• 정보학연구
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• 제8권1호
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• pp.95-112
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• 2005

This paper will look into the Main Substance and Some Problems of 24 hours Advance Cargo Manifest Declaration Rule, focuses on the Policy implication of Korea's and counter measures of our parties concerned about 24-hour advance vessel manifest rule. The 24-hour rule requires cargo owners to submit cargo manifest information to U.S. Customs 24 hours before vessel sailing from the final foreign port to a U.S. port. Cargo manifest information must be complete, accurate, and timely. As of February 2, 2003 manifest information can be submitted by paper or electronically. Cargo descriptions must be at a level of detail consistent with Harmonized Tariff Schedule (HTS) codes used by U.S. Customs. HTS codes are 10 digits. Electronic submissions are made via the Automated Manifest System (AMS) run by U.S. Customs.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5123-5126
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• 2014

Background: To evaluate the diagnostic performance of IOTA simple rules in differentiating between benign and malignant ovarian tumors. Materials and Methods: A study of diagnostic performance was conducted on women scheduled for elective surgery due to ovarian masses between March 2007 and March 2012. All patients underwent ultrasound examination for IOTA simple rules within 24 hours of surgery. All examinations were performed by the authors, who had no any clinical information of the patients, to differentiate between benign and malignant adnexal masses using IOTA simple rules. Gold standard diagnosis was based on pathological or operative findings. Results: A total of 398 adnexal masses, in 376 women, were available for analysis. Of them, the IOTA simple rules could be applied in 319 (80.1%) including 212 (66.5%) benign tumors and 107 (33.6%) malignant tumors. The simple rules yielded inconclusive results in 79 (19.9%) masses. In the 319 masses for which the IOTA simple rules could be applied, sensitivity was 82.9% and specificity 95.3%. Conclusions: The IOTA simple rules have high diagnostic performance in differentiating between benign and malignant adnexal masses. Nevertheless, inconclusive results are relatively common.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3835-3838
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• 2015

Objective: To evaluate the diagnostic performance of IOTA simple rules in predicting malignant adnexal tumors by non-expert examiners. Materials and Methods: Five obstetric/gynecologic residents, who had never performed gynecologic ultrasound examination by themselves before, were trained for IOTA simple rules by an experienced examiner. One trained resident performed ultrasound examinations including IOTA simple rules on 100 women, who were scheduled for surgery due to ovarian masses, within 24 hours of surgery. The gold standard diagnosis was based on pathological or operative findings. The five-trained residents performed IOTA simple rules on 30 patients for evaluation of inter-observer variability. Results: A total of 100 patients underwent ultrasound examination for the IOTA simple rules. Of them, IOTA simple rules could be applied in 94 (94%) masses including 71 (71.0%) benign masses and 29 (29.0%) malignant masses. The diagnostic performance of IOTA simple rules showed sensitivity of 89.3% (95%CI, 77.8%; 100.7%), specificity 83.3% (95%CI, 74.3%; 92.3%). Inter-observer variability was analyzed using Cohen's kappa coefficient. Kappa indices of the four pairs of raters are 0.713-0.884 (0.722, 0.827, 0.713, and 0.884). Conclusions: IOTA simple rules have high diagnostic performance in discriminating adnexal masses even when are applied by non-expert sonographers, though a training course may be required. Nevertheless, they should be further tested by a greater number of general practitioners before widely use.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4377-4380
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• 2016

Background: To compare diagnostic performance in differentiating benign from malignant ovarian masses between IOTA (the International Ovarian Tumor Analysis) simple rules and subjective sonographic assessment. Materials and Methods: Women scheduled for elective surgery because of ovarian masses were recruited into the study and underwent ultrasound examination within 24 hours of surgery to apply the IOTA simple rules by general gynecologists and to record video clips for subjective assessment by an experienced sonographer. The diagnostic performance of the IOTA rules and subjective assessment for differentiation between benign and malignant masses was compared. The gold standard diagnosis was pathological or operative findings. Results: A total of 150 ovarian masses were covered, comprising 105 (70%) benign and 45 (30%) malignant. Of them, the IOTA simple rules could be applied in 119 (79.3%) and were inconclusive in 31 (20.7%) whereas subjective assessment could be applied in all cases (100%). The sensitivity and the specificity of the IOTA simple rules and subjective assessment were not significantly different, 82.9% vs 86.7% and 94.0% vs 94.3% respectively. The agreement of the two methods in prediction was high with a Kappa index of 0.835. Conclusions: Both techniques had a high diagnostic performance in differentiation between benign and malignant ovarian masses but the IOTA rules had a relatively high rate of inconclusive results. The IOTA rules can be used as an effective screening technique by general gynecologists but when the results are inconclusive they should consult experienced sonographers.

