group A, normal (n, 15); group B, PCI without any stimulation intervention (n, 15); group C, PCI with SA (n, 15); group D, PCI with rTMS (n, 15). Rota-rod test and Ladder rung walking test (LWT) were done weekly for 8 weeks after PCI. SA or rTMS was started from post-PCI 4^th day as protocol for 8 weeks. H/E stain and IHC were done. Western blot and qRT-PCR study were performed for MAP2 and BDNF from ipsilesional M1 peri-infarction tissue. Brain MRI study was conducted to quantify the volume of cerebral infarction. As a result, left forelimb and hindlimb function significantly improved more in group C and D than control group, with expressed more BDNF and MAP2. And brain MRI showed focal infarction of right M1 after PCI, and infarction volume progressively decreased in group C and D than group B from post-PCI 5^th to 8^th week. SA or rTMS was more effective than no intervention group on neuromotor function of PCI rat model. The functional recovery was associated with stimulation intervention-related neurogenesis.

• Geomechanics and Engineering
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• 제6권6호
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• pp.593-612
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• 2014

The uplift response of symmetrical square anchor plates has been evaluated in physical model tests and numerical simulations using Plaxis. The behavior of square anchor plates during uplift test was studied by experimental data and finite element analyses in loose sand. Validation of the analysis model was also carried out with 50 mm, 75 mm and 100 mm Length square plates in loose sand. Agreement between the uplift responses from the physical model tests and finite element modeling using PLAXIS 2D, based on 100 mm computed maximum displacements was excellent for square anchor plates. Numerical analysis using square anchor plates was conducted based on the hardening soil model (HSM). The research has shown that the finite element results are higher than the experimental findings in loose sand.

• 보건교육건강증진학회지
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• 제30권1호
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• pp.27-39
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• 2013

Objectives: The purpose of the study was to test a model of physical activity of elderly living in Korea, determine significant factors contributing the physical activity, and examine significant paths in the model. Methods: A cross-sectional study was conducted using a convenience sample of 207 elderly men and women, aged 60 and older, residing in Busan Metropolitan City. Data were collected from July to August 2009 and analyzed using Predictive Analytics Software (PASW) and Analysis of a Moment Structures (AMOS). Results: The fitness of the modified model was confirmed to be appropriate (${\chi}^2$ = 55.61, ${\chi}^2$/df = 1.32, p = .078, RMSEA = .04, GFI = .96, AGFI = .91, NFI = .90, NNFI = .94, CFI = .97, PNFI = .48). The elder's age, previous exercise behavior, and self-efficacy were significant in explaining the variance in their physical activity. We found that (a) perceived health status, perceived benefits, perceived barriers, and social support directly affected self-efficacy; (b) previous exercise behavior and perceived health status directly affected perceived benefits; (c) previous exercise behavior directly affected perceived barriers; and (d) and education level, extent of pocket money, and economic level directly affected social support. Conclusions: The younger the age, the more previous exercise experience, and the higher the self-efficacy, the more S. Korean elders demonstrated improved physical activity.

• Bulletin of the Korean Chemical Society
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• 제33권4호
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• pp.1123-1127
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• 2012

P-gp (P-glycoprotein) is a member of the ATP binding cassette (ABC) family of transporters. It transports many kinds of anticancer drugs out of the cell. It plays a major role as a cause of multidrug resistance (MDR). MDR function may be a cause of the failure of chemotherapy in cancer and influence pharmacokinetic properties of many drugs. Hence classification of candidate drugs as substrates or nonsubstrate of the P-gp is important in drug development. Therefore to identify whether a compound is a P-gp substrate or not, in silico method is promising. Recursive Partitioning (RP) method was explored for prediction of P-gp substrate. A set of 261 compounds, including 146 substrates and 115 nonsubstrates of P-gp, was used to training and validation. Using molecular descriptors that we can interpret their own meaning, we have established two models for prediction of P-gp substrates. In the first model, we chose only 6 descriptors which have simple physical meaning. In the training set, the overall predictability of our model is 78.95%. In case of test set, overall predictability is 69.23%. Second model with 2D and 3D descriptors shows a little better predictability (overall predictability of training set is 79.29%, test set is 79.37%), the second model with 2D and 3D descriptors shows better discriminating power than first model with only 2D descriptors. This approach will be used to reduce the number of compounds required to be run in the P-gp efflux assay.

• 한국보건간호학회지
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• 제31권2호
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• pp.220-233
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• 2017

Purpose: This study compared the body composition and health conservation of low and high physical activity groups in professional retired elderly. Methods: The participants were 132 professional retired elders using a university of education for the elderly and senior welfare centers in D and K city. Data were collected through interviews from November to December in 2015. The body composition was measured using an Inbody 230 and the health conservation was measured using Sung's (2005) Health Conservation Scale. The low and high physical activity groups were divided by CHAMPS (The Community Healthy Activities Model Program for Seniors Questionnaire). The collected data were analyzed using a $x^2$ test, independentt-test, andbinary logistic regression using the SPSS/WIN 20.0 program. Results: The body composition (body mass index, body fat percentage, and fitness score) and health conservation score were higher in the high physical activity group than in the low physical activity group. The result shows that the body weight (OR=10.62) is the highest risk factor influencing the physical activity in professional career-retired elders. Conclusion: These results suggest that to induce physical activity level among professional retired elders, nursing interventions are needed to increase the health conservation and body composition, particularly in controlling the body weight.