• 대한한의학회지
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• 제18권2호
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• pp.108-118
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• 1997

In our study, we tried to quantify Qi through establishing the interpretive method which would be used for inspecting the interrelationship between the Qi in Oriental Medicine and the physiological signals measured at the acupoint. We found out that some physiological signals measured at the acupoint of Meridian could be considered as a scientific Qi. Circulation rules of Qi probating the linkage between physiological signals and Qi are presented as promoting and counteracting rules of the Five Evolutive Phases within the traditional Oriental medicine literatures. We found that promoting and counteracting relations of the Five Evolutive Phases based on the New table about the rule of causing unbalance state(nTRCUS) can be widely used as a interpreting device for verifying the interrelation of human physiological signals and Qi. Standardizing the measured physiological signals into percentage could make relative comparison and judgement of the Five Evolutive Phases deviation possible. Though the physiological signals measured by instruments have different physical values, we could have the interpretation by the same promoting and counteracting rules of the Five Enolutive Phases. We measured EAV indices for 24 hours and discussed them in the view of Qi Circulation in Meridian.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4773-4780
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• 2014

Background: To investigate the effects of small interference RNA (siRNA) targeting BCR/ABL mRNA on proliferation and apoptosis in the K562 human chronic myeloid leukemia (CML) cell line and to provide a theoretical rationale and experimental evidence for its potential clinical application for anti-CML treatment. Materials and Methods: The gene sequence for BCR/ABL mRNA was found from the GeneBank. The target gene site on the BCR/ABL mRNA were selected according to Max-Planck-Institute (MPI) and rational siRNA design rules, the secondary structure of the candidate targeted mRNA was predicted, the relevant thermodynamic parameters were analyzed, and the targeted gene sequences were compared with BLAST to eliminate any sequences with significant homology. Inhibition of proliferation was evaluated by MTT assay and colony-formation inhibiting test. Apoptosis was determined by flow cytometry (FCM) and the morphology of apoptotic cells was identified by Giemsa-Wright staining. Western blotting was used to analyze the expression of BCR/ABL fusion protein in K562 cells after siRNA treatment. Results: The mRNA local secondary structure calculated by RNA structure software, and the optimal design of specific siRNA were contributed by bioinformatics rules. Five sequences of BCR/ABL siRNAs were designed and synthesized in vitro. Three sequences, siRNA1384, siRNA1276 and siRNA1786, which showed the most effective inhibition of K562 cell growth, were identified among the five candidate siRNAs, with a cell proliferative inhibitory rate nearly 50% after exposure to 12.5nmol/L~50nmol/L siRNA1384 for 24,48 and 72 hours. The 50% inhibitory concentrations ($IC_{50}$) of siRNA1384, siRNA1276 and siRNA1786 for 24hours were 46.6 nmol/L, 59.3 nmol/L and 62.6 nmol/L, respectively, and 65.668 nmol/L, 76.6 nmol/L, 74.4 nmol/L for 72 hours. The colony-formation inhibiting test also indicated that, compared with control, cell growth of siRNA treated group was inhibited. FCM results showed that the rate of cell apoptosis increased 24 hours after transfecting siRNA. The results of annexinV/PI staining indicated that the rate of apoptosis imcreased (1.53%, 15.3%, 64.5%, 57.5% and 21.5%) following treamtne with siRNAs (siRNA34, siRNA372, siRNA1384, siRNA1276 and siRNA1786). Morphological analysis showed td typical morphologic changes of apoptosis such as shrunken, fragmentation nucleus as well as "apoptotic bodies" after K562 cell exposure to siRNA. Western blot analysis showed that BCR/ABL protein was reduced sharply after a single dose of 50nmol/L siRNA transfection. Conclusions: Proliferation of K562 cells was remarkbly inhibited by siRNAs (siRNA1384, siRNA1276 and siRNA1786) in a concentration-dependent manner in vitro, with effective induction of apoptosis at a concentration of 50 nmol/L. One anti-leukemia mechanism in K562 cells appeared that BCR/ABL targeted protein was highly down-regulated. The siRNAs (siRNA1384, siRNA1276 and siRNA1786) may prove valuable in the treatment of CML.

• 지능정보연구
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• 제28권4호
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• pp.287-308
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• 2022

최근 비트코인을 필두로한 암호화폐의 폭발적인 성장이 금융 시장의 주요 이슈로 떠오르고 있다. 이에 전 세계적인 암호화폐 투자의 관심이 증가하고 있지만, 24시간 365일 운영되는 시장과 가격 변동성, 그리고 기하 급수적으로 증가하고 있는 암호화폐 종류는 암호화폐 투자자들에게 리스크로 제공되고 있어, 특히 암호화폐 포트폴리오를 구상하는데 있어 추천에 적합하지 않는 암호화폐들을 구분하여 투자자들의 리스크를 감소시킬 수 있는 연구의 필요성이 제기되고 있다. 이에 본 논문은 기존에 있었던 단순히 암호화폐 가격의 미래를 예측하여 수익률을 극대화 하거나, 수익률에 초점을 맞추어 암호화폐 포트폴리오를 구성하는 연구들과 달리, 투자자들의 성향을 반영하고, 투자에 적합한 암호화폐를 머신러닝 기법 중 하나인 Apriori 알고리즘을 활용하여 추천하되, 추천에 적합한 알트코인들을 비트코인의 유사도와 연관규칙을 중심으로 선별하여, 투자자들의 리스크를 감소시킬 수 있는 적합한 추천 방식과 해석을 제시한다.

• 한국농공학회논문집
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• 제59권4호
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• pp.17-26
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• 2017

In this study, EPANET model which is using on the pipe network analysis was applied to Haenam irrigation district has provided irrigation water by pipeline system about 1,125ha and then have built pipe network to study area and supply performance evaluation of existing structure was analyzed by SPA (Single Period Analysis) in EPANET. As model results of simulation average ratio of maximum supply quantity/irrigation water requirements(base demand) was analyzed by 2.63. It means also that was analyzed as being capable of ensuring the water supply capacity. It was provided the necessary information for the maintenance facility through analyzed hydraulic behaviors in the pipeline inside such as flow velocities, pressures and hydraulic grade lines. It was satisfied with the allowable design criteria that was compared analyzed results with presented allowable design standards at agricultural production infra improvement project planning and design (Pipeline design standard). In order to analyze efficiency promotions of irrigation water, using Extended Period Simulation it was compared supply quantity with irrigation water requirements while pumps set operating pattern in 24 hours, then efficiency promotions of irrigation water was determined through analyzed oversupply water quantity and occurrence time by branch lines. According to results for oversupply quantity in Haenam district by time and end of branch lines efficiency promotions of irrigation water was suggested from 0.33 % to 37.59 %. To draw reasonable operating rules for water use and through this research, it is expected to be helpful for efficient water use and operational management of agricultural pipeline system to the current agricultural irrigation.

• 항공우주정책ㆍ법학회지
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• 제28권2호
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• pp.63-96
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• 2013

지난 2010년 제정되어 2011년 8월과 10월에 개정된 미국 교통부의 행정입법 '항공 여객의 보호증진에 관한 법규(Enhancing Airline Passenger Protections, EAPP)'는 항공 소비자의 보호를 위한 연방정부의 입법으로 우리에게 시사하는 바가 크다. 특히 오늘날 장시간 활주로 지연과 관련한 항공사의 의무사항, 항공사의 고객 서비스강화, 항공권 광고와 판매 시에 발생하는 문제점 인식 등을 감안할 때 항공업계의 현 시류를 잘 반영하고 있다. 먼저, 장시간 활주로 지연과 관련하여 국내선 3시간, 국제선 4시간을 초과하는 활주로 대기 금지, 활주로에서 2시간 이상 대기 시 승객에게 물과 음식 제공, 화장실과 의료서비스 상시 제공, 지연발생 최초 30분과 이후 매 30분 간격으로 진전사항 공지 및 항공기 출입문이 열려있을 때 승객의 하기 가능성 안내 등이 규정되어 있다. 그 밖에도 고객서비스에 관한 절차와 계획의 수립을 비롯하여 그러한 계획을 활주로 지연에 관한 비상계획절차, 운송약관 등과 함께 항공사의 인터넷 웹사이트에 공시할 의무도 부과 하였다. 또한 고객 불만사항 처리를 위해 각 항공사는 모니터링 전담자를 배치하여야 하고, 고객 불만사항 처리시한도 법으로 마련되었다. 그리고 최근 이용자가 많은 SNS를 통한 고객 불만사항 처리에 관한 규정도 도입되었다. 또한 항공권 초과판매로 인한 비자발적 탑승거부 상황에 대한 규정도 마련하였다. 즉, 자발적 탑승 유예자 모집 시에 지급 대가를 명확히 제시하고, 비자발적 탑승거부승객에 대한 배상기준도 마련하였다. 또한, 항공권 판매광고 시에 총액운임 표시제도를 도입하였다. 이에 따르면 항공권 광고에서 항공운임은 실제 소비자가 구매할 때 지급하여야 하는 총액운임을 표시하여야 하며, 항공권 구매를 조건으로 기타 여행상품과의 묶음판매도 규제하고 있다. 이와 같은 법규가 시행된 이후 여러 건의 법적 쟁송이 있었다. 그 주요한 사건으로 우선, 스피릿 항공사건을 들 수 있다. 이 사건은 원고 항공사들이 법 내용 중 총액운임 표시제, 환불규정, 구매 후 추가 지불금지 규정이 자사의 헌법상 권리인 표현의 자유를 침해할 뿐만 아니라 그 법규의 내용이 지나치게 자의적이고 일관성이 없으므로 무효라고 주장하였다. 이 밖에도 상당수 법규 위반 사례가 확인되었는데 대표적인 사건이 유나이티드 항공사건이라 할 수 있다. 본 사안에서 유나이티드 항공은 장시간 활주로 지연상황에서 승객들에게 하기가능 사항을 적절히 고지하지 않았고, 그러한 지연상황을 DOT에 보고하면서 일부 사항을 누락시켜 문제가 되었다. 한편, 이러한 시대적 요구에 발맞추어 최근 우리 항공법도 항공 소비자 보호에 관한 규정을 추가하였다. 하지만 활주로 지연과 관련한 다양한 피해구제책의 마련, 항공권 초과판매에 따른 비자발적 탑승거절에 따른 보상기준 제시, 항공권 광고 시에 운임표시에 관한 총액 운임제의 기준 마련, 인터넷을 활용한 항공운송계약 체결과 관련한 소비자 보호제도 기반조성 등에 관한 사항들은 향후 추가 논의를 거쳐 도입될 필요가 있을 것으로 본다.

• 한국수자원학회논문집
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• 제54권spc1호
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• pp.1095-1105
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• 2021

기후변화에 따른 집중호우, 태풍 등의 발생빈도의 증가로 인하여 댐 운영의 고도화가 요구되고 있다. 일반적으로 댐 운영의 경우 강우예측, 강우-유출, 홍수추적 등 다양한 수리수문학적 요소들을 반영하여 수행되나 기 계획된 특정 규칙에 기반한 댐 운영 모형의 경우, 때때로 개별 모듈들의 불확실성과 복합적인 인자들로 인하여 댐의 방류량을 능동적으로 제어하는데 제약이 있을 수 있다. 본 연구는 남강댐 직하류 홍수피해 예방을 위하여 댐의 방류량 결정 등 효율적인 댐 운영을 지원하기 위해 딥러닝 기반 LSTM (Long Short-Term Memory) 모형을 구축하고, 선행시간별 댐직하류 수위예측 정확도를 분석하는 것을 목적으로 한다. LSTM 모형의 입력자료는 댐 운영에 사용되는 기초자료 및 하류 장대동 수위관측소의 수위 자료를 시 단위로 2009년부터 2021년 7월까지 수집하였다. 2009년부터 2018년 자료는 모형의 학습과 검증 및 2019년부터 2021년 7월 자료는 선행시간을 7개(1 h, 3 h, 6 h, 9 h, 12 h, 18 h, 24 h)로 구분하여 관측 수위와 예측 수위를 비교·분석하였다. 그 결과, 선행시간 1시간의 예측결과는 평균적으로 MAE가 0.01 m, RMSE가 0.015 m, NSE가 0.99 로 관측 수위에 매우 근접한 예측 결과를 나타내었다. 또한, 선행시간이 길어질수록 예측 정확도는 근소하게 감소하였지만, 관측 수위의 시간적 패턴을 유사하게 안정적으로 예측하는 것으로 분석되었다. 따라서 수리수문학적 비선형의 복잡한 자료간의 특징을 자동으로 추출하여 예측 자료를 생산하는 LSTM 모형은 댐 방류량 의사결정에 있어 활용이 가능할 것으로 판단된다